A practical photocatalytic strategy for radical (deuterio)difluoromethylation using imidazolium reagents.

The difluoromethyl group (CFH) has garnered significant interest in medicinal chemistry owing to its unique biochemical and physicochemical properties. Its deuterated counterpart (CFD), building on the established utility of CFH, exhibits multifaceted potential for advancing biomedical research and therapeutic development. While the incorporation of the difluoromethyl group (CFH) into drug molecules has matured, efficient installation of its deuterated counterpart (CFD) remains a formidable challenge in medicinal chemistry.

Gastrointestinal perforation caused by a pancreaticojejunal anastomotic stent: a postoperative case report following pancreaticoduodenectomy.

Background: Placement of a support tube during pancreaticojejunal anastomosis has been shown to reduce the incidence of postoperative pancreatic fistula in patients with a non-dilated pancreatic duct. However, increasing reports of long-term complications, such as the presence of an indwelling support tube in the anastomosis, have raised concerns. Despite this, short-term complications, such as gastrointestinal perforation in the absence of tube displacement, remain relatively rare.

An interpretable machine learning model for predicting early liver metastasis after pancreatic cancer surgery.

Background: Liver metastasis is the most frequent site of distant metastasis in pancreatic ductal adenocarcinoma (PDAC), significantly contributing to poor prognosis. This study aims to develop and validate a machine learning (ML) model for predicting early liver metastasis (ELM) following pancreatic cancer surgery.

Method: This retrospective study included 407 pancreatic cancer patients who underwent surgery at the First Affiliated Hospital of Soochow University between January 2015 and December 2023, aiming to develop and validate a predictive model.

inositol affects the health, metabolome, and lactation performance of peripartum dairy cows.

Introduction: Yeast culture (YC) has become a crucial microecological preparation for regulating the ruminal environment and improving ruminant health. -inositol is an effective substance in YC, our study aimed to investigate whether -inositol can regulate metabolism and influence the health of dairy cows. Therefore, this study explored the effects of -inositol on the health, metabolome, and lactation performance of peripartum dairy cows using both and models.

Nickel-embedded three-in-one pyridyl-quinoline-linked covalent organic framework photocatalysts for universal C(sp) cross-coupling reactions.

Metallaphotocatalysis, integrating interlocked photocatalytic cycles and transition-metal catalysis, harmonizes the ground state and excited state reactivities, enabling cross-couplings under mild conditions and expanding the scope of accessible transformations. However, homogeneous dual metallaphotocatalysts often suffer from limitations such as low catalyst stability, high metal loading, and challenges in catalyst recycling. In this study, we engineered a class of nickel-incorporated pyridyl-quinoline-linked covalent organic frameworks (Ni-PQCOFs) serving as robust and efficient heterogeneous metallaphotocatalysts.

Hepatitis E virus infection and renal injury in non-immunocompromised host: clinical investigation and rabbit model study.

Background: Hepatitis E virus (HEV)-associated renal injury is mainly reported in immunocompromised patients. Here we investigated HEV-associated renal injury in non-immunocompromised acute hepatitis E (AHE) patients and rabbits.

Methods: A total of 35 non-immunocompromised AHE patients were tested for kidney function parameters and HEV markers.

Tomatidine Ameliorates Diabetes-Induced Cognitive Impairment and Tau Hyperphosphorylation Through the AMPK-TFEB Pathway.

Diabetes is associated with an increased risk of cognitive impairment. Autophagy-lysosomal dysfunction is a key feature of diabetes that contributes to dementia. Transcription factor EB (TFEB) is a master regulator of the autophagy-lysosomal function.

Multidimensional Assessment of Psychiatric Adverse Events Related to Proton Pump Inhibitors: A Real-World, Pharmacovigilance Study.

Introduction: Limited research has been conducted on the association between proton pump inhibitors (PPIs) use and psychiatric adverse events (AEs), leaving the understanding of PPIs-related psychiatric AEs in real-world settings unclear.

Objectives: We aim to identify psychiatric AEs highly relevant to five commonly prescribed PPIs and to delve into the clinical characteristics of the population experiencing psychiatric AEs, as well as the time-to-onset pattern of the reported AEs.

Methods: We performed disproportionality analysis to evaluate the PPI-related psychiatric AEs risk signal using data from the FDA adverse event reporting system.

Exosomes enriched with miR-31-3p from keratinocytes under oxidative stress promote vitiligo progression by destructing melanocytes and activating CD8 T cells.

Vitiligo is a skin disease characterized by the destruction of epidermal melanocytes due to oxidative stress. Keratinocytes are the main responder to oxidative stress and facilitate melanocyte loss by inducing melanocyte death and recruiting antigen-specific CD8 T cell to skin to destroy melanocytes. It has been proved that keratinocytes secrete functional exosomes, but the role of exosomes secreted from keratinocytes under oxidative stress in vitiligo pathogenesis is unknown.

A new metriacanthosaurid theropod dinosaur from the Middle Jurassic of Yunnan Province, China.

Metriacanthosaurid theropods represent a basal-branching lineage of tetanurans. Members of this clade are mainly medium to large-sized and lived in Laurasia during the Middle Jurassic to the Early Cretaceous. In this clade, , , and from the Late Jurassic are well represented by the nearly complete specimens, but the incompleteness of Middle Jurassic taxa hinders our knowledge of the origin and early evolution of Metriacanthosauridae.

Halogen-atom transfer of fluoroiodomethane for photoredox-catalyzed fluoromethylation.

This study presents a photoredox-catalyzed and aminoborane-mediated halogen-atom transfer (XAT) approach for the activation of fluoroiodomethane, facilitating the generation of monofluoromethyl radicals. The methodology described herein outlines an economical and versatile strategy for the synthesis of monofluoromethyl compounds by fluoroiodomethane.

Ferritinophagy: multifaceted roles and potential therapeutic strategies in liver diseases.

Ferritinophagy, the selective autophagic degradation of ferritin to release iron, is emerging as a critical regulator of iron homeostasis and a key player in the pathogenesis of various liver diseases. This review comprehensively examines the mechanisms, regulation, and multifaceted roles of ferritinophagy in liver health and disease. Ferritinophagy is intricately regulated by several factors, including Nuclear Receptor Coactivator 4 (NCOA4), Iron regulatory proteins and signaling pathways such as mTOR and AMPK.

Cascade Radical Cyclization of Propargylamines for Functionalized 3-Arylthioquinoline Formation.

A novel and efficient strategy for the direct synthesis of 3-arylthioquinoline derivatives via radical induced tandem cyclization of propargylamines with diaryl disulfides was developed. This protocol undergoes a cascade sulfuration/ cyclization/ oxidation/ aromatization pathway to afford the desired products in a broad substrate scope using readily available starting materials under mild conditions. Based on this strategy, we further modified 3-arylquinolines to obtain two novel deep blue fluorescent molecules, QLSCz and QLSTCz, with good optical properties through two-step synthesis by oxidation and electron donor modification.

Multifunctional self-healing and pH-responsive hydrogel dressing based on cationic guar gum and hyaluronic acid for on-demand drug release.

Pathogen invasion and persistent inflammatory storms caused by bacterial infections are the main challenges to the healing of infected wounds. Herein, this study proposed a pH-responsive polysaccharide hydrogel dressing (CG-HA) composed of cationic guar gum (CG) and hyaluronic acid (HA). Additionally, Zn and ferulic acid (FA)/β-cyclodextrin (β-CD) inclusion complexes (FA/β-CD) were co-introduced into the CG-HA hydrogel to form the desired FA/β-CD@CG-HA-Zn hydrogel.

C4d immunostaining facilitates differentiation of pemphigoid nodularis from prurigo nodularis.

Pemphigoid nodularis and prurigo nodularis have similar clinicopathological features and are difficult to distinguish. Enzyme-linked immunosorbent assays (ELISA) and direct/indirect immunofluorescence can support the diagnosis of pemphigoid nodularis, but sometimes show contradictory results or are unavailable. We aimed to develop a practical method for differentiating between pemphigoid nodularis and prurigo nodularis.

Reductive sulfinylation by nucleophilic chain isomerization of sulfonylpyridinium.

Sulfur-containing units are fundamental components widely found in bioactive compounds, prompting notable efforts toward developing synthetic methodologies for incorporating sulfur functionality into organic precursors. The synthesis of sulfinate esters and sulfinamides has garnered significant interest owing to their immense potential for applications, especially in drug development. However, most existing synthetic protocols suffer from some limitations.

Near-infrared light-enhanced polydopamine-based multifunctional nanoparticles for combination of chemodynamic and NO gas therapy in the treatment of osteosarcoma.

The emergence of treatment approaches that integrate conventional phototherapy with additional adjuvant treatments has garnered considerable interest. In this study, we proposed a complex utilizing Fe and polydopamine as a carrier, co-loaded with the nitric oxide initiator L-arginine (L-Arg) and the photosensitizer indocyanine green (ICG), as a potential strategy for the "photothermal/photodynamic/Chemodynamic/nitric oxide gas therapy" of osteosarcoma. Nanoparticles have the ability to undergo degradation within the mildly acidic conditions present in the tumor microenvironment.

An improved invagination pancreaticojejunostomy technique associated with a lower incidence of pancreatic fistula: A single-center study.

Purpose: This study compared the incidence of postoperative pancreatic fistula (POPF) between standard invagination pancreaticojejunostomy (PJ) and an improved PJ technique after pancreaticoduodenectomy and evaluated the clinical utility of the improved PJ procedure.

Methods: Clinical and postoperative data of 363 patients who underwent pancreaticoduodenectomy at the First Affiliated Hospital of Soochow University from February 2018 to October 2021 were analyzed retrospectively. In our cohort, 155 patients underwent the improved PJ technique (group A), and 208 underwent standard invagination PJ (group B).

Dynamic location model for designated COVID-19 hospitals in China.

In order to effectively cope with the situation caused by the COVID-19 pandemic, cases should be concentrated in designated medical institutions with full capability to deal with patients infected by this virus. We studied the location of such hospitals dividing the patients into two categories: ordinary and severe. Genetic algorithms were constructed to achieve a three-phase dynamic approach for the location of hospitals designated to receive and treat COVID-19 cases based on the goal of minimizing the cost of construction and operation isolation wards as well as the transportation costs involved.

Preparation and performance control of ultra-low near-infrared reflectivity coatings with super-hydrophobic and outstanding mechanical properties.

The development of ultra-low near-infrared reflectivity coatings with outstanding engineering properties remains a challenge in laser stealth materials research. Herein, we reported a laser stealth coating with outstanding mechanical properties, super-hydrophobicity, and an ultra-low near-infrared reflectivity for 1.06 μm wavelength.

Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis.

Chemoresistance is the primary reason for poor prognosis in patients with pancreatic cancer (PC). Recent studies have indicated that ferroptosis may improve chemoresistance, but the underlying mechanisms remain unclear. In this study, significant upregulation of heat shock protein 90α (Hsp90α) expression is detected in the peripheral blood and tissue samples of patients with chemoresistant PC.

Alterations in genes involved in glycolysis and hypoxia affect the prognosis of pancreatic cancer.

Purpose: To construct a prognostic model for pancreatic cancer based on glycolytic and hypoxic metabolic subtypes. To analyze the biological characteristics of these subtypes and explore potential therapeutic options.

Methods: We obtained mRNA, simple nucleotide variation (SNP), and clinical data for pancreatic cancer from The Cancer Genome Atlas (TCGA).

Pyridinium-Based Fluorosulfonamide Reagents Enabled Photoredox-Catalyzed Radical Fluorosulfonamidation.

Sulfamoyl fluorides, as a crucial building block of SuFEx, have garnered extensive research interest due to their unique properties. However, the direct radical fluorosulfonamidation process for the synthesis of sulfamoyl fluorides has been overlooked. We herein disclosed a practical procedure for constructing a redox-active fluorosulfonamide radical reagent named fluorosulfonyl--pyridinium tetrafluoroborate (PNSF) from SOF.

Electrochemical deoxygenative amination of stabilized alkyl radicals from activated alcohols.

Alkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions.