Sex-dependent behavioral and neuronal alterations in the F2 generation of a neurodevelopmental mouse model for schizophrenia.

Schizophrenia is a complex neurodevelopmental disorder influenced by genetic and environmental factors. Using a maternal methylazoxymethanol acetate (MAM) exposure model, we investigated behavioral, neuronal, and glial alterations in the F2 generation to explore the intergenerational effects of prenatal neurodevelopmental disruption. Our study demonstrates that prenatal MAM exposure induces the transgenerational transmission of schizophrenia-like phenotypes in F2 offspring.

Tropisetron modulates the firing activity of pyramidal and fast-spiking hippocampal CA1 neurons in a mouse model of Alzheimer's disease.

Background: Hyperexcitability of hippocampal CA1 pyramidal neurons contributes to cognitive deficits in Alzheimer's disease (AD). Tropisetron, a 5-HT receptor antagonist and partial α7 nicotinic acetylcholine receptor (α7nAChR) agonist, has shown neuroprotective effects, but its impact on hippocampal neuronal excitability remains unclear.

Objective: This study aimed to examine the effects of tropisetron on CA1 pyramidal neurons and fast-spiking interneurons in wild-type (WT) and hAPP-J20 AD model mice, a transgenic model for early-onset AD.

Early prediction of sepsis-induced cardiorenal syndrome: superiority of myoglobin over troponin I.

Backgrounds: This study aimed to perform risk stratification for sepsis-induced cardiorenal syndrome (CRS) and develop an early prediction model enabling the timely identification of high-risk patients within the first 24 h of admission.

Methods: This study retrospectively extracted septic patient data from the Shanghai Tongji Hospital between 2015 and 2020, with CRS occurrence set as the outcome measure. The Least Absolute Shrinkage and Selection Operator regression followed by multivariable logistic regression was applied to screen the candidate variables and develop the prediction model.

IRAS/Nischarin is associated with attenuated deficit of cognition during morphine abstinence in mice.

Opioid withdrawal leads to impairments in cognitive functions that are now recognized as a major negative consequence and a key target for intervention in drug addiction. Imidazoline receptor antisera-selected (IRAS) protein is a candidate for the I1 imidazoline receptor. Studies have revealed that IRAS plays an important part in the development of morphine tolerance and dependence.

Factors influencing the occurrence of postoperative kinesiophobia in patients with lumbar disc herniation.

This study was intended to analyze the potential risk factors associated with postoperative onset of kinesiophobia in patients with lumbar disc herniation and to construct a predictive model using logistic regression and decision tree methods. We retrospectively evaluated the clinical data of 342 lumbar disc herniation patients who underwent surgical treatment between January 2021 and December 2023, grouped them according to the occurrence of postoperative kinesiophobia, applied multifactorial logistic regression to determine the main influencing factors, and constructed a prediction model with the help of SPSS Modeler software to further evaluate its predictive effect. The study found that the incidence of kinesiophobia was 37.

Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease.

Objective: Kidney fibrosis is a key pathological feature in the progression of chronic kidney disease (CKD), traditionally diagnosed through invasive kidney biopsy. This study aimed to develop and validate a noninvasive, multi-center predictive model incorporating machine learning (ML) for assessing kidney fibrosis severity using biochemical markers.

Methods: This multi-center retrospective study included 598 patients with kidney fibrosis from four hospitals.

A new metriacanthosaurid theropod dinosaur from the Middle Jurassic of Yunnan Province, China.

Metriacanthosaurid theropods represent a basal-branching lineage of tetanurans. Members of this clade are mainly medium to large-sized and lived in Laurasia during the Middle Jurassic to the Early Cretaceous. In this clade, , , and from the Late Jurassic are well represented by the nearly complete specimens, but the incompleteness of Middle Jurassic taxa hinders our knowledge of the origin and early evolution of Metriacanthosauridae.

[Effect of different acupuncture and moxibustion methods on muscle inflammation and muscle atrophy related proteins in the gastrocnemius of rats with knee osteoarthritis].

Objectives: To compare the effects of filiform acupuncture, electroacupuncture (EA) and moxibustion on gastrocnemius inflammation and muscle atrophy related proteins in rats with knee osteoarthritis (KOA).

Methods: A total of 40 Wistar rats were randomly divided into blank control, model, filiform acupuncture, EA and moxibustion groups, with 8 rats in each group. The KOA model was established by intra-articular injection of sodium iodate into the right knee joint in the model group and treatment groups (filiform acupuncture, EA and moxibustion groups).

The superiority of veno-arterial over veno-venous extracorporeal membrane oxygenation for operative support of lung transplantation.

Background: Veno-arterial (V-A) and veno-venous (V-V) extracorporeal membrane oxygenation (ECMO) are crucial support modalities during lung transplantation, yet their comparative effectiveness remains unclear.

Methods: We conducted an 8-year retrospective analysis of 62 lung transplant recipients who received intraoperative ECMO (29 V-A, 33 V-V). Baseline characteristics, surgical parameters, and clinical outcomes were compared.

Effect of early essential newborn care on breastfeeding and outcomes of mothers/newborns post-cesarean section: a randomized controlled trial in China.

Background: The implementation of early essential newborn care (EENC) is important to maternal and neonatal health. However, few studies have conducted a complete procedure of EENC in cesarean section. This study aimed to systematically evaluate the effects of EENC during and after cesarean section.

Elevated Serum and Urinary Secreted Protein Acidic and Rich in Cysteine Levels are Novel Biomarkers of Kidney Fibrosis Severity.

Background: Interstitial fibrosis is the primary determinant of the progression of chronic kidney disease (CKD), and noninvasive identification of interstitial fibrosis is a major challenge. We aimed to explore the diagnostic value of secreted protein acidic and rich in cysteine (SPARC) in serum and urine in kidney fibrosis.

Methods: Single-cell transcriptome analysis was used to measure SPARC expression in healthy reference kidneys and those of patients with CKD.

Resting-state functional magnetic resonance imaging and support vector machines for the diagnosis of major depressive disorder in adolescents.

Background: Research has found that the amygdala plays a significant role in underlying pathology of major depressive disorder (MDD). However, few studies have explored machine learning-assisted diagnostic biomarkers based on amygdala functional connectivity (FC).

Aim: To investigate the analysis of neuroimaging biomarkers as a streamlined approach for the diagnosis of MDD in adolescents.

Construction and validation of a nomogram prediction model for postoperative recurrence of lumbar disc herniation treated with percutaneous laminectomy.

The aim was to investigate the independent risk factors for postoperative recurrence of lumbar disc herniation treated by percutaneous intervertebral laminectomy, and to establish a nomogram prediction model accordingly. Data on patients with lumbar disc herniation were collected from January 2018 to December 2023 in our hospital, and single-factor and multifactorial logistic regression analyses were used to determine the independent risk factors for postoperative recurrence of lumbar disc herniation and establish the corresponding nomogram. The receiver operating characteristic curves were plotted the area under the curve was calculated, and the calibration curves and decision curves were plotted to evaluate the model performance.

[DNA barcode screening, identification of germplasm resources, and analysis of genetic diversity of Anemarrhena asphodeloides].

Anemarrhena asphodeloides is a common medicinal material used in clinical prescriptions and Chinese patent medicine. In this study, the Illumina platform was used to obtain the chloroplast genome sequences of seven kinds of A. asphodeloides from different areas.

The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3.

Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid peroxidation. It may be involved in atherosclerosis development. Products of phospholipid oxidation play a key role in atherosclerosis.

D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophrenia.

The hypothesis of N-methyl-D-aspartate receptor (NMDAR) dysfunction for cognitive impairment in schizophrenia constitutes the theoretical basis for the translational application of NMDAR co-agonist D-serine or its analogs. However, the cellular mechanism underlying the therapeutic effect of D-serine remains unclear. In this study, we utilize a mouse neurodevelopmental model for schizophrenia that mimics prenatal pathogenesis and exhibits hypoexcitability of parvalbumin-positive (PV) neurons, as well as PV-preferential NMDAR dysfunction.

PPARα is involved in high-fat diet-induced risk avoidance impairment the regulation of hippocampal BDNF.

Risk avoidance behaviors are essential for survival. "Uncontrollable" risk-taking behaviors in animals or humans may have severe adverse consequences. In humans, a large proportion of psychiatric disorders are accompanied by impairments in risk avoidance.

The effects of serotonergic psychedelics in synaptic and intrinsic properties of neurons in layer II/III of the orbitofrontal cortex.

Rationale: Serotonergic psychedelics show promise in the treatment of psychiatric disorders, including obsessive-compulsive disorder. Dysfunction of the orbitofrontal cortex (OFc) has been implicated in the pathophysiology of compulsive behavior, which might be a key region for the efficacy of psychedelics. However, the effects of psychedelics on the neural activities and local excitation/inhibition (E/I) balance in the OFc are unclear.

Lateral septal nucleus, dorsal part, and dentate gyrus are necessary for spatial and object recognition memory, respectively, in mice.

Introduction: Cognitive impairment includes the abnormality of learning, memory and judgment, resulting in severe learning and memory impairment and social activity impairment, which greatly affects the life quality of individuals. However, the specific mechanisms underlying cognitive impairment in different behavioral paradigms remain to be elucidated.

Methods: The study utilized two behavioral paradigms, novel location recognition (NLR) and novel object recognition (NOR), to investigate the brain regions involved in cognitive function.

[Effects of different acupuncture and moxibustion methods on articular cartilage morphology and NF-κB p65/NLRP3 pathway in rats with knee osteoarthritis].

Objective: To compare the effects of filiform needling, electroacupuncture (EA) and moxibustion on articular cartilage morphology and nuclear transcription factor-κB (NF-κB) p65/ Nod-like receptor protein 3 (NLRP3) pathway in rats with knee osteoarthritis (KOA).

Methods: Wistar rats were randomly divided into blank control， model, filiform needling, EA and moxibustion groups, with 8 rats in each group. The KOA model was established by injecting sodium iodoacetate into the right knee cavity.

The high frequency oscillation in orbitofrontal cortex is susceptible to phenethylamine psychedelic 25C-NBOMe in male rats.

Serotoninergic psychedelics induced extensive alterations in perception and cognition, which has been attributable to its disruptive effect on oscillatory rhythms of prefrontal cortex. However, there is a lack of information how serotoninergic psychedelics affect the intra-prefrontal network, which intrinsically interact to accomplish perceptual processing. Uncovering the altered neural network caused by psychedelics helps to understand the mechanisms of their psychoactive effects and contribute to develop biological markers of psychedelic effects.

[Effect of Silencing on Mitophagy in Leukemia Cells K562].

Objective: To explore the effect of on mitophagy in leukemia cells K562.

Methods: K562 cells were induced with different concentrations of mitophagy inducer carbonylcyanide-m-chlorophenylhydrazone (CCCP) for 6, 12 and 24 hours, and the cell viability was detected by the CCK-8 assay. K562 cells were divided into NC, -siRNA, -siRNA+CCCP, and CCCP group, while Western blot was used to detect the expression of UVRAG protein.

IRAS/Nischarin modulates morphine reward by glutamate receptor activation in the nucleus accumbens of mouse brain.

The I imidazoline receptor and its candidate protein imidazoline receptor antisera-selected (IRAS)/Nischarin are linked to μ opioid receptor (MOR) functions associated with MOR trafficking. We previously demonstrated that IRAS may play an important role in the development of morphine tolerance and physical dependence in vivo. However, the effects of IRAS on morphine psychological dependence are not fully understood.