Systemic immune-inflammation index and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis.

Background: The systemic immune-inflammation index (SII) has been a marker and prognostic indicator of several diseases. However, its utility in pregnancy is unknown. Herein, we reviewed the evidence on the ability of SII to predict gestational diabetes mellitus (GDM) and preeclampsia (PE).

[Expression of Concern] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues.

Following the publication of this paper, for the western blots shown in Fig. 1A, where the expression levels of salt‑inducible kinase 1 were detected in ovarian cancer tissues, it was drawn to the Editor's attention by a concerned reader that the β‑actin loading controls for patients 4, 6 and 7 were strikingly similar in appearance. Moreover, several of the protein bands in this figure were strikingly similar to data which subsequently appeared in another paper written by different authors at different research institutes that was published in the journal , although this paper has since been retracted.

Solar-Driven Direct Lithium Extraction from Low-Quality Brines.

Owing to the crucial role in energy transformation for decarbonization, sustainable lithium (Li) supply has become growingly critical. Low-quality brines hold vast potential due to infinite reserves and diverse distribution but desire green and cost-effective extraction techniques against low Li concentrations and high magnesium-to-lithium ratios. Solar-driven direct lithium extraction (SDLE) systems combining conventional evaporation and DLE techniques can overcome the present challenges of Li extraction, promising to advance the exploitation of low-quality brines while simultaneously producing fresh water.

Targeting HDAC8 sensitizes tyrosine kinase inhibitors in the elimination of B-cell acute lymphoblastic leukemia cells through degradation of HIF-1α.

Tyrosine kinase inhibitors (TKIs) only partially inhibit the growth of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph B-ALL) cells, and often lead to rapid relapse. Therefore, it is essential to elucidate the mechanisms of resistance and develop novel treatment strategies. Histone deacetylases (HDACs) are often dysregulated in hematological malignancies, and many HDAC inhibitors have shown potent antitumor activities.

Three-dimensional cell sheet model improves prediction accuracy of osteogenic potential for biodegradable magnesium-based metals.

Biodegradable metals have been increasingly utilized clinically due to their biosafety and pro-osteogenic properties. However, conventional monolayer cell-based preclinical safety evaluation methods based on ISO10993-5 consistently indicate significant cytotoxicity that contradicts outcomes. In this study, we aimed to establish an evaluation model that better correlates with performance.

Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis.

Thyroid cancer is a common endocrine malignancy associated with various inflammatory factors. This research aimed to explore the causal relationships between 41 inflammatory factors and the risk of thyroid cancer using Mendelian randomisation (MR) analysis. MR analysis was performed using genetic data from two publicly available European genome-wide association studies (GWAS).

Impact assessment of the ophthalmology discipline construction project at Tianjin Medical University Eye Hospital.

Objectives: Research impact is an emerging measure of research achievement alongside traditional academic outputs such as publications. We present the results of applying the Framework to Assess the Impact from Translational Health Research (FAIT) to the ophthalmology discipline construction project at Tianjin Medical University Eye Hospital.

Methods: Data were gathered via in-depth interviews and document analysis to report on the three major FAIT methods: the Payback Framework, an assessment of costs against monetized outcomes and a narrative account of the impact generated from ophthalmology discipline construction project.

Enhanced enzyme stability at the interphase of water-oil for continuous-flow olefin epoxidation.

The practical applications of enzymes often require their immobilization for multiple recycling or long-term running. However, practically efficient enzyme immobilization methods are lacking. Herein, we present an enzyme immobilization approach by engineering a porous "interphase" between water and oil around the surfaces of Pickering emulsion droplets.

Research progress of dissolving microneedles in the field of component administration of traditional Chinese medicine.

In recent years, dissolving MNS technology, as an emerging transdermal drug delivery technology, has shown unique advantages and broad application prospects in the fields of transdermal drug delivery, transcutaneous immunity, beauty and skin care, food testing, and disease diagnosis. The active ingredients of traditional Chinese medicine have shown remarkable efficacy in treating various diseases. However, the mode of administration of traditional Chinese medicine (TCM) limits its potential for clinical application and promotion to a certain extent.

Machine learning coupling microbial succession to decipher gas stripping-reinforced sulfate reduction for hydrogen sulfide removal.

Machine learning-assisted gas stripping optimization is showing great potential of removing hydrogen sulfide (HS) in the acidogenesis phase to enhance sulfate reduction. Herein, response surface methodology (RSM) and artificial neural network (ANN) were employed unprecedentedly to model the sulfate reduction rate after removal of HS. Under the COD/SO ratio of 8.

Community Structure, Growth-Promoting Potential, and Genomic Analysis of Seed-Endophytic Bacteria in .

is an important plant in desert ecosystems. Its seed-endophytic bacteria may play a critical role in plant growth and environmental adaptation processes. This study systematically analyzed the community composition and potential plant growth-promoting (PGP) functions of seed-endophytic bacteria associated with .

Ultrasound-assisted extraction of neuroprotective antioxidants from Ganoderma lucidum.

Ganoderma lucidum (GL), a traditional Chinese medicinal fungus, is rich in triterpenoids and phenols with antioxidant properties. Nevertheless, current extraction techniques limit the efficient utilization of bioactive components from GL. This study aims to optimize the extraction process of triterpenoids and phenols, enhance their antioxidant activities, and assess their neuroprotective activities against oxidative damage.

Shared diagnostic genes and potential mechanisms between asthma and lung cancer revealed by integrated transcriptomic analysis and machine learning.

Lung cancer, a severe malignancy with poor prognosis, poses a formidable public health challenge. Beyond conventional risk factors such as smoking, evidence suggests that chronic respiratory diseases also contribute to its development. Among these, asthma, the second most prevalent chronic respiratory condition, is recognized as a risk factor for lung cancer.

Irisin improves acute kidney injury induced by ischemia-reperfusion through targeting energy metabolism reprogramming.

The kidney possesses a highly complex reabsorption function, with tubular epithelial cells (TECs) being the primary functional units. The TECs mainly rely on fatty acid oxidation (FAO) for energy supply. FAO is hindered during ischemia-reperfusion (I/R)-induced acute kidney injury (AKI), leading to impairments in oxidative phosphorylation.

A Patient Charter to Improve Care for Hepatocellular Carcinoma.

Purpose: To establish a patient charter that articulates the principles of quality care for individuals living with hepatocellular carcinoma (HCC), aiming to improve patient outcomes and survival rates globally.

Methods: A multidisciplinary group comprising healthcare professionals, patient advocacy representatives, and policymakers convened to identify the critical areas of unmet need in HCC care. The group shared patient experiences, barriers, and insights - particularly with input from Patient Advocacy Groups (PAGs) - to better understand the challenges faced by patients.

Prevalence and correlates of anxiety disorders and depressive disorders among older adults with non-communicable diseases: results from China Mental Health Survey.

Background: Anxiety disorders (ADs) and depressive disorders (DDs) are prevalent among older adults with non-communicable diseases (NCDs), yet nationally representative epidemiological data from China remain limited. This study, as a part of the 2013-2015 China Mental Health Survey (CMHS), aimed to assess the prevalence of ADs and DDs and identify associated factors among older adults with NCDs in China.

Method: A total of 5,428 patients aged 60 years and above with reported NCDs were selected from the CMHS.

Astrocytes expressing mutant hnRNPA1 induce non-cell-autonomous motor neuron death.

Pathogenic mutation of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is causative to amyotrophic lateral sclerosis (ALS). Neuron death resulting from pathogenic hnRNPA1 may not require its presence across all pertinent cells types, including neurons, glia, and muscles. Rather, the exclusive presence of pathogenic hnRNPA1 in a specific cell type, such as astrocytes, may suffice to substantially alter cellular functions.

Practical strategies for film-side sowing technology to enhance root lodging resistance and grain yield in spring maize on the loess plateau.

In the spring maize cropping system, film-side sowing technology can improve crop yield stability and film recycling in the dry farming zone by optimizing the film cover pattern, resulting in a synergistic effect of moisture conservation, yield enhancement, and on-farm film residue management. However, the effect on the resistance to lodging is not clear. Consequently, a two-year agricultural trial was designed to evaluate how distinct ground-cover cultivation strategies influence root architecture, biomechanical performance, lodging incidence, grain production efficiency, and economic profitability.

Perceived quality symbols in short-video social media drive ski tourism behavior.

The rise of short-video social media platforms has transformed consumer decision-making in tourism, particularly in high-risk activities such as ski tourism. This study, grounded in semiotic theory, explored the influence of perceived quality symbols on short-video content on tourists' behavioral motivation, risk perception, and intention to participate in ski tourism. Using a mixed-methods approach, qualitative analysis identified key symbolic dimensions-environmental quality, informational quality, interactive quality, vlogger quality, and service quality-while quantitative analysis validated the "perceived quality symbol-motivation-behavior" model.

Clinicians' experience on the effectiveness of pharmacotherapy in patients with first-episode depression: a randomized controlled trial based on pharmacogenomics.

Background: Due to differences in drug efficacy, the risk of adverse reactions, and individual differences between patients, clinicians face significant challenges in terms of selecting drugs for the treatment of depression. However, no previous studies have compared the efficacy of antidepressant treatments between psychiatrists with different levels of experience based on pharmacogenomics approach.

Methods: A total of 178 patients were recruited and randomly assigned to pharmacogenomics-guided treatment group or regular treatment control group.

ADSC-EVs Activate Autophagy Via the AKT/FOXO1 Pathway to Inhibit Tendon Fibrosis.

Background: Extracellular vesicles (EVs) from adipose-derived mesenchymal stem cells (ADSCs) play an important role in tendon healing and regeneration. However, the role of EVs in regulating tendon fibrosis during autophagy has not previously been reported.

Purpose: To investigate the effect of EVs from ADSCs (ADSC-EVs) on the autophagy-mediated regulation of tendon fibrosis.

GA-HIDMS-PSO-BPNN Model-Based Suppression of Cross-Interference in Absorption Spectra for Dual-Gas Sensing.

Cross-interference from overlapping absorption spectra of different gases significantly limits the precision and stability of gas concentration detection using traditional absorption spectroscopy. This study proposes a novel model integrating the global search capability of the genetic algorithm (GA), the local optimization ability of the heterogeneous improved dynamic multiswarm particle swarm optimization (HIDMS-PSO), and the nonlinear modeling of the backpropagation neural network (BPNN), termed the GA-HIDMS-PSO-BPNN model, to solve the cross-interference problem in tunable diode laser absorption spectroscopy (TDLAS) for a dual-gas sensor detecting CH and CO. In a 1500 s stability test, the model demonstrates reliable performance, achieving standard deviations of 24.

Clinical efficacy of human biological dressing transplantation for refractory wounds in middle-aged and elderly patients.

Objectives: To evaluate the clinical efficacy of human biological dressing (human acellular dermal matrix) transplantation in the management of refractory wounds among middle-aged and elderly patients.

Methods: A retrospective observational study was conducted involving 104 middle-aged and elderly patients (74 males, 30 females; aged 56-95 years) with refractory wounds treated at the First Affiliated Hospital of Wenzhou Medical University from January 2023 to December 2024. Following debridement, wound areas ranged from 1.

Association of sugar-sweetened, artificially sweetened, and unsweetened tea with all-cause and cause-specific mortality: a prospective cohort study in UK biobank.

Although previous observational studies have revealed a significant relationship between tea consumption and reduced mortality risk, the associations of adding sugar or alternative sweeteners to tea with mortality risks are still largely unknown. This study aimed to evaluate the associations of consumption of unsweetened, sugar-sweetened, and artificially sweetened tea with all-cause and cause-specific mortality. A total of 180,344 participants in the UK Biobank were eligible for this study.