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In recent years, dissolving MNS technology, as an emerging transdermal drug delivery technology, has shown unique advantages and broad application prospects in the fields of transdermal drug delivery, transcutaneous immunity, beauty and skin care, food testing, and disease diagnosis. The active ingredients of traditional Chinese medicine have shown remarkable efficacy in treating various diseases. However, the mode of administration of traditional Chinese medicine (TCM) limits its potential for clinical application and promotion to a certain extent. The combination of dissolving MNS technology and transdermal administration of traditional Chinese medicine can not only simplify the application process of traditional Chinese medicine, but also promote the modernization process of traditional Chinese medicine and realize the "reduction," "toxicity reduction," and "efficiency increase" of traditional Chinese medicine. This article reviews the advances in the preparation and application research of dissolving MNS in traditional Chinese medicine. It provides a reference for further exploring the development and clinical application of efficient soluble MNS in traditional Chinese medicine.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380715 | PMC |
http://dx.doi.org/10.3389/fphar.2025.1623476 | DOI Listing |
Chem Biodivers
September 2025
Chongqing Key Laboratory of Development and Utilization of DaoDi Medicinal Materials in Three Gorges Reservoir Area, Chongqing Three Gorges Medical College, Chongqing, P. R. China.
Three new steroidal saponins, kingianoside L-N (1-3), whose structures were elucidated through comprehensive spectroscopic analysis, and 15 known compounds (4-18) were isolated from Polygonatum kingianum var. grandifolium, a source of the traditional antihyperglycemic medicine Polygonati rhizome. The effects of compounds 1-13 on α-glucosidase activity were evaluated in vitro.
View Article and Find Full Text PDFJ Med Chem
September 2025
School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, PR China.
The prevalence of AGA is continuously rising, with an earlier age of onset. Currently, only minoxidil and finasteride have received FDA approval for the treatment of AGA, inadequately addressing the pressing clinical needs. Recently, the involvement of the Wnt/β-catenin signaling pathway in AGA has attracted increased research interest.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
September 2025
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Ulcerative colitis (UC) is a serious inflammatory bowel disease with a significantly increasing incidence globally. Current treatment options often exhibit unstable efficacy and notable side effects, making the exploration of alternative therapies particularly important. Peucedanum praeruptorum Dunn, a traditional Chinese medicine, contains various bioactive compounds, among which praeruptorin A (PA) has garnered attention for its anti-inflammatory potential.
View Article and Find Full Text PDFCrit Rev Food Sci Nutr
September 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
Natural products have emerged as a vital source of active ingredients in medicine, food, and cosmetics due to their unique biological activities, safety profiles, and sustainability. However, most bioactive compounds in natural products are intensely bitter, limiting their use in pharmaceuticals and foods. The bitter taste attributes vary markedly among different compound classes, predominantly due to their structural characteristics.
View Article and Find Full Text PDFXenobiotica
September 2025
Department of Pharmacy, Binhai County People's Hospital, Yancheng 224500, China.
To study the effects of calycosin on palmitic acid-induced HepG2 cells, as well as the potential mechanisms of action. Potential targets of calycosin for the alleviation of insulin resistance were predicted by network pharmacology. Glucose concentration in the culture medium was determined by the GOD-POD method.
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