Functional characterization of odorant binding proteins in Pharsalia antennata provides insights into diverse binding properties and the importance of C-terminal residues.

The cerambycid beetles are important components in the terrestrial ecosystem as they play a dual role in both degrading dying trees and killing healthy plants. The factors including human activity, habitat contraction, climate changes and pesticide use have been shaping the adaptation of beetles to host plants and the environment. As suggested in research on the functions of beetles' olfactory proteins, odorant binding proteins (OBPs) have been found to be involved in insecticide resistance other than chemoreception.

Gender-specific assessment of lipid profiles correlation with serum uric acid in non-dialysis chronic kidney disease patients: Prospective observational cross-sectional study.

Background: Serum uric acid (SUA) serves as an important marker for assessing kidney function in chronic kidney disease (CKD) patients. Emerging reports suggest a potential relationship between SUA and dyslipidemia. The study aims to examine the correlation between SUA and lipid profiles in CKD population.

The effects of Shenkang suppository on kidney function and gut microbiota in nondialysis patients with chronic kidney disease stages 3-4: A randomized controlled trial.

Background: Chronic kidney disease (CKD) patients have high prevalence and mortality rates; however, current treatment options remain limited. The Shenkang suppository (SKS) is a traditional Chinese medicine used in the clinical management of CKD. Increasing evidence suggests a close relationship between the gut microbiome and CKD.

Advantages and effectiveness of AI three-dimensional reconstruction technology in the preoperative planning of total hip arthroplasty.

In order to explore the application effect of artificial intelligence (AI) 3D reconstruction technology in total hip arthroplasty (THA), this study included a total of 109 patients with unilateral femoral head ischemic necrosis. According to the preoperative planning method, they were divided into the AI group (n = 55) and the 2D group (n = 54). The operating time, intraoperative bleeding, length of hospital stay length, prosthesis conformity, imaging indicators and Harris scores.

Metal-Organic Framework-Based Self-Powered Chemodynamic Therapy Nanosystem: CaO@PCN-222(Fe) and Its Mixed Matrix Membranes for Promoting Infected Wound Healing.

Bacterial infections pose an increasing threat to human health. Chemodynamic therapy (CDT), which utilizes nanozymes to catalyze HO into highly toxic hydroxyl radicals (·OH), offers a promising disinfection strategy because of its high efficacy, broad-spectrum antibacterial activity, and low risk of inducing drug resistance. Herein, we developed a self-powered CDT nanocomposite, CaO@PCN-222(Fe), via a facile one-pot synthesis for wound disinfection.

Identifying potential biomarkers in the hippocampus of chronic fatigue syndrome rats treated with moxibustion at Zusanli (ST36): a proteomics study.

Objective: To observe the effects of moxibustion at Zusanli (ST36) on rats with chronic fatigue syndrome (CFS) and to analyze the mechanisms of moxibustion through hippocampal Proteomics.

Methods: Male Sprague-Dawley (SD) rats were randomly divided into three groups: control group (CON), model group (MOD), and moxibustion group (MOX), with 12 rats in each group. The MOD and MOX groups underwent chronic multi-factor stress stimulation for 35 d to establish the CFS model.

Reversible surface reconstruction of metal-organic frameworks for durable oxygen evolution reaction.

Metal-organic frameworks (MOFs) are regarded as prospective electrocatalysts for the oxygen evolution reaction (OER). Nevertheless, controllably reversible reconstruction of MOFs, yielding highly active catalytic sites for durable OER, has not been extensively studied. Herein, Ni-BPM (BPM = 4,4'-dihydroxybiphenyl-3,3'-dicarboxylic acid) equipped with open metal sites was selected as a potential electrocatalyst, and orientated MOF electrodes were fabricated a sacrificial lattice-matched-template method.

CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer.

Unlabelled: The arginine methyltransferase coactivator-associated arginine methyltransferase 1 (CARM1) is amplified/overexpressed in a variety of cancers, including triple-negative breast cancer (TNBC), spurring the interest of developing CARM1 inhibitors (CARM1i). In this study, we discovered that CARM1i treatment leads to elevated CARM1 levels as well as activation of AKT, which could result in long-term treatment resistance in breast cancer cells. CARM1 methylated MAP2K4 at arginine 58 in TNBC, and methylated-MAP2K4 localized to the nucleus and potentiated the proliferation- and metastasis-promoting functions of MAP2K4 via activation of JNK signaling.

The efficacy of acupuncture-based chinese medicine in chronic fatigue syndrome: A meta-analysis.

Background: The efficacy of acupuncture therapy in treating chronic fatigue syndrome remains a matter of intense debate owing to contradictory findings. This article describes a systematic review and meta-analysis to study its effect on fatigue, functional mobility, and mental health.

Methods: A thorough search of PubMed, PEDro, CINAHL, SportDiscus, and Scopus was performed.

Intestinal microbiota improves inflammation and cognitive function in the brain of a7nAChR deficient rat through the gut brain axis.

To investigate the role of intestinal flora and cholinergic anti-inflammatory pathways in the gut-brain axis, using oral gavage and intraperitoneal injection of methyllycaconitine (MLA). MLA was administered at a dose of 4 mg/kg for 30 days, either orally or via intraperitoneal injection. Rats were then assessed for behavioral changes, inflammatory markers, neurotransmitters, neuroreceptors, and intestinal mucosal barrier integrity.

Segmentation of the Left Ventricle and Its Pathologies for Acute Myocardial Infarction After Reperfusion in LGE-CMR Images.

Due to the association with higher incidence of left ventricular dysfunction and complications, segmentation of left ventricle and related pathological tissues: microvascular obstruction and myocardial infarction from late gadolinium enhancement cardiac magnetic resonance images is crucially important. However, lack of datasets, diverse shapes and locations, extreme imbalanced class, severe intensity distribution overlapping are the main challenges. We first release a late gadolinium enhancement cardiac magnetic resonance benchmark dataset LGE-LVP containing 140 patients with left ventricle myocardial infarction and concomitant microvascular obstruction.

Review of the Research Progress and Future Prospects of Acupuncture in the Treatment of Chronic Fatigue Syndrome.

Chronic Fatigue Syndrome (CFS) is an unexplained, persistent, or recurring fatigue accompanied by physical and cognitive decline that cannot be relieved, lasting for a duration of more than 6 months. This article provides a systematic review of the background of CFS, the application of acupuncture in traditional Chinese medicine for fatigue symptoms, the early application and effectiveness assessment of acupuncture in CFS treatment, analysis of acupuncture's relief effect on the main symptoms of CFS, assessment of acupuncture's improvement effect on the quality of life of CFS patients, comparative studies between acupuncture and conventional treatment methods, mechanism research on acupuncture treatment for CFS, the position and role of acupuncture in multidisciplinary comprehensive treatment, as well as challenges and limitations in acupuncture treatment for CFS. The aim is to provide scientific evidence for the clinical treatment of acupuncture.

Symptom network structure of anxiety, depression, and their impact on quality of life in patients undergoing percutaneous coronary intervention: a cross-sectional study.

Aims: Although anxiety and depression are frequently linked to coronary heart disease, a network analysis of comorbid anxiety and depression and their association with quality of life (QoL) in patients undergoing percutaneous coronary intervention (PCI) remains unclear from the perspective of symptom interactions. We aimed to investigate the network structure and symptom patterns of anxiety and depression, and their relationship with QoL in patients undergoing PCI.

Methods And Results: This study included 528 patients undergoing PCI.

The critical role of Sirt1 in ischemic stroke.

Ischemic stroke, the most prevalent form of stroke, is responsible for the highest disability rates globally and ranks as the primary cause of mortality worldwide. Sirt1, extensively investigated in neurodegenerative disorders, is the most well-known and earliest member of the sirtuins family. However, its mechanism of action during ischemic stroke remains ambiguous.

Arg-Gly-Asp engineered mesenchymal stem cells as targeted nanotherapeutics against kidney fibrosis by modulating m6A.

Background The recent surge in research on extracellular vesicles has generated considerable interest in their clinical applications. Extracellular vesicles derived from mesenchymal stem cells (MSC-EV) have emerged as a promising cell-free therapy for chronic kidney disease (CKD), offering an alternative to traditional Mesenchymal stem/stromal cells (MSCs) in extracellular vesicle-based nanotherapeutics. However, challenges such as in vivo off-target effects and limited bioavailability have impeded the wider adoption of MSC-EV in clinical settings.

Anti-CD137 agonist antibody-independent and clinically feasible preparation of tumor-infiltrating lymphocytes from soft tissue sarcoma and osteosarcoma.

Background: Tumor infiltrating lymphocytes (TILs) therapy has been proved for treatment of metastatic melanoma and is under investigation for other types of solid tumors. However, these successes are threatened by discontinued supply of GMP-grade anti-CD137 agonist, a key TIL preparation reagent. Therefore, exploring a GMP-adherent method for expanding endogenous TILs without anti-CD137 agonist is urgent.

Oncogenic RAS induces a distinctive form of non-canonical autophagy mediated by the P38-ULK1-PI4KB axis.

Cancer cells with RAS mutations exhibit enhanced autophagy, essential for their proliferation and survival, making it a potential target for therapeutic intervention. However, the regulatory differences between RAS-induced autophagy and physiological autophagy remain poorly understood, complicating the development of cancer-specific anti-autophagy treatments. In this study, we identified a form of non-canonical autophagy induced by oncogenic KRAS expression, termed RAS-induced non-canonical autophagy via ATG8ylation (RINCAA).

What are the symptom trajectories of self-regulatory fatigue among family caregivers of stroke survivors? A protocol of mixed-methods study in Chinese rehabilitation settings.

Introduction: Stroke presents a considerable burden not only to patients but also to their families and society at large. In many instances, stroke patients opt for home rehabilitation, relying on family caregivers for daily assistance. This dynamic significantly influences the physiological, psychological and social well-being of these caregivers.

Near-Infrared Phosphorescent Silver Nanoclusters/Polyethylenimine Nanocomposites for Photothermal Conversion.

Emerging as a promising functional material, metal nanoclusters that emit near-infrared (NIR) radiation have garnered significant attention due to their distinctive properties. Nonetheless, the rational design of NIR-emissive metal nanoclusters still faces substantial challenges. Herein, we demonstrate a self-assembly strategy for constructing NIR-emissive nanocomposites (abbreviated as ) using water-soluble Ag-NCs (Ag(mba), where Hmba = 2-mercaptobenzoic acid) and branched polyethylenimine (PEI) ( = 750,000).

A distinctive form of autophagy induced by oncogenic RAS.

RAS mutations enhance macroautophagy/autophagy in tumor cells, crucial for their growth and survival, making autophagy a promising therapeutic target for RAS-mutant cancers. However, the distinction between RAS-induced autophagy and physiological autophagy is not well understood. We recently identified a unique form of autophagy, RAS-induced non-canonical autophagy via ATG8ylation (RINCAA), which differs from starvation-induced autophagy.

Relationship between TyG-related index and hearing loss in people over 45 s in China.

Background: Triglycerides and fasting glycemic index are biomarkers used to assess the risk of insulin resistance and metabolic syndrome. It and its derivatives such as the TyG-BMI index are currently able to reflect the degree of insulin resistance and are closely related to a variety of metabolic diseases. The relationship between the TyG-BMI index and hearing loss remains underexplored, particularly in the context of aging and public health.

A Porphyrin-Based Metal-Organic Framework Nanozyme with Superior Peroxidase-like Activity for Combating Antibacterial Infections and Promoting Wound Healing.

As an antibacterial agent, HO is widely used to combat pathogenic bacterial infections clinically. To mitigate potential side effects associated with a high dosage of HO, it is pivotal to improve its antibacterial efficacy. Herein, a nanoscale porphyrin-based mesoporous metal-organic framework (MOF) nanozyme, Nano-PCN-222(Fe), was readily prepared by a one pot.

SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase.

Background: Bladder cancer is one of the most common malignancies of the urinary system. Despite significant advances in diagnosis and treatment, the compromised therapeutic effect of chemotherapeutic agents, such as Oxaliplatin (OXA), remains a major clinical challenge. Thus, a combination therapy is required to enhance the OXA's therapeutic effectiveness and improve patient outcomes.