SLC25A1 reprograms mitochondrial and fatty acid metabolism to promote the progression of acute myeloid leukemia.

Abnormal metabolic reprogramming is a hallmark of acute myeloid leukemia (AML), contributing to leukemia initiation, progression and drug resistance. The key mitochondrial citrate transporter SLC25A1 plays an essential role in regulating cellular energy metabolism and shows to play an important role in lipid metabolism regulation. However, the role of SLC25A1 in the pathogenesis and aberrant lipid metabolism in AML remain unexplored.

An integrative analysis reveals mechanisms of Prunella vulgaris in thyroid cancer metastasis.

Background: Lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) is a major contributor to poor prognosis. Prunella vulgaris (P. vulgaris), a traditional medicinal herb, has shown potential in inhibiting PTC metastasis, but its molecular mechanism remains unclear.

Characteristics of the first confirmed case of human infection with mpox virus clade Ib in China.

Mpox clade Ib is significant as it is associated with human cases and plays a key role in understanding the transmission and public health implications of mpox outbreaks. Here we present a case report of the first confirmed human infection of clade Ib in China, which occurred in December 2025 in Zhejiang Province. The case was a 28-year-old woman from South Africa who had sexual contact with an asymptomatic man from the Democratic Republic of the Congo.

Electrodeposition of Cu Sn alloy coatings with enhanced corrosion resistance durability and self cleaning properties.

In this study, a Cu-Sn superhydrophobic coating was fabricated on the surface of X70 steel via the electrodeposition method, resulting in an optimal contact angle of 164.2 ± 1.2°.

Comparative efficacy and safety in low-intensity treatment for acute myeloid leukemia in older patients: a systematic review and network meta-analysis.

Background: Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with a median age at diagnosis of 68 years. The outcomes in older or unfit AML patients on intensive chemotherapy are poor, and thus, it is necessary to explore alternative strategies. In recent years, non-intensive therapies have transformed the standard of care for this population.

Ultralow-Threshold Lithium Niobate Photonic Crystal Nanocavity Laser.

Thin film lithium niobate (TFLN) has emerged as a promising platform for modern complete photonic integrated circuits due to its exceptional optical properties. The development of rare-earth-ion-doped TFLN has led to significant advancements in on-chip microlasers. However, challenges persist in developing energy-efficient, low-threshold lasers on TFLN.

Arg-Gly-Asp engineered mesenchymal stem cells as targeted nanotherapeutics against kidney fibrosis by modulating m6A.

Background The recent surge in research on extracellular vesicles has generated considerable interest in their clinical applications. Extracellular vesicles derived from mesenchymal stem cells (MSC-EV) have emerged as a promising cell-free therapy for chronic kidney disease (CKD), offering an alternative to traditional Mesenchymal stem/stromal cells (MSCs) in extracellular vesicle-based nanotherapeutics. However, challenges such as in vivo off-target effects and limited bioavailability have impeded the wider adoption of MSC-EV in clinical settings.

Noise-tolerant LiDAR approaching the standard quantum-limited precision.

Quantum-inspired imaging techniques have been proven to be effective for LiDAR with the advances of single photon detectors and computational algorithms. However, due to the disturbance of background noise and the varies of signal in outdoor environment, the performance of LiDAR is still far from its ultimate limit set by the quantum fluctuations of coherent probe light. In this work, we propose and demonstrate a LiDAR from the detection perspective for approaching the standard quantum-limited performance.

The first reported case of monkeypox virus clade Ⅰb infection in china-clinical presentation and epidemiologic implications.

Recently, Monkeypox Virus (MPXV) clade Ib has caused serious health hazards in several countries. Herein, we report the first case of a clade Ib MPXV infection in China. MPXV was detected in a 28-year-old female on January 2, 2025.

Characterization and Engineering of a Bisabolene Synthase Reveal an Unusual Hydride Shift and Key Residues Critical for Mono-, Bi-, and Tricyclic Sesquiterpenes Formation.

Sesquiterpene synthases (STSs) catalyze carbocation cascade reactions with various hydrogen shifts and cyclization patterns that generate structurally diverse sesquiterpene skeletons. However, the molecular basis for hydrogen shifts and cyclizations, which determine STS product distributions, remains enigmatic. In this study, an elusive STS SydA was identified in the biosynthesis of sydonol, which synthesized a new bisabolene-type sesquiterpene with a unique saturated terminal pendant isopentane.

Unconventional (anti)ferroelectricity in van der Waals group-IV monochalcogenides.

Fundamentally, ferroelectrics must belong to a noncentrosymmetric space group, limiting the exploration of more new ferroelectric materials. We circumvent this limitation by triggering structure distortion and inducing ferroelectricity in centrosymmetric van der Waals group-IV monochalcogenide GeSe semiconductor that features unexpected intrinsic out-of-plane antiferroelectricity. Double-type and single-type hysteresis loops from electric measurements, bonding distortion observed in in-situ atomic imaging, and perpendicular polarization uncovered by first-principles calculations, confirm the intrinsic out-of-plane antiferroelectricity and the antiferroelectric-ferroelectric transition induced by the vertical external electric-field.

Efficacy, physicochemical and processing properties of oat peptides prepared via ultrasonication-assisted organic acid hydrolysis.

Currently, the low efficiency and pollution issues associated with biological and chemical methods for the preparation of functional peptides continue to pose challenges, restricting the large-scale production and utilization of functional peptides. This study has found that the ultrasound-assisted organic acid-surfactant system is an efficient and green method for the preparation of functional peptides. The probe ultrasonication-assisted tartaric acid system successfully degraded oat globulins into peptides with a degree of hydrolysis (DH) of 22.

Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China.

Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains.

Assembly of Four Ternary Polyoxometalate Aggregates by Integrating Presynthesized {XWNbO} (X = Si/Ge) Units Using Molybdenum-Oxo Clusters.

Polyoxometalates (POMs) have good potential for applications in different fields, including conducting materials, optics, and electrocatalysis. Of particular significance is the synthesis and development of addendum POMs. Molybdenum-oxo clusters, which are renowned for their diverse structures and electronic properties, were utilized to facilitate the synthesis of innovative materials.

Crucial roles of asprosin in cisplatin-induced ferroptosis and acute kidney injury.

Ferroptosis is a type of non-apoptotic regulated cell death characterized by iron accumulation and lipid peroxidation. Cisplatin is an effective chemotherapy drug with several serious side effects including acute kidney injury (AKI). Asprosin is a peptide contributing to metabolism regulation and metabolic disorders.

Phase Tailoring of InSe Toward van der Waals Vertical Heterostructures via Selenization of γ-InSe Semiconductor.

The polymorphic nature of InSe leads to excellent phase-dependent physical properties including ferroelectricity, photoelectricity, and especially the intriguing phase change ability, making the precise phase modulation of InSe of fundamental importance but very challenging. Here, the growth of InSe with desired-phase is realized by temperature-controlled selenization of van der Waals (vdW) layered bulk γ-InSe. Detailed results of Raman spectroscopy, scanning electron microscopy (SEM), and state-of-the-art spherical aberration-corrected transmission electron microscopy (Cs-TEM) clearly and consistently show that β-InSe, 3R α-InSe, and 2H α-InSe can be perfectly obtained at ≈270, ≈300, and ≈600 °C, respectively.