Reversing the Reaction Order Between FA and Rb Enhances the Photovoltaic Performance of Blade-Coated Perovskite Solar Cells.

Manipulating the kinetics of the reaction between A-site cations and Pb-I frameworks holds paramount importance for achieving high-quality, phase-homogeneous FA-dominant perovskites. It has been observed that when rubidium (Rb) serves as an A-site cation dopant, it tends to accumulate in the bulk region of the perovskite structure due to its pronounced affinity for Pb-I frameworks compared to FA. Consequently, Rb ions struggle to alleviate the exaggerated tensile strain induced by the bulky FA cations on the perovskite surface.

Differential associations of dietary inflammatory potential, antioxidant capacity, and Mediterranean diet adherence with biological aging: A UK Biobank study.

Background: Biological aging, distinct from chronological age, significantly impacts chronic disease risk and is a crucial target for health interventions. While diet is hypothesized to influence aging through inflammatory and oxidative pathways, systematic evidence from large populations remains limited. To address this gap, we used UK Biobank data with complementary dietary indices assessing inflammatory and antioxidant properties, providing comprehensive insights into diet-aging links.

Genetic characteristics analysis of influenza A(H1N1) virus in Jiaxing, China, in the postepidemic era.

Background: Following the lifting of COVID-19 pandemic control measures, a progressive increase in influenza A virus activity, particularly the H1N1 subtype, has been observed in Jiaxing. This study systematically characterized the genomic evolution of influenza A(H1N1) viruses circulating in Jiaxing, China during the 2023-2024 epidemic seasons through whole-genome sequencing and phylogenetic analysis.

Methods: Viral RNA was detected by quantitative real-time PCR (qPCR) and 83 influenza A(H1N1) isolates (48 from 2023 and 35 from 2024 surveillance) were selected for whole-genome sequencing.

Association between metabolic-associated fatty liver disease and risk of cardiometabolic multimorbidity: a disease trajectory analysis in UK Biobank.

Objective: While metabolic-associated fatty liver disease (MAFLD) has been associated with individual cardiometabolic diseases (CMDs), its role in the dynamic progression to cardiometabolic multimorbidity (CMM) remains unclear. We investigated the association of MAFLD, its severity and subtypes with CMM in individuals with no or one CMD at baseline.

Methods: This prospective cohort study involved 386,651 individuals (344,415 without and 42,236 with a single CMD at baseline) from the UK Biobank.

Genotypic Diversity and Pre-Treatment Resistance Characteristic Analysis Among Newly Diagnosed HIV-1-Positive MSM from 2020-2022 in Jiaxing City, China.

Background: Since the first recorded HIV-1 infection in 1998, Jiaxing City has seen increasing HIV infections among men who have sex with men (MSM), necessitating targeted research to understand HIV-1 subtypes and drug resistance patterns to improve prevention and treatment strategies.

Objectives: The study aimed to assess the variety of HIV-1 subtypes, the pre-treatment drug re-sistance (PDR) among MSM in Jiaxing, China, and transmission dynamics of drug-resistant strains. The findings may contribute to the development of targeted HIV prevention and control strategies for the MSM population.

Ancient DNA reveals a two-clanned matrilineal community in Neolithic China.

Studies of ancient DNA from cemeteries provide valuable insights into early human societies, and have strongly indicated patrilocality. Here, we analysed ancient DNA alongside archaeological contexts and multiple stable isotopic data from 60 individuals in 2 separate cemeteries at the Fujia archaeological site in eastern China, dating between 2750 and 2500 BCE. Our findings suggest the existence of an early-described matrilineal community in the Neolithic period, characterized by high endogamy and a population practicing millet agriculture near the coast.

Tracking relaxation dynamics of polaritons and reservoir states in organic exciton-polaritons.

Organic exciton-polaritons have garnered significant attention in optoelectronic devices and photochemistry, primarily due to their micrometer-scale diffusion lengths and tunable energy levels. Recent studies have underscored the critical role of reservoir states in the dynamical processes following polaritonic relaxation. However, questions remain regarding the peak assignments of reservoir states and their specific functions during relaxation.

Proton transfer kinetics modulated by single-residue substitution in photobasic FR-1V/hCRABPII.

Fluorescent proteins with large Stokes shifts have become indispensable in biological imaging due to their improved signal-to-noise ratio and reduced self-absorption. While traditional photoacid systems have optimization limitations, photobasic fluorescent proteins provide a promising alternative novel excited-state proton transfer (ESPT) mechanisms. We study how single amino acid variations affect the photophysical properties of FR-1V/hCRABPII microenvironment regulation.

Characteristics of wetting behavior under unloading in natural granite residual soil.

Excavation of foundation pits induces stress release in the soil, leading to deformation driven by the redistribution of internal stresses and particle adjustment. Rainfall infiltration further increases soil water content, weakening particle bonding through the dissolution of cementing agents, and inducing additional wetting deformation. However, there has only been limited experimental research examining the deformation behavior of soil under the coupled effects of unloading and wetting, especially in water-rich excavation conditions, where these factors interact dynamically.

Complete Genome Sequence Analysis of the First Imported Mpox Virus Clade Ib Variant in China.

Mpox, a zoonotic disease caused by the mpox virus (MPXV), has seen a significant shift in its epidemiological status since 2022, evolving from an initial local outbreak to a global epidemic. This recent outbreak of MPXV mainly emerged in several European and American countries and subsequently spread to over 100 countries and regions worldwide. The rapid evolution of MPXV, coupled with increased international interactions, has led to a gradual rise in mpox cases in certain regions of Asia, mostly involving MPXV clade II and its branch strains.

The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study.

Background: The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio, a composite marker of low-grade inflammation and lipid metabolism, is reportedly associated with the occurrence of new cardiovascular diseases (CVDs) in certain people. However, the predictive value of the hs-CRP/HDL-C ratio for long-term mortality in the general population remains unclear.

Methods: This retrospective cohort study included data from 9,492 adults obtained from the National Health and Nutrition Examination Survey (NHANES) (2015-2018) in the United States.

Substrate interactions guide cyclase engineering and lasso peptide diversification.

Lasso peptides are a diverse class of naturally occurring, highly stable molecules kinetically trapped in a distinctive [1]rotaxane conformation. How the ATP-dependent lasso cyclase constrains a relatively unstructured substrate peptide into a low entropy product has remained a mystery owing to poor enzyme stability and activity in vitro. In this study, we combined substrate tolerance data with structural predictions, bioinformatic analysis, molecular dynamics simulations and mutational scanning to construct a model for the three-dimensional orientation of the substrate peptide in the lasso cyclase active site.

Genome-wide characterization of the GRF transcription factors in potato ( L.) and expression analysis of genes during potato tuber dormancy and sprouting.

Growth-regulating factors (GRFs) are transcription factors that play a pivotal role in plant growth and development. This study identifies 12 GRF transcription factors (StGRFs) and analyzes their physicochemical properties, phylogenetic relationships, gene structures and gene expression patterns using bioinformatics. The StGRFs exhibit a length range of 266 to 599 amino acids, with a molecular weight of 26.

Excited-State Dynamics of a CRABPII-Based Microbial Rhodopsin Mimic.

Microbial rhodopsin, a pivotal photoreceptor protein, has garnered widespread application in diverse fields such as optogenetics, biotechnology, biodevices, etc. However, current microbial rhodopsins are all transmembrane proteins, which both complicates the investigation on the photoreaction mechanism and limits their further applications. Therefore, a specific mimic for microbial rhodopsin can not only provide a better model for understanding the mechanism but also can extend the applications.

Leveraging machine learning models for peptide-protein interaction prediction.

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising candidates for drug development. However, predicting peptide-protein complexes by traditional computational approaches, such as docking and molecular dynamics simulations, still remains a challenge due to high computational cost, flexible nature of peptides, and limited structural information of peptide-protein complexes.

Cost effectiveness of implantable cardioverter defibrillators for 1.5 primary prevention of sudden cardiac arrest in China: an analysis from the Improve SCA study.

Objectives: Implantable cardioverter defibrillator (ICDs) for primary prevention (PP) of sudden cardiac arrest (SCA) is underutilized in developing countries. The Improve SCA study has identified a subset of 1.5 primary prevention (1.

Association of non-HDL-C/apoB ratio with long-term mortality in the general population: A cohort study.

Background: In general, the identification of cholesterol-depleted lipid particles can be inferred from non-high-density lipoprotein cholesterol (non-HDL-C) concentration to apolipoprotein B (apoB) concentration ratio, which serves as a reliable indicator for assessing the risk of cardiovascular disease. However, the ability of non-HDL-C/apoB ratio to predict the risk of long-term mortality among the general population remains uncertain. The aim of this study is to explore the association of non-HDL-C/apoB ratio with long-term all-cause and cardiovascular mortality in adults of the United States.

Research on prevention and control technology of classified rockburst in TBM construction of deeply buried tunnels.

Rock blasting and other geological disasters occur frequently in the TBM construction of deeply buried tunnels and seriously threaten construction safety and progress. Therefore, it is extremely important to conduct scientific research for effective prevention and control of rockbursts in construction. Based on a large number of field rockburst data, this study analyses the influence of rockburst on construction safety and efficiency by using statistical theory and summarizes the temporal and spatial characteristics of rockburst time, location and influence range.

Mechanism of Wenshen Xuanbi Decoction in the treatment of osteoarthritis based on network pharmacology and experimental verification.

To investigate the mechanism of Wenshen Xuanbi Decoction (WSXB) in treating osteoarthritis (OA) via network pharmacology, bioinformatics analysis, and experimental verification. The active components and prediction targets of WSXB were obtained from the TCMSP database and Swiss Target Prediction website, respectively. OA-related genes were retrieved from GeneCards and OMIM databases.

Teacher-Assessed Linguistic and Social Abilities in Chinese Children's Reading Acquisition: A Longitudinal Study.

The study explored the relationship between teacher assessments of students' general language-cognitive and social-emotional abilities and Chinese children's reading development over an academic year. A series of reading measures (including reading vocabulary, reading comprehension, and lexical inferencing ability) were administered to Chinese-speaking second graders ( = 123) across time. Meanwhile, their six head teachers and assistant head teachers were asked to complete assessments of their language-cognitive and social-emotional abilities prior to the first data collection.

Leveraging Machine Learning Models for Peptide-Protein Interaction Prediction.

Peptides play a pivotal role in a wide range of biological activities through participating in up to 40% protein-protein interactions in cellular processes. They also demonstrate remarkable specificity and efficacy, making them promising candidates for drug development. However, predicting peptide-protein complexes by traditional computational approaches, such as Docking and Molecular Dynamics simulations, still remains a challenge due to high computational cost, flexible nature of peptides, and limited structural information of peptide-protein complexes.

Two-Dimensional Electronic Spectroscopy of the Far-Red-Light Photosystem II Reaction Center.

Understanding the role of specific pigments in primary energy conversion in the photosystem II (PSII) reaction center has been impeded by the spectral overlap of its constituent pigments. When grown in far-red light, some cyanobacteria incorporate chlorophyll- and chlorophyll- into PSII, relieving the spectral congestion. We employ two-dimensional electronic spectroscopy to study PSII at 77 K from sp.

β-Sitosterol activates autophagy to inhibit the development of hepatocellular carcinoma by regulating the complement C5a receptor 1/alpha fetoprotein axis.

Hepatocellular carcinoma (HCC) is highly refractory. β-Sitosterol has been reported to suppress proliferation and migration as well as interfere with cell metabolism in tumors. However, there is limited information on the effects of β-sitosterol on HCC.

Inhibition of PRMT1 alleviates sepsis-induced acute kidney injury in mice by blocking the TGF-β1 and IL-6 trans-signaling pathways.

Sepsis-induced acute kidney injury (SI-AKI) causes renal dysfunction and has a high mortality rate. Protein arginine methyltransferase-1 (PRMT1) is a key regulator of renal insufficiency. In the present study, we explored the potential involvement of PRMT1 in SI-AKI.

Heteropolymer improves p-i junction in perovskite solar cells.

The p-i heterojunction imbedded underneath the perovskite layer plays a vital role in determining the efficiency and stability of inverted perovskite solar cells (PSCs). We found that poly[bis(4-phenyl) (2,4,6-trimethylphenyl) amine] (PTAA) suffers from the severely chain entanglement resulting in poor contact with perovskite. In this work, PTAA layer was treated by poly[(2,6-(4,8-bis(5-(2-ethylhexylthio)-4-fluorothiophen-2-yl)-benzo[1,2-b:4,5-b'] dithiophene))-alt-(5,5-(1',3'-di-2-thienyl-5',7'-bis(2-ethylhexyl) benzo[1',2'-c:4',5'-c'] dithiophene-4,8-dione)] (PBDB-T-SF) diluted solution in chlorobenzene.