Deep Eutectic Solvent: Improve the Constituents in Plantago asiatica L. (PAL) Extract Oral Absorption in Rats.

Plantago asiatica L. (PAL) is a prevalent perennial herb utilized for both culinary and medicinal purposes. This article examines the impact of deep eutectic solvent (DES, composed of choline chloride and lactic acid) on the pharmacokinetics of chemical constituents in PAL extract.

The application of therapeutic plasma exchange in sepsis and septic shock: A narrative review.

Sepsis, characterized by a dysregulated host response to infection that leads to life-threatening organ dysfunction, remains a leading cause of mortality in the intensive care unit (ICU). Despite continuous optimization of treatment strategies, mortality rates remain high. Therapeutic plasma exchange (TPE) has emerged as a promising adjunctive therapy, offering benefits through the removal of harmful substances and the replenishment of essential plasma components.

Advantages and effectiveness of AI three-dimensional reconstruction technology in the preoperative planning of total hip arthroplasty.

In order to explore the application effect of artificial intelligence (AI) 3D reconstruction technology in total hip arthroplasty (THA), this study included a total of 109 patients with unilateral femoral head ischemic necrosis. According to the preoperative planning method, they were divided into the AI group (n = 55) and the 2D group (n = 54). The operating time, intraoperative bleeding, length of hospital stay length, prosthesis conformity, imaging indicators and Harris scores.

Anticoagulant regimens for different therapeutic plasma exchange modes.

Therapeutic plasma exchange (TPE) is widely used in various fields of clinical practice. There are two main modes of TPE: centrifugal TPE (cTPE) and membrane TPE (mTPE). No matter which mode of TPE, anticoagulant therapy is essential to prevent clotting in the extracorporeal circuit.

Influence of natural deep eutectic solvent pretreatment on the yield and composition of essential oil derived from Cyperi Rhizoma.

This study systematically investigated the effect of hydrodistillation (HD) on the yield of essential oil derived from Cyperi Rhizoma following ultrasonic pretreatment using natural deep eutectic solvents (NADES) as the medium. The parameters for ultrasonic pretreatment were analyzed using single-factor experiments and response surface methodology (RSM) to optimize the yield of essential oil. The findings indicated that the ideal settings for ultrasonic pretreatment were as follows: The water content of NADES-5, with a molar ratio of lactic acid to choline chloride of 3.

An exploratory mixed methods study on shared decision-making and antibiotic prescribing for pet cats and dogs in Singapore veterinary clinics.

Veterinarians primarily engage pet owners in shared decision-making (SDM) to enhance treatment outcomes and owner satisfaction, but not specifically for antibiotic stewardship. This study aims to understand how SDM occurs and how to better involve pet owners in appropriate antibiotic prescribing for their pets. This is a concurrent mixed methods study, anchoring on survey data collected from 1080 pet cat/dog owners (March─December 2023) supplemented by qualitative insights from 19 veterinarians (January─July 2022).

DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts.

The intestinal lymphatic system is essential for lipid absorption, yet its regulatory mechanisms remain poorly understood. Here, we identify DHHC5, an Asp-His-His-Cys (DHHC) motif-containing palmitoyl acyltransferase, as a critical regulator of intestinal lymphatic integrity and lipid uptake. Whole-body inducible knockout () mice were resistant to diet-induced obesity and exhibited impaired intestinal lipid absorption due to lymphatic dysfunction.

Systemic complications and management strategies in liver cancer patients undergoing interventional therapy.

Liver cancer presents unique challenges due to its systemic impact and complex treatment modalities. Patients often experience a range of complications, including cardiovascular, renal, hematological, and metabolic abnormalities, which can significantly affect treatment outcomes and quality of life. This article emphasizes the integration of multidisciplinary strategies and artificial intelligence-driven diagnostics, which have the potential to improve patient outcomes by optimizing early detection and targeted management of these complications.

Integrated metabolome-transcriptome analyses reveal key pathways regulating staminate catkin development and pollen maturation in .

Introduction: Flavonoids are the major metabolites in . However, our understanding of the role that flavonoids play in staminate catkin development and pollen maturation is still limited.

Methods And Results: Here, we performed a metabolome analysis during staminate catkin development and pollen maturation in .

Electrospun Silver-Modified PZT/PVDF Composites for High-Performance Piezoelectric Energy Harvester.

Piezoelectric materials based on polyvinylidene fluoride (PVDF) are widely regarded as ideal candidates for the fabrication of piezoelectric energy harvesters (PEHs). However, the relatively low power output of PVDF limits its widespread application and poses a significant challenge to the advancement of PEHs. To address this issue, we have designed a novel PEH using silver-modified lead zirconate titanate/PVDF (pPZT@Ag/PVDF), which achieves a remarkable balance between high output performance and long-term stability.

Study on the essential components in Cyperi Rhizoma from different regions of China based on 3D van Krevelen diagram.

Investigate the correlation between essential components and Cyperi Rhizoma from various regions of China using the 3D van Krevelen diagram. Head-space hyphenated with Gas chromatography-mass spectrometry (HS-GC-MS) was employed to analyze the essential components of Cyperi Rhizoma from different regions of China. The 3D van Krevelen diagram was generated using Matlab 8.

Knowledge, attitudes, and practices of antibiotic use and antimicrobial resistance for pet cats and dogs in Singapore: A cross-sectional study.

Objectives: Antibiotic use in pets can contribute to antimicrobial resistance (AMR) in both humans and pets. Despite increasing pet ownership in Asia, there is a paucity of data on pet owners' knowledge, attitudes, and practices regarding antibiotic use for pets. Hence, the aim of this study was to explore the knowledge, attitudes and practices of antibiotic use and AMR for pets amongst cat and/or dog owners in Singapore.

The VALUE of antibiotic stewardship for companion animals: Understanding appropriate antibiotic prescribing for pet cats and dogs in veterinary clinics in Singapore.

Background: Understanding the factors influencing antibiotic prescribing for pets can inform future interventions to prevent development and spillover of antimicrobial resistance (AMR) from pets to other animals, humans and the wider environment.

Material And Methods: We conducted interviews with 19 veterinarians (January-July 2022) to explore factors influencing antibiotic prescribing for cats and dogs. Thematic analysis was performed using a VALUE model and themes were segmented by consultation touchpoints.

Pet Owners' Knowledge of Antibiotic Use and Antimicrobial Resistance and Their Antibiotic Practices: Comparison Between Contexts of Self and Pet.

: This study aimed to compare pet owners' knowledge of antibiotic use, understanding of antimicrobial resistance (AMR) and antibiotic practices for themselves and their pets to guide behavioral interventions to reduce AMR. : A cross-sectional study conducted between March 2023 and December 2023 involved 1080 pet owners recruited from 16 veterinary clinics in Singapore. An anonymous self-administered survey assessed the participants' knowledge of antibiotic use and AMR as well as their adherence to recommended antibiotic practices for themselves and their pets.

A Porphyrin-Based Metal-Organic Framework Nanozyme with Superior Peroxidase-like Activity for Combating Antibacterial Infections and Promoting Wound Healing.

As an antibacterial agent, HO is widely used to combat pathogenic bacterial infections clinically. To mitigate potential side effects associated with a high dosage of HO, it is pivotal to improve its antibacterial efficacy. Herein, a nanoscale porphyrin-based mesoporous metal-organic framework (MOF) nanozyme, Nano-PCN-222(Fe), was readily prepared by a one pot.

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia.

Background: Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depression, bridging etiological factors to behavioral manifestations and connecting insights from animal models to diverse clinical populations.

Methods: We analyzed datasets from both rodents and humans.

ADAR1 Promotes the Progression and Temozolomide Resistance of Glioma Through p62-Mediated Selective Autophagy.

Background: Resistance to temozolomide (TMZ) remains is an important cause of treatment failure in patients with glioblastoma multiforme (GBM). ADAR1, as a member of the ADAR family, plays an important role in cancer progression and chemotherapy resistance. However, the mechanism by which ADAR1 regulates GBM progression and TMZ resistance is still unclear.

Research on the application effect of arthroscopic access modification in meniscal injury repair.

Objective: To investigate the application value of arthroscopic channel modification in meniscal injury repair.

Methods: We retrospectively analyzed the data of 100 patients with meniscus injuries treated with knee arthroscopy from December 2022 to December 2023 and divided them into a control group and a modified group according to the application of "arthroscopic access modification technology". We compared the operation time, postoperative hospitalization time, VAS score, Lysholm knee function score, postoperative complications, and postoperative images of the patients in these two groups.

Effectiveness of non-invasive brain stimulation on depressive symptoms targeting prefrontal cortex in functional magnetic resonance imaging studies: a combined systematic review and meta-analysis.

The prefrontal cortex (PFC) is a critical non-invasive brain stimulation (NIBS) target for treating depression. However, the alterations of brain activations post-intervention remain inconsistent and the clinical moderators that could improve symptomatic effectiveness are unclear. The study aim was to systematically review the effectiveness of NIBS on depressive symptoms targeting PFC in functional magnetic resonance imaging (fMRI) studies.

Expectation of antibiotics amongst owners of dogs and/or cats during non-routine visits to veterinary clinics in Singapore: a cross-sectional study.

Objectives: The present study aimed to assess the factors associated with pet owners' expectations for receiving antibiotics for their pet dogs and/or cats and the factors associated with pets (dogs and/or cats) receiving antibiotics during non-routine veterinary clinic consultations in Singapore.

Methods: A cross-sectional study was conducted on consenting pet owners who attended 16 veterinary clinics in Singapore, between March and December 2023. An online survey measured participants' knowledge of antibiotic use, prior antibiotic use experience, expectation for antibiotics and receipt of antibiotics during the last non-routine clinic consultation for their pets.

Liquid biopsy in cancer current: status, challenges and future prospects.

Cancer has a high mortality rate across the globe, and tissue biopsy remains the gold standard for tumor diagnosis due to its high level of laboratory standardization, good consistency of results, relatively stable samples, and high accuracy of results. However, there are still many limitations and drawbacks in the application of tissue biopsy in tumor. The emergence of liquid biopsy provides new ideas for early diagnosis and prognosis of tumor.

Context-specific fatty acid uptake is a finely-tuned multi-level effort.

Fatty acids (FAs) are essential nutrients that play multiple roles in cellular activities. To meet cell-specific needs, cells exhibit differential uptake of FAs in diverse physiological or pathological contexts, coordinating to maintain metabolic homeostasis. Cells tightly regulate the localization and transcription of CD36 and other key proteins that transport FAs across the plasma membrane in response to different stimuli.