Deep Eutectic Solvent: Improve the Constituents in Plantago asiatica L. (PAL) Extract Oral Absorption in Rats.

Plantago asiatica L. (PAL) is a prevalent perennial herb utilized for both culinary and medicinal purposes. This article examines the impact of deep eutectic solvent (DES, composed of choline chloride and lactic acid) on the pharmacokinetics of chemical constituents in PAL extract.

Punicalin ameliorates vascular endothelial cell pyroptosis and dysfunction induced by hyperlipidemia and hyperglycemia through activation of PPARγ.

Vascular endothelial dysfunction, a form of chronic endothelial inflammation, frequently occurs in patients with diabetes, hyperlipidemia, and hyperglycemia, which is a key trigger of cardiovascular diseases. Emerging evidence has indicated that pyroptosis plays a crucial role in endothelial dysfunction and potentially represents a promising therapeutic strategy. Punicalin (PUN), a bioactive compound derived from ellagitannins, has demonstrated great potential of anti-inflammatory and anti-pyroptosis.

Influence of natural deep eutectic solvent pretreatment on the yield and composition of essential oil derived from Cyperi Rhizoma.

This study systematically investigated the effect of hydrodistillation (HD) on the yield of essential oil derived from Cyperi Rhizoma following ultrasonic pretreatment using natural deep eutectic solvents (NADES) as the medium. The parameters for ultrasonic pretreatment were analyzed using single-factor experiments and response surface methodology (RSM) to optimize the yield of essential oil. The findings indicated that the ideal settings for ultrasonic pretreatment were as follows: The water content of NADES-5, with a molar ratio of lactic acid to choline chloride of 3.

Study on the essential components in Cyperi Rhizoma from different regions of China based on 3D van Krevelen diagram.

Investigate the correlation between essential components and Cyperi Rhizoma from various regions of China using the 3D van Krevelen diagram. Head-space hyphenated with Gas chromatography-mass spectrometry (HS-GC-MS) was employed to analyze the essential components of Cyperi Rhizoma from different regions of China. The 3D van Krevelen diagram was generated using Matlab 8.

Explore on screening COX-2 inhibitors from the essential oil of Thunb. By molecular docking and molecular dynamics simulation.

This study aimed to investigate Thunb. with respect to the potential ingredients with anti-inflammatory activity from its essential oil by study. To this regard, the essential oil of Thunb.

Rhynchophylline inhibits methamphetamine dependence via modulating the miR-181a-5p/GABRA1 axis.

Ethnopharmacological Relevance: Uncaria rhynchophylla (Miq.) Miq. ex Havil.

Extraction, separation and kinetics of phenylethanosides from L. by an innovative extraction technology-deep eutectic solvent-based ultrasound-assisted extraction.

In this paper, the total phenylethanosides (TPS) were extracted efficiently by an innovative extraction technology--deep eutectic solvent-based ultrasound-assisted extraction (DES-UAE) from L. Ten diverse types of DESs were synthesized as alternative extraction solutions. The extraction efficiency of DES-3 (constituted by choline chloride and lactic acid) was much higher than those of other DESs.

[Kinetics and variation of volatile components of Atractylodis Macrocephalae Rhizoma during hot-air drying].

The present study explored the kinetics and variation of volatile components of Atractylodis Macrocephalae Rhizoma during the hot-air drying process to obtain the optimal process parameters under multiple goals such as drying efficiency and drying quality. The dry basis moisture content and drying rate curves along with the change of drying time of Atractylodis Macrocephalae Rhizoma were investigated at five levels of drying air temperatures(30, 40, 50, 60, and 70 ℃). The relationship between moisture ratio and time in the drying process of Atractylodis Macrocephalae Rhizoma was fitted and verified by Midilli model, Page model, Overhults model, Modified Page model, Logaritmic model, Two terms Exponential model, and Newton model.

Exploration of a ternary deep eutectic solvent for the efficient extraction of plantamajoside, acteoside, quercetin and kaempferol from Plantago asiatica L.

Introduction: In the present study, ternary deep eutectic solvent-based ultrasound-assisted extraction was developed for the efficient extraction of plantamajoside, acteoside, quercetin and kaempferol from Plantago asiatica L.

Methodology: Six kinds of choline chloride-based ternary deep eutectic solvents (TDESs) were prepared as potential extraction solutions. In order to obtain optimal extraction efficiency, a series of extraction conditions were investigated by single-factor test and orthogonal test.

[The mechanical properties and moisture permeability of eudragit L100/S100 free films affected by plasticizers and membrane materials ratio].

The free membrane of Eudragit L100/S100 which is pH-sensitive, colon-specific was prepared by plane casting films. The film humidity, species and amount of plasticizers, the ratio of membrane material was investigated. The rate of membrane permeability and mechanical properties were used as indicators of orthogonal experiment, and its related properties were studied.