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Investigate the correlation between essential components and Cyperi Rhizoma from various regions of China using the 3D van Krevelen diagram. Head-space hyphenated with Gas chromatography-mass spectrometry (HS-GC-MS) was employed to analyze the essential components of Cyperi Rhizoma from different regions of China. The 3D van Krevelen diagram was generated using Matlab 8.0 software to visualize the data. Additionally, high-performance liquid chromatography (HPLC) was utilized to quantify the content of cyperenone, nootkatone, and α-cyperone in Cyperi Rhizoma samples from diverse regions of China. A total of 132 chemical components were identified in Cyperi Rhizoma, encompassing alkanes, alkenes, alcohols, aldehydes, ketones, acids, esters, sesquiterpenes, and oxidized sesquiterpenes, among others. The 3D van Krevelen diagram effectively illustrated the categories, quantities, and proportions of these components and highlighted region-specific characteristics. For instance, terpenoid content was highest in samples from Guangdong, while alcohols, aldehydes, and ketones were most abundant in those from Shandong. The highest levels of alkenes, monoterpenes, and sesquiterpenes were observed, whereas oxidized terpenes showed the lowest concentrations. The HPLC findings corroborated the conclusions derived from the 3D van Krevelen diagram. The 3D van Krevelen diagram effectively depicted the distribution of essential components in Cyperi Rhizoma from different regions of China, facilitating the transition from numerical data to graphical representation. This method provides an intuitive visualization of the compositional characteristics of Cyperi Rhizoma across various regions of China.
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http://dx.doi.org/10.1016/j.chroma.2025.465942 | DOI Listing |
Front Med (Lausanne)
July 2025
School of Traditional Chinese Medicine, Anhui University of Chinese Medicine, Hefei, China.
Objective: This study aimed to evaluate the therapeutic efficacy of Invigorating Spleen and Replenishing Kidney and Resolving Phlegm Prescription (ISRKRPP) in treating obesity-type polycystic ovary syndrome (PCOS) and to analyze the prescription regularity through data mining technology.
Methods: Databases were retrieved up to September 30, 2024. RCTs on obesity-type PCOS treated with ISRKRPP and Western medicine (WM) were included.
Front Nutr
July 2025
Department of Clinical Nutrition, West China Hospital, Sichuan University, Chengdu, China.
Objectives: Accumulating clinical evidence demonstrates the therapeutic potential of Traditional Chinese Medicine (TCM) in mitigating depressive disorders. This research focuses on quercetin, a principal bioactive constituent shared among five classical TCM antidepressant formulations, to systematically decode its multi-target mechanisms via an integrative framework combining neuroinflammatory modulation and synaptic plasticity regulation.
Methods: A tripartite experimental design was implemented.
RSC Adv
July 2025
School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology Xianning 437100 China
Diabetic cardiomyopathy (DCM) is a major contributor to heart failure in diabetic patients, characterized by complex pathophysiological mechanisms and a lack of effective targeted therapies. Cyperi Rhizoma (CR), a traditional Chinese medicinal herb, has shown potential in regulating Qi and improving metabolic disorders, yet its therapeutic mechanisms in DCM remain unclear. This study systematically explored the bioactive components and underlying mechanisms of CR in the treatment of DCM by integrating network pharmacology, molecular docking, molecular dynamics simulation (MDS), and experiments.
View Article and Find Full Text PDFBMC Chem
July 2025
Department of Pharmacy, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.
This study systematically investigated the effect of hydrodistillation (HD) on the yield of essential oil derived from Cyperi Rhizoma following ultrasonic pretreatment using natural deep eutectic solvents (NADES) as the medium. The parameters for ultrasonic pretreatment were analyzed using single-factor experiments and response surface methodology (RSM) to optimize the yield of essential oil. The findings indicated that the ideal settings for ultrasonic pretreatment were as follows: The water content of NADES-5, with a molar ratio of lactic acid to choline chloride of 3.
View Article and Find Full Text PDFJ Chromatogr A
June 2025
Department of Pharmacy, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, China. Electronic address:
Investigate the correlation between essential components and Cyperi Rhizoma from various regions of China using the 3D van Krevelen diagram. Head-space hyphenated with Gas chromatography-mass spectrometry (HS-GC-MS) was employed to analyze the essential components of Cyperi Rhizoma from different regions of China. The 3D van Krevelen diagram was generated using Matlab 8.
View Article and Find Full Text PDF