Integrating network pharmacology and experimental validation deciphers the improving effect and mechanisms of Shenwu Yizhi capsule on cognitive impairment in vascular dementia rats.

The therapeutic mechanisms of Shenwu Yizhi Capsule (SWYZC), a widely used treatment for vascular dementia (VD), remain unclear. This study integrated network pharmacology and experimental methods to elucidate the effects and mechanisms of SWYZC on cognitive function in VD rats. A VD model was established via bilateral common carotid artery occlusion (2-VO).

Design, synthesis, and biological activity of novel para-substituted phenylamino and phenyl derivatives of northebaine as selective delta opioid receptor agonists.

The delta opioid receptor (DOR) is a promising target for developing analgesics with fewer side effects compared to mu opioid receptor (MOR) agonists. However, non-peptidyl DOR-selective agonists remain limited. Using the "message-address" concept in opioid ligand design, we designed and synthesized a series of para-substituted N-cyclopropylmethyl-7α-phenyl-6,14-endoetheno-tetrahydronorthebaines to explore their binding affinity and selectivity for DOR over MOR and kappa opioid receptor (KOR).

Electroacupuncture Pretreatment Alleviates Myocardial Ischemia-Reperfusion Injury by Inhibiting Engulfment by Microglia in the Lateral Hypothalamus.

Aim: The occurrence of myocardial ischemia-reperfusion injury (MIRI) is accompanied by neuroinflammatory reactions and is closely related to the overactivation of microglia. Currently, effective clinical strategies to prevent MIRI are unclear. This study investigated potential therapeutic targets and the mechanisms of electroacupuncture pretreatment (EA-pre) for MIRI.

[Development of core outcome set for traditional Chinese medicine interventions in diabetic peripheral neuropathy].

This study developed a core outcome set(COS) for traditional Chinese medicine(TCM) interventions in diabetic peripheral neuropathy(DPN), standardizing evaluation metrics for TCM efficacy and providing a new framework for DPN treatment and management. A systematic search was conducted across databases, including CNKI, Wanfang, and PubMed, targeting clinical trial literature published between January 1, 2013, and January 1, 2023. The search focused on extracting outcome indicators and measurement tools used in TCM treatments for DPN.

O-GlcNAcylation: A molecular switch linking brain health to neurodegeneration.

Neurodegenerative disorders are typically caused by harmful protein accumulation and nerve cell damage. A post-translational modification called O-linked N-acetylglucosamine ylation acts as a critical regulator in these disorders by controlling protein behavior, cell signaling, and energy balance. This modification is dynamically balanced through the cooperative actions of O-linked N-acetylglucosamine transferase and O-GlcNAcase.

Regional Differences, Distributional Dynamics and Spatial Convergence of Pharmacist Human Resources in China: A Healthcare Tiers Difference Perspective.

Purpose: This study aims to analyze the regional and hierarchical disparities in the distribution of pharmacist human resources in China from 2012 to 2022, with the goal of identifying underlying trends and challenges. The findings are intended to serve as a basis for optimizing the equitable and efficient allocation of pharmacist resources to better support healthcare system development.

Patients And Methods: Data were collected from the China Health Statistics Yearbook and China Statistics Yearbook.

Synovial Organoids and Cell Culture Models: An Ideal Platform for Exploring Traditional Chinese Medicine in Rheumatoid Arthritis.

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia, inflammation, and pannus formation. Although conventional therapies are effective, they are often associated with significant side effects. Traditional Chinese medicine (TCM), known for its high safety profile and multitarget therapeutic effects, has shown unique potential in the treatment of RA.

Electroacupuncture pretreatment ameliorates cerebral ischemia/reperfusion injury by inhibiting the miR-124/NF-κB/Fas signaling pathway.

Background: The mechanism of electroacupuncture (EA) pretreatment for cerebral ischemia-reperfusion injury (CIRI) is unclear. This study aimed to investigate whether EA pretreatment attenuates CIRI through the miR-124/nuclear factor kappa B (NF-κB)/Fas signaling pathway.

Methods: Following 7 days of EA pretreatment at Baihui (GV20), Fengfu (GV16), and Dazhui (GV14), CIRI rats were established.

PRP and hypertonic glucose injections improve outcomes in patients with early- to middle-stage knee osteoarthritis: a multicenter retrospective study.

Background: Platelet-rich plasma (PRP) injection therapy and hyperosmotic glucose hyperplasia therapy are commonly used methods for treating knee osteoarthritis (KOA). This study evaluates the differences in efficacy and cost-effectiveness between the two therapies. 

Methods: This study retrospectively analyzed 257 patients with knee osteoarthritis from October 2021 to November 2023, and divided them into PRP injection group and hypertonic glucose injection group according to their different treatment methods.

Benzofuranyl-pyrazole as a Novel Scaffold for and Potent Anticancer Therapeutics That Directly Disrupt the 'Undruggable' MYC Oncogene and Potentiate Immune Checkpoint Blockage.

Targeting the 'undruggable' MYC oncogene remains a challenging objective. Despite substantial research efforts, a majority of MYC direct inhibitors discovered so far lack efficacy. Herein, benzofuranyl-pyrazole has been identified as a structurally novel scaffold directly disrupting MYC function.

Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation.

Background: Bronchial asthma (BA) is regarded as one of the most prevalent chronic respiratory diseases worldwide. Yanghe Pingchuan Granules (YPG), a traditional Chinese medicine (TCM) compound, has been employed extensively in treating BA. However, the precise mechanism by which it exerts its therapeutic effects remains to be fully elucidated.

Immune-mediated membranous nephropathy: Innovations in pathogenetic modeling and mechanistic insights.

Membranous nephropathy (MN), an autoimmune cause of adult nephrotic syndrome, is driven by podocyte-targeting antibodies against PLA2R/THSD7A. Current models fail to fully capture human disease progression. This review evaluates three transformative approaches: (1) Heterologous antibody-induced models enabling acute injury replication; (2) Antigen-driven immunization modeling adaptive immunity; and (3) GBF-on-Chip platforms mimicking filtration barrier dynamics.

Hesperidin attenuates lipopolysaccharide-induced endometritis by inhibiting mitochondrial oxidative stress via activating the AMPK/PGC-1α signalling pathway.

Endometritis is a prevalent condition of the reproductive system that leads to significant tissue damage in the uterus, thereby seriously impacting the health and quality of life of these patients. Hesperidin (HES), a natural flavonoid glycoside, displays various biological activities. Nonetheless, the protective effect of HES treatment against endometritis remains uncertain.

Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation.

Cerebral edema is characterized by fluid accumulation, and the glymphatic system (GS) plays a pivotal role in regulating fluid transport. Using the Tenecteplase system, magnesium salt of salvianolic acid B/ginsenoside Rg1 (SalB/Rg1) was injected intravenously into mice 4.5 h after middle cerebral artery occlusion and once every 24 h for the following 72 h.

Association between number of missing teeth and stroke risk: an analysis of NHANES 2011-2020 data.

Background: Stroke is the second leading cause of death globally and the third leading cause of disability, severely impacting quality of life and increasing healthcare costs. Identifying underlying causes is critical for effective management. Oral health is closely linked to stroke occurrence, and tooth loss is a common oral health issue.

An insight review on the potential anti-hypertensive effects of Moringa oleifera.

Hypertension is a leading cause of cardiovascular-related morbidity and mortality worldwide. In recent years, there has been growing interest in exploring natural products for managing hypertension, with Moringa oleifera emerging as a promising natural candidate for blood pressure regulation. This review investigates the anti-hypertensive potential of M.

Discovery of ()-1,3-Diphenyl-2-Propen-1-One Derivatives as Potent and Orally Active NLRP3 Inflammasome Inhibitors for Colitis.

The pyrin domain-containing protein 3 (NLRP3) inflammasome may be a potential target for the treatment of inflammatory bowel disease (IBD), and inhibiting the activation of the NLRP3 inflammasome is of great significance for the treatment of IBD. In this study, 27 novel chalcone derivatives were designed and synthesized. Enzyme-linked immunosorbent assay (ELISA) analysis revealed that most of the compounds inhibited IL-1β secretion, with exhibiting the most significant activity, showing IC values of 0.

Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer.

The pregnane X receptor (PXR), a ligand-activated nuclear receptor, plays a central role in regulating the metabolism of both endogenous substances and xenobiotics. In recent years, increasing evidence has highlighted its involvement in chronic diseases, particularly metabolic disorders and cancer. PXR modulates drug-metabolizing enzymes, transporters, inflammatory factors, lipid metabolism, and immune-related pathways, contributing to the maintenance of hepatic-intestinal barrier homeostasis, energy metabolism, and inflammatory responses.

Presacral tumors: a retrospective analysis of 112 cases with emphasis on diagnostic challenges and surgical outcomes.

Background: Presacral tumors are rare entities with heterogeneous pathology including malignant potential. Due to nonspecific symptoms mimicking common anorectal diseases, misdiagnosis remains a major challenge that may delay treatment and worsen prognosis, particularly for malignant variants. This study analyzes diagnostic pitfalls and surgical outcomes in a large single-center cohort.

The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.

Accumulating evidence indicates that arsenic (As) exposure causes a decline in sperm quality. This study aimed to investigate the impact of As exposure on spermatogonial senescence. GC-1 cells were exposed to NaAsO (10 μM).

Comparative Untargeted Metabolomic Analysis of Fruiting Bodies from Three Species.

spp. are medicinal fungi with significant therapeutic value, but their taxonomic ambiguity and frequent market adulteration have hindered their standardized utilization. In this study, untargeted metabolomics based on UPLC-Q-TOF-MS was employed to systematically analyze the metabolic profiles of three species: .

A Mendelian randomization study of the associations between depression, anxiety and clinical conditions including thyroid nodules, flatulence, and irregular menstruation.

Objective: Given the high prevalence of psychological and physical conditions as well as the limited understanding of the potential causal links, we aim to explore the associations between psychological problems (depression and anxiety) and physical health issues (thyroid nodules, flatulence, menstrual disorders).

Methods: Genetic data on depression and anxiety were sourced from the Psychiatric Genomics Consortium and the FinnGen database, respectively. Meanwhile, datasets of the Epidemiological Network were employed to investigate thyroid nodules, flatulence, and menstrual irregularities.

Zuoqing granules attenuate ulcerative colitis via macrophage polarization modulation: involvement of the PPAR-γ/NF-κB/STAT1 signaling axis.

Background: Although our prior clinical study demonstrated the efficacy of Zuoqing granules (ZQGs) in treating ulcerative colitis (UC), the underlying immunomodulatory mechanisms remained unclear. This study systematically investigated ZQG's therapeutic effects through macrophage polarization modulation and related signaling pathways using both and models.

Methods: , dextran sulfate sodium (DSS)-induced UC rats were divided into normal control, DSS model, and ZQG treatment groups (high/medium/low doses).

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration.

Periodontitis is a multifactorial inflammatory disease involving pathogenic biofilm formation, amplified oxidative stress, and impaired tissue regeneration. In addition to its complicated pathology, effective treatment of periodontitis is challenged by a dynamic oral microenvironment that prevents drug retention. To overcome these issues, an anti-bacterial, ROS-scavenging, and tissue-regenerative hydrogel system (HQUP@TF127) is developed.

Comparative analysis of key flavonoid synthesis genes in the transcriptome of Cayratia Japonica and therapeutic target prediction for ulcerative colitis : Functional & integrative genomics.

Cayratia japonica is a traditional Chinese herbal plant rich in flavonoid compounds, with anti-inflammatory and anti-cancer properties. Although Cayratia japonica has been used for medicinal purposes for centuries, the mechanisms underlying flavonoid biosynthesis in this plant remain largely unexplored. In this study, combining transcriptomics and bioinformatics, we constructed a transcriptome database for three tissues of Cayratia japonica.