Electrocatalytic Hydrogen Precipitation Performances of B and Ce Codoped CoP/NiCoP over a Wide pH Range.

Exploring efficient, low-cost, and pH-versatile electrocatalysts for hydrogen precipitation is vital for the development of practical hydrogen production via water electrolysis. However, most existing electrocatalysts suffer from limitations such as high overpotentials, a reliance on expensive noble metals, or poor stability under extreme pH conditions, hindering their practical application. Among the many electrocatalytic materials, transition metal phosphides (TMPs) are considered a promising class of hydrogen evolution reaction (HER) catalytic materials due to their abundant reserves and tunable electronic structures.

"One stone three birds": Andrographis paniculata-derived exosome-like nanoparticles mitigate dextran sulfate sodium-induced colitis.

Background: Ulcerative colitis (UC), a chronic inflammatory bowel disease, is characterized by a multifactorial etiology and limited therapeutic options. Recent advancements in plant-derived exosome-like nanoparticles (PDENs) have demonstrated promising potential for UC treatment. This study explored the therapeutic efficacy of Andrographis paniculata-derived exosome-like nanoparticles (APELNs) in alleviating dextran sodium sulfate (DSS)-induced colitis.

Pillar[5]arene-based crosslinked covalent network for efficient heavy metal ion adsorption.

A crosslinked covalent network was synthesized aldimine condensation using a novel pillar[5]arene-derived decaamine. This network can be processed into aerogels and serves as an effective adsorbent for heavy metal ions.

Acid-free photocatalytic recovery of valuable metals from spent ternary lithium battery cathode materials using acetonitrile and dichloromethane.

The environmentally friendly leaching technology is the core direction to recover valuable metals from spent lithium batteries (LIBs). A new photocatalytic activation combined with organic solvent leaching is developed. Under the optimal experimental conditions, the leaching efficiencies for Li, Mn, and Co are 72.

An RNA G-quadruplex within the sclerostin 3' untranslated region enhances sclerostin expression by blocking miR-4648 binding.

Sclerostin (SOST) serves as a pivotal negative regulator of bone formation, and its dysregulated expression is implicated in the pathogenesis of skeletal disorders, including osteoporosis. While substantial progress has been made in elucidating the intracellular signaling pathways activated by SOST, the molecular mechanisms governing its expression remain less well understood. In this study, we identify an RNA G-quadruplex (RG4) secondary structure within the 3' untranslated region (3' UTR) of SOST.

Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation.

Objective: To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.

Study Design: Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.

FNDC3B promotes gastric cancer metastasis via interacting with FAM83H and preventing its proteasomal degradation.

Background: Gastric cancer (GC) is one of the most prevalent digestive tract malignancies, with metastasis being a major contributor to poor prognosis in patients. Fibronectin type III domain-containing 3B (FNDC3B) plays pivotal roles in various tumors, yet its role in GC remains unknown.

Methods: We utilized a GC immunohistochemistry (IHC) chip and specimens to identify high expression of FNDC3B in GC.

NuanXin Formula inhibits bone resorption to combat osteoporosis by attenuating osteoclast oxidative phosphorylation.

Ethnopharmacological Relevance: Osteoporosis is a chronic metabolic bone disorder characterized by excessive bone resorption. The NuanXin Formula (NX) is a classical traditional Chinese medicine formula that can warm and tonify kidney Yang, as well as replenish Qi and blood, which are essential for maintaining bone health and regulating bone metabolism. Nevertheless, the functions and mechanisms of NX in osteoporosis therapy remain unclear.

MicroRNA Classifier Based on EUS-FNA for the Early Detection of Occult Liver Metastasis in Pancreatic Ductal Adenocarcinoma.

Objective: This study aimed to investigate whether microRNAs (miRNAs) quantified from primary pancreatic ductal adenocarcinoma (PDAC) samples could serve as potential biomarkers for identifying PDAC with occult liver metastasis.

Summary Background Data: Undetectable occult liver metastasis impair the survival of PDAC. Novel biomarkers are immediately required to detect occult liver metastasis in PDAC.

scRNA-seq and scATAC-seq reveal that Sertoli cell mediates spermatogenesis disorders through stage-specific communications in non-obstructive azoospermia.

Non-obstructive azoospermia (NOA) belongs to male infertility due to spermatogenesis failure. However, evidence for cell type-specific abnormalities of spermatogenesis disorders in NOA remains lacking. We performed single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase-accessible chromatin sequencing (scATAC-seq) on testicular tissues from patients with obstructive azoospermia (OA) and NOA.

High-Entropy Doping Enabling Ultrahigh Power Density for Advanced Sodium-Ion Batteries.

Sodium-ion batteries (SIBs), owing to the plentiful sodium resources, are considered a viable large-scale energy storage substitute for lithium-ion batteries. Recently, NaV(PO)F (NVPF) has been increasingly investigated as an SIBs cathode material. However, the development of this cathode material is hindered by low intrinsic electronic conductivity, poor cycling stability at high rates, and low energy density.

Evaluation of cinitapride's efficacy and safety in treating functional dyspepsia with overlapping symptoms: a real-world study in Chinese healthcare settings.

Objective: Cinitapride, a gastrointestinal prokinetic, is commonly used for treating functional dyspepsia. However, large-scale, real-world data on its efficacy, especially in patients with overlapping symptoms, are limited. The aim of this study was to evaluate the clinical effectiveness and safety of cinitapride in Chinese patients with functional dyspepsia, including those with overlapping symptoms, in a real-world setting.

Phosphorylation-dependent regional motility of the ciliary kinesin OSM-3.

Kinesin motor proteins, vital for intracellular microtubule-based transport, display region-specific motility within cells, a phenomenon that remains molecularly enigmatic. This study focuses on the localized activation of OSM-3, an intraflagellar transport kinesin crucial for the assembly of ciliary distal segments in Caenorhabditis elegans sensory neurons. Fluorescence lifetime imaging microscopy unveiled an extended, active conformation of OSM-3 in the ciliary base and middle segments, where OSM-3 is conveyed as cargo by kinesin-II.

[Comparison of two registration methods for constructing virtual craniodentofacial patients based on cone beam computed tomography images].

Objective: To compare the registration accuracy of cone beam computed tomography (CBCT) images while registering to virtual craniodentofacial patients based on soft tissue and the dentition registration method.

Methods: Virtual dentofacial patients out of 13 selected participants who needed CBCT scanning were established by impression with a registered-block impression (RBI) based on digital dental images, three-dimensional (3D) facial images and maxillofacial CBCT images. CBCT images were processed in the Mimics software program, establishing the craniofacial virtual patients based on CBCT images (CCTs).

Buried Interface Engineering for MAPbI Perovskite Solar Cells by the Novel Carbon Nitride Synergistic Strategy.

Carrier recombination, which arises from defects present at both the buried interface and throughout the bulk phase, hinders performance improvement in perovskite solar cells (PSCs). Nonetheless, the current strategies still face some pressing issues. Herein, we demonstrate a novel synergistic strategy of carbon nitride (CN) as a buried modified layer and a perovskite antisolvent additive to reduce energy loss resulting from nonradiative recombination.

miR-278-3p targets ATG16L1 to modulate autophagy and suppresses CLas proliferation in Diaphorina citri.

The phloem-limited bacterium Candidatus Liberibacter asiaticus (CLas) is the primary cause of citrus Huanglongbing (HLB) and is transmitted by the Asian citrus psyllid, Diaphorina citri. MicroRNAs (miRNAs) are key posttranscriptional regulators involved in various biological processes, yet their role in D. citri's response to CLas infection remains unclear.

PD-L1 siRNA incorporation into a cationic liposomal tumor mRNA vaccine enhances cytotoxic T cell activation and prevents immune evasion.

Engaging antigen-presenting cells and T lymphocytes is essential for invigorating the immune system's response to cancer. Nonetheless, challenges such as the low immunogenicity of tumor antigens, the genetic heterogeneity of tumor cells, and the elevated expression of immune checkpoint molecules frequently result in resistance to immunotherapy or enable immune evasion by tumors. To overcome this resistance, we developed a therapeutic tumor vaccine employing cationic liposomes to encapsulate MC38 total RNA alongside PD-L1 siRNA (siPD-L1).

Annotation-free genetic mutation estimation of thyroid cancer using cytological slides from multi-centers.

Thyroid cancer is the most common form of endocrine malignancy and fine needle aspiration (FNA) cytology is a reliable method for clinical diagnosis. Identification of genetic mutation status has been proved efficient for accurate diagnosis and prognostic risk stratification. In this study, a dataset with thyroid cytological images of 310 indeterminate (TBS3 or 4) and 392 PTC (TBS5 or 6) was collected.

PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.

Recurrent spontaneous abortion (RSA) brings tremendous difficulties to clinical treatment and prognosis. Pre-B-cell leukemia homeobox 1 (PBX1), as a functional transcription factor, involves in the regulation of cell apoptosis and proliferation. However, the underlying mechanism of PBX1 in RSA treatment has not been explored.

To evaluate the clinical efficacy of decompression for large cystic lesions in mandible by digital technology.

Objectives: This study aimed to quantitatively evaluate the therapeutic effect of decompression on mandibular cystic lesions using three-dimensional volumetric analysis and investigate factors influencing volume reduction patterns.

Methods: A retrospective cohort of 44 patients with mandibular cystic lesions, including 12 unicystic ameloblastomas (UAB), 12 odontogenic keratocysts (OKC), and 20 nonkeratinizing cysts (NKC), was analyzed. Volumetric measurements before and after decompression were obtained using Three- dimensional (3D) Slicer software and CBCT data.

Exploring the Underlying Mechanism of Weiling Decoction Alleviates Cold-Dampness Diarrhea Based on Network Pharmacology, Transcriptomics, Molecular Docking and Experimental Validation.

: Cold-dampness diarrhea (CDD) is a common gastrointestinal disorder in children, characterized by diarrhea and intestinal barrier dysfunction. Weiling decoction (WLD) is frequently used in clinical practice to treat CDD, a condition triggered by multiple factors. However, the molecular mechanisms underlying its therapeutic effects remain poorly understood.

Adverse events of 20-22G second-generation endoscopic ultrasound-guided fine-needle biopsy needles for solid lesions in the upper gastrointestinal tract and adjacent organs: Systematic review and meta-analysis.

Objectives: Previous research has conducted meta-analyses on the diagnostic accuracy of endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). However, studies on adverse events (AEs) have been limited and sporadic and have included a highly diverse group of patients (with upper and lower gastrointestinal tract issues) and needles of varying sizes (19-22-25G). The purpose of this systematic review and meta-analysis was to determine the incidence of AEs related to the utilization of 20-22G second-generation EUS-FNB needles subsequent to puncture of the upper gastrointestinal tract and adjacent organs.

Bacterial pneumonia patients with elevated globulin levels did not get infected with SARS-CoV-2: two case reports.

Background: COVID-19 began in December 2019, rapidly spreading worldwide. China implemented a dynamic zero-COVID strategy and strict control measures after the outbreak. However, Guangzhou city ended closed-off management by the end of November 2022, leading to exposure to SARS-CoV-2.

A machine learning enhanced EMS mutagenesis probability map for efficient identification of causal mutations in Caenorhabditis elegans.

Chemical mutagenesis-driven forward genetic screens are pivotal in unveiling gene functions, yet identifying causal mutations behind phenotypes remains laborious, hindering their high-throughput application. Here, we reveal a non-uniform mutation rate caused by Ethyl Methane Sulfonate (EMS) mutagenesis in the C. elegans genome, indicating that mutation frequency is influenced by proximate sequence context and chromatin status.