Quantitative characterization of types 1 and 2 macular neovascularization in neovascular age-related macular degeneration with intravitreal conbercept: an analysis utilizing optical coherence tomography angiography.

Aim: To quantitatively assess central macular thickness (CMT), macular neovascularization (MNV) area, vascular tortuosity (VT), and vascular dispersion (VDisp) in neovascular age-related macular degeneration (nAMD), type 1 and type 2 MNV, by means of optical coherence tomography (OCT) and OCT angiography (OCTA) techniques.

Methods: In this retrospective and observational case series, patients were classified into type 1 or type 2 MNV groups. A comprehensive panel of OCT and OCTA metrics was evaluated, including CMT, MNV area, VT, and VDisp.

Insight into enhancing the resistance to K, HO and SO over MnVO supported on TiO in NH-SCR denitration reaction.

Alkali metal poisoning remains an essential issue causing the deactivation of vanadate-based catalysts for selective catalytic reduction (SCR) catalysts of NO with NH. In this paper, MnVO was loaded onto TiO (mwt%MnVO/TiO, m = 3, 5, 7) to improve the low-temperature activity and resistance to K poisoning. The activity tests demonstrated that 5 wt%MnVO/TiO catalyst was remarkably resistance to SO and HO, sustaining a NO conversion of over 90 % in the temperature range of 200-340 °C even after K poisoning.

APALORD: An R-based tool for differential alternative polyadenylation analysis of long-read RNA-seq data.

Alternative polyadenylation (APA) is a critical co/post-transcriptional process that enhances RNA isoform diversity, regulating mRNA stability, localization and translation in a spatiotemporal manner. Over the past decade, long-read (LR) RNA sequencing techniques have advanced rapidly, producing datasets that could offer insights into APA mechanisms. Here we introduce (Alternative Polyadenylation Analysis of LOng-ReaDs), an R-based analysis tool for APA analysis of LR RNA-seq data.

Comparative Accuracy of Millimeter-Wave Radar and Polysomnography in Sleep Apnea Detection.

BACKGROUND Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a common and serious sleep disorder characterized by recurrent episodes of partial or complete airway obstruction during sleep. Polysomnography is considered the gold standard for diagnosing OSAHS and evaluating its severity. However, traditional sensory monitoring methods, while effective, are often cumbersome, expensive, and unsuitable for home use.

An Isoform-Specific RUNX1C-BTG2 Axis Governs AML Quiescence and Chemoresistance.

Unlabelled: Aberrant levels or structures of RNA isoforms are a hallmark of many cancers, including acute myeloid leukemia (AML), yet their role in AML chemoresistance remains unclear. We conducted a paired analysis of RNA isoform changes in patients with AML before therapy and at relapse after chemotherapy and identified intragenic DNA methylation at the proximal promoter of the transcription factor RUNX1, which resulted in elevated expression of the long-isoform RUNX1C through its alternative distal promoter. The unique N-terminal region of RUNX1C orchestrated an isoform-specific transcriptional program that promoted chemoresistance, with its direct target BTG2 playing a role in chemotherapy resistance.

A general strategy for the efficient utilization of Microbiocide by using polyacrylic acid sodium as a flexible framework material.

Introduction: Copper sulfide nanoparticles are ideal carrier materials for the preparation of controlled release nano-systems that can effectively improve the utilization efficiency and environmental safety of microbicides because of their excellent antimicrobial activity, low environmental toxicity, and controllable structure.

Objectives: This study aims to elucidate the general rules of loading and release of drugs in pH-responsive nano-delivery systems based on CuS NPs and develop a general strategy for efficient utilization of microbicide and sustainable plant disease management.

Methods: Three microbicide-loaded copper sulfide nanoparticles (Microbicide@PAS-CuS NPs) were fabricated via a one-pot route by using polyacrylic acid sodium (PAS) as a flexible framework carrier material and berberine sulfate (BBR), bronopol (BNP), and kasugamycin (KSM) as the loaded microbicides.

[Changes of Phytoplankton Community Structure and Influencing Factors in Erhai Lake].

Phytoplankton is the most important primary producer in lakes， and its community structure can reflect the changes in lake ecosystems. In order to understand the changes of phytoplankton functional community structure and its influencing factors in Erhai Lake， a plateau lake， the phytoplankton community composition， water quality changes， and zooplankton and zoobenthos abundance in Erhai Lake were continuously observed every quarter from 2022 to 2023. The results showed that 7 phyla and 81 genera of phytoplankton were identified from 2022 to 2023.

Comparative chloroplast genome analyses of potentilleae: insights into genome characteristics, mutational hotspots, and adaptive evolution.

Potentilleae Sweet is a large tribe within Rosaceae Juss., with over 1700 species across 13 genera worldwide. Some achievements have been obtained in the study of phylogenetic relationships among Potentilleae genera and its origin and diversification, while its chloroplast (cp.

Outcomes Between Fresh Embryo and First Frozen-Thawed Embryo Transfer in Donor Sperm In-Vitro Fertilisation.

Objective: To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.

Study Design: Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.

Membrane fusogenic liposomes facilitate the production of immunostimulatory extracellular vesicles for enhanced cancer therapy.

Cancer therapy based on extracellular vesicles faces several practical challenges, such as low production, inadequate stability, and inefficiency, making it difficult to achieve ideal therapeutic effects. To address these issues, a novel engineering technology of EVs was developed based on the autonomous "fusion-exocytosis" process. Specifically, membrane fusogenic liposomes (MFLs) with unique physical and chemical properties were engineered by tailoring the components, which could interact with cells to facilitate mutual fusion of lipid membranes and release fusogenic extracellular vesicles (FEVs).

Iterative Screening of Vitamin E-Based Functional Lipid Nanoparticles for mRNA Delivery.

Ionizable lipids are crucial for the effective delivery of mRNA by using lipid nanoparticles (LNPs). Endowing ionizable lipids with tailored biological properties could potentially augment the therapeutic efficacy of mRNA-based treatments. Herein, a functional vitamin E (VE)-based lipid library with distinct head groups was designed and synthesized.

NiCoP/CoO composite electrocatalyst with p-n heterojunction promotes urea oxidation in direct urea fuel cells.

Direct urea fuel cells (DUFCs) have great potential in recovering chemical energy from wastewater containing urea. The efficiency of the urea oxidation reaction (UOR) on the anode of a DUFC has a significant influence on its power output. Currently, the development of UOR catalysts with high catalytic activity and durability remains extremely challenging.

Identification of Novel Laccase from Ganoderma lucidum and Application in Biotransformation to Bio-based Fragrances Using Alkaline Lignin as Raw Material.

A novel laccase, Lac3, was purified from Ganoderma lucidum fermentation broth by salting out, gel filtration chromatography, and Native-PAGE protein recovery. The molecular mass of Lac3 was 58.4 kDa as estimated by SDS-PAGE and exhibited catalytic properties with 2,2'-Biazobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) as substrate.

Brain structural alterations and cognitive dysfunction in lung cancer patients without brain metastasis.

This study explored the relationship between cognitive function and brain structure in lung cancer (LCs) patients without brain metastases and healthy controls (HCs). A cohort of 75 chemotherapy-naive LCs without brain metastases and 29 age-, sex-, and education-matched HCs underwent cognitive assessments and structural MRI. The MRI focused on cortical thickness, surface area, and volume of subcortical structures.

The Fie1-PRC2 complex regulates H3K27me3 deposition to balance endosperm filling and development in cereals.

Polycomb repressive complex 2 (PRC2)-mediated H3K27me3 deposition is vital for cell fate determination during Arabidopsis thaliana endosperm development. Unlike the transient endosperm in Arabidopsis, cereals follow a different developmental program after the cellularization phase, producing a persistent endosperm. In contrast to the single, constitutively expressed Fertilization Independent Endosperm (FIE) gene in Arabidopsis, cereals have evolved a duplicated, grain-specific counterpart, such as maize ZmFie1 and rice OsFie1.

Innovative laparoscopic 'Tunnel' approach in managing hiatal hernia with gastroesophageal reflux disease: a retrospective study.

Background: Hiatal hernia (HH) is a major cause of gastroesophageal reflux disease (GERD), and laparoscopic repair combined with anti-reflux surgery is a common treatment. However, postoperative complications such as vagus nerve injury remain a concern. This study introduces a novel Laparoscopic "Tunnel" Approach aiming to minimize damage to the vagus nerve and preserve perigastric vessels.

Integrating Electrochemical Electrodes into Mass Spectrometry Ionization Sources for Detection of Transient Intermediates.

Identifying short-lived transient intermediates is challenging due to their brief lifetimes (as short as nanoseconds and even picoseconds) and therefore low concentrations in many chemical processes. Conducting electrochemical reactions within mass spectrometry ion sources (i.e.

Engineered vesicular cancer vaccines for immunosuppressive microenvironment reversion and in situ vaccine generation.

It is crucial to reverse immunosuppressive tumor microenvironment (TME) and effectively activate both cellular and humoral immunity in cancer immunotherapy. We have found that decitabine, an epigenetic regulator, can increase antigen exposure and induce double-stranded RNA (dsRNA) accumulation in tumor cells. The corresponding cell-derived nanovesicles (NV) have the ability to stimulate both cellular and humoral immunity due to the internal dsRNA.

Antrum Preservation Versus Antrum Resection in Laparoscopic Sleeve Gastrectomy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Purpose: To compare the effects of laparoscopic sleeve gastrectomy (LSG) with antrum preservation (AP) and antrum resection (AR) on weight loss and postoperative complications.

Methods: A meta-analysis of randomized controlled trials (RCTs) followed PRISMA guidelines. The databases searched included PubMed, Web of Science, Embase Medline, and the Cochrane Library up to October 2022.

Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism: A case report.

Background: Cardiac arrest caused by acute pulmonary embolism (PE) is the most serious clinical circumstance, necessitating rapid identification, immediate cardiopulmonary resuscitation (CPR), and systemic thrombolytic therapy. Extracorporeal CPR (ECPR) is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be implemented.

Case Summary: We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical activity.

PDCD11 Stabilizes C-MYC Oncoprotein by Hindering C-MYC-SKP2 Negative Feedback Loop to Facilitate Progression of p53-Mutant Breast and Colon Malignancies.

C-MYC is a proto-oncoprotein whose dysregulation triggers tumorigenesis and tumor progression in ≈70% of cancer cases. It is presently demonstrated that aberrantly upregulated MYC is caused by the overexpressed and "extra-nucleolar" PDCD11 in p53-mutant breast and colon cancer cells, which is highly correlated to tumor progression, metastasis, and recurrence. In the nucleoplasm, PDCD11 binds to the TAD of C-MYC to prevent SKP2, a transcriptional target of C-MYC as well as one of the major E3 ligase components targeting C-MYC, from interacting with and ubiquitinating C-MYC in feedback.

PBX1 attenuates inflammation and apoptosis of trophoblast cells induced by LPS through downregulating the transcription of TMUB1: PBX1 ameliorates RSA development.

Recurrent spontaneous abortion (RSA) brings tremendous difficulties to clinical treatment and prognosis. Pre-B-cell leukemia homeobox 1 (PBX1), as a functional transcription factor, involves in the regulation of cell apoptosis and proliferation. However, the underlying mechanism of PBX1 in RSA treatment has not been explored.

Predictive value of enhanced CT and pathological indicators in lymph node metastasis in patients with gastric cancer based on GEE model.

Objectives: A predictive model was developed based on enhanced computed tomography (CT), laboratory test results, and pathological indicators to achieve the convenient and effective prediction of single lymph node metastasis (LNM) in gastric cancer.

Methods: Sixty-six consecutive patients (235 regional lymph nodes) with pathologically confirmed gastric cancer who underwent surgery at our hospital between December 2020 and November 2021 were retrospectively reviewed. They were randomly allocated to training (n = 38, number of lymph nodes = 119) and validation (n = 28, number of lymph nodes = 116) datasets.

Evaluating the Potential of Quantitative Susceptibility Mapping for Detecting Iron Deposition of Renal Fibrosis in a Rabbit Model.

Background: As ferroptosis is a key factor in renal fibrosis (RF), iron deposition monitoring may help evaluating RF. The capability of quantitative susceptibility mapping (QSM) for detecting iron deposition in RF remains uncertain.

Purpose: To investigate the potential of QSM to detect iron deposition in RF.

Comparison between lymph and non-lymph node resection in patients with stage IA non-small-cell lung cancer: A retrospective study.

Objective: This retrospective study aimed to determine the need for lymph node resection during surgical treatment in patients with stage IA non-small-cell lung cancer (NSCLC).

Materials And Methods: A total of 1428 patients diagnosed with cT1N0M0 1 A stage NSCLC who underwent surgery were divided into two groups: lymphadenectomy (n = 1324) and nonlymphadenectomy (n = 104). The effects of lymph node resection on overall survival (OS) and recurrence-free survival (RFS) and on clinicopathological factors that affected the prognosis of the patients were investigated.