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Article Abstract
Objective: To compare the pregnancy outcomes of embryo transfer (ET) and frozen-thawed embryo transfer (FET) after controlling for maternal confounding factors.
Study Design: Descriptive analytical study. Place and Duration of the Study: Reproductive Medicine Centre, Children's Hospital of Shanxi and Women Health Centre of Shanxi, Affiliated Hospital of Shanxi Medical University, Taiyuan, China, from January 2015 to September 2022.
Methodology: Clinical data and pregnancy outcomes of 1,051 sperm-donor in-vitro fertilisation IVF/ICSI embryo-transfer cycles, divided into initial FET and fresh ET groups, were compared. Primary outcomes included clinical pregnancy rate, miscarriage rate, and live birth rate.
Results: Significant differences were observed in clinical pregnancy and live birth rates (44.02% vs. 53.63%, p = 0.018; 34.78% vs. 44.87%, p = 0.012) but not in miscarriage or ectopic pregnancy rates (18.52% vs. 14.41%, p = 0.339; 2.47% vs. 1.94%, p = 0.752) between the groups.
Conclusion: In 1,065 sperm-donor IVF cycles, frozen-thawed embryos yielded higher clinical pregnancy and live birth rates, particularly with single ET. FET is a successful, safe, and preferable option for couples using donor sperm in assisted reproductive technologies.
Key Words: Donor sperm, Fresh embryo transfer, Frozen-thawed embryo transfer, Pregnancy outcome, Assisted reproductive technique.
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| http://dx.doi.org/10.29271/jcpsp.2025.06.703 | DOI Listing |
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