0.003°/h bias instability of honeycomb disk resonator gyroscope achieved by mode reversal combined mode deflection control method.

Microelectromechanical systems (MEMS) gyroscopes with higher precision have always been a focal point of research. Due to limitations in resonant structure, fabrication processes, and measurement and control techniques, MEMS gyroscopes with bias instability better than 0.01°/h are still rare and expensive.

A Polymer-Oriented Synthesis Of Triazinyl Functionalized Mesoporous Organic Polymer Encapsulating Uitrafine Metal Clusters for Alkynes Semi-Hydrogenation.

Preparation of highly dispersed ultrafine metal clusters (MCs)- based catalysts with good stability and preeminent catalytic performance is a challenging problem for heterogeneous catalysis. Herein, we design and controllably synthesize a triazinyl functionalized mesoporous organic polymer (TRI-MOP) through a polymer-oriented synthesis strategy using polyethyleneimine (PEI) as pore-forming agent. The obtained TRI-MOP material possesses abundant worm-like mesopores, rich triazinyl groups, and high stability.

High expression of SOX9 is a diagnostic and prognostic indicator of glioma.

Background: Glioblastoma (GBM) originates from neuroepithelial tissue and is one of the most common intracranial malignant tumors in adults, with high recurrence rate and poor prognosis. In recent years, SOX9 has been reported to play an important role in many diseases and cancers, and is a promising target, but it has been rarely reported in GBM.

Methods: RNA sequencing data of GBM were obtained from the Cancer Genome Atlas (TCGA) database and the Genotype-Tissue Expression (GTEx) database for analysis of SOX9 expression and differentially expressed genes (DEGs).

Global trends and heterogeneity in the burden of brain and central nervous system cancers among children and adolescents: An analysis based on GBD 2021 data.

Background: Brain and central nervous system (CNS) cancers are among the most challenging pediatric malignancies, with significant impacts on neurodevelopment, quality of life, and long-term outcomes. However, comprehensive global assessments across demographic and socio-economic strata remain limited.

Methods: Using data from the Global Burden of Disease Study 2021 (GBD 2021), we analyzed trends in incidence and disability-adjusted life years (DALYs) for pediatric brain and CNS cancers from 1990 to 2021.

The new insight into the microscopic enhancement mechanism of microwave absorption based on the electromagnetic heterogeneous interface of carbon nanocavity.

Reasonable microstructure design is an effective strategy to obtain high-efficiency microwave absorbers. The current explanation for the mechanism of microwave absorption enhancement by microstructures is limited to impedance matching and attenuation constant variation, which lacks a more intuitive understanding. To investigate the microwave absorption enhancement mechanisms arising from hollow structural features and heterointerfaces, a N-doped carbon framework with hollow cavities (H-NC) and embedded iron nanoparticles (H-NC/Fe) was strategically designed and synthesized.

Global incidence trends and projections of Alzheimer disease and other dementias: an age-period-cohort analysis 2021.

Background: Alzheimer disease (AD) is a growing global health issue, with incidence varying by gender, age, and region. Understanding these trends is essential for developing effective prevention strategies as the population ages. Unlike previous Global Burden of Disease (GBD) studies that primarily focussed on prevalence and mortality, we offer a novel perspective by examining historical incidence trends and projecting future patterns of AD and other dementias using advanced analytical approaches.

Toxic effects of co-exposure to polystyrene nanoplastics and arsenic in zebrafish (Danio rerio): Oxidative stress, physiological and biochemical responses.

The issue of nanoplastics (NPs) in the aquatic environment has recently received considerable attention. Arsenic (As) is a relatively abundant and toxic metalloid element in aquatic environments. However, the potential toxic effects of As on aquatic organisms under the influence of NPs remain uncertain.

Autonomous 3D Self-Sensing Hybrid Membrane Actuator for Interactive Communicating.

The advancement of intelligent soft actuators is progressively emphasizing the incorporation of environmental sensing capability to actuation, thereby enhancing the adaptability and interactivity of artificial systems. In the current situation where the sensing and actuation functions of soft actuators are generally separated, this work proposes an autonomous three-dimensional (3D) noncontact sensory actuator (NSA), based on the coupling of ″dielectric polarization-electrothermal conversion-thermal actuation″ triple effects. Specifically, the NSA hybrid membrane is composed of multiple interpenetrating networks, including a boron nitride nanosheet (BNNS) dielectric network for electrostatic field sensing and polarization, a silver nanowires (AgNWs) percolation network for dielectric enhancement and electrothermal conversion, and thermally contracted shape memory fiber (SMF) and thermally expanded polydimethylsiloxane (PDMS) networks for directional actuation.

Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques.

Tertiary lymphoid organs have been identified in the arterial adventitia in both mouse models of atherosclerosis and patients with atherosclerosis, yet their role in the disease remains insufficiently explored. Here we present a spatially resolved single-cell transcriptome atlas of human atherosclerotic plaques, identifying 14 distinct cell types and providing evidence of plaque tertiary lymphoid organs (PTLOs). The development of PTLOs was associated with the expression of lymphangiogenic chemokine genes and the adhesion molecule gene in fibroblast-like smooth muscle cells.

[Simulation and Prediction of Spatiotemporal Variation Characteristics of Nitrogen Non-point Source Pollution in Henan Province Based on FLUS and InVEST Models].

To elucidate the characteristics of nitrogen non-point source pollution in Henan Province under the influence of climate change, this study initially utilized the InVEST model to simulate the temporal and spatial distribution of the N non-point source pollution load in Henan Province from 2000 to 2020, subsequently coupling the FLUS model with the InVEST model, nitrogen point source pollution load, and its spatial distribution in Henan Province from 2030 to 2050 under SSP2-4.5 and SSP5-8.5 climate scenarios.

Removal of Sulfonamide Antibiotics in Peracetic Acid-Mediated Natural Polyphenol Systems via an Overlooked Polymerization Pathway: Role of -Quinones.

Natural polyphenols can be oxidized into reactive quinones, which might play a key role in the removal of specific contaminants in natural polyphenol-related advanced oxidation processes (AOPs). In this study, peracetic acid (PAA) was employed in combination with natural protocatechuic acid (PCA) to remove sulfonamide antibiotics (SAs) from water. More than 95% removal of sulfamethoxazole (SMX) and other SAs was observed in the PCA/PAA system, and neutral pH conditions (5.

Machine learning-based prognostic modeling integrating PANoptosis in head and neck squamous cell carcinoma.

Background: Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous and aggressive cancer, posing challenges for prognosis and treatment. The role of PANoptosis in HNSCC remains unclear, despite its potential impact on the tumor immune microenvironment.

Methods: We obtained the single-cell RNA sequencing dataset GSE181919 from the GEO database and used the AUCell R package to analyze PANoptosis enrichment and heterogeneity, identifying key PANoptosis-related genes at the single-cell level.

Flexible fibrous electrodes for implantable biosensing.

Flexible fibrous electrodes have emerged as a promising technology for implantable biosensing applications, offering significant advancements in the monitoring and manipulation of biological signals. This review systematically explores the key aspects of flexible fibrous electrodes, including the materials, structural designs, and fabrication methods. A detailed discussion of electrode performance metrics is provided, covering factors such as conductivity, stretchability, axial channel count, and implantation duration.

Global trends and projections of Parkinson's disease incidence: a 30-year analysis using GBD 2021 data.

Background And Objectives: Parkinson's disease (PD) is a neurodegenerative disorder marked by the progressive loss of dopaminergic neurons, leading to motor dysfunction and non-motor symptoms like cognitive decline and depression. With the aging global population, PD incidence is anticipated to rise, especially in regions with rapidly growing elderly populations. This study leverages Global Burden of Disease (GBD) 2021 data to analyze the burden of PD by region, sex, and age group, examining trends from 1992 to 2021 and projecting the future burden to 2030.

leaves: a functional beverage for alleviating hepatic inflammation and modulating gut microbiota in diabetic mice.

leaves (MHL), consumed as a daily beverage in Chinese folk tradition and recently recognized as a new food material, are abundant in polyphenols and bioactive compounds that demonstrate hypoglycemic, lipid-lowering, and anti-inflammatory effects. However, the antidiabetic mechanisms have not been fully elucidated. This study aimed to investigate the protective mechanisms of leaves' extract (MHLE) against type 2 diabetes mellitus (T2DM).

Duplicate CgCREBL2β involved in the response of oyster upon high-temperature stress through the induction of glycolysis and haemocyte apoptosis.

The cAMP response element-binding protein-like 2 (CREBL2) is involved in the regulation of response to environmental stress. A CREBL2 homologue, CgCREBL2β, was identified in the Pacific oyster Crassostrea gigas and considered a paralog derived from CREBL2 duplication. In the present study, its evolutionary characteristics and involvement in the regulation of glucose metabolism and cell apoptosis after 6 h and 60 h of high-temperature stress were investigated.

Multiscenario Land Use Change Simulation and Its Impact on Ecosystem Service Function in Henan Province Based on FLUS-InVEST Model.

Studying the impact of future land use changes on regional ecosystem services (ES) is crucial for sustainable development planning in the region. However, there is a lack of research specifically targeting Henan Province under different future scenarios. Therefore, this study simulates four ES functions-water yield (WY), carbon storage (CS), habitat quality (HQ), and nutrient delivery ratio (NDR)-for the historical period in Henan Province.

Study on risk assessment of tunnel construction across mined-out region based on combined weight-two-dimensional cloud model.

In this thesis, a risk assessment framework based on the Pressure-State-Response (PSR) model is proposed for the risk assessment problem of crossing the mined-out region in tunnel construction. The subjective weights of the indicators are determined by the G1 method, the objective weights are determined by the improved CRITIC method combined with the Random Forest (RF) machine learning method, and the combined weights are calculated using the game-theoretic combination assignment method. On this basis, a two-dimensional cloud model was constructed to merge the risk frequency and consequence degree to comprehensively assess tunnel construction's safety risk across the mined-out region.

Investigation of an Adsorption Model of Wet Coal That Considers Coal Seam Gas Pressure and Temperature Effects.

To investigate the effects of gas pressure and temperature in different coal seams on the adsorption behavior of water-bearing coal, an equilibrium constant was introduced to combine the L-F model and dual-L model to construct an excess adsorption model that accounts for changes in the volume and density of the adsorption phase. The results showed that the newly developed model effectively described the gas adsorption behavior of coal under varying temperature and moisture conditions. In the initial stage of gas pressure increase, the methane molecules rapidly occupied the micropore adsorption sites, leading to a rapid increase in adsorption phase density.

Global trends and burden of idiopathic epilepsy: regional and gender differences from 1990 to 2021 and future outlook.

Background: Idiopathic epilepsy (IE) remains a significant neurological disorder, contributing to substantial global morbidity and mortality. This study aims to comprehensively evaluate the global burden of IE from 1990 to 2021, focusing on trends in incidence, mortality, and disability-adjusted life years (DALYs) across different geographic regions. Additionally, the study projects IE burden trends through 2036, providing insights for future public health interventions.

Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing.

Background: Spatial transcriptomics is a powerful tool that integrates molecular data with spatial information, thereby facilitating a deeper comprehension of tissue morphology and cellular interactions. In our study, we utilized cutting-edge spatial transcriptome sequencing technology to explore the development of the mouse heart and construct a comprehensive spatiotemporal cell atlas of early murine cardiac development.

Results: Through the analysis of this atlas, we elucidated the spatial organization of cardiac cellular lineages and their interactions during the developmental process.

Hydrogen-Bonded Organic Framework Films Integrated with Wavy Structured Design for Wearable Bioelectronics.

The integration of hydrogen-bonded organic frameworks (HOFs) with flexible electronic technologies offers a promising strategy for monitoring detailed health information, owing to their inherent porosity, excellent biocompatibility, and tunable catalytic capabilities. However, their application in wearable and real-time health monitoring remains largely unexplored, primarily due to the mechanical mismatch between the traditionally fragile HOFs particles and the softness of human skin. Herein, this study demonstrates an epidermal biosensor that maintains reliable sensing capability even under extreme deformation and complex environmental conditions by integrating HOFs films with wavy bioelectrodes.

GABA mitigates mitochondrial apoptosis induced by high temperature stress in the Pacific oyster (Crassostrea gigas).

Background: High temperature is a critical environmental factor leading to mass mortality in oyster aquaculture in China. Recent advancements highlight the physiological regulation function of γ-aminobutyric acid (GABA) in the adaptation of environmental stress.

Methods And Results: This study examined the physiological responses of the Pacific oyster (Crassostrea gigas) upon high temperature exposure, focusing on the histopathological changes in gill, the GABA concentration, the mRNA expression and activities of apoptosis-related genes.

In situ structural-functional synchronous dissection of dynamic neuromuscular system via an integrated multimodal wearable patch.

Neuromuscular abnormality is the leading cause of disability in adults. Understanding the complex interplay between muscle structure and function is crucial for effective treatment and rehabilitation. However, the substantial deformation of muscles during movement (up to 40%) poses challenges for accurate assessment.