Duplicate CgCREBL2β involved in the response of oyster upon high-temperature stress through the induction of glycolysis and haemocyte apoptosis.

The cAMP response element-binding protein-like 2 (CREBL2) is involved in the regulation of response to environmental stress. A CREBL2 homologue, CgCREBL2β, was identified in the Pacific oyster Crassostrea gigas and considered a paralog derived from CREBL2 duplication. In the present study, its evolutionary characteristics and involvement in the regulation of glucose metabolism and cell apoptosis after 6 h and 60 h of high-temperature stress were investigated.

Effect of Celastrus Orbiculatus Extract on proliferation and apoptosis of human Burkitt lymphoma cells.

The lymphoma incidence rate is on the rise, with invasive forms particularly prone to relapse following conventional treatment, posing a significant threat to human life and wellbeing. Numerous studies have shown that traditional Chinese botanical drug medicine offers promising therapeutic benefits for various malignancies, with previous experimental findings indicating that Celastrus orbiculatus extract effectively combats digestive tract tumors. However, its impact on lymphoma remains unexplored.

The expression patterns of exosomal miRNAs in the Pacific oyster after high-temperature stress or Vibrio stimulation.

The exosomal miRNA plays a crucial role in the intercellular communication response to environmental stress and pathogenic stimulation. In the present study, the expression of exosomal miRNAs in the Pacific oyster Crassostrea gigas after high-temperature stress or Vibrio splendidus stimulation was investigated through high-throughput sequencing. The exosomes were identified to be teardrop-like vesicles with the average size of 81.