Effect of different concentrations of gibberellins on antibiotics and nutrient removal using microalgae-bacteria consortia system.

Phytohormone gibberellins (GAs) were utilized to enhance the removal of tetracycline antibiotics and nutrients from swine wastewater by different algal-bacterial symbiosis. Compared to microalgae monoculture, microalgae-activated sludge, and microalgae-, microalgae-endophytic bacteria showed better growth, photosynthetic, and purification performance. At 50 mg L GAs addition concentration, the specific growth rate of -endophytic bacterial (S395-2) system was 0.

Nanosecond pulsed electric field-empowered physical-chemical cascade ferroptosis therapy for triple-negative breast cancer.

Bis-allylic hydrogen atoms of polyunsaturated fatty acids (PUFAs) in biological membranes are major initiation sites of ferroptosis. However, the location of PUFAs in the hydrophobic interior of the lipid bilayer makes it challenging for most ferroptosis-inducing drugs to interact with the PUFAs to promote lipid peroxidation (LPO), potentially limiting the occurrence of ferroptosis. Herein, we propose a new generalized method named physical-chemical cascade ferroptosis (PCCF) for triggering ferroptosis by disrupting the integrity of the cell membrane to expose bis-allylic hydrogen atoms that react with nanozyme MnFI under nanosecond pulsed electric field (nsPEF) assistance.

Exercise-related immune gene signature for hepatocellular carcinoma: machine learning and multi-omics analysis.

Background: Exercise is known to regulate the immune system. However, its prognostic value in hepatocellular carcinoma (HCC) remains largely unknown.

Objective: This study aims to construct a machine learning-based prognostic signature using exercise-related immune genes (EIGs) to predict prognosis in HCC.

Association of behavioral factors, liver function and NAFLD: Bayesian Mendelian randomization.

Background: The causal associations between behavioral factors (BFs) and the risk of non-alcoholic fatty liver disease (NAFLD), and whether liver function mediates these associations, remain unclear. Therefore, this study aimed to assess these associations.

Methods: We performed two-sample Mendelian randomization (2SMR) and multivariable MR (MVMR) analysis using summary-level data to assess the associations between BFs and NAFLD.

Spatial discovery of pyrotinib overcoming HER2-positive breast cancer resistance by breaking fibroblast-induced immune barriers.

Background: The TCbHP regimen, consisting of combining docetaxel (T), carboplatin (Cb), trastuzumab (H), and pertuzumab (P), is the preferred neoadjuvant treatment for locally advanced human epidermal growth factor 2 (HER2)-positive breast cancer. However, about 40 % of patients develop resistance to this treatment. Adding TKIs like pyrotinib to anti-HER2 antibodies may enhance efficacy and reduce resistance, but the mechanisms are not fully understood.

lncSLERT Promotes Liver Metastasis in Colorectal Cancer by Down-Regulating HUNK Expression via RBM15-Mediated m6A Modification.

Background: Metastasis is a hallmark of cancer and the leading cause of cancer-related mortality. However, the mechanism underlying liver metastasis in colorectal cancer (CRC) remains incompletely understood. This study explores the role of long non-coding RNA (lncRNA) SLERT in promoting CRC liver metastasis by downregulating HUNK expression.

Dynamic Parameterization and Optimized Flight Paths for Enhanced Aeromagnetic Compensation in Large Unmanned Aerial Vehicles.

Aeromagnetic detection is a geophysical exploration technology that utilizes aircraft-mounted magnetometers to map variations in the Earth's magnetic field. As a critical methodology for subsurface investigations, it has been extensively applied in geological mapping, mineral resource prospecting, hydrocarbon exploration, and engineering geological assessments. However, the metallic composition of aircraft platforms inherently generates magnetic interference, which significantly distorts the measurements acquired by onboard magnetometers.

ZBP1 senses splicing aberration through Z-RNA to promote cell death.

RNA splicing, a highly regulated process performed by the spliceosome, is essential for eukaryotic gene expression and cellular function. Numerous cellular stresses, including oncogenic insults, dysregulate RNA splicing, often provoking inflammatory responses and cell death. However, the molecular signals generated by splicing aberrations and the mechanism by which cells sense and respond to these signals remain poorly understood.

Epibulbar osseous choristoma.

Osseous choristoma constitutes the rarest category of choristoma affecting pediatric ocular regions. It predominantly composed of ectopically ossified tissue, which can involve anywhere in the eye and typically manifest as isolated anomalies. This study presents the case of an 8-year-old male patient diagnosed with epibulbar osseous choristoma.

Robust MOF-Based Composite Solid-State Electrolyte Membrane for High-Performance Lithium-Metal Batteries.

In this work, we construct a robust MOF-based flexible composite membrane based on PVDF-HFP, UIO-66, and ionic liquid (IL). Through their synergistic reinforcement effect, the obtained solid-state electrolytes can simultaneously achieve high ionic conductivity, good mechanical properties, and flame retardance. The abundant pores of the MOF are capable of loading IL, which not only builds continuous ion channels and facilitates the dissociation of Li but also balances the mechanical properties and electrochemical performance.

Associations and mediators between vitiligo and cardiovascular diseases: a Mendelian randomization study.

Previous studies yielded conflicting results on the associations between vitiligo and cardiovascular diseases (CVD), and its underlying mechanisms remain unclear. This MR study aims to elucidate the underlying causal association between vitiligo and the risk of CVD, as well as the potential mediator. Using summary statistics from genome-wide association study (GWAS), we conducted a bidirectional two-sample Mendelian randomization (MR) analysis and mediation analysis to investigate the causal association between vitiligo and 13 CVD outcomes and potential mediators.

Polydopamine Chelate Modified Separators for Lithium Metal Batteries with High-Rate Capability and Ultra-Long Cycling Life.

Lithium metal batteries (LMBs) have gained significant attention because of their high theoretical energy density. However, under high-rate charge and discharge conditions, lithium metal anodes are susceptible to dendrite formation, compromising battery safety. Creating multifunctional separators offers an effective and cost-efficient solution for addressing fast charging and safety challenges in LMBs.

Effects of drinking slightly acidic electrolyzed water on the growth health, blood physiology, and intestinal development in mice.

Slightly acidic electrolyzed water (SAEW) as a disinfectant might be ingested by humans and animals along with food and drinking water. The present study explored whether adding SAEW to drinking water affects the drinking water intake, food intake, body weight, intestinal morphology, digestive enzyme activity, and antioxidant enzyme activity of mice. This will provide a theoretical basis for the biosafety of SAEW as a food and drinking water disinfectant.

A new broom sweeps clean: CLDN16 surpasses the BRAF-V600E mutation as an unrivaled biomarker in papillary thyroid cancer.

Objective: This study assessed CLDN16 as a potential replacement or improvement biomarker for papillary thyroid cancer (PTC), addressing the limitations associated with the prevalently used BRAF-V600E mutation.

Design: Database analyses, tissue validation, RNA sequencing, and functional assays were conducted to evaluate CLDN16 as a PTC biomarker and its clinical application.

Methods: CLDN16 expression was examined in PTC and normal thyroid/para-tumor tissues and compared across various cancer types.

Inhibition of manganese ion migration and dissolution by selective ions sieving effect of MOF-based solid electrolytes.

Lithium manganese oxide (LiMnO) is a promising cathode material for Li-ion batteries due to its abundant reserves and high discharge voltage. However, the dissolution and migration of transition metal Mn ions during the cycling process will cause a significant deterioration of capacity. In this study, a MOF-based quasi-solid electrolyte (UiO-QSE) is proposed to tackle this issue.

Lymph node yield does not affect the cancer-specific survival of patients with T1 colorectal cancer: a population-based retrospective study of the U.S. database and a Chinese registry.

Purpose: This study aimed to investigate the association between lymph node yield (LNY) and cancer-specific survival (CSS) in patients with T1 colorectal cancer (CRC) via data from two large cohorts.

Methods: We analyzed data from 4186 patients in the SEER cohort (2010-2015) and 533 patients from CHCAMS (2014-2019). Patients were categorized into two groups based on whether their LNY was above or below the guideline-recommended threshold of 12 nodes.

Long-term survival outcomes of laparoscopic surgery in patients with colorectal cancer: A propensity score matching retrospective cohort study.

Objective: Colorectal cancer (CRC) surgeries can be performed using either laparoscopic or open laparotomy approaches. However, the long-term outcomes based on tumor location and age remain unclear. This study compared the long-term outcomes of laparoscopic and laparotomy surgeries in patients with CRC, focusing on tumor location and age to identify suitable subgroups and determine an optimal cut-off age.

Titin gene mutations enhance radiotherapy efficacy via modulation of tumour immune microenvironment in rectum adenocarcinoma.

Objective: This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes in the tumour immune microenvironment.

Methods: Data on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation between TTN mutations and immune cell infiltration.

Development of an oral cancer detection system through deep learning.

Objective: We aimed to develop an AI-based model that uses a portable electronic oral endoscope to capture intraoral images of patients for the detection of oral cancer.

Subjects And Methods: From September 2019 to October 2023, 205 high-quality annotated images of oral cancer were collected using a portable oral electronic endoscope at the Chinese PLA General Hospital for this study. The U-Net and ResNet-34 deep learning models were employed for oral cancer detection.

Endoplasmic reticulum-targeted biomimetic nanoparticles induce apoptosis and ferroptosis by regulating endoplasmic reticulum function in colon cancer.

Colorectal cancer (CRC) is a major threat to human health, as it is one of the most common malignancies with a high incidence and mortality rate. The cancer cell membrane (CCM) has significant potential in targeted tumor drug delivery due to its membrane antigen-mediated homologous targeting ability. The endoplasmic reticulum (ER) in cancer cells plays a crucial role in apoptosis and ferroptosis.

Poly(lactic acid hydroxyacetic acid)-poly(ethylene glycol)-modified ginsenoside Rg3 nanomedicine enhances anti-tumor effect in hepatocellular carcinoma.

Objective: This research aims to improve the bioavailability and anti-hepatocellular carcinoma (HCC) efficacy of Ginsenoside Rg3 by modification with poly (lactic acid hydroxyacetic acid)-poly(ethylene glycol) (PLGA-PEG).

Methods: PLGA-PEG-Rg3 was obtained by emulsification and evaluated it physiochemical characterization by FTIR, SEM, laser particle-size analyzer and HPLC. The effect of the PLGA-PEG-Rg3 and Rg3 on HepG2 cells was compared studies, including cell proliferation, transwell and a series of apoptosis detection, and HCC model.