METTL3-mediated m6A modification promotes ferroptosis in adenomyosis through GPX4 in a YTHDF1-dependent manner.

Adenomyosis, a prevalent gynecologic disorder affecting women of reproductive age, is characterized by the presence of ectopic endometrial tissue within the myometrium. The involvement and underlying mechanisms of ferroptosis in adenomyosis have not been fully elucidated. Recently, m6A RNA modification has been found to regulate various biological processes.

The Characteristics of Primary Multiple Evanescent White Dot Syndrome: Comparison of Adolescent, Young and Middle-Aged, Elderly.

Purpose: To observe the characteristics of primary multiple evanescent white dot syndrome (MEWDS) in adolescent patients, young and middle-aged patients and elderly patients.

Methods: The primary MEWDS patients with at least 3-month follow-up were retrospectively evaluated. We extracted the characteristics of the study population (age, gender, laterality, ametropia, time of onset et al.

Development of a VirB12 gene-deleted Brucella abortus A19 strain as a vaccine candidate for differentiating infected from vaccinated animals in cattle and establishment of a differentiating ELISA assay.

Objective: To evaluate the application of a VirB12 gene-deleted Brucella abortus A19 strain (A19-ΔVirB12) as a vaccine for differentiating infected from vaccinated animals in cattle and to develop an indirect ELISA (i-ELISA) for serological differentiation between vaccinated and naturally infected animals.

Methods: A total of 115 Holstein cattle were immunized with A19-ΔVirB12 vaccine at 6 X 1010 CFUs, and sera were collected at 15, 30, 60, 90, 120, 150, and 180 days after vaccination. To determine the optimal threshold, serum from 180 infected cattle and 204 cattle immunized with A19-ΔVirB12 vaccine were confirmed positive for brucellosis tested by serum agglutination tests and a commercial ELISA kit.

[Rapid screening of 125 pesticide residues in tea substitutes by multi-plug filtration cleanup method combined with gas chromatography-tandem mass spectrometry].

A rapid screening method for 125 pesticide residues of different polarities in tea substitutes matrix was developed using rapid screening combined with gas chromatography-tandem mass spectrometry （GC-MS/MS）. The targets were separated on DB-1701MS quartz capillary column （30 m×0.25 mm×0.

CXCL8 is essential for cervical cancer cell acquired radioresistance and acts as a promising therapeutic target in cervical cancer.

Acquired radioresistance critically challenges cervical cancer radiotherapy management. Clinically relevant radioresistant cell models remain scarce, and CXCL8's role in cervical cancer-despite its tumorigenic/therapy-resistant associations in other cancers-is poorly characterized. Two radioresistant cervical cancer cell strains were established.

Assessment and recalibration of seventeen lung cancer risk prediction models in approximately one million Chinese population utilising healthcare big data: a retrospective cohort analysis.

Background: A number of lung cancer prediction models have been developed worldwide. However, there have been limited validation studies conducted specifically on Chinese populations. The objective of this study is to evaluate the feasibility and performance of 17 global lung cancer risk prediction models when applied to Chinese healthcare big data.

Health assessment of snacks and desserts in Guizhou Province: Analysis of fatty acids and sugar content.

Introduction: Dietary patterns, particularly the excessive consumption of snacks high in fats and sugars, remain a pivotal factor producing adverse impact on the global prevalence of obesity and chronic diseases. However, the current situation is that there is insufficient study on the nutritional value and health risks of local snacks and desserts of Guizhou Province. To fill this gap, this study aimed to analyze the fatty acid (FA) composition and sugar content of popular snacks and desserts in Guizhou Province.

Emerging insights on the ultrasonication assisted modification of multi-scale structure-digestibility relationships in starches: A review.

The inherent properties of native starches impose limitations on their applicability in food contexts due to their susceptibility to processing conditions. Similarly, modifying starches is crucial for improving their functionality. The relationship between the structure and digestibility dynamics of starches remains a significant area of interest.

Comparison of protein composition and structural characterization of prolamin from Jiuzao extracted with different alkaline-alcohol methods.

This study evaluated the efficiency of extracting prolamin from Baijiu Jiuzao using different alkaline alcohol methods, and established an improved method based on the optimization of precipitation process and dialysis steps. Post-dilution acid precipitation enhanced recovery from 29.00 % to 83.

Ningbo Schizophrenia Cohort (NSC)-a longitudinal ambispective cohort based on electronic health records: cohort profile.

Purpose: Electronic health records (EHR) passively generate large datasets on real-world patient populations in easily retrievable form, allowing the cost-efficient and timely execution of epidemiological cohorts on a broad array of topics. However, EHR-based cohorts specialising in mental disorders have not yet been reported. Ningbo has made significant achievements in healthcare data management in China.

STCDB4ND: a signal transduction classification database for neurological diseases.

Neurological disorders pose significant global health challenges due to their complex etiology and insufficient understanding of underlying mechanisms. Signal transduction pathways are critical in the pathophysiology of these diseases and have been extensively studied to develop therapeutic interventions. However, existing databases for biological signal pathways often overlook the dynamic interactions between entities within these pathways and lack standardized representations of the signaling processes.

The impact of gelatinization property differences based on amylopectin structure variations on the glutinous rice flour properties and quality of Daifuku.

The study investigated the effects of paste viscosity for glutinous rice flour (GRF), based on differences in amylopectin structure, on the physicochemical properties of GRF and the quality of Daifuku. Ten GRF from two types (Indica variety: IGRF and Japonica variety: JGRF) were selected and the results showed the viscosity, amylopectin content, percentage of long-branched chains, enthalpy, and setback value of IGRF were significantly higher than JGRF and the Daifuku maintained an excellent appearance, which was related to higher proportion of B and B chain can form more double helix structure after pasting, resulting in higher hardness and compact gel network structure with improved water retention capacity. In contrast, the higher proportion of short chains in JGRF exhibited a slow retrogradation rate and formed an unstable gel network structure.

A genome-wide cross-trait analysis characterizes the shared genetic architecture between lung and gastrointestinal diseases.

Lung and gastrointestinal diseases often occur together, leading to more adverse health outcomes than when a disease of one of these systems occurs alone. However, the potential genetic mechanisms underlying lung-gastrointestinal comorbidities remain unclear. Here, we leverage lung and gastrointestinal trait data from individuals of European, East Asian and African ancestries, to perform a large-scale genetic cross trait analysis, followed by functional annotation and Mendelian randomization analysis to explore the genetic mechanisms involved in the development of lung-gastrointestinal comorbidities.

Feasibility analysis of nondestructive detection of multiple parameters of highland barley by near-infrared spectroscopy.

Background: Highland barley is widely regarded as a premium cereal grain due to its exceptional nutritional profile. This study employed near-infrared spectroscopy technology for the quantitative assessment of five critical parameters in highland barley: total starch, amylose, protein, β-glucan, and total phenols. To optimize spectral data processing, the most effective preprocessing method was identified among six options (standard normal transformation, multivariate scattering correction, normalization (Nor), detrend (DE), first derivative (FD), second derivative (SD)).

Downregulating FGGY carbohydrate kinase domain containing promotes cell senescence by activating the p53/p21 signaling pathway in colorectal cancer.

Carbohydrate kinases serve an oncogenic role in several types of cancer; however, the function of FGGY carbohydrate kinase domain containing (FGGY) in colorectal cancer (CRC) remains unknown. The present study investigated the function and possible molecular mechanisms of FGGY in CRC. The results showed that elevated levels of FGGY mRNA and protein were observed in CRC tissues, and a higher expression of FGGY was associated with advanced N stage and reduced overall survival time in patients with CRC.

A strategy to improve the detection accuracy and universality of highland barley muti-quality attributes based on near infrared spectroscopy combined with model transfer method.

This study utilized direct standardization (DS), piecewise direct standardization (PDS), and DS-PDS algorithms to facilitate model transfer across instruments during the detection of highland barley (HB), and to calibrate HB samples in various states. Following the model transfer, the slave instrument results showed significant improvement. After DS processing, optimal results were achieved for total starch (prediction set correlation coefficient, R = 0.

Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways.

Background: Raised erosive gastritis (REG) is a chronic gastritis with a high risk of malignant transformation. Current treatments often result in high recurrence rates and complications. Jianpi Qinghua Sanyu Yin (JPQHSYY), a traditional Chinese medicine, shows promise in treating REG.

Hexane extract from roots: wound healing properties and membrane-disruptive activities against methicillin-resistant .

Introduction: The extensively used Hemsl. (Lauraceae) in traditional Chinese medicine has been specifically employed for wound healing and treating skin diseases in cattle and horses, suggesting its potential antibacterial properties. To explore the antibacterial activities of plants, we investigated the chemicals, antibacterial activities and wound healing and of the n-hexane fraction of roots (LCH).

Multicenter study of ovarian cancer score for diagnosing ovarian cancer.

Background: Early detection is crucial for improving survival of patients with ovarian cancer (OC), yet current diagnostic tools lack adequate sensitivity and specificity, especially for early stage disease. The study aimed to validate the serum small extracellular vesicles (sEV) protein based Ovarian Cancer Score (OCS) in detecting OC.

Methods: This multicenter study included 1183 adult females with adnexal masses from four hospitals in China (October 2019-April 2023).

Analysis of printing temperature effect on texture modification: Potential of soy protein isolate-based bigel for swallowing-friendly food.

This work prepared the soy protein isolate (SPI)-beeswax-based bigel loaded with β-carotene, and the effect of printing temperature (PT) on texture regulation was investigated. During printing, increasing PT weakened the rheological properties and printability of ink. However, the mechanical strength and deformation resistance at non-linear regions of products were strengthened after printing.

AthRiboNC: an Arabidopsis database for ncRNAs with coding potential revealed from ribosome profiling.

Non-coding RNAs (ncRNAs) are traditionally considered incapable of encoding proteins, but new evidence suggests that small open reading frames (sORFs) within ncRNAs can actually encode biologically functional small peptides. Despite growing recognition of their importance, a systematic exploration of plant ncRNAs with coding potential has remained largely uncharted territory, especially in the context of their translational activities. By collecting and analyzing Ribo-Seq data from 226 Arabidopsis thaliana samples, we have integrated extensive information on Arabidopsis ncRNAs with coding potential and developed the AthRiboNC database, a novel and dedicated database that consolidates extensive information on ncRNAs with coding potential in Arabidopsis.

miR394 and LCR cooperate with TPL to regulate AM initiation.

Plant architecture is a main determinate of crop yield, and lateral branching significantly influences the number of inflorescences and seeds. The mechanism of axillary bud initiation remains unclear. This work aimed to examine how miRNAs regulate axillary bud initiation.

A comprehensive review of starch-based technology for encapsulation of flavor: From methods, materials, and release mechanism to applications.

Encapsulation of flavor and aroma compounds in appropriate materials and forms has long been an important issue. Encapsulation of flavor in inexpensive, stable, and widely used starch-based materials could preserve or mask characteristic aroma compounds, improve flavor thermal and oxidative stability, control release, and increase bioavailability. However, several technical challenges still hinder the application of starch-based encapsulated flavor complexes in the food industry.