AI-augmented prediction of high-risk PINK1 variants associated with Parkinson's disease: integrating multilayered bioinformatics, MD simulation, and deep learning.

Parkinson's disease is a prevalent neurodegenerative disease, in which genetic mutations in many genes play an important role in its pathogenesis. Among these, a mutation in the PINK1 gene, a mitochondrial-targeted serine/threonine putative kinase 1 that protects cells from stress-induced mitochondrial dysfunction, is implicated in autosomal recessive Parkinsonism. However, the exact etiology is not well understood.

The synergistic potential of camrelizumab and rivoceranib in advanced hepatocellular carcinoma: a review of current evidence.

Camrelizumab, a PD-1 inhibitor, and rivoceranib, a VEGFR tyrosine kinase inhibitor, have emerged as a promising combination therapy for advanced or unresectable hepatocellular carcinoma (HCC). This review explores the clinical efficacy and therapeutic potential of this dual treatment approach. A comprehensive literature search was conducted using PubMed/MEDLINE and Google Scholar to evaluate key clinical trials, including the pivotal CARES-310 trial.

Neuroprotective Agents With Reperfusion Therapies in Ischemic Stroke: Evidence From Recent Randomized Trials.

This systematic review evaluates the effectiveness and safety of adjunctive neuroprotective therapies administered in combination with reperfusion treatments, either intravenous (IV) thrombolysis, mechanical thrombectomy, or both, in adult patients with acute ischemic stroke (AIS). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search of four major databases was conducted with filters applied to include English-language randomized controlled trials (RCTs) published within the last five years. From an initial 622 records, 10 eligible RCTs were identified and analyzed.

Weight Loss That Lasts: Reviewing the Long-Term Impact of GLP-1 Receptor Agonists.

This systematic review evaluates the long-term efficacy and safety of GLP-1 receptor agonists in the management of obesity, focusing on data from high-quality randomized controlled trials published between 2018 and 2025. This review synthesizes findings from studies assessing agents such as semaglutide, liraglutide, tirzepatide, and exenatide in diverse populations, including adults with and without type 2 diabetes and adolescents with severe obesity. Most studies demonstrated sustained weight loss and favorable glycemic control over treatment durations of 40-120 weeks.

Exploring the potential of ultrasound: Novel approaches to collagen extraction, modifications, and polypeptide preparation.

Collagen, a protein of considerable abundance in animal tissues, is increasing recognized in food industry for its potent nutritional properties and health benefits. Nevertheless, the suboptimal extraction rate and inefficiencies associated with conventional collagen processing posed significant barriers to its widespread application. Recent advances have spurred interest in the utilization of the ultrasound (US) technology as means to improve collagen extraction processes.

Evaluating the Impact of Audits and Re-audits on Adherence to the Ottawa Knee Rules in a High-Volume UK Trauma Centre.

Background The Ottawa Knee Rules (OKR) are a validated clinical decision-making tool designed to minimise unnecessary radiographs in knee trauma, thereby reducing radiation exposure, optimising resource utilisation, and streamlining patient management. This study audits and re-audits the clinical compliance with OKR in radiography referrals by the Orthopaedic and Emergency Department (ED) teams at Salford Royal NHS Foundation Trust. Methodology A two-cycle retrospective audit was conducted, examining knee X-ray request forms submitted between October 2023 and March 2024 (Cycle 1) and March 2024 and September 2024 (Cycle 2).

Antibiotic Prophylaxis in Orthopaedic Surgery: A Review and Institutional Experience.

Background: Surgical site infections (SSIs) are a significant complication in orthopaedic surgery. Effective use of antimicrobial prophylaxis is critical in reducing their incidence without promoting resistance.

Objectives: To review current evidence on antibiotic prophylaxis in orthopaedic surgery and to analyse data from our institution on the effectiveness of current prophylaxis protocols.

Effect of Dietary Supplementation of Biochars on Growth Performance, Bone Mineralization, Footpad Health, Lymphoid Organs Weight, Antibody Titers of Newcastle Disease and Infectious Bronchitis Disease in Broiler Chicks.

This study evaluated the effect of biochars on growth performance, nutrient digestibility, carcass yield, bone mineralization, litter quality and footpad lesions in broilers. Eight hundred day-old chicks were randomly divided into four treatments, 10 replicates per treatment (20 birds/replicate) for 35 days. Treatments were basal diet (control), a control diet with corncob (CC) biochar (1%), a control diet with wheat straw (WS) biochar (1%) and a control diet with sugarcane bagasse (SCB) biochar (1%).

A Cinderella story in antimicrobials: CDPDP's perfect fit for multiple-pathway bacterial inhibition.

The rapid rise of antibiotic resistance among bacterial pathogens threatens global health, rendering many existing drugs ineffective and creating an urgent demand for new therapeutic strategies. To the best of our knowledge, this is the first work reporting the detailed antibacterial mechanism of action of twelve targeted genes. Here, we evaluated the marine-derived compound CDPDP for its antibacterial activity against Staphylococcus aureus (S.

Transcriptional variation of meat quality marker genes in different age and sex groups of Balkhi breed sheep.

In the present study, the effects of age and sex on the expression of meat quality marker genes such as the FASN (Fatty Acid Synthase), C/EBPα (CCAAT Enhancer Binding Protein Alpha), PLIN1 (Perilipin-1), PPARγ (Peroxisome Proliferator Activated Receptor Gamma), and SIRT1 (Sirtuin1) were explored. The total RNA was extracted, the cDNA library was constructed, and mRNA was quantified through qRT-PCR from the samples of young and mature sheep of male and female Balkhi breeds. Moreover, the correlation of expression levels of these genes with body and measurement traits was also explored in Balkhi sheep.

Retraction: Outcomes of Gallbladder Drainage Techniques in Acute Cholecystitis: Percutaneous Versus Endoscopic Methods.

[This retracts the article DOI: 10.7759/cureus.73504.

Synopsis of Chinese Banks, 1906 (Plecoptera, Chloroperlidae), with description of a new species.

A new species of the genus Banks, 1906 (Plecoptera, Chloroperlidae), Rehman, Huo & Du, , is described from Liaoning Province, China, with diagnostic features and color images of the adult habitus included. The terminalia of the new species are compared with those of related species, and key similarities and distinguishing characteristics are highlighted. In addition, the male of Zwick, 1972 is described from China for the first time, as previous records included only females.

Recurrent Acrodermatitis Enteropathica in a Pediatric Patient: A Rare Case Report with Zinc Deficiency and Complications.

Introduction: Acrodermatitis enteropathica (AE) is a rare genetic disorder that results in impaired zinc absorption due to a mutation in the SLC39A4 gene, leading to systemic zinc deficiency with characteristic dermatologic, immunologic, and gastrointestinal manifestations.

Case Presentation: This case report presents a 6-year-old boy with recurrent AE, exhibiting widespread vesiculopustular lesions, alopecia, chronic diarrhea, and poor growth, symptoms typical of zinc deficiency syndromes. Initial diagnosis was supported by low serum zinc levels, elevated C-reactive protein, and IgE, indicating an inflammatory process.

Dissenting an Uncommon Diagnosis at Unusual Origin: A Case Report of Teratocarcinosarcoma of Sinonasal Cavity - A Rare Malignancy.

Introduction: Teratocarcinosarcoma is an extremely rare and aggressive malignancy of the nasal cavity and paranasal sinuses, comprising epithelial, mesenchymal, and neuroectodermal components. Due to its aggressive behavior, early diagnosis and a multimodal treatment approach are essential for improving outcomes.

Case Presentation: We report the case of a 55-year-old male who presented with bilateral nasal discharge, recurrent epistaxis, progressive nasal swelling, and left-sided epiphora over several months.