AI-augmented prediction of high-risk PINK1 variants associated with Parkinson's disease: integrating multilayered bioinformatics, MD simulation, and deep learning.

Parkinson's disease is a prevalent neurodegenerative disease, in which genetic mutations in many genes play an important role in its pathogenesis. Among these, a mutation in the PINK1 gene, a mitochondrial-targeted serine/threonine putative kinase 1 that protects cells from stress-induced mitochondrial dysfunction, is implicated in autosomal recessive Parkinsonism. However, the exact etiology is not well understood.

Salinity-induced variations in growth performance, stress biomarkers and biochemical profiles of striped catfish (Pangasianodon hypophthalmus, Sauvage, 1878).

Environmental salinity affects the growth, survival rate and physiological functions of fish. In this study, the effects of salinity stress on Pangasianodon hypophthalmus (Sauvage, 1878) fingerlings were examined over a 90-day period. After acclimatization, a total of 300 P.

Dual-model approach for accurate chest disease detection using GViT and swin transformer V2.

The precise detection and localization of abnormalities in radiological images are very crucial for clinical diagnosis and treatment planning. To build reliable models, large and annotated datasets are required that contain disease labels and abnormality locations. Most of the time, radiologists face challenges in identifying and segmenting thoracic diseases such as COVID-19, Pneumonia, Tuberculosis, and lung cancer due to overlapping visual patterns in X-ray images.

Effectiveness of Feed-Based Monovalent Vaccine in Farmed Carp.

() is responsible for causing abdominal dropsy, swimming abnormalities, skin ulcerations, and pale gills in fish. Vaccination is an essential strategy for disease prevention in aquaculture. This study evaluated the efficacy of an oral vaccine against in ().

Alleviating cadmium-induced stress in maize: the role of zinc sulphate application on growth and biochemical responses.

Cadmium stress (Cd) damages plant growth and development by causing oxidative damage and plant physiological and biochemical attributes. However, zinc sulphate (ZnS) may act as an acute stress signal to alleviate the toxic effects of Cd stress by upregulating the antioxidant defense mechanism and enhancing nutrient absorption. This study aimed to evaluate the impact of ZnS foliar application on mitigating the toxic effects of Cd stress in maize seedlings.

Thiram-driven XBP1 and CHOP pathways orchestrate ER stress and avian tibial dyschondroplasia via metabolic inflammatory axis.

Thiram, one of the most widely used dithiocarbamate fungicides, has turned out to be a very potent cellular metabolic homeostasis disruptor through the induction of endoplasmic reticulum (ER) stress. The present study examines the mechanistic foundation of thiram-induced tibial dyschondroplasia in birds, emphasizing ER stress and inter-organ crosstalk. According to our findings, thiram caused impairment in the function of hepatocytes, as well as inducing an inflammatory cascade of signals in the tibial growth plate and liver tissues.

Impact of Thiourea on Wheat's Morpho-Physiological and Ionic Attributes ( L.) under Lead Stress: Reducing the Translocation of Lead from Soil to Roots, Shoots, and Grains.

Wheat ( L.) is a key cereal crop broadly consumed across the earth. Nonetheless, abiotic stressor influences such as toxic metals severely limit its production.

Omega-3 Fatty Acids, Lecithin, Sterols, Vitamins and Lipid Oxidation of Olein and Super Olein Fractions of Fish Oil Produced by Winterization.

To concentrate omega-3 fatty acids (-3) in fish oil (FO), olein and super olein fraction (OF) of FO were produced by winterization. For this purpose, FO was slowly cooled to -50°C (24 h), the mixture of crystallized and non-crystallized phases was separated, filtrate was coded as OF (yield 32%), 35% of OF was kept for storage study and analytical purpose, remaining 65% was further slowly cooled down to -75°C (24 h) and filtered, filtrate was coded as super olein (SF, yield 23%). GC-MS analysis showed that unsaturated fatty acids increased due to successive winterization.

Correction: Impact of duck stocking density on growth performance, digestive enzymes, blood biochemistry, and antioxidant capacity of the Labeo rohita reared in an integrated ponds system.

[This corrects the article DOI: 10.1371/journal.pone.

Triboelectric Nanogenerator Drives Electrochemical Water Splitting for Hydrogen Production: Fundamentals, Progress, and Challenges.

Currently, triboelectric nanogenerators (TENGs) are drawing significant attention owing to their potential in harvesting wave and wind energy from environment as well as their capability for driving electrochemical water splitting for hydrogen fuel production. This review aims to summarize the recent progress of ocean wave and wind energy harvesting TENGs and TENG-driven electrochemical water splitting processes for hydrogen evolution reaction. For better understanding, this review begins from the fundamentals of TENG and electrochemical water splitting.

Conservation agriculture effects on ecosystem health and sustainability - A review of rice-wheat cropping system.

Conventional tillage, extreme climate events, increasing weed incidence, pest and disease pressures, and diminished farm input availability negatively impact crop yield, stability, profitability, and water productivity in South Asia's rice-wheat (R-W) systems. This article reviews and evaluates the effectiveness and benefits of conservation agriculture (CA) practices in improving soil health, water productivity, and sustainability in R-W systems. CA practices focus on minimum soil disturbance, permanent soil cover, and crop rotations.

PRONTO-TK: a user-friendly PROtein Neural neTwOrk tool-kit for accessible protein function prediction.

Associating one or more Gene Ontology (GO) terms to a protein means making a statement about a particular functional characteristic of the protein. This association provides scientists with a snapshot of the biological context of the protein activity. This paper introduces PRONTO-TK, a Python-based software toolkit designed to democratize access to Neural-Network based complex protein function prediction workflows.

Optimization of an ultrasound-assisted extraction method to obtain gallic acid-rich extracts from mango seed kernels.

Gallic acid is a widely recognized bioactive compound that falls under the category of secondary polyphenolic metabolites and is fairly found in mango fruit waste, specifically in mango seed kernel (MSK). This study aimed to adopt a green extraction approach to extract this valuable compound via ultrasound-assisted extraction (UAE) without using organic solvents but only water to obtain hazard-free extracts, and the cost of extraction can be minimal. pH (2-8), solvent ratio (20-60 mL/g), temperature (30-60°C) and time (30-60 min) of extraction were the independent variables used for extraction optimization.

Hyperspectral identification of oil adulteration using machine learning techniques.

Food adulteration is a global concern, drawing attention from safety authorities due to its potential health risks. Detecting and categorizing oil adulteration is crucial for consumer safety and food industry integrity. This research explores hyperspectral imaging (HSI) analysis to identify substandard oil adulteration at different stages.

Biopolymer Materials in Triboelectric Nanogenerators: A Review.

In advancing the transition of the energy sector toward heightened sustainability and environmental friendliness, biopolymers have emerged as key elements in the construction of triboelectric nanogenerators (TENGs) due to their renewable sources and excellent biodegradability. The development of these TENG devices is of significant importance to the next generation of renewable and sustainable energy technologies based on carbon-neutral materials. This paper introduces the working principles, material sources, and wide-ranging applications of biopolymer-based triboelectric nanogenerators (BP-TENGs).

Magnetic Material in Triboelectric Nanogenerators: A Review.

Nowadays, magnetic materials are also drawing considerable attention in the development of innovative energy converters such as triboelectric nanogenerators (TENGs), where the introduction of magnetic materials at the triboelectric interface not only significantly enhances the energy harvesting efficiency but also promotes TENG entry into the era of intelligence and multifunction. In this review, we begin from the basic operating principle of TENGs and then summarize the recent progress in applications of magnetic materials in the design of TENG magnetic materials by categorizing them into soft ferrites and amorphous and nanocrystalline alloys. While highlighting key role of magnetic materials in and future opportunities for improving their performance in energy conversion, we also discuss the most promising choices available today and describe emerging approaches to create even better magnetic TENGs and TENG-based sensors as far as intelligence and multifunctionality are concerned.

Investigating the growth promotion potential of biochar on pea (Pisum sativum) plants under saline conditions.

Pea, member of the plant family Leguminosae, play a pivotal role in global food security as essential legumes. However, their production faces challenges stemming from the detrimental impacts of abiotic stressors, leading to a concerning decline in output. Salinity stress is one of the major factors that limiting the growth and productivity of pea.

Clean energy transition and climate vulnerabilities: A comparative analysis of European and non-European developed countries.

Currently, the world faces an existential threat of climate change, and every government across the globe is trying to come up with strategies to tackle the severity of climate change in every way possible. To this end, the use of clean energy rather than fossil fuel energy sources is critical, as it can reduce greenhouse gas emissions and pave the way for carbon neutrality. This study examines the impact of the energy cleanability gap on four different climate vulnerabilities, such as ecosystem, food, health, and housing vulnerabilities, considering 47 European and non-European high-income countries.

Molecular characterization of Aeromonas hydrophila detected in Channa marulius and Sperata sarwari sampled from rivers of Punjab in Pakistan.

Aeromonas hydrophila is one of the major pathogenic bacteria responsible for causing severe outbreaks at fish farms and is also a major global public health concern. This bacterium harbors many virulence genes. The current study was designed to evaluate the antidrug and virulence potential of A.

Assessing the environmental sustainability gap in G20 economies: The roles of economic growth, energy mix, foreign direct investment, and population.

There is serious debate among researchers regarding the sustainability implications of economic prosperity and energy dependence. Energy consumption has a critical linkage with economic growth, but it also degrades environmental quality. Therefore, it is important to investigate the relationship between economic growth, the energy mix, and environmental sustainability.

From Body Monitoring to Biomolecular Sensing: Current Progress and Future Perspectives of Triboelectric Nanogenerators in Point-of-Care Diagnostics.

In the constantly evolving field of medical diagnostics, triboelectric nanogenerators (TENGs) stand out as a groundbreaking innovation for simultaneously harnessing mechanical energy from micromovements and sensing stimuli from both the human body and the ambient environment. This advancement diminishes the dependence of biosensors on external power sources and paves the way for the application of TENGs in self-powered medical devices, especially in the realm of point-of-care diagnostics. In this review, we delve into the functionality of TENGs in point-of-care diagnostics.

Optimizing rice-fish co-culture: Investigating the impact of rice spacing density on biochemical profiles and production of genetically modified tilapia (Oreochromis spp.) and Cyprinus carpio.

Rice fish co-culture synergistically boosts food production, resulting in numerous advantages across the environmental, social, and financial domains. A study was conducted to investigate the effects of three different rice spacing densities, rice high density (RHD) 9inch×12inch, rice medium density (RMD) 12inch × 12inch, rice low density (RLD) 15inch×12inchon both rice and fish. Various parameters were assessed to evaluate the performance of the co-culture system, including water quality, growth parameters, muscle quality, soil characteristics, rice stem characteristics, and rice yield parameters.