Weakly and Self-Supervised Class-Agnostic Motion Prediction for Autonomous Driving.

Understanding motion in dynamic environments is critical for autonomous driving, thereby motivating research on class-agnostic motion prediction. In this work, we investigate weakly and self-supervised class-agnostic motion prediction from LiDAR point clouds. Outdoor scenes typically consist of mobile foregrounds and static backgrounds, allowing motion understanding to be associated with scene parsing.

DAPK1 acts as a positive regulator of hypertension via induction of vasoconstriction.

Death-associated protein kinase 1 (DAPK1) is a tumor suppressor gene involved in apoptosis, autophagy, and tumor progression. However, its role in hypertension (HTN) remains largely unexplored and lacks systematic evaluation. We administered adeno-associated virus (AAV) harboring short hairpin RNA targeting DAPK1 or control short hairpin RNA to male spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats.

Dynamic View Synthesis From Small Camera Motion Videos.

Novel view synthesis for dynamic 3D scenes poses a significant challenge. Many notable efforts use NeRF-based approaches to address this task and yield impressive results. However, these methods rely heavily on sufficient motion parallax in the input images or videos.

Neural Vector Fields: Generalizing Distance Vector Fields by Codebooks and Zero-Curl Regularization.

Recent neural networks based surface reconstruction can be roughly divided into two categories, one warping templates explicitly and the other representing 3D surfaces implicitly. To enjoy the advantages of both, we propose a novel 3D representation, Neural Vector Fields (NVF), which adopts the explicit learning process to manipulate meshes and implicit unsigned distance function (UDF) representation to break the barriers in resolution and topology. This is achieved by directly predicting the displacements from surface queries and modeling shapes as Vector Fields, rather than relying on network differentiation to obtain direction fields as most existing UDF-based methods do.

Mechanistic insights into Jianpi Qinghua Sanyu Yin treatment of raised erosive gastritis: ceRNA-mediated PI3K/AKT signaling pathways.

Background: Raised erosive gastritis (REG) is a chronic gastritis with a high risk of malignant transformation. Current treatments often result in high recurrence rates and complications. Jianpi Qinghua Sanyu Yin (JPQHSYY), a traditional Chinese medicine, shows promise in treating REG.

Effect of Helicobacter pylori infection on survival outcomes of patients undergoing radical gastrectomy after neoadjuvant chemotherapy: a multicenter study in China.

Background: Neoadjuvant chemotherapy (NAC) has been confirmed to improve the prognosis of patients with advanced gastric cancer (AGC). However, no study has investigated whether Helicobacter pylori (HP) infection affects the postoperative survival of patients who receive NAC.

Methods: This retrospective cohort study included 307 patients with AGC who underwent laparoscopic radical gastrectomy after NAC at three hospitals in China between January 1, 2016, and April 31, 2020.

Dual-Camera All-in-Focus Neural Radiance Fields.

We present the first framework capable of synthesizing the all-in-focus neural radiance field (NeRF) from inputs without manual refocusing. Without refocusing, the camera will automatically focus on the fixed object for all views, and current NeRF methods typically using one camera fail due to the consistent defocus blur and a lack of sharp reference. To restore the all-in-focus NeRF, we introduce the dual-camera from smartphones, where the ultra-wide camera has a wider depth-of-field (DoF) and the main camera possesses a higher resolution.

Weakly Supervised Segmentation on Outdoor 4D Point Clouds With Progressive 4D Grouping.

Recently, some weakly supervised 3D point cloud segmentation methods have been proposed to develop effective models with minimum annotation efforts. Our previous work, W4DTS, proposes a challenging task that utilizes only 0.001% points in outdoor point cloud datasets to achieve an effective segmentation model.

BokehMe++: Harmonious Fusion of Classical and Neural Rendering for Versatile Bokeh Creation.

Despite significant advancements in simulating the bokeh effect of Digital Single Lens Reflex Camera (DSLR) from an all-in-focus image, challenges remain in processing highlight points, preserving boundary details for in-focus objects and processing high-resolution images efficiently. To tackle these issues, we first develop a ray-tracing-based bokeh simulator. An innovative pipeline with weight redistribution is introduced to handle highlight rendering.

Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis.

Background: Metastasis remains the leading cause of cancer mortality. The natural product brusatol (Bru) has exhibited promising anticancer activity; however, the target proteins of Bru and the underlying mechanisms in suppressing tumor metastasis remain unclear.

Purpose: We aim to identify the target of Bru and examine its role in suppressing tumor metastasis.

Neferine attenuates hypertensive cardiomyocyte apoptosis and modulates key signaling pathways: An in vivo and in vitro study.

Background: Although neferine exhibits obvious therapeutic effects against hypertension, its effects on cardiac protection remain unknown.

Purpose: This study aimed to investigate its potential cardioprotective effects and associated mechanisms.

Methods: Spontaneously hypertensive rats (SHRs) were randomly divided into four groups, namely SHR, SHR + Neferine-L (2.

Trifolin attenuates hypertension-mediated cardiac injury by inhibiting cardiomyocyte apoptosis: Mechanistic insights and therapeutic potential.

Background: Hypertension-induced cardiac disease is a common complication and a significant contributor to mortality in hypertensive patients, largely due to cardiomyocyte apoptosis. Although Trifolin has been identified as a potential antihypertensive compound, its therapeutic role in hypertension-induced cardiac injury remains uncertain.

Purpose: This study aims to evaluate the protective effects of Trifolin and explore the underlying mechanisms of its action against hypertension-induced cardiac injury.

Multi-octave two-color soliton frequency comb in integrated chalcogenide microresonators.

Mid-infrared (MIR) Kerr microcombs are of significant interest for portable dual-comb spectroscopy and precision molecular sensing due to strong molecular vibrational absorption in the MIR band. However, achieving a compact, octave-spanning MIR Kerr microcomb remains a challenge due to the lack of suitable MIR photonic materials for the core and cladding of integrated devices and appropriate MIR continuous-wave (CW) pump lasers. Here, we propose a novel slot concentric dual-ring (SCDR) microresonator based on an integrated chalcogenide glass chip, which offers excellent transmission performance and flexible dispersion engineering in the MIR band.

Baicalin ameliorates angiotensin II-induced cardiac hypertrophy and mitogen-activated protein kinase signaling pathway activation: A target-based network pharmacology approach.

Baicalin, a flavonoid glycoside from Scutellaria baicalensis Georgi., exerts anti-hypertensive effects. The present study aimed to assess the cardioprotective role of baicalin and explore its potential mechanisms.

Therapeutic potential of Pien Tze Huang in colitis-associated colorectal cancer: mechanistic insights from a mouse model.

Background: Pien Tze Huang (PZH), a traditional Chinese medicine formulation, is recognized for its therapeutic effect on colitis and colorectal cancer. However, its protective role and underlying mechanism in colitis-associated colorectal cancer (CAC) remain to be elucidated.

Methods: A CAC mouse model was established using AOM/DSS.

Instance Consistency Regularization for Semi-Supervised 3D Instance Segmentation.

Large-scale datasets with point-wise semantic and instance labels are crucial to 3D instance segmentation but also expensive. To leverage unlabeled data, previous semi-supervised 3D instance segmentation approaches have explored self-training frameworks, which rely on high-quality pseudo labels for consistency regularization. They intuitively utilize both instance and semantic pseudo labels in a joint learning manner.

Self-Supervised 3D Scene Flow Estimation and Motion Prediction Using Local Rigidity Prior.

In this article, we investigate self-supervised 3D scene flow estimation and class-agnostic motion prediction on point clouds. A realistic scene can be well modeled as a collection of rigidly moving parts, therefore its scene flow can be represented as a combination of rigid motion of these individual parts. Building upon this observation, we propose to generate pseudo scene flow labels for self-supervised learning through piecewise rigid motion estimation, in which the source point cloud is decomposed into local regions and each region is treated as rigid.

CMFAN: Cross-Modal Feature Alignment Network for Few-Shot Single-View 3D Reconstruction.

Few-shot single-view 3D reconstruction learns to reconstruct the novel category objects based on a query image and a few support shapes. However, since the query image and the support shapes are of different modalities, there is an inherent feature misalignment problem damaging the reconstruction. Previous works in the literature do not consider this problem.

Textbook oncological outcomes and prognosis after curative gastrectomy in advanced gastric cancer: A multicenter study.

Background: The impact of achieving textbook oncological outcome (TOO) as a multimodal therapy quality indicator on the prognosis of advanced gastric cancer (AGC) remains inadequately assessed.

Methods: Patients with AGC who underwent curative gastrectomy between January 2010 and December 2017 at two East Asian medical centers were included. TOO was defined as achieving the textbook outcome (TO) and receiving neoadjuvant and/or adjuvant chemotherapy (NCT or ACT).

OSATS scoring confirms ICG enhancement of performance in laparoscopic radical gastrectomy: a post-hoc analysis of a randomized controlled trial.

Background: Indocyanine green (ICG) fluorescence imaging is effective in increasing the number of lymph node dissections during laparoscopic radical gastrectomy; however, no studies have attempted to explain this phenomenon.

Methods: This study utilized the data from a previous randomized controlled trial (FUGES-012 study) investigating ICG-guided laparoscopic radical gastrectomy performed between November 2018 and July 2019. The Objective Structured Assessments of Technical Skills (OSATS) scoring system was used to grade videos from the ICG and non-ICG groups.

Evaluation of dynamic recurrence risk for locally advanced gastric cancer in the clinical setting of adjuvant chemotherapy: a real-world study with IPTW-based conditional recurrence analysis.

Background: The long-term dynamic recurrence hazard of locally advanced gastric cancer (LAGC) in the clinical setting of adjuvant chemotherapy (ACT) remains unclear.

Purpose: This study aimed to investigate the dynamic recurrence risk of LAGC in patients who received ACT or not.

Methods: The study assessed data from patients with LAGC who underwent radical gastrectomy between January, 2010 and October, 2015.

An international multi-institution real-world study of the optimal surveillance frequency for stage II/III gastric cancer: the more, the better?

Background: Due to lacking evidence on surveillance for gastric cancer (GC), this study aimed to determine the optimal postsurgical surveillance strategy for pathological stage (pStage) II/III GC patients and compare its cost-effectiveness with traditional surveillance strategies.

Methods: Prospectively collected data from stage II/III GC patients ( n =1661) who underwent upfront surgery at a large-volume tertiary cancer center in China (FJMUUH cohort) between January 2010 and October 2015. For external validation, two independent cohorts were included, which were composed of 380 stage II/III GC patients at an tertiary cancer center in U.