Counterion-mediated modulation of electroadhesion in polyanionic/polycationic hydrogels: mechanisms and performance.

Reversible electroadhesive polyelectrolyte gels have emerged as promising materials for flexible electronic and soft robotic applications. While current research predominantly emphasizes polymer design and structural optimization to enhance both the reversibility and strength of electroadhesion, fundamental limitations persist in elucidating ion-mediated interfacial mechanisms. Herein, the synergistic effects of ion species selection and interfacial engineering were systematically investigated through the development of distinct polyelectrolyte hydrogel assemblies.

A bayesian network model for neurocognitive disorders digital screening in Chinese population: development and validation study.

Background: Neurocognitive disorders (NCDs), classified under the ICD-10 codes F00-F09, are a category of mental disorders associated with brain disease, injury, or systemic conditions leading to cerebral dysfunction. NCDs represent a significant disease burden and an increasingly critical global public health challenge. Early screening for neurocognitive disorders is conducive to improving patients' quality of life and reducing healthcare costs.

Aminated Lignin/Cellulose-Based Hydrogel with High Adhesion for Wearable Sensors.

Hydrogels play a significant role in the flexibility, stretchability, and conductivity of wearable sensors. However, it is still a challenge to achieve multifunctional hydrogel sensors with excellent mechanical strength, outstanding self-adhesion, and high stimulus responsiveness for meeting various demands of practical applications. Here, this work presents a one-pot method to prepare a conductive hydrogel with multifunction by introducing aminated lignosulfonate (A-LS) and aminated cellulose nanocrystals (A-CNC) into the hydrogel matrix.

Cardiovascular-kidney-metabolic syndrome modifies smoking-related risk for cardiovascular diseases: findings from an observational cohort study in UK Biobank.

Background: The present study aims to investigate the association of smoking behaviors and cardiovascular-kidney-metabolic (CKM) syndrome with incident cardiovascular disease (CVD), and to evaluate whether the cardiovascular benefits of smoking cessation vary across different CKM conditions.

Methods: This study included 242,636 white European participants from the UK Biobank who were classified as CKM syndrome Stages 0 to 3 and free of CVD at baseline. Covariates adjusted Cox proportional hazards models were employed to evaluate the associations of CKM syndrome with the risks of total CVD, stroke, coronary heart disease (CHD), major adverse cardiovascular events (MACE), and 13 CVD subtypes.

Waterborne blocked isocyanate crosslinked cationic starch/polyvinyl alcohol coating for improving barrier and mechanical properties of paper-based materials.

Green and renewable paper-based packaging materials are gaining more and more popularity, however, issues such as poor barrier and mechanical properties need to be solved. Herein, cationic starch (CS) and polyvinyl alcohol (PVA) were used as paper coatings, with waterborne blocked isocyanate (WBI) serving as a cross-linking agent to eliminate the hydroxyl groups. CS/PVA and CS/PVA/WBI were coated on kraft paper using a bar coating machine at 8 g/m.

A large dataset covering the Chinese national sign language for dual-view isolated sign language recognition.

Isolated Sign Language Recognition (ISLR), which seeks to automatically align sign videos with corresponding glosses, has recently gained considerable attention from the artificial intelligence community. This technology has the potential to bridge the communication gap between hearing people and the deaf community. However, the development of ISLR is hindered by the scarcity of sign language datasets.

oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice.

Background: In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation and impaired sexual performance. The aim of this study was to investigate the potential effects of oligosaccharides (MOO) on depression and its concomitant symptom, sexual dysfunction.

Methods: Chronic unpredictable mild stress (CUMS)-induced depression model was constructed, and the effects of MOO on depression and sexual abilities were evaluated.

TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets.

Available large-scale genome-wide association study (GWAS) summary datasets predominantly stem from European populations, while sample sizes for other ethnicities, notably Central/South Asian, East Asian, African, Hispanic, etc., remain comparatively limited, resulting in low precision of causal effect estimations within these ethnicities when using Mendelian randomization (MR). In this paper, we propose a trans-ethnic MR method, TEMR, to improve the statistical power and estimation precision of MR in a target population that is underrepresented, using trans-ethnic large-scale GWAS summary datasets.

Engineering Green- to Blue-Emitting CsPbBr Quantum Dots in Nanozeolite with High Stability for Backlight Display Application.

The performance of blue devices utilizing perovskite quantum dots (PQDs) has lagged remarkably behind that of green light-emitting diodes because of low luminescence quantum yields and poor spectral stability. Here, benefiting from the rapid and short diffusion paths within the nanosized silicalite-1 (N-Si-1) zeolite (∼40 nm) channels, CsPbBr PQDs encapsulated within N-Si-1 show a high dispersion with an ultrasmall particle size of ∼2.38 nm and a blue emission of 474 nm with a high photoluminescence quantum yield (PLQY) of 44.

A comprehensive evaluation on the associations between hearing and vision impairments and risk of all-cause and cause-specific dementia: results from cohort study, meta-analysis and Mendelian randomization study.

Background: Epidemiological studies show inconsistent links between hearing/vision impairment and dementia risk. Using multisource data, we investigated how single or combined sensory impairments relate to risks of all-cause and specific types of dementia.

Methods: We employed a triangulation approach combining three methodologies.

A novel constraint-based structure learning algorithm using marginal causal prior knowledge.

Causal discovery with prior knowledge is important for improving performance. We consider the incorporation of marginal causal relations, which correspond to the presence or absence of directed paths in a causal model. We propose the Marginal Prior Causal Knowledge PC (MPPC) algorithm to incorporate marginal causal relations into a constraint-based structure learning algorithm.

Multi-perspective evaluation on spent lithium iron phosphate recycling process: For next-generation technology option.

The recycling of spent lithium iron phosphate batteries has recently become a focus topic. Consequently, evaluating different spent lithium iron phosphate recycling processes becomes necessary for industrial development. Here, based on multiple perspectives of environment, economy and technology, four typical spent lithium iron phosphate recovery processes (Hydro-A: hydrometallurgical total leaching recovery process; Hydro-B(HO/O): hydrometallurgical selective lithium extraction process; Pyro: Pyrometallurgical recovery process; Direct: Direct regeneration process) were compared comprehensively.

Bibliometric analysis and key messages of integrating Chinese and Western Medicine for COVID-19.

Background: The coronavirus disease 2019 (COVID-19) has been a global pandemic since it broke out, and integrated Chinese and Western medicine (ICWM) has played an important role in the prevention and treatment of COVID-19. We aimed to analyze the published literature on ICWM for COVID-19 at home and abroad, and compare their differences on hotspots and research fronts.

Methods: Publications before Oct 31, 2022 were retrieved from the Web of Science core database (WOS), PubMed, China National Knowledge Infrastructure database (CNKI), Wanfang Data Knowledge Service Platform (Wanfang), China Science and Technology Journal Database (VIP), China Biology Medicine disc (CBM), CiteSpace and VOSviewer to summarize the basic characteristics of publications, countries, institutions, keywords, and citations.

MRSL: a causal network pruning algorithm based on GWAS summary data.

Causal discovery is a powerful tool to disclose underlying structures by analyzing purely observational data. Genetic variants can provide useful complementary information for structure learning. Recently, Mendelian randomization (MR) studies have provided abundant marginal causal relationships of traits.

Response of C:N:P stoichiometry to long-term drainage of peatlands: Evidence from plant, soil, and enzyme.

Drought induced by climate warming and human activities regulates carbon (C) cycling of peatlands by changing plant community composition and soil properties. Estimating the responses of peatlands C cycling to environmental changes requires further study of C: nitrogen (N): phosphorus (P) stoichiometric ratios of soil, plants, and enzyme activities. However, systematic studies on the stoichiometry of above-ground and below-ground ecosystems of peatlands post drainage remain scarce.

Causal associations between female reproductive behaviors and psychiatric disorders: a lifecourse Mendelian randomization study.

Background: The timings of reproductive life events have been examined to be associated with various psychiatric disorders. However, studies have not considered the causal pathways from reproductive behaviors to different psychiatric disorders. This study aimed to investigate the nature of the relationships between five reproductive behaviors and twelve psychiatric disorders.

The effect of electrical parameters of eddy current sensor on metal film thickness measurement performance and the optimization method.

Eddy current sensors have been widely used in the field of micro- and nano-measurements. The detection circuit is a key part of eddy current sensors. In particular, the electrical parameters in the signal conversion circuit have an important effect on the measurement performance.

Comparing the efficacy and safety of medications in adults with hypertrophic cardiomyopathy: a systematic review and network meta-analysis.

Background: Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease. The purpose of this study was to evaluate the efficacy and safety of several medications and recommend better drug treatments for adults with HCM.

Methods: A review of PubMed, Embase, the Cochrane Controlled Register of Trials (CENTRAL), ClinicalTrials.

The long-term mediation role of cytokines on the causal pathway from maternal gestational age to offspring eye diseases: Lifecourse-Network Mendelian randomization.

Background: Gestational duration has a significant impact on eye diseases. A large number of evidences suggest that cytokines are associated with gestational duration and eye diseases. However, the causal relationships among cytokines, maternal gestational impairment and offspring eye diseases remain unclear.

Identifying optimal first-line immune checkpoint inhibitors based regiments for advanced non-small cell lung cancer without oncogenic driver mutations: A systematic review and network meta-analysis.

Background: Immune checkpoint inhibitors (ICIs) have changed the treatment pattern of advanced and metastatic NSCLC. A series of ICI based therapies have emerged in the first-line treatment field, but the comparative efficacy was unclear.

Method: We searched multiple databases and abstracts of major conference proceedings up to Apri1, 2022 for phase III randomised trials of advanced driver-gene wild type NSCLC patients receiving first-line therapy.

Hydrophobicity Tailoring of Ferric Covalent Organic Framework/MXene Nanosheets for High-Efficiency Nitrogen Electroreduction to Ammonia.

Electrocatalytic nitrogen reduction reaction (NRR) represents a promising sustainable approach for NH synthesis. However, the poor NRR performance of electrocatalysts is a great challenge at this stage, mainly owing to their low activity and the competitive hydrogen evolution reaction (HER). Herein, 2D ferric covalent organic framework/MXene (COF-Fe/MXene) nanosheets with controllable hydrophobic behaviors are successfully prepared via a multiple-in-one synthetic strategy.

Therapeutic drug combinations against COVID-19 obtained by employing a collaborative filtering method.

Unlabelled: The outbreak of coronavirus disease 2019 (COVID-19) has severely harmed human society and health. Because there is currently no specific drug for the treatment and prevention of COVID-19, we used a collaborative filtering algorithm to predict which traditional Chinese medicines (TCMs) would be effective in combination for the prevention and treatment of COVID-19. First, we performed drug screening based on the receptor structure prediction method, molecular docking using q-vina to measure the binding ability of TCMs, TCM formulas, and neo-coronavirus proteins, and then performed synergistic filtering based on Laplace matrix calculations to predict potentially effective TCM formulas.

Isotopic evidence for increased carbon and nitrogen exchanges between peatland plants and their symbiotic microbes with rising atmospheric CO concentrations since 15,000 cal. year BP.

Whether nitrogen (N) availability will limit plant growth and removal of atmospheric CO by the terrestrial biosphere this century is controversial. Studies have suggested that N could progressively limit plant growth, as trees and soils accumulate N in slowly cycling biomass pools in response to increases in carbon sequestration. However, a question remains over whether longer-term (decadal to century) feedbacks between climate, CO and plant N uptake could emerge to reduce ecosystem-level N limitations.

Research on the Vitality Evaluation of Parks and Squares in Medium-Sized Chinese Cities from the Perspective of Urban Functional Areas.

Medium-sized cities are increasingly committed to the planning and construction of urban public spaces to meet people's demand for high-quality urban life. Parks and squares are important parts of urban public spaces, and their vitality represents the quality of public spaces to a certain extent and reflects the happiness index of urban residents. At present, the functional areas and transportation networks of medium-sized cities are still developing.