Association of longer-term versus shorter-term antihypertensives prescriptions and clinical outcomes in patients with hypertension: A population-based propensity score matching study.

Introduction: Previous studies have shown that longer-term prescriptions could improve medication adherence of patients with chronic diseases. However, no evidence demonstrated the impact of a longer supply duration on patients' clinical outcomes. The objective is to estimate the association between longer-term prescriptions with patients' clinical outcomes.

HBV infection, liver enzymes and their association with adverse liver disease and all-cause death: a matched retrospective cohort study in Eastern China.

Background: China has historically been a high-prevalence area for hepatitis B virus (HBV) infection, leading to a high incidence of adverse liver diseases and significant disease burden. However, comprehensive data on HBV infection and associated adverse liver diseases in the Chinese population remain limited. This study aimed to analyse the risk factors for adverse liver outcomes in patients who tested positive for hepatitis B surface antigen (HBsAg).

Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database.

Purpose: Triple therapy of chronic obstructive pulmonary disease (COPD), consisting of inhaled corticosteroid (ICS), long-acting β2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) has shown benefits in patients with COPD. However, little is known about the use of triple therapy in Chinese patients. This study aims to describe the treatment patterns and the utilization of triple therapy in COPD patients based on real-world data from China.

Impacts of COPD exacerbation history on mortality and severe cardiovascular events among patients with COPD in China: a retrospective cohort study.

Background: Chronic Obstructive Pulmonary Disease (COPD) exacerbations are associated with increased mortality and cardiovascular events. However, there is limited evidence on the relationship between COPD exacerbations and mortality and cardiovascular outcomes in China.

Methods: This retrospective cohort study included Chinese patients with COPD aged ≥ 40 years from the Yinzhou regional electronic health records database.

Antihypertensive medications and cancer risk: Evidence from 0.27 million patients with newly diagnosed hypertension.

Background: Whether specific antihypertensive treatments increase cancer risk in patients with hypertension is still controversial. We aimed to estimate the associations of different antihypertensive treatments with cancer risk in real-world settings.

Methods: A longitudinal cohort study was designed in a population of 1.

Assessment and recalibration of seventeen lung cancer risk prediction models in approximately one million Chinese population utilising healthcare big data: a retrospective cohort analysis.

Background: A number of lung cancer prediction models have been developed worldwide. However, there have been limited validation studies conducted specifically on Chinese populations. The objective of this study is to evaluate the feasibility and performance of 17 global lung cancer risk prediction models when applied to Chinese healthcare big data.

Associations of long-term exposure to fine particle and its components with ischemic stroke: A cohort study in China.

Background: Several studies have demonstrated that prolonged exposure to PM is associated with elevated risks of developing ischemic stroke (IS). However, evidence on the association of PM components with IS is still lacking. Thus, we aimed to estimate the association of 15 chemical components of PM with risk of IS in a cohort study.

Incidence and Risk of Heart Failure in Patients With Coronary Heart Disease and Stroke: A Population-Based Cohort Study.

Heart failure (HF) is a major global health issue, with coronary heart disease (CHD) and stroke being risk factors with different mechanisms. The risk of HF in stroke patients remain poorly characterized despite the potential contributions of "stroke-heart syndrome." This study aimed to evaluate HF incidence and risk factors across different cardiovascular disease (CVD) subtypes in a large population-based Chinese cohort.

Comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on cardiovascular outcomes in older adults with type 2 diabetes mellitus: a target trial emulation study.

Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are both recommended as first-line antihypertensive agents for patients with diabetes. While pharmacological mechanisms suggest that ACEIs may provide better cardiovascular protection than ARBs, this potential benefit has not been fully established in previous observational studies of patients with diabetes.

Methods: An active-comparator new-user design within target trial emulation framework was implemented using Yinzhou Regional Health Care Database (YRHCD).

External Validation of SCORE2-Diabetes Risk Prediction Model in Chinese Patients with Diabetes.

Aims: The updated 2023 European Guideline recommended SCORE2-Diabetes to estimate cardiovascular disease (CVD) risk in patients with diabetes; however, external validation is lacking. The study aims to validate SCORE2-Diabetes in Chinese and assess its broader applicability and adaptability across diverse settings.

Methods And Results: This study included patients with diabetes aged 40-90 without prior CVD from a population-based Chinese cohort.

Statin Use and Risk of Intracerebral Hemorrhage in Chinese Population: A Target Trial Emulation Study.

Background And Objectives: Statins have been shown to prevent major vascular events in a wide range of individuals. However, their potential mechanisms-such as impairing fibrinogen cleavage and reducing thrombin generation-raise concerns on increased risk of intracerebral hemorrhage (ICH). Given the inconsistent findings of previous trials and observational studies, this study aims to assess the effect of statins on ICH risk in Chinese population.

Associations Between Metals and Nonmetals in Drinking Water, Cardiovascular Events, and Diet.

Background: Metals and nonmetals in drinking water could potentially influence cardiovascular health. The relationship between poor-quality drinking water, major adverse cardiovascular events (MACE), and diet is not well studied.

Objectives: The aim of this study was to determine whether long-term exposure to metals (copper, manganese, aluminum, zinc, and cadmium) and nonmetals (selenium, sulfate, and nitrate-nitrogen) in drinking water was associated with MACE outcomes, and whether the dietary patterns could modify the association between long-term exposure to low-quality drinking water and MACE.

Development of chronic obstructive pulmonary disease after a tuberculosis episode in a large, population-based cohort from Eastern China.

Background: Although smoking is considered the primary cause of chronic obstructive pulmonary disease (COPD), there is a growing realization that there may be important secondary risk factors. Tuberculosis may lead to lung impairment; however, whether residual lung damage results in clinically significant, long-term outcomes, independent of smoking, has not been well studied. We aimed to investigate the association between tuberculosis and the subsequent development of COPD using a large, population-based cohort study.

Associations of waist circumference and BMI with the trajectory of cardiometabolic multimorbidity in hypertensive patients: A multi-state model.

Background And Aims: The burden of cardiometabolic multimorbidity (CMM) in hypertensive patients is substantial, and obesity may play an important role in progression of CMM. We aim to explore associations of obesity with the transition patterns from hypertension to first cardiometabolic disease (FCMD), CMM, and death.

Methods And Results: 21 286 hypertensive patients over 40 were enrolled in Yinzhou Health Information System from 2010 to 2015, followed until June 30, 2022.

The role of miRNAs in the associations between particulate matter and ischemic stroke: A nested case-control study.

Epidemiological studies have reported that atmospheric particulate matter (PM) contributes to ischemic stroke (IS). Biological studies also indicated that the pathway where PM induces IS involves several pathological processes. Moreover, exposure to PM can alter the expression of specific microRNAs (miRNAs) and ultimately accelerate the onset of IS by regulating related pathways.

Association of residential greenness and sleep duration in adults: A prospective cohort study in China.

Background: Exposure to residential greenness has been linked with improved sleep duration; however, longitudinal evidence is limited, and the potential mediating effect of ambient fine particulate matter (PM) has yet to be assessed.

Methods: We obtained data for 19,567 participants across seven counties in a prospective cohort in Ningbo, China. Greenness was estimated using Normalized Difference Vegetation Index (NDVI) within 250-m, 500-m and 1000-m buffer zones, while yearly average PM concentrations were measured using validated land-use regression models, both based on individual residential addresses.

Interaction between walkability and fine particulate matter on ischemic heart disease: A prospective cohort study in China.

Background: Previous studies have suggested that neighborhoods characterized by higher walkability are related to a reduced risk of ischemic heart disease (IHD), whereas exposure to PM is positively associated with risk of IHD. Nevertheless, their joint impact on IHD warrants further investigation.

Methods: This prospective cohort study was performed in Yinzhou, Ningbo, China, comprising 47,516 participants.

Relationship of SSVEP response between flash frequency conditions.

This study delves into the application of Brain-Computer Interfaces (BCIs), focusing on exploiting Steady-State Visual Evoked Potentials (SSVEPs) as communication tools for individuals facing mobility impairments. SSVEP-BCI systems can swiftly transmit substantial volumes of information, rendering them suitable for diverse applications. However, the efficacy of SSVEP responses can be influenced by variables such as the frequency and color of visual stimuli.

Optimizing user experience in SSVEP-BCI systems.

The emergence of brain-computer interface (BCI) technology provides enormous potential for human medical and daily applications. Therefore, allowing users to tolerate the visual response of SSVEP for a long time has always been an important issue in the SSVEP-BCI system. We recruited three subjects and conducted visual experiments in groups using different frequencies (17 and 25Hz) and 60Hz light.

Outdoor light at night, air pollution and risk of incident type 2 diabetes.

Background: Air pollution and outdoor light at night (LAN) have been reported to be related to type 2 diabetes (T2D). However, their interaction with risk of T2D remains uncertain. Therefore, our study aimed to explore the relationship between outdoor LAN, air pollution and incident T2D.

The Effect of Sodium Glucose Cotransporter-2 Inhibitors on Hemoglobin A1c Variability and Acute Kidney Injury: A Causal Mediation Analysis.

Purpose: The role of lower hemoglobin A1c (HbA1c) variability in the effect of sodium glucose cotransporter-2 inhibitors (SGLT2i) on acute kidney injury (AKI) remains unclear. We compared AKI risk between SGLT2i and dipeptidyl peptidase 4 inhibitors (DPP4i) initiators. Additionally, we aimed to explore the extent to which SGLT2i's influence on AKI risk is mediated by reducing long-term HbA1c variability.

Enhancing the Management of Non-Specific Neck Pain through Gamification: Design and Efficacy of a Health Application.

Chronic non-specific neck pain (CNNP) poses a substantial health and economic burden in China. This study introduces a gamified motion-sensing health application framework to address the limitations of existing health applications. The gamified cervical spine somatic exercise application employs motion capture technology alongside the smartphone's built-in sensors to simulate accurate somatic interactions.