Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Previous studies have shown that longer-term prescriptions could improve medication adherence of patients with chronic diseases. However, no evidence demonstrated the impact of a longer supply duration on patients' clinical outcomes. The objective is to estimate the association between longer-term prescriptions with patients' clinical outcomes.
Methods: A retrospective population-based propensity score-matched cohort study was conducted on the Chinese Electronic Health Records Research in Yinzhou database between January 2017 and June 2022. Prescriptions with the supply duration of antihypertensives >28 days were considered as longer-term prescriptions. The primary outcome was hospitalization for cardiovascular diseases. Secondary outcomes included medication adherence measured by medication possession ratio ≥80 % and visit frequency during the follow-up. Cox proportional hazard model and conditional logistic regression were used to estimate effects in the censored at treatment switch or discontinuation analyses.
Results: 25,625 adult hypertension patient pairs were included in the propensity score matched cohort. The median follow-up time was 180 days. Compared with patients receiving shorter-term prescriptions, lower hospitalization rates for cardiovascular diseases were observed in patients with longer-term prescriptions (hazard ratio: 0.88, 95 %CI: 0.80-0.98). The proportion of adherent patients in the longer-term group was higher than that in the shorter-term group (odds ratio: 1.91, 95 % CI: 1.84-1.98). The longer-term group also had fewer patients with ≥1 visit per month during the follow-up (odds ratio: 0.19, 95 %CI: 0.18-0.20). Subgroup and sensitive analysis showed consistent results.
Conclusions: Longer-term prescriptions can improve patients' clinical outcomes and decrease their visit frequency. Promoting longer-term prescriptions can help mitigate the challenge of limited health resources and reduce disease burden.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.sapharm.2025.08.009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Implementation and Early Outcomes of an Antimicrobial Stewardship Program in South Korea.
Antibiotics (Basel)
August 2025
Department of Infectious Diseases, Inje University Haeundae Paik Hospital, Busan 48108, Republic of Korea.
: Antimicrobial stewardship programs (ASPs) are essential for promoting the rational use of antibiotics and combating resistance. In South Korea, implementation has recently accelerated, but real-world data on short-term program performance remain limited. This study evaluated the early outcomes of a newly launched ASP at a tertiary hospital.
View Article and Find Full Text PDFAssociation of longer-term versus shorter-term antihypertensives prescriptions and clinical outcomes in patients with hypertension: A population-based propensity score matching study.
Res Social Adm Pharm
August 2025
Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University, Beijing, China; International Research Center for Medicinal Administration, Peking University, Beijing, China. Electronic address:
Introduction: Previous studies have shown that longer-term prescriptions could improve medication adherence of patients with chronic diseases. However, no evidence demonstrated the impact of a longer supply duration on patients' clinical outcomes. The objective is to estimate the association between longer-term prescriptions with patients' clinical outcomes.
View Article and Find Full Text PDFClinical Practice Guideline: Assessment and Treatment of Adolescents and Young Adults With Substance Use Disorders and Problematic Substance Use (Excluding Tobacco).
J Am Acad Child Adolesc Psychiatry
August 2025
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts; Boston Children's Hospital Department of Psychiatry and Behavioral Sciences, Boston, Massachusetts.
Objective: To enhance the quality of care and clinical outcomes for adolescents with Substance use disorder (SUD) and problematic substance use (PSU). The aims are twofold: 1) to summarize empirically-based guidance about the psychosocial, behavioral, and psychopharmacologic treatment of SUDs and PSU in adolescents and young adults; and 2) to summarize expert-based guidance about the assessment and clinical management of these disorders.
Method: Statements about the treatment of SUD / PSU are based upon empirical evidence derived from a critical systematic review of the scientific literature conducted by the Brown Evidence-Based Practice Center under contract with the Agency for Healthcare Research and Quality (AHRQ).
Use of Direct Oral Anticoagulants Following Cardiac Implantable Electronic Device Placement.
Pacing Clin Electrophysiol
August 2025
Division of Cardiology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.
Background: Small studies have described the safety of uninterrupted direct oral anticoagulant (DOAC) use in atrial fibrillation (AF) patients undergoing elective, cardiac implantable electronic device (CIED) placement. Real-world practice patterns and associated outcomes remain poorly defined.
Objective: Describe DOAC usage trends following uncomplicated, outpatient CIED placement in AF patients and evaluate clinical outcomes based on DOAC status at discharge.
Predictors of Incident Benzodiazepine Co-prescription Among Patients Prescribed Long-term Opioids.
J Gen Intern Med
July 2025
Center for Healthcare Policy and Research, UC Davis, Sacramento, CA, USA.
Background: Opioid and benzodiazepine co-prescription is associated with overdose, particularly among patients prescribed long-term opioids.
Objectives: Identify predictors of incident benzodiazepine and opioid co-prescription using two separate and complementary large-scale patient cohorts.
Design: Two retrospective cohort studies: (a) statewide dataset based on California's prescription drug monitoring program (PDMP, 7/1/2016-12/1/2018) and (b) national sample of commercial and Medicare Advantage enrollees from the Optum Labs Data Warehouse (OLDW, 7/1/2016-12/1/2021).