Pilose antler peptide enhances diabetic fracture healing by modulating the CREB-Smad2/3-Runx2 signaling axis.

Ethnopharmacological Relevance: Cervi Cornu Pantotrichum, a cornerstone of traditional medicine, is prized for its bone-enhancing and metabolic-regulating effects. Pilose antler peptide (PAP), extracted from this remedy, offers a promising solution for diabetic fracture nonunion, a debilitating condition marked by hyperglycemia-impaired bone healing.

Aim Of The Study: This study investigates PAP's efficacy in accelerating diabetic fracture repair and delineates its molecular mechanisms, merging ethnopharmacological heritage with modern science.

Evolutionary Insights and Flowering Regulation of in Coconut Palm.

() is a critical transcription factor that plays a significant role in regulating plant growth and development. Mining the coconut SPL family offers valuable insights into the regulation of important agronomic traits, including the length of the juvenile phase. In this study, 25 were identified and were classified into eight subfamilies.

Cytotoxic effects of flurbiprofen on rat adipose-derived stem cells.

Adipose-derived stem cells (ADSCs) offer a novel approach for treating orthopaedic diseases. Flurbiprofen is a non-steroidal anti-inflammatory analgesic drug used in bone injury therapy. However, its cytotoxicity to ADSCs remains unclear.

Design of High-Performance MXene-Based 2D Membranes for Desalination via Machine Learning and Hybrid Optimization Algorithms.

The global scarcity of freshwater resources has intensified the demand for efficient seawater desalination technologies. However, conventional approaches, such as reverse osmosis and nanofiltration, often suffer from high energy consumption and limited membrane performance. MXene, a promising two-dimensional (2D) material, offers unique structural and surface chemical properties that can enhance membrane-based separations.

Large-scale evaluation of soybean germplasm reveals geographic patterns in shade tolerance and identifies elite genotypes for intercropping systems.

Shade tolerance is crucial for developing soybean varieties that are well-suited for intercropping systems. This study evaluated 460 soybean accessions from a global germplasm collection at two contrasting locations in China: Heilongjiang (HLJ) and Inner Mongolia (NM). The experiment used a split-plot design within a randomized complete block setup, with three replications at each site.

MSMCE: A novel representation module for classification of raw mass spectrometry data.

Mass spectrometry (MS) analysis plays a crucial role in the biomedical field; however, the high dimensionality and complexity of MS data pose significant challenges for feature extraction and classification. Deep learning has become a dominant approach in data analysis, and while some deep learning methods have achieved progress in MS classification, their feature representation capabilities remain limited. Most existing methods rely on single-channel representations, which struggle to effectively capture structural information within MS data.

Comprehensively characterize the soybean CAM/CML gene family, as it provides resistance against both the soybean mosaic virus and pathogens.

Introduction: Calmodulin (CAM) and calmodulin-like (CML) proteins are essential calcium sensors that mediate plant responses to biotic and abiotic stresses. In soybean (Glycine max L. Merr.

Multiscale analysis of equatorial sclera anisotropy: Revealing discrepancies in fiber orientation and mechanical properties.

The sclera, the eye's primary load-bearing tissue, substantially influences the globe's response to intraocular pressure. Although the mechanical properties of the anterior and posterior segments have been extensively studied, the equatorial sclera's properties remain underexplored, limiting our understanding of ocular conditions like myopia, ocular trauma, and glaucoma. Traditional studies that rely solely on fiber orientation to explain scleral mechanics may overlook the tissue's complex biomechanical behavior.

Blood MALT1 expression levels reflect the lymph node stage and disease-free survival in patients with non-small cell lung cancer.

Mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) promotes cancer development via both cancer cell-intrinsic and -extrinsic mechanisms, and can regulate cancer immunity and immune escape. Therefore, the present study aimed to assess the expression levels of MALT1 in blood samples and the association with clinical features, treatment options and survival outcomes in patients with non-small cell lung cancer (NSCLC). Peripheral blood mononuclear cells (PBMCs) from a total of 125 patients with resectable NSCLC prior to treatment (neoadjuvant therapy or surgery) were collected.

Discovery of indane and naphthalene derivatives as USP7 inhibitors.

Protein deubiquitination via deubiquitinases is a crucial aspect of the dynamic modification of biomacromolecules. The deubiquitinase USP7 plays a key role in tumorigenesis through diverse pathways, thus representing a promising novel target for anti-cancer therapies. In this paper, in order to find novel USP7 inhibitors, a series of compounds scaffold-hopping from the reported USP7 inhibitor CP41 were designed, synthesized and biologically evaluated.

An end-to-end mass spectrometry data classification model with a unified architecture.

Mass spectrometry, known for its high sensitivity, selectivity, rich structural information, and rapid analysis capabilities, is widely used in disease diagnosis and bioanalysis. Despite progress in classification methods/tools for data collection in the past decade, problems such as complex data processing, weak model characterization, and large interbatch differences persist. To address these problems, we present MS-DREDFeaMiC, a deep neural network framework for disease diagnosis and bioanalysis via mass spectrometry data that enables end-to-end training.

Efficacy and safety of puerarin injection as an adjunctive therapy for chronic heart failure: a systematic review and meta-analysis.

Objective: Puerarin injection is used for the treatment of chronic heart failure (CHF). The objective of this study is to investigate the efficacy and safety of puerarin injection as an adjunct therapy for CHF through a meta-analysis and systematic review.

Methods: We conducted a comprehensive literature search across eight databases, including PubMed, Embase, Web of Science, and Cochrane Library, up to 1 March 2025, to identify the required randomized controlled trials (RCTs).

Soybean productivity can be enhanced by understanding rhizosphere microbiota: evidence from metagenomics analysis from diverse agroecosystems.

Background: Microbial communities associated with roots play a crucial role in the growth and health of plants and are constantly influenced by plant development and alterations in the soil environment. Despite extensive rhizosphere microbiome research, studies examining multi-kingdom microbial variation across large-scale agricultural gradients remain limited.

Results: This study investigates the rhizosphere microbial communities associated with soybean across 13 diverse geographical locations in China.

Gradient Nanostructures and Machine Learning Synergy for Robust Quantitative Surface-Enhanced Raman Scattering.

Surface-Enhanced Raman Scattering (SERS) holds significant promise for trace-level molecular detection but faces challenges in achieving reliable quantitative analysis due to signal variability caused by non-uniform "hot spots" and external factors. To address these limitations, a novel SERS platform based on gradient nanostructures is developed using shadow sphere lithography, enabling the acquisition of diverse spectral features from a single analyte concentration under identical conditions. The gradient design minimizes fabrication variability and enhances spectral diversity, while the machine learning (ML) model trained on the multi-spectral dataset significantly outperformed traditional single-spectrum approaches, with the test Mean Squared Error (MSE) reduced by 84.

Midwifery students' perceptions and learning experiences during clinical practice: a qualitative systematic review.

Objectives: This systematic review aimed to investigate, critically appraise, and synthesize qualitative evidence related to midwifery student perceptions and learning experiences during clinical practice.

Introduction: Midwifery students are expected to acquire strong competencies during pre-registration education. Clinical practice offers valuable opportunities for the students to develop essential practical capacities.

Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis.

Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis, potentially triggered by viral infection (Lu et al., 2024). We generated and characterized a human induced pluripotent stem cell (hiPSC) line from skin fibroblasts of a patient with MDA5-DM.

Roles of METTL3 and NLRP3 in pyroptosis and prospects in SCIRI.

Spinal cord ischemia-reperfusion injury (SCIRI) leads to severe neurological deficits, with pyroptosis emerging as a key driver of inflammation and neuronal death. Recent studies suggest that methyltransferase-like 3 (METTL3), a critical RNA methyltransferase, may regulate the nucleotide-binding oligomerized structural domain-like receptor protein 3 (NLRP3) inflammasome activation via N6-Methyladenosine (m6A) modification, yet direct evidence in SCIRI remains limited. This review synthesizes current knowledge on the METTL3-NLRP3 axis in pyroptosis, explores its therapeutic potential, and identifies critical research gaps for future investigation.

Integrative QTL mapping and candidate gene analysis for main stem node number in soybean.

Main stem node number (MSNN) is a key yield-related quantitative trait that directly affects the number of branches and seeds per soybean plant. In this study, a QTL mapping using SLAF sequencing and candidate gene analyses were used to determine the detailed genetic basis of MSNN across a diverse set of soybean line. This study investigated the variation characteristics of MSNN in 325 recombinant inbred lines (RILs) obtained from the hybridization of Qihuang 34 and Dongsheng 16.

Identification of Quantitative Trait Loci for Node Number, Pod Number, and Seed Number in Soybean.

Optimizing soybean yield remains a crucial challenge in meeting global food security demands. In this study, we report a comprehensive genetic analysis of yield-related traits in soybeans using a recombinant inbred line (RIL) population derived from crosses between 'Qihuang 34' (GH34) and 'Dongsheng 16' (DS16). Phenotypic analysis across two years (2023-2024) revealed significant variations between parental lines.

Constructing Dense Morphology of Sn with High Reversibility under High Areal-capacity for Anode-Free Tin Batteries.

Sn electrode possesses high reversibility, redox kinetics and corrosion resistance, as well as non-toxic and environmental compatibility, which is competitive candidate for aqueous batteries. However, due to huge size of deposition particles and "dead Sn", it is a great challenge to obtain high areal-capacity (>5 mAh cm) and high coulombic efficiency (>99 %) simultaneously. Here, we demonstrate a highly reversible Sn redox electrochemistry with high areal-capacity enabled by thiourea additive.

Population pharmacokinetic modeling and exposure-response analysis of anrikefon: insights and implications in clinical analgesia.

Background: Anrikefon (HSK21542), a potent and selective peripheral kappa opioid receptor (KOR) agonist developed by Haisco, effectively blocks pain and itch signals.

Aim: To develop a population pharmacokinetic (PK) model for anrikefon and conduct exposure-response (E-R) analysis for safety and efficacy in postoperative pain patients.

Method: The Population PK analysis uses NONMEM software with data from six trials.

Uncovering molecular mechanisms of soybean response to C heavy ion irradiation through integrated transcriptomic and metabolomic profiling.

Ion beam mutagenesis is an advanced technique capable of inducing substantial changes in plants, resulting in noticeable alterations in their growth. However, the precise molecular mechanisms underlying the effects of radiation on soybeans remain unclear. This study investigates the impact of ionizing radiation on soybean development through a comprehensive approach that integrates transcriptomics and metabolomics.

Aerosol inhalation of rhIL-10 improves acute lung injury in mice by affecting pulmonary neutrophil phenotypes through neutrophil-platelet aggregates.

This study investigates the therapeutic effects of recombinant human IL-10 (rhIL-10) administered via aerosol inhalation in acute lung injury (ALI), with a particular focus on neutrophils. It explores how rhIL-10, in the presence of platelets, modulates neutrophil polarization to ameliorate acute lung injury. Initially, the ALI model established in mice demonstrated that aerosol inhalation of rhIL-10 significantly mitigated the cytokine storm in the lungs, reduced pulmonary edema, and alleviated histopathological damage to lung tissue.

Diagnostic accuracy of Xpert MTB/RIF Ultra for detecting pulmonary tuberculosis and rifampicin resistance: a systematic review and meta-analysis.

Background: Public health issues related to tuberculosis still exist. Because Xpert MTB/RIF Ultra is more effective than conventional TB diagnostic techniques are, it is now regarded as an emerging technology. The diagnostic accuracy of Xpert MTB/RIF Ultra for tuberculosis was assessed in this systematic study.

Towards Highly Stable Sn Electrolyte for Aqueous Tin Batteries Using Hydroquinone Antioxidant.

Sn redox chemistry in aqueous acidic electrolyte was characterized with high reversibility and kinetics, which is considered as competitive anode material for aqueous batteries. Unfortunately, divalent Sn is unstable in aqueous electrolyte. It was revealed that Sn is easy to be oxidized to tetravalent Sn by dissolved oxygen and then forms precipitate through hydrolysis process, leading to serious performance decay.