Nonlinear focusing of atom clouds by a short-focal-length magnetic lens.

Utilizing the Stern-Gerlach effect, magnetic lenses are used to focus atom clouds, reducing their dimensions, and boosting the central cloud density. In this research, a theoretical model based on nonlinear Zeeman splitting in high-intensity magnetic fields is established to explore the nonlinear focusing of a tightly focused magnetic lens. The research concentrates on the motion and focusing of Rb atoms in various Zeeman substates within an atom fountain under pulsed magnetic fields and establishes a correlation between the field curvature and the effective focal length.

Construction of a program for physical simulation of cold atom interferometry.

Realistic and accurate simulations are crucial for developing quantum sensors such as cold atom gyroscopes, gravimeters, and gradiometers in the field of cold atom interferometers (CAIs). However, current simulations lack the necessary specifications for CAIs. In this study, we constructed a physical model for CAIs and designed a detailed simulation program, including the model construction, input and output parameter selection, program design, and computational acceleration.

Investigating factors affecting the quality of water resources by multivariate analysis and soft computing approaches.

This study used data from a large dam site to model changes in groundwater quality variables. Several indicators were investigated to check the quality of water sources for the site for different purposes. The factor analysis results displayed that four factors control 87.

Digitalization of surgical features improves surgical accuracy via surgeon guidance and robotization.

The evolution of surgical techniques aims to augment surgeons' capabilities through digital guidance and robotization for higher precision and consistency. Currently, surgeries heavily rely on surgeon's experience and visual judgment, causing operation variations. Artificial intelligence (AI) offers a solution by extracting and digitizing surgical trajectories and features from videos to provide digital guidance.

Experimental investigation of RF phase noise transfer in acousto-optic modulators for atom gravimeters.

Phase noise remains a critical limitation in enhancing the sensitivity of atom interferometric inertial sensors. While current analyses of phase noise predominantly focus on Raman laser beat frequency locking processes, a significant oversight persists in characterizing radio-frequency (RF) driving-induced phase noise during acousto-optic modulator (AOM) operation - a standard component used for frequency shifting and rapid switching in atomic interference systems. Through systematic experiments, we elucidate the transmission mechanisms of AOM RF phase noise in atomic gravimeters and quantify its impact using phase noise power spectral density analysis.

Epigenetic roles of lysine-specific demethylase 1 (LSD1) in cancer metabolism.

Lysine-specific demethylase 1 (LSD1) is a histone demethylase with a crucial role in cancer initiation and progression. Several LSD1 inhibitors and degraders are undergoing clinical trials. Metabolic reprogramming, a key hallmark of cancer cells, allows them to survive in harsh environments.

Research on the effects of inconsistent initial velocity of the atom clouds in atom gravity gradiometers.

The initial state of atom clouds significantly influences the performance of cold-atom inertial sensors, particularly for atom gravity gradiometers (AGGs), where the consistency of the initial state of two atom clouds greatly affects measurement performance. By analyzing the mechanism of polarization gradient cooling (PGC), we investigate its effect on the initial velocity consistency of atomic clouds. In the course of this study, we compare different PGC models and identify a model that has the least influence on initial velocity consistency.

Targeting PKC as a Therapeutic Strategy to Overcome Chemoresistance in TNBC by Restoring Aurora Kinase B Expression.

Triple-negative breast cancer (TNBC) poses a significant challenge due to its high mortality rates, primarily attributed to resistance against chemotherapy regimens containing taxanes like paclitaxel. Thus, developing combinatorial strategies to override resistance is a pressing need. By taking advantage of a library screening with various kinase inhibitors, we found that the small-molecule inhibitor enzastaurin targeting protein kinase C (PKC) could overcome resistance in TNBC cells.

Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progression.

Background: Metastasis is a leading cause of cancer-related deaths, with the liver being the most frequent site of metastasis in colorectal cancer. Previous studies have predominantly focused on the influence of the primary tumor itself on metastasis, with relatively limited research examining the changes within target organs.

Methods: Using an orthotopic mouse model of colorectal cancer, single-cell sequencing was employed to profile the transcriptomic landscape of pre-metastatic and metastatic livers.

Determining Optimal Talker Variability for Nonnative Speech Training: A Systematic Review and Bayesian Network Meta-Analysis.

Purpose: This meta-analysis study aimed to determine the optimal level of talker variability in training to maximize second-language speech learning.

Method: We conducted a systematic search for studies comparing different levels of talker variability in nonnative speech training, published through July 2024. Two independent reviewers screened studies for eligibility, extracted data, and assessed the risk of bias.

Impact of the frequency error of direct digital synthesizers on the evaluation of two-photon light shift in atom gravimeters.

One major systematic error for free-fall atom gravimeters is the effect of two-photon light shift (LS2). In the process of evaluating LS2, the results can be affected by the residual frequency error of direct digital synthesizers due to necessary experimental parameter changes. In this paper, the impact of the coupling effect between the frequency error and LS2 has been investigated and analyzed, along with the related physical mechanisms.

Inhibition of Chk1 with Prexasertib Enhances the Anticancer Activity of Ciclopirox in Non-Small Cell Lung Cancer Cells.

Lung cancer is a leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most prevalent lung cancer subtype. Ciclopirox olamine (CPX), an off-patent fungicide, has been identified as a new anticancer agent.

Differentiated thyroid cancer with osteo-granulomatousinflammation: A case report.

Objective: Cryptococcus, a genus of fungi, primarily includes Cryptococcus neoformans and Cryptococcus gattii, both known to cause human infections. Skeletal infections are rare, and there have been no reported cases of bone cryptococcal infection in conjunction with differentiated thyroid carcinoma.

Subject And Methods: A 56-year-old female presented with a one-month history of "cough and throat irritation.

Improving the Ionic Conductivity and Anode Interface Compatibility of LLZO/PVDF Composite Polymer Electrolytes by Compositional Tuning.

Utilizing aluminum-doped nano LLZO (LiLaZrAlO) as the ceramic filler, we synthesized and optimized LLZO/PVDF/LiClO composite polymer electrolytes (CPEs) to achieve high ionic conductivity and good interfacial stability with metallic lithium. The research examines how the PVDF grade and the mass ratio of PVDF to LiClO affect the ionic conductivity, lithium metal compatibility, and overall performance of CPEs. The CPE using Kynar PVDF 741 and a PVDF-to-LiClO mass ratio of 2:1 emerged as superior, displaying a high ionic conductivity at room temperature (0.

Research on the mechanism and application of wedge cutting blasting with hole-inner delay.

To increase the efficiency of deep-hole blasting driving in mine rock tunnels, an innovative pattern of wedge cutting blasting with hole-inner delay was proposed. First, the blasting mechanisms of conventional and innovative wedge cutting patterns were theoretically investigated. The results showed that the resistance from large upper rock blocks and the clamping action from the surrounding rock were the major challenges of conventional cutting methods.

Strategies that regulate LSD1 for novel therapeutics.

Histone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases. LSD1 dysregulation is closely associated with cancer, viral infections, and neurodegenerative diseases, etc.

Haeme Oxygenas-1-Induced Liver Regeneration Protects Graft Against Small-for-Size Syndrome in Rats.

Background: Haeme oxygenase (HO-1) affords protection against ischemia/reperfusion (I/R) injury; however, its effects on liver regeneration remain poorly explored. Our previous studies have shown that HO-1 is probably involved in liver regeneration, but its role in small-for-size syndrome (SFSS) is still unclear. Therefore, this study aims to investigate the effects of HO-1 on small-for-size graft (SFSG) and the underlying mechanism.

Lithiophilic and Eco-Friendly Nano-Se Seeds Unlock Dendrite-Free and Anode-Free Li-Metal Batteries.

A 3D host design for lithium (Li)-metal anodes can effectively accommodate volume changes and suppress Li dendrite growth; nonetheless, its practical applicability in energy-dense Li-metal batteries (LMBs) is plagued by excessive Li loading. Herein, we introduced eco- and human-friendly Se seeds into 3D carbon cloth (CC) to create a robust host for efficient Li deposition/stripping. The highly lithiophilic nano-Se endowed the Se-decorated CC (Se@CC) with perfect Li wettability for instantaneous Li infusion.

Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers.

The abnormal activation of Cullin RING E3 Ligases (CRLs) is closely associated with the occurrence and development of various cancers. Targeting the neddylation pathway represents an effective approach for cancer treatment. In this work, we reported that WS-299, structurally featuring a coumarin moiety attached to the triazolopyrimidine, exhibited excellent anti-proliferative activity in MGC-803 and HGC-27 cells.