Reconstructing time-domain data from discontinuous Percept™ PC and RC output using external data acquisition and linear filtering.

Background: The Medtronic Percept™ PC and RC are deep brain stimulation (DBS) systems with recording capability. However, when the stimulation frequency is changed, the recordings were segmented, introducing interruptions that shift each segment in the time domain.

New Method: Ex-vivo, stimulation frequency was changed while local field potential was being recorded in both leads.

A New Phase Indium Tin Oxide (ITO) Activated Selective CO Reduction into Formate for Underwater Antifouling Glass.

Designing unique electrocatalysts that utilizes carbon dioxide reduction reaction (CORR) for real applications is highly appreciated, yet still suffers from low selectivity, stability, and compatibility. Herein, we first report a new two-dimensional metastable-phase transparent conducting oxide: 1T phase indium tin oxide (m-ITOs) with the space group of P-3m1 (164), which is totally different from that of the stable cubic phase ITO (Ia-3 (206)). The internal indium tin catalytic pairs in m-ITOs trigger the strong electronic coupling, move up the p-band center, and stabilize the adsorption of HCOO* for increased formate production.

Improving peroxidase-like activity of porphyrin-based metal-organic framework by metal ratio tuning for detection and degradation of aflatoxin B in dried fruits.

Herein, the tetra (4-carboxyphenyl) porphyrin (TCPP) based metal-organic frameworks with high peroxidase (POD)-like activity were designed and fabricated for detection and degradation of aflatoxin B (AFB) in dried fruits. The strategy of metal ratio (Fe/Co/Ni) tuning was adopted to obtain the optimal enzymatic activity of TCPP-Fe/Co/Ni. The aptamer-modified TCPP-Fe/Co/Ni/ssDNA composite specifically binds AFB, with the presence of AFB inhibiting the POD-like activity of the material, thus establishing a rapid and sensitive colorimetric method for AFB detection.

Performance simulations for a spaceborne ozone lidar mission.

The future range resolved spaceborne ozone differential absorption lidar (SODIAL) is expected to fill the current observation gap, especially in areas where in-situ observation and passive remote sensing are difficult. The spaceborne ozone lidar preparatory research mission (SOLPRM) proposed by the State Administration of Science, Technology, and Industry for National Defense, People's Republic of China, aims to develop the SODIAL. This study globally simulated and estimated the observational performance of SODIAL through MERRA-2, CALIPSO, and GOME-2 satellite data.

Advances and obstacles of T cell-based immunotherapy in gynecological malignancies.

T cell-mediated immunotherapy has revolutionized oncology by enabling precision immune responses against malignant cells. Chimeric Antigen Receptor (CAR) T-cell therapy, which involves genetically reprogramming T lymphocytes to recognize tumor-specific antigens, has shown clinical success in hematologic malignancies and is expanding its potential in solid tumors. Gynecological cancers, including ovarian, cervical, and endometrial carcinomas, present persistent therapeutic challenges due to their aggressive recurrence patterns and limited responses to conventional therapies in advanced disease stages.

ZMYND8 promotes the Warburg effect and tumorigenesis through c-Myc activation in pancreatic cancer.

Pancreatic cancer (PC) is a digestive tract tumour with an extremely poor patient prognosis and prominent metabolic abnormalities. However, the molecular mechanisms underlying metabolic reprogramming in the progression of pancreatic cancer remain poorly understood. Here, we employed an epigenetic siRNA library to identify a crucial regulator, ZMYND8, which is involved in glycolysis in PC cells.

Fabrication of bifunctional gold nanoparticles for self-calibration UV-Vis/surface-enhanced Raman spectroscopy dual-mode analysis of Hg in milk.

Multimodal optical detection are good candidates in accuracy improvement in complex food detection, without sacrificing rapidity and sensitivity. Herein, bifunctional gold nanoparticles (AuNPs/4-MBA/Cy/T) based on step-by-step modification of 4-mercaptobenzoic acid, cysteamine, and thymine-1-acetic acid were fabricated for self-calibration ultraviolet-visible spectroscopy (UV-Vis)/surface-enhanced Raman spectroscopy (SERS) dual-mode detection of mercury ions (Hg) in milks. The bifunctional UV-Vis and SERS analysis can be attributed to the localized surface plasmon resonance (LSPR) properties of AuNPs.

Targeting PKC as a Therapeutic Strategy to Overcome Chemoresistance in TNBC by Restoring Aurora Kinase B Expression.

Triple-negative breast cancer (TNBC) poses a significant challenge due to its high mortality rates, primarily attributed to resistance against chemotherapy regimens containing taxanes like paclitaxel. Thus, developing combinatorial strategies to override resistance is a pressing need. By taking advantage of a library screening with various kinase inhibitors, we found that the small-molecule inhibitor enzastaurin targeting protein kinase C (PKC) could overcome resistance in TNBC cells.

2D Metastable-Phase Hafnium Oxide Triggers Hydrogen Spillover for Boosting Hydrogen Production.

Hydrogen (H) manipulation plays a significantly important role in many important applications, in which the occurrence of hydrogen spillover generally shows substrate-dependent behavior. It therefore remains an open question about how to trigger the hydrogen spillover on the substrates that are generally hydrogen spillover forbidden. Here a new metastable-phase 2D edge-sharing oxide: six-hexagonal phase-hafnium oxide (Hex-HfO, space group: P6mc (186)) with the coordination number of six is demonstrated, which serves as an ideal platform for activating efficient hydrogen spillover after loading Ru nanoclusters (Ru/Hex-HfO).

Metastable Phase Noble-Metal-Free Core-Shell Structure for Efficient Electrocatalytic Nitrobenzene Transfer Hydrogenation.

In order to study the catalytic behavior of a metastable-phase catalyst in electrocatalytic hydrogenation, we report a new metastable-phase noble-metal-free core-shell catalyst with a metastable hexagonal closest packed (hcp) phase Ni as the shell and face-centered-cubic (fcc) phase Cu as the core (Cu@hcp Ni NPs) for electrocatalytic hydrogenation of nitrobenzene (Ph-NO) to aniline (Ph-NH). Using HO as the hydrogen source, it achieves up to 99.63% Ph-NO conversion and ∼100% Ph-NH selectivity, with an improved activity turnover frequency (TOF: 6640 h), much higher than those of hcp Ni NPs (5183.

Creating Bridged-H* Bond Structure for Boosting Electrocatalytic Hydrogen Evolution via Phosphorus-Doped Iridium Nanosheets.

Iridium (Ir) is recognized to have extremely high catalytic activity in the hydrogen evolution reaction (HER). However, there are still technical challenges in maximizing the utilization of Ir atoms in the catalytic reaction process through dimensional regulation strategies. Herein, an innovative strategy is utilized to fabricate porous phosphorus-doped iridium (P-Ir) with a 2D structure, specifically the reduction of 1T phase-IrO (1T-IrO) nanosheets using phosphine gas.

Clinical analysis of different intestinal reconstruction methods after primary cytoreductive surgery combined with rectal resection for advanced ovarian cancer.

Objective: To compare different intestinal reconstruction methods after intestinal resection for advanced ovarian malignancy.

Methods: Retrospective data of patients with advanced ovarian malignancy were collected and then assigned into three groups: primary intestinal anastomosis, protective enterostomy and colostomy. General clinical characteristics, intraoperative findings and postoperative outcomes were compared between the three groups.

Control mechanism of Escherichia coli invasion by micro-nano bubbles in drinking water distribution system.

Sudden biological contamination in Drinking Water Distribution System (DWDS) significantly threatens the safety of drinking water, with E. coli invasions being particularly hazardous to human health. Traditional disinfection methods (i.

Establishing the Link Between Oxygen Vacancy and Activity Enhancement in Acidic Water Oxidation of Trigonal Iridium Oxide.

Developing durable IrO-based electrocatalysts with high oxygen evolution reaction (OER) activity under acidic condition is crucial for proton exchange membrane electrolyzers. While oxygen defects are considered potentially important in OER, their direct relationship with catalytic activity has yet to be established. In this study, we introduced abundant oxygen vacancies through Re doping in 2D IrO (ReIrO), demonstrating their decisive role in enhancing OER performance.

Optimizing Acidic Oxygen Evolution Reaction via Modulation Doping in Van der Waals Layered Iridium Oxide.

Anodic oxygen evolution reaction (OER) exhibits a sluggish four-electron transfer process, necessitating catalysts with exceptional catalytic activity to enhance its kinetic rate. Van der Waals layered oxides are ideal materials for catalyst design, yet its stability for acidic OER remains large obstacle. Doping provides a crucial way to improve the activity and stability simultaneously.

Optimizing Acidic Oxygen Evolution with Manganese-Doped Ruthenium Dioxide Assembly.

Ruthenium dioxide (RuO) is one of the promising catalysts for the acidic oxygen evolution reaction (OER). However, designing RuO catalysts with good activity and stability remains a significant challenge. In this work, we propose the manganese (Mn)-doped RuO assembly as a catalyst for the OER with improved activity and stability.

Design and fabrication of self-calibration colorimetric/fluorescence/SERS tri-modal optical sensor for highly rapid and accurate detection of mercury ions in foods.

The improvement of detection accuracy without loss of rapidity and sensitivity by optical sensors in complex food analysis is still full of challenges owing to the matrix interference. Herein, a novel and simple self-calibration colorimetric/fluorescence/surface-enhanced Raman spectroscopy (SERS) tri-modal optical sensor based on aminated Rhodamine 6G (R6G-NH) was developed for highly rapid, sensitive, and accurate detection of Hg in food samples. The high recognition specificity of R6G-NH for Hg can be achieved through the metal chelation interaction between Hg and -NH, -COOH groups in R6G-NH with formation of R6G-NH-Hg-R6G-NH complex.

Tailoring Morphology of MgO with Mg-MOF for the Enhanced Adsorption of Congo Red.

The active site is a highly anticipated property of adsorbent in the field of separation, as it enables a concurrent enhancement of both adsorption efficiency and adsorption rate. Herein, employing morphology-oriented regulation, we successfully fabricated heterogeneous MgO adsorbent from a magnesium-based metal-organic framework (MOF) precursor, octahedral MgO-M and laminated sheets MgO-P, for the capture of Congo red (CR). Specifically, the octahedron MgO-M exhibits a greater abundant of moderately and strongly alkaline sites, which facilitate the adsorption of CR.

Recent advances of MOF-based SERS substrates in quantitative analysis of food contaminants: a review.

Advancements in food-contaminant detection technologies can significantly improve food safety and human health. Surface-enhanced Raman spectroscopy (SERS) has become the preferred analytical method for food-safety detection owing to its numerous advantages, which include unique 'molecular fingerprinting' features, high sensitivity, rapid responses, and non-invasive characteristics. Raman-signal enhancements rely heavily on high-performance SERS substrates.

Emerging methods and applications in 3D genomics.

Since the advent of Hi-C in 2009, a plethora of high-throughput sequencing methods have emerged to profile the three-dimensional (3D) organization of eukaryotic genomes, igniting the era of 3D genomics. In recent years, the genomic resolution achievable by these approaches has dramatically increased and several single-cell versions of Hi-C have been developed. Moreover, a new repertoire of tools not based on proximity ligation of digested chromatin has emerged, enabling the investigation of the higher-order organization of chromatin in the nucleus.

Recent advances in understanding the immune microenvironment in ovarian cancer.

The occurrence of ovarian cancer (OC) is a major factor in women's mortality rates. Despite progress in medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. The tumor microenvironment (TME) includes cancer cells, fibroblasts linked to cancer (CAFs), immune-inflammatory cells, and the substances these cells secrete, along with non-cellular components in the extracellular matrix (ECM).

Crape myrtle LiGAoxs displaying activities of gibberellin oxidases respond to branching architecture.

In the realm of ornamental horticulture, crape myrtle (Lagerstroemia indica) stands out for its aesthetic appeal, attributed largely to its vibrant flowers and distinctive branching architecture. This study embarked on a comprehensive exploration of the gibberellin oxidase (GAox) gene family in crape myrtle, illuminating its pivotal role in regulating GA levels, a key determinant of plant developmental processes. We identified and characterized 36 LiGAox genes, subdivided into GA2ox, GA3ox, GA20ox, and GAox-like subgroups, through genomic analyses.