The multi-dimensional regulatory mechanism of Sirt6 in heart health: From cell death pathways to targeted therapy for cardiovascular diseases.

Sirtuin 6 (Sirt6) is a member of the Sirtuin family, exhibiting histone deacetylase and ADP-ribosyltransferase activity. This enzyme is involved in several pathways, such as epigenetic regulation and inflammation control. It is essential for preserving cardiac equilibrium and postponing the emergence of cardiovascular disorders.

Ultrasound-responsive diagnostic and therapeutic micro-/nanoplatforms for biomedical applications and clinical translation.

Ultrasound is a widely utilized diagnostic and therapeutic tool in biomedicine due to its non-invasiveness, biocompatibility, cost-effectiveness, and high tissue penetration depth. With the continuous development of materials science and nanomedicine, ultrasound-based diagnosis and treatment have achieved significant advancements. By combining ultrasound as a trigger with responsive biomaterials, platforms with diagnostic and therapeutic performance for specific diseases could be established, offering a promising approach for the development of precise medicine.

Modulating covalency competition and neutral microenvironment in cobalt spinel catalysts enables sustainable peracetic acid activation and ultrafast antibiotics degradation.

Conventional cobalt spinel oxides, widely employed in advanced oxidation processes, suffer from limited catalytic activity due to competitive overlap of O 2p orbitals between tetrahedral (Co) and octahedral cobalt (Co). Furthermore, their narrow pH activity window near neutrality severely restricts environmental applicability. To address these limits, the theories of covalency competition and microenvironment modulation are introduced to simulate the catalytic process and propose optimization strategies.

Heterogeneity-aware high-efficiency federated learning with hybrid synchronous-asynchronous splitting strategy.

Federated Learning (FL) offers a promising privacy-preserving framework for collaborative global model training without exposing local private data. However, system heterogeneity in FL causes the straggler issue, where resource-limited edge devices delay global model aggregation. Existing approaches, such as asynchronous mechanisms or kick-out methods, primarily focus on optimizing model convergence efficiency but often overlook edge resource constraints, potentially resulting in model bias toward high-performance devices or omission of critical data.

Comparison of 68Ga-FAPI-04 and 18F-FDG in Primary Splenic Angiosarcoma.

Primary splenic angiosarcoma is a rare, aggressive tumor, characterized by rapid metastasis and poor prognosis. Herein, we report a case of 18F-FDG and 68Ga-FAPI-04 PET/CT imaging in a 57-year-old man with primary splenic angiosarcoma. 68Ga-FAPI-04 PET/CT presented much higher uptake in the lesions compared with 18F-FDG PET/CT, showing better diagnostic performance.

Global trends and prospects of endothelial keratoplasty from 2004 to 2023: a bibliometric analysis.

Background: Endothelial keratoplasty (EK) has revolutionized the treatment of corneal diseases by offering a less invasive alternative to traditional full-thickness keratoplasty. Over the past decades, EK techniques have evolved significantly, improving surgical outcomes, expediting recovery, and reducing postoperative complications. Nevertheless, challenges such as postoperative rejection and endothelial cell loss persist.

A comorbidity of cardiac atherosclerotic disease with cardiac myxomas being concomitantly treated by coronary artery bypass grafting coupling with tumor resection: a case report.

Introduction And Importance: Cardiac atherosclerotic disease (CAD), the leading cause to cardiovascular disease-related death, coexisting with cardiac myxoma, the commonest benign primary cardiac neoplasm, is rare. The treatment of the comorbidity is complicated due to the rarity and inexperience.

Case Presentation: A 65-year old male patient with intermittent chest tightness and shortness of breath for 10 years was admitted for further work-up.

Research progress in glioma-related epilepsy (Review).

Epilepsy is a frequently occurring complication in patients with gliomas that substantially impairs their quality of life. The onset of epilepsy in patients with gliomas is driven by multiple mechanisms, including tumour-induced compression of the peripheral neural network, the release of neurotransmitters and inflammatory factors by tumour cells, alterations in the tumour microenvironment, and changes in gene expression. Collectively, these factors contribute to the abnormal excitability of local neurons, ultimately triggering seizures.

Deciphering cellular heterogeneity and pathway dynamics in urinary samples: a UMAP-Based approach to understanding acute kidney injury.

Background: Acute kidney injury (AKI) is characterized by rapid loss of renal function and is associated with severe clinical outcomes. Understanding the cellular heterogeneity in urine samples during AKI may provide insights into the underlying pathophysiological mechanisms and potential therapeutic targets.

Objectives: To explore the cellular composition and gene expression patterns in urine samples from AKI and non-AKI conditions using Uniform Manifold Approximation and Projection (UMAP) to identify key cellular interactions and pathway activations related to AKI.

The impact of public health shocks on fertility intentions: evidence from the COVID-19 pandemic in China.

Background: China's persistent fertility decline poses serious long-term demographic and socioeconomic challenges. The COVID-19 pandemic has introduced additional uncertainty, raising questions about how external shocks affect fertility intentions in real time.

Objective: This study examines the causal impact of localized COVID-19 shocks on fertility intentions in China, as measured by high-frequency digital search data that capture real-time behavioral shifts.

Optimized thermoelectric properties of SnSe through the joint strategies of Sn-content fine-tuning and CuAgSe alloying.

Polycrystalline SnSe has been widely explored due to its relatively low thermal conductivity. Yet its thermoelectric performance is limited due to its poor electrical conductivity. In this work, polycrystalline SnSe alloyed with different contents of CuAgSe were fabricated by a high-energy balling and melting method, combined with spark plasma sintering.

Endogenous Enzyme Stimulation of Localized Catalytic DNA Assembly for High-Contrast microRNA Imaging and Reliable Evaluation of Drug Resistance.

Localized DNA circuits have emerged as a powerful platform for real-time visualization of disease-associated biomolecules in living cells, enabling deeper insights into complex biological processes. However, their extensive applications have been limited by a low probe utilization efficiency and nonspecific background signals. Here, we present a cell-specifically triggered localized catalytic assembly (TCA) circuit designed for high-contrast, reliable imaging of microRNAs (miRNAs).

Chinese Nurses' Perceptions of Intra-Organizational Workplace Psychological Violence: A Qualitative Study.

Intra-organizational workplace psychological violence has a significant impact on the physical and mental health of nurses. This study aimed to explore Chinese nurses' perceptions of intra-organizational workplace psychological violence and examine their attitudes, coping strategies, and the ramifications of such violent incidents. Semi-structured interviews were conducted with 18 nurses from a tertiary hospital in China, and the data were analyzed using the Colaizzi 7-step analysis method.

Integrin αvβ6-Targeted PET/CT Imaging of Non-Small Cell Lung Cancer with [Ga]Ga-Trivehexin: Improved Preoperative Lymph Node Staging and Association with Immunohistochemistry.

Integrin αvβ6, an epithelial-specific integrin, plays a crucial role in the development and prognosis of multiple tumors and has emerged as a potential target for cancer diagnosis and treatment. The novel integrin αvβ6-targeted radiotracer [Ga]Ga-Trivehexin shows excellent targeting specificity and favorable tumor-to-background contrast. In this prospective clinical study (NCT05835570) involving 58 participants with non-small cell lung cancer (NSCLC), [Ga]Ga-Trivehexin and 2-deoxy-2-[F]fluoro-D-glucose ([F]FDG) positron emission tomography/computed tomography (PET/CT) showed perfect diagnostic accuracy (100%, 58/58) for the detection of primary tumors.

[Expert consensus on local anesthesia application in pediatric dental therapies].

Dental treatments for children and adolescents have unique clinical characteristics that differ from dental care for adults in terms of children's physiology, psychology, and behavior. These differences impose specific requirements on the application of local anesthesia in pediatric dental procedures. This article presents expert consensus on the principles of local anesthesia techniques in pediatric dental therapies, including the use of common anesthetic drugs and dosage control, safety and efficacy evaluation, and prevention and management of complications.

The Causal Relationship Between Circulating Inflammatory Proteins and Tinnitus: A Mendelian Randomization Study Mediated by Blood Metabolites.

Purpose: Tinnitus is a complex disease whose pathophysiological mechanisms are still not fully elucidated. Dysregulation of circulating inflammatory proteins and metabolites is thought to play a crucial role in tinnitus pathophysiology, but the causal relationships and specific biological pathways linking these factors to tinnitus persistence remain unestablished.

Methods: We performed a two-sample Mendelian randomization (MR) analysis using tinnitus genome-wide association study (GWAS) data from FinnGen biobanking and GWAS data from metabolites and circulating inflammatory factors in GWAS directories.

Efficacy and safety of the Shugan Jieyu capsule as a complementary treatment for functional dyspepsia: A systematic review and meta-analysis.

Background: To evaluate the efficacy and safety of the Shugan Jieyu capsule as a complementary treatment for functional dyspepsia (FD).

Methods: Seven electronic databases were searched for randomized controlled trials (RCTs) on Shugan Jieyu capsule treatment for FD with a scientifically rigorous search strategy. The quality of the literature was assessed using the Risk of Bias 2 tool, a meta-analysis was performed with RevMan v5.

Pelvic lipomatosis-A silent intruder in the pelvis: Clinical insights from a case report and literature analysis.

Rationale: This study aims to highlight the diagnostic challenges and multidisciplinary management of pelvic lipomatosis (PL), emphasizing imaging's pivotal role and the need for early intervention to mitigate long-term morbidity. With fewer than 200 reported cases, PL remains underrecognized; this case underscores its potential to mimic common gastrointestinal/urinary disorders, advocating for heightened clinical suspicion.

Patient Concerns: A 42-year-old male presented with a 2-day history of colicky abdominal pain under the xiphoid process, ac companied by nausea, vomiting, and watery stools.

Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.

Background: To assess the clinical benefits of Selenium (Se) supplementation in patients with Hashimoto thyroiditis (HT).

Methods: Eight databases were searched for randomized controlled trials. The outcomes of interest were thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).

Endovascular embolization for ruptured intracranial aneurysms: efficacy and effects on oxidative stress levels.

Objective: This study aimed to investigate the efficacy of endovascular embolization in treating ruptured intracranial aneurysms (RIAs).

Methods: RIA patients (n = 89) were grouped according to different surgical methods. The control group (n = 42) received aneurysm clipping surgery, whereas the observation group (n = 47) received endovascular embolization.

Attitudes and opinions of pharmacy undergraduates towards the integration of innovation and entrepreneurship programs into professional education.

Background: Innovation and entrepreneurship (I&E) ability has been defined as one of the key elements and expected outcomes of personal and professional development among pharmacy students. As an emerging trend in pharmacy undergraduate training, the organic integration of I&E elements in professional education offers a critical means to cultivate high-quality pharmacy professionals. However, the current methods of doing so have not incorporated adequate consultation with pharmacy undergraduates, who are key stakeholders in I&E and professional education.

System with Thermal Management for Synergistic Water Production, Electricity Generation and Crop Irrigation.

Sustainable water, energy and food (WEF) supplies are the bedrock upon which human society depends. Solar-driven interfacial evaporation, combined with electricity generation and cultivation, is a promising approach to mitigate the freshwater, energy and food crises. However, the performance of solar-driven systems decreases significantly during operation due to uncontrollable weather.

Lipidomic profiling of human bile distinguishes cholangiocarcinoma from benign bile duct diseases with high specificity and sensitivity: a prospective descriptive study.

Background: Cholangiocarcinoma (CCA) is a rare and highly aggressive malignancy originating in the bile ducts. Owing to limitations involving pathological sampling, the clinical differentiation of CCA from benign biliary diseases remains challenging. This study aimed to evaluate the differences between the bile lipidomes of CCA patients and those of patients with benign disease to develop a bile lipid classifier that can help to differentiate CCA from benign conditions.

Perirenal fat thickness may be a significant predictor of prognosis and postoperative renal function in renal cancer surgery patients.

Renal cell carcinoma accounts for a significant number of kidney malignancy-related fatalities globally. Perirenal Fat Thickness (PRFT) may indicate a state of nutritional excess in patients, which is potentially directly linked to both the incidence and prognosis of kidney cancer. This study investigated the association between perirenal fat thickness (PRFT) and overall survival (OS), as well as the predictive value of PRFT for postoperative estimated glomerular filtration rate (eGFR) in patients with renal cell carcinoma (RCC).