Clinical efficacy of selenium supplementation in patients with Hashimoto thyroiditis: A systematic review and meta-analysis.

Background: To assess the clinical benefits of Selenium (Se) supplementation in patients with Hashimoto thyroiditis (HT).

Methods: Eight databases were searched for randomized controlled trials. The outcomes of interest were thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TgAb), thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).

Lower serum GPX4 and GSH/GSSG ratio are associated with poor prognosis in severe community-acquired pneumonia.

Objectives: Disruption of redox homeostasis and ferroptosis have been increasingly implicated in the pathogenesis of inflammatory lung injury. Glutathione peroxidase 4 (GPX4) and the ratio of reduced to oxidized glutathione (GSH/GSSG) are key regulators in this process. However, the clinical significance of ferroptotic factors in severe community-acquired pneumonia (CAP) is still lacking.

A case report of familial type 2 diabetes mellitus combined with hypothyroidism and multiple autoimmune diseases.

Gene mutations in the Janus kinase/signal transducer and activator of transcription signaling (JAK/STAT) pathway can promote the occurrence of type 2 diabetes mellitus (T2DM) and autoimmune diseases. We report on two patients with T2DM (a mother and her adult son) with concomitant Hashimoto's thyroiditis and autoimmune diseases. The son was diagnosed with systemic sclerosis and antiphospholipid syndrome, while the mother was diagnosed with primary biliary cholangitis.

Machine Learning and Interpretability Study for Predicting 30-Day Unplanned Readmission Risk of Schizophrenia: A Retrospective Study.

Purpose: To build a 30-day unplanned readmission (UPR) risk prediction model based on machine learning (ML) and SHapley Additive exPlanation (SHAP) with data obtained from the electronic medical records (EMRs) of patients with schizophrenia, so as to provide support for early intervention in clinical treatment.

Patients And Methods: This retrospective study selected 1,123 patients with schizophrenia who were hospitalized at least once from January 1, 2021 to June 30, 2024 according to their EMRs. Models were constructed after screening variables using the multiple linear regression and feature importance methods.

LncRNA LUCAT1 as a prognostic biomarker in cholangiocarcinoma through targeting miR-141-3p: clinical and functional insights.

Background: Cholangiocarcinoma (CHOL) has a poor prognosis due to its asymptomatic progression, challenges in early detection, and limited treatment options. The lncRNA LUCAT1 is highly expressed in several cancers, including lung, gastric, ovarian, and osteosarcoma tissues.

Aim: This study investigates the potential of LUCAT1 as a diagnostic and prognostic biomarker for CHOL.

Association between periventricular hyperintensity or deep white matter hyperintensity and outcomes of patients with ischemic stroke.

Introduction: This study investigates the association between white matter hyperintensities (WMH), specifically periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH), and the prognosis and recurrence risk in patients with ischemic stroke.

Methods: A retrospective analysis was conducted on 278 patients with acute ischemic stroke, including 112 with PVH and 166 with DWMH. Key outcome measures included functional outcome (modified Rankin Scale score), mortality, neurological recovery, and stroke recurrence at 3, 6, and 12 months after treatment.

Association between insomnia and its symptoms and cognitive impairment in community-dwelling older adults in China: A multicenter study.

BackgroundLimited evidence exists on insomnia symptoms' association with mild cognitive impairment (MCI) and dementia in older Chinese adults across rural and urban areas.ObjectiveTo examine associations between insomnia symptoms, sleep duration, and cognitive impairment.MethodsThis cross-sectional study utilized data from China's Multicenter Dementia Survey (2019-2020), examining the association between insomnia symptoms, sleep duration, and cognitive impairment, using logistic and linear regression models.

The application of CBL and mind mapping combined with Mini-CEX teaching mode in the cultivation of clinical competence of ultrasound residents.

Objective: This study aims to evaluate the efficacy of the Mini Clinical Evaluation Exercise (Mini-CEX) in conjunction with Case-Based Learning (CBL) and mind mapping methodologies in fostering the clinical competencies of ultrasound residents.

Methods: A cohort of forty-two general practitioners who underwent standardized training at the Department of Ultrasound Medicine at Tianyou Hospital, affiliated with Wuhan University of Science and Technology, from December 1, 2022 to December 1, 2024, were selected for this research. These practitioners were randomly assigned to either an experimental group or a control group using a random number table.

Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis.

Introduction: Inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with poorer prognosis of gastric cancer (GC) patients and may guide treatment decisions. This meta-analysis aims to evaluate the impact of NLR and PLR on the prognosis of GC patients undergoing neoadjuvant chemotherapy (NAC).

Methods: Cochrane, Embase, PubMed and Web of science were searched for studies up to November 30, 2024.

Prognostic assessment of sarcopenia in patients with fractures: a systematic review and meta-analysis.

Background: Currently, the prevalence of sarcopenia is on the rise. Sarcopenia may significantly affect the prognosis of fracture patients by increasing postoperative complications, diminishing quality of life, and raising mortality rates. This studyaims to investigate the impact of sarcopenia on the prognosis of fractures.

Synergistic inhibition of gastric cancer cell proliferation by concanavalin A and silibinin via attenuation of the JAK/STAT3 signaling pathway and molecular docking analysis.

Background: In the current period of pharmaceutical discovery, herbal remedies have shown to be an unmatched supply of anticancer medications. Plants and their derivatives, through analogues, play a vital role in cancer treatment.

Objectives: The current investigation assessed the effectiveness of inhibiting the growth of gastric cancer cells in AGS cells by blocking the JAK/ STAT3 signalling pathways using the natural medicines Concanavalin A (Con-A) and silibinin (SB).

Marital Status-Specific Associations Between Multidomain Leisure Activities and Cognitive Reserve in Clinically Unimpaired Older Adults: Based on a National Chinese Cohort.

It is unclear how marital status moderates the association between multidomain leisure activities and the progression of cognitive decline in community-dwelling older adults. Data from the Chinese Longitudinal Healthy Longevity Survey with up to 10 years of follow-up were used. The study included participants aged ≥65 years without cognitive impairment at baseline.

Integrating traditional omics and machine learning approaches to identify microbial biomarkers and therapeutic targets in pediatric inflammatory bowel disease.

Background: Pediatric inflammatory bowel disease (IBD), especially Crohn's disease, significantly affects gut health and quality of life. Although gut microbiome research has advanced, identifying reliable biomarkers remains difficult due to microbial complexity.

Methods: We used RNA-seq-based microbial profiling and machine learning (ML) to find robust biomarkers in pediatric IBD.

Neural connections and molecular mechanisms underlying motor skill deficits in genetic models of autism spectrum disorders.

Autism spectrum disorders (ASDs) comprise a broad category of neurodevelopmental disorders that include repetitive behaviors and difficulties in social interactions. Notably, individuals with ASDs exhibit significant impairments in motor skills even prior to the manifestation of other core symptoms. These skills are crucial for daily activities, such as communication, imitation, and exploration, and hold significant importance for individuals with ASDs.

Dyadic Effects of Stigma and Self-Compassion on Resilience of Schizophrenic Patients and Caregivers During Recovery: An Actor-Partner Interdependence Mediation Model.

Purpose: In this study, dyadic analysis was used to explore the dyadic effect of stigma on resilience and whether self-compassion plays a mediating role in the dyadic relationship between schizophrenia patients and primary caregivers during recovery.

Methods: A total of 210 patients with schizophrenia and their primary caregivers from a tertiary hospital in Hubei Province were selected as the research objects by convenience sampling method. The investigation was conducted with the General Information Questionnaire, Stigma Scale, Self-Compassion Scale and Connor-Davidson Resilience Scale.

Short-chain chlorinated paraffins induce hippocampal damage and glycerophospholipids disruption contributing to neurobehavioral deficits in mice.

Short-chain chlorinated paraffins (SCCPs), a class of widely used industrial chemicals, have raised significant health concerns due to their persistence, bioaccumulation, and potential neurotoxicity. This study investigated the neurotoxic effects of SCCPs on the hippocampus and their impact on brain glycerophospholipid metabolism in mice. Behavioral tests revealed that 50 mg/kg SCCPs exposure significantly reduced spontaneous activity and impaired learning and memory.

Effects of detergent component sodium dodecyl sulfate on growth hormone secretion in GH3 cells: Implications for pediatric exposure and accidental ingestion.

IntroductionSodium dodecyl sulfate (SDS), a widely used surfactant in detergents, has raised concerns due to its potential health risks, particularly in children. This study evaluates the impact of SDS exposure on GH secretion in GH3 cells, focusing on oxidative stress as a key mechanism.MethodsGH3 cells were treated with varying concentrations of SDS (0.

Exploring the positive association of blood lipid levels with prostate cancer risk and their relationship to pathological features in the Chinese population.

Presently, the majority of investigations into the effects blood lipids on prostate cancer (PCa) primarily involve Western populations. Our study endeavors to investigate the impact of blood lipid levels on the risk of PCa among the Chinese population and to elucidate their potential association with the pathological characteristics of PCa. This study drew data from a dataset for early warning of PCa from the China National Population Health Science Data Center, encompassing 2624 patients who had undergone prostate biopsy.

Association between home dwelling situations, neighborhood social interactions, and subjective cognitive decline plus among older adults: A cross-sectional study.

BackgroundHome-dwelling situations (HDS) and neighborhood social interactions (NSI) significantly impact older adults' post-retirement lives. However, their relationship with subjective cognitive decline plus (SCD-plus), a potential biomarker of preclinical Alzheimer's disease (AD), remains uncertain.ObjectiveTo explore the association between NSI, HDS and SCD-plus among older adults.

Caffeine improves hypoxia/reoxygenation induced neuronal cell injury through inhibiting cellular ferroptosis: an study.

Objective: Ferroptosis, a regulated cell death pathway driven by lipid peroxidation and iron overload, is implicated in neuronal injury caused by hypoxia/reoxygenation (H/R). Caffeine, a widely consumed psychoactive compound, has shown neuroprotective effects in various central nervous system disorders, but its role in regulating ferroptosis remains unclear. This study investigates the neuroprotective effects of caffeine on ferroptosis and its regulation of ACSL4, a key ferroptosis-related protein.

Dual-branch image projection network for geographic atrophy segmentation in retinal OCT images.

Existing geographic atrophy (GA) segmentation tasks can only use 3D data, ignoring the fact that a large number of B-scan images contain lesion information. In this work, we proposed a multistage dual-branch image projection network (DIPN) to learn feature information in B-scan images to assist GA segmentation. Considering that segmenting 3D data slices using a 2D network architecture ignores the neighboring information between volume data slices, we introduced ConvLSTM.

Constructing and Validating Models for Predicting Gleason Grade Group Upgrading following Radical Prostatectomy in Localized Prostate Cancer: A Comparison between Machine Learning Algorithms and Conventional Logistic Regression.

Introduction: The occurrence of Gleason grade group upgrading (GGU) significantly impacts treatment strategy developments. We aimed to develop an optimal predictive model to assess the risk of GGU in patients with localized prostate cancer (PCa), by comparing traditional logistic regression (LR) with seven machine learning algorithms.

Methods: A retrospective collection of clinical data was conducted on patients who underwent radical prostatectomy at Wuhan Central Hospital (January 2017 to December 2023, n = 177) and Jiangxi Cancer Hospital (July 2019 to February 2024, n = 87).

Meta-analysis of minimally invasive transforaminal lumbar interbody fusion versus oblique lumbar interbody fusion for treating lumbar degenerative diseases.

Objective: This study aims to perform a meta-analysis that integrates multiple literature sources to evaluate the clinical efficacy of oblique lumbar interbody fusion (OLIF) versus minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) for treating lumbar degenerative diseases (LDD).

Methods: A systematic search was conducted across various databases, including CNKI, VIP, WANFANG DATA, SinoMed, PubMed, Cochrane Library, Embase, and Web of Science, for clinical comparative studies on OLIF and MIS-TLIF for treating LDD, covering the time frame from the inception of the databases to September 2024. Following PRISMA guidelines, studies were screened, assessed, and data were extracted rigorously.

Clinical significance of serum Helicobacter pylori antibody cytotoxin-associated gene A levels in patients with unstable angina.

Objectives: We investigated the clinical significance of serum Helicobacter pylori cytotoxin-associated gene A (CagA) antibody levels in 768 patients with unstable angina (UA).

Methods: Serum CagA levels were measured using ELISA. Demographic data, serum biomarkers, and SYNTAX scores were collected.