Clinical practice guidelines for rituximab treatment in children with steroid-sensitive nephrotic syndrome.

Background: Steroid-sensitive nephrotic syndrome is a prevalent glomerular disease in children. The 2021 guidelines for glomerular disease management by Kidney Disease: Improving Global Outcomes and the 2023 recommendations for steroid-sensitive nephrotic syndrome management by International Pediatric Nephrology Association recommend rituximab for frequently relapsing nephrotic syndrome and steroid-dependent nephrotic syndrome in children. However, there is considerable variation in rituximab application, including administration timing, dose, frequency, concomitant medications, and follow-up schedules.

Therapeutic efficacy of Yangyin Shugan capsules against premature ovarian insufficiency: results from a multicenter, placebo-controlled trial.

Objectives: This multicenter, double-blind, randomized, placebo-controlled trial evaluated the efficacy and safety of Yangyin Shugan (YYSG) capsules in women with premature ovarian insufficiency (POI).

Methods: This study enrolled 548 Chinese women with POI (August 2016-June 2021) from 13 Guangdong hospitals. After screening, 333 participants were randomized (2:1) to receive YYSG capsules or placebo for 12 weeks.

Retrospective Analysis of Factors Associated with a Prolonged Nucleic Acid Conversion Time in Patients with COVID-19 at Fangcang Shelter Hospital.

Objective: The aim of this study was to explore the related factors for prolonged nucleic acid conversion time (NCT) in patients with SARS-CoV-2 Omicron variant, so as to help to prevent and control the epidemic.

Methods: This study retrospectively included 307 patients diagnosed with mild to moderate COVID-19 who were hospitalized in Shanghai International Exhibition Fangcang Shelter Hospital. Nucleic acid amplification detection method was used to detect 2019-nCoV nucleic acid in nasopharyngeal swab samples.

Effect of oxytocin on cardiovascular modulation in normal and post-traumatic stress disorder model rats.

Oxytocin (OXT) is associated with cardioprotective effects and shows to alleviate symptoms of post-traumatic stress disorder (PTSD). This study investigates blood pressure and electrocardiographic (ECG) parameters in anesthetized normal rats utilizing intravenous (iv) and intracerebroventricular (icv) administration of oxytocinergic agents. We also assessed the effects of cervical vagotomy on the cardiovascular responses to iv OXT.

Associations of Academic Study- and Non-Study-Related Sedentary Behaviors with Incident Obesity in Children and Adolescents.

: To assess the associations between academic study- and non-study-related sedentary behaviors and the risk of overweight/obesity in children and adolescents, as well as their joint association with sugar-sweetened beverage (SSB) consumption. : Sedentary behaviors and SSB consumption were assessed using self-reported questionnaires. Overweight/obesity were defined by age- and sex-specific body mass index cut-off values according to the criteria of "Screening for overweight and obesity among school-age children and adolescents" in China.

A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP.

Acquired multidrug resistance impedes the clinical application of paclitaxel. Here, we disclosed that the taxane SB-T-101141 efficiently contributed to a novel ferroptosis-like cell death of Paclitaxel-resistant and parental breast cancer cells. Functionally, SB-T-101141 facilitated the production of iron and ferrous ions along with reactive oxygen species (ROS), composed of lipid ROS and lipid peroxidation-derived aldehydes, including malonaldehyde (MDA), and glutathione (GSH) depletion.

SRGN-mediated reactivation of the YAP/CRISPLD2 axis promotes aggressiveness of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a major contributor to global cancer-related mortality. Serglycin (SRGN) is involved in the progression of various cancers, and its overexpression is related to poor prognosis in HCC patients. Its biological role in HCC aggressiveness is unknown.

Chemically Induced Nuclear Pore Complex Protein Degradation via TRIM21.

Despite the exciting progress of bifunctional degrader molecules, also known as proteolysis-targeting chimeras (PROTACs), the rapidly expanding field is still significantly hampered by the lack of available E3 ligase ligands. Our research bridges this gap by uncovering a series of small-molecule ligands to the E3 ligase TRIM21 through DNA-Encoded Library (DEL) technology. We confirmed their interaction with TRIM21 using crystallography and demonstrated their antiproliferative effects across various cancer cell types.

Dyadic Effects of Stigma and Self-Compassion on Resilience of Schizophrenic Patients and Caregivers During Recovery: An Actor-Partner Interdependence Mediation Model.

Purpose: In this study, dyadic analysis was used to explore the dyadic effect of stigma on resilience and whether self-compassion plays a mediating role in the dyadic relationship between schizophrenia patients and primary caregivers during recovery.

Methods: A total of 210 patients with schizophrenia and their primary caregivers from a tertiary hospital in Hubei Province were selected as the research objects by convenience sampling method. The investigation was conducted with the General Information Questionnaire, Stigma Scale, Self-Compassion Scale and Connor-Davidson Resilience Scale.

Phenotypic adaptation and genomic variation of associated with its northern introduction along southeastern coast of China.

Introduction: Mangroves play a crucial role within coastal wetland ecosystems, with frequently utilized for introduction studies and cultivation research. Investigating the rapid adaptability of across diverse environmental conditions offers valuable insights into how mangroves can effectively acclimate to global climate fluctuations.

Methods: In this study, following a common gardenexperiment, we investigated variations in morphological traits between twodistinct populations of , Quanzhou (QZ) and Wenzhou (WZ),originating from the same introduction site Zhangzhou (ZZ).

Publisher preferences for a journal transparency tool: A modified three-round Delphi study.

Background: We propose the creation of a journal transparency tool (JTT), which will allow users to obtain information about a given scholarly journal's operations and policies. We are obtaining preferences from different stakeholders to inform the development of this tool. This study aimed to identify the publishing community's preferences for the JTT.

Down-regulation of platelet-derived growth factor receptor β in pericytes increases blood-brain barrier permeability and significantly enhances α-synuclein in a Parkinson's Disease 3D cell model in vitro under hyperglycemic condition.

Background: Parkinson's Disease (PD) often presents with a compromised blood-brain barrier (BBB), which hyperglycemia may exacerbate. Pericytes, a key cell for BBB integrity, are potential therapeutic targets for neurodegenerative disorders. Few studies have developed 3D PD cell models incorporating neurovascular units (NVU) through the co-culture of human endothelial, pericytes, astrocytes, and SH-SY5Y cells to evaluate BBB impairment and the role of pericytes under hyperglycemic condition.

A predictive walking energy model based on gait phase with suspended backpack.

Walking with heavy loads is a common task in military affairs and daily life. Considering that the shoulder and leg muscles fatigue will be caused during walking, which will affect the walking endurance and physical health. However, the suspended backpack is found to improve the energy efficiency of walking with a load.

Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs.

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) has emerged as a promising therapeutic target for cancer treatment. However, the current PIN1 inhibitors have shown limited efficacy in animal models, leaving the question of whether PIN1 is a proper oncologic target still unanswered. By screening a 1 trillion DNA-encoded library (DEL), we identified novel nonacidic compounds.

Assessment of the Respiratory Disease Mortality Risk from Single and Composite Exposures to PM and Ozone - Guangzhou City, Guangdong Province, China, 2018-2021.

What Is Already Known About This Topic?: Fine particulate matter (PM) and ozone (O) are prevalent pollutants in the atmosphere, which threaten human health, especially the respiratory system. Typically, people are exposed to a mixture of various pollutants in the environment. Thus, the single and combined effects of both pollutants need to be investigated.

Integrating single-cell and spatial transcriptomics to elucidate the crosstalk between cancer-associated fibroblasts and cancer cells in hepatocellular carcinoma with spleen-deficiency syndrome.

Background And Aim: Most patients with hepatocellular carcinoma (HCC) in China have been diagnosed with spleen deficiency syndrome (SDS), which accelerates the progression of HCC by disrupting the tumor microenvironment homeostasis. This study aimed to investigate the intercellular crosstalk in HCC with SDS.

Experimental Procedure: An HCC-SDS mouse model was established using orthotopic HCC transplantation based on reserpine-induced SDS.

Exploring the role of psychological assistance hotlines in improving mental health problems among Chinese adult women: A perspective based on social expectations and gender roles.

This paper looks at how social expectations and gender roles affect the mental health of Chinese women. Traditional Chinese culture, influenced by Confucianism and patriarchy, still has a negative impact on women's mental well-being, despite efforts for gender equality. Women's mental health is vital for both individuals and society, and this study aims to understand these issues better to help shape policies and interventions.

Molecular mechanism of salinity and waterlogging tolerance in mangrove .

Mangrove forests are colloquially referred to as "Earth's kidneys" and serve many important ecological and commercial functions. Salinity and waterlogging stress are the most important abiotic stressors restricting the growth and development of mangroves. is the greatest latitudinally-distributed salt mangrove species in China.

Monogenic Causes Identified in 23.68% of Children with Steroid-Resistant Nephrotic Syndrome: A Single-Centre Study.

Introduction: Steroid-resistant nephrotic syndrome (SRNS) is the second most common cause of end-stage kidney disease in children, mostly associated with focal segmental glomerulosclerosis (FSGS). Advances in genomic science have enabled the identification of causative variants in 20-30% of SRNS patients.

Methods: We used whole exome sequencing to explore the genetic causes of SRNS in children.

A prognostic model based on DNA methylation-related gene expression for predicting overall survival in hepatocellular carcinoma.

Background: Hepatocellular carcinoma (HCC) continues to increase in morbidity and mortality among all types of cancer. DNA methylation, an important epigenetic modification, is associated with cancer occurrence and progression. The objective of this study was to establish a model based on DNA methylation risk scores for identifying new potential therapeutic targets in HCC and preventing cancer progression.

A Study of Elderly Patients' Preference for "Internet + Nursing Service" Based on Discrete Choice Experiments.

Objective: To investigate the preference of elderly patients for "Internet + Nursing Service", so as to provide reference for accurately matching their service needs.

Methods: Based on discrete choice experiments, the elderly patients' "Internet + Nursing Service" choice preference questionnaire was prepared, and 410 elderly patients were interviewed face-to-face. The Conditional Logit Model was used for quantitative analysis of the experimental data.