Optimal stimulation site and fiber tracts in subthalamic deep brain stimulation for Meige syndrome.

Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has emerged as an effective therapy for Meige syndrome (MS). However, the optimal stimulation site within STN and the most effective stimulation fiber tracts have not been investigated.

Methods: Based on the discovery cohort (n = 65), we first identified the optimal stimulation site within the STN using the sweet spot mapping method.

[Two cases of X-linked adrenoleukodystrophy presenting with Addison's disease as the initial manifestation and analysis of novel ABCD1 variants].

Clinical data of two patients with X-linked adrenoleukodystrophy (X-ALD) initially presenting as Addison's disease were collected from the Department of Endocrinology, First Medical Center of Chinese PLA General Hospital. Relevant medical history, clinical features, laboratory tests, and genetic results were analyzed. The two male patients, aged 7 years (case 1) and 15 years (case 2), initially presented with generalized skin hyperpigmentation, without any family history of similar disorders.

Comparative Analysis of MRI Features and Overall Survival: IDH-Wildtype Diffuse Lower-grade Glioma and Glioblastoma in Adults.

Rationale And Objectives: In depth comparison of imaging features and overall survival (OS) between IDH wild-type diffuse lower-grade glioma and glioblastoma (GB), providing precise guidance for early risk stratification and optimized clinical decision-making.

Materials And Methods: Retrospective inclusion of IDH wild-type glioma patients admitted between January 2017 and January 2024. Patients were classified into GB (histological and molecular) and lower-grade glioma not elsewhere classified (LGNEC) based on fifth edition of the Central Nervous System Tumor Classification Standards.

CD126 umbilical cord mesenchymal stem cells sensitive to IL-6 ameliorate inflammatory bowel disease by producing TGF-β1.

Background: Human umbilical cord mesenchymal stem cells (HUMSCs) are effective therapies for inflammatory bowel disease. However, the mechanisms remain unresolved. We found HUMSCs express CD126 (IL-6 receptor), which indicated CD126 sub-populations might show a distinct response to inflammation.

Low-temperature plasma efficiently promotes blood coagulation with less thermal injury in porcine models.

How to maintain the efficacy of blood coagulation while minimizing thermal damage has been a significant challenge in the optimization of clinical electrosurgical units (ESUs). Recent studies have reported that reactive species produced by low-temperature plasma (LTP) can promote blood coagulation. In this study, two forms of home-made atmospheric pressure plasma jets (APPJs) were compared to argon plasma coagulation (APC) and utilized in three different porcine bleeding models.

A risk score model for post-endoscopic retrograde cholangiopancreatography complications in elderly patients with choledocholithiasis.

Background: Endoscopic retrograde cholangiopancreatography (ERCP) is the preferred treatment for choledocholithiasis. This study aimed to identify the independent risk factors for post-ERCP complications in elderly patients with choledocholithiasis and establish a risk score model.

Methods: This study enrolled patients over the age of 75 with choledocholithiasis, who underwent ERCP at two hospitals.

An easily machine learning-based tool for preliminary risk assessment of microvascular invasion in hepatocellular carcinoma.

Background: Microvascular invasion (MVI) is a crucial risk factor for postoperative recurrence in patients with hepatocellular carcinoma (HCC). Accurate preoperative assessment of MVI and appropriate resection margins (RM) could reduce recurrence rates of HCC.

Methods: A total of 1651 eligible patients who underwent liver resection between January 1, 2018 and June 30, 2023 were retrospectively collected.

Causal effect of conventional anti-dementia drugs on economic burden: an orthogonal double/debiased machine learning approach.

Background: The Inflation Reduction Act (IRA) did not introduce a cap on out-of-pocket (OOP) for newly approved Alzheimer's Disease (AD) drugs, such as lecanemab which is covered under Medicare Part B. Therefore, expanding the use of conventional anti-dementia drugs is critical to addressing the growing economic burden of dementia. In this study, we aimed to evaluate the causal relationship between specific conventional anti-dementia drug use and various healthcare costs with the Double/Debiased Machine Learning (DML) approach.

2024 Update of Chinese Guidelines for Management of Hyperuricemia and Gout Part II: Recommendations for Patients With Common Comorbidities.

Objective: The aim of this updated guideline is to provide comprehensive recommendations for the management of gout in patients with common comorbidities, such as chronic kidney disease (CKD), cardiovascular disease (CVD), diabetes, osteoarthritis (OA), and gastrointestinal disorders.

Methods: This guideline was developed by a multidisciplinary expert panel consisting of specialists in endocrinology, rheumatology, nephrology, cardiology, gastroenterology, and methodology. The development process adhered to standard methodologies, including PICO (population, intervention, comparator, and outcomes) question deconstruction, systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) for evidence and recommendation evaluation, Delphi voting, and expert consensus.

Probiotics restore enteric HDL3 secretion and improve prognosis in patients with end-stage renal disease.

Randomized double-blind trials have shown that probiotic mixtures significantly increase high-density lipoprotein (HDL) levels and reduce the risk of cardiovascular disease mortality in end-stage renal disease (ESRD) patients. Meta-analysis with prospective cohort studies further confirms that elevated HDL is a protective factor for ESRD outcomes. In severe renal injury models, including 5/6 nephrectomy and apolipoprotein E-deficient ( ) mice, probiotics restored cardiac function, mirroring the cardioprotective effects seen in humans.

The Femoral Neck-Shaft Offset: A Key Element in the Reconstruction of Intertrochanteric Fracture.

Background: Anteromedial cortex reduction and accurate placement of the cephalomedullary nail is the key point to confront implant failure of intertrochanteric fractures. Existing intramedullary nails cannot compensate for femoral neck-shaft offset (FNSO), potentially undermining surgical outcome. This study aimed to investigate the effect of FNSO on anteromedial cortex reduction and accurate placement of the cephalomedullary nail for intertrochanteric fractures.

Partial splenectomy and pericardial devascularization for symptomatic patients with portal hypertension: a single-center retrospective study.

Background: The dilemma of current treatments for symptomatic patients with portal hypertension is how to resolve the problems of the varices and hypersplenism simultaneously and meanwhile preserve the splenic function. Partial splenectomy and pericardial devascularization is a potential alternative to currently used approaches, but it is incompletely defined. This study aimed to evaluate the efficacy and safety of partial splenectomy and pericardial devascularization.

[Robotic autonomous surgery in gastrointestinal practice: a viable pathway or an aspirational vision in the artificial intelligence era?].

The deep integration of artificial intelligence (AI) and multimodal data in the medical field presents vast application prospects, with its implementation in robotic surgery still in the early stages. Surgical robots assist surgeons in decision-making and operation through quantifiable data and visualized imaging, where data serves as the key driver of innovation for AI in robotic surgery. AI is pushing the boundaries of robotic autonomy, enhancing the surgical experience and improving both the quality and efficiency of procedures.

A novel anatomically guided strategy for evaluation of sufficient myotomy during peroral endoscopic myotomy in patients with achalasia.

Background And Aims: Peroral endoscopic myotomy (POEM) necessitates proper orientation of the anatomical landmarks throughout the whole procedure to assess the myotomy, which is the main target of POEM. Insufficient myotomy renders the procedure ineffective and may lead to nonresponse or recurrence, although longer myotomy may increase the risk of reflux. The current conventional methods for esophagogastric junction (EGJ) detection are often operator-dependent, time-consuming, and have questionable accuracy.

Biomarkers to predict the severity of acute pancreatitis.

Acute pancreatitis (AP) is pancreatic inflammation caused by abnormal activation of trypsinogen, and moderately severe or severe acute pancreatitis (SAP) can lead to systemic inflammatory response syndrome (SIRS) and organ failure, associated with high mortality. Therefore, early prediction of the severity of acute pancreatitis is particularly important to improve patient survival rate and reduce complications. Currently, many scoring systems (e.

Dual effects of bisphosphonates on bone metabolism and implant osseointegration: mechanisms, risks and clinical strategies.

Osseointegration is the fundamental mechanism facilitating the direct bonding between implants and bone tissue, which significantly influences the success and long-term stability of the implant. Bisphosphonates, potent antiresorptive agents, are widely utilized in the treatment of osteoporosis and other bone metabolic disorders due to their capacity to inhibit osteoclast activity. However, their effects on implant osseointegration present a 'double-edged sword.

Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration.

The incidence of open bone defects caused by high kinetic and potential energy injuries has significantly increased. Bone grafting, typically in the form of granules, is widely recognized as the most effective treatment. However, current bone graft system is not considered ideal due to issues such as mismatched shapes and dislocation.

Prognostic value of red cell distribution width-to-albumin ratio in septic patients with malignancies: A retrospective cohort study based on the MIMIC-IV database.

ObjectiveTo investigate the prognostic value of red cell distribution width-to-albumin ratio (RAR) in sepsis patients with malignancies and evaluate its association with in-hospital mortality.MethodsThe retrospective cohort study was conducted using data extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Participants were stratified into quartiles (Q1-Q4) based on RAR levels measured within 24 hours of intensive care unit admission.

Identification of a prognostic signature consisting of three macrophage-related genes for glioblastoma based on bulk and single-cell transcriptomes analyses.

Background: Tumor-associated macrophages have been implicated in the progression and treatment resistance of glioblastoma (GBM). This study aimed to identify macrophage-related genes associated with prognosis and therapeutic response in GBM.

Materials And Methods: Bulk RNA-seq data from 533 patients with GBM were downloaded from the Cancer Genome Atlas (TCGA) and Chinese Glioma Genome Atlas (CGGA) databases.

Nail Lichen Planus in 81 Patients: A Retrospective Study of Clinical Characteristics, Histopathological Features, and Long-Term Treatment Outcomes.

Nail lichen planus (NLP) is a rare, chronic inflammatory nail disorder that can result in irreversible damage. While clinical awareness is growing, long-term real-world data-particularly incorporating histopathological confirmation and treatment outcomes-remains limited. We retrospectively analyzed 81 biopsy-confirmed NLP cases (2016-2024) from a Chinese dermatology center to characterize their epidemiological, clinical, histological features, treatment responses, and long-term outcomes.