Translation and psychometric evaluation of the Chinese version of The Prediction-Related Experiences Questionnaire (PRE-Q-C).

Objective: Prediction is a fundamental cognitive process that facilitates adaptive interactions with the environment. The Prediction-Related Experiences Questionnaire (PRE-Q), a 19-item measure, assesses individuals' everyday predictive abilities. This study aimed to develop and validate a Chinese version (PRE-Q-C) by translating and adapting the original scale and examining its psychometric properties in a large Chinese sample.

Deficiency of the RNA-binding protein RBMS1 improves myocardial fibrosis and heart failure.

Background And Aims: Previous studies have highlighted the significance of RNA-binding proteins and alternative splicing (AS) in the progression of complex diseases, but the specific involvement of AS in heart failure (HF) remains unclear. This study aimed to elucidate the role of RNA-binding motif single-stranded interacting protein 1 (RBMS1), an RNA-binding protein, in the development of HF by regulating AS and its effect on cardiac fibrosis.

Methods: The level of RBMS1 was investigated in the hearts of both HF patients and mice.

Housing prices in China follow Zipf's law.

This study verifies that housing prices in China follow Zipf's law by analyzing the average housing prices in 200 Chinese cities between 2015 and 2023. The Kolmogorov-Smirnov (KS) test further supports this conclusion. Furthermore, the study explores housing price trends in different city tiers and uses rank clocks to reveal price fluctuations, which is not captured by the Zipf's law.

Mechanistic and Thermodynamic Studies on Copper-Catalyzed Directing Group-Assisted C-4/C-8 Amination of Aryl Amines with Cyclic Amines.

In the mechanistic study, we studied the pyridine amide (PA)-directed 1-naphthylamine C-4/C-8 amination reaction in a Cu-catalyzed system with pyrazole as an oxidant and morpholine in an alkaline environment. We studied the three possible single-electron transfer (SET) pathways for the C-4 amination and found that the free radical-cation intermediate generated by the intermolecular SET step was more favorable. For the C-8 amination, the C8-H activation process occurs before the reaction with the cyclic amine, and the Cu complex formed by the base ion ligand makes the reaction easier.

Dynamics and Interactions of OmpF Porin in an Asymmetric Bacterial Outer Membrane including LPS, ECA, and CPS.

Outer membrane (OM) proteins play a vital role in the physiology of Gram-negative bacteria, and outer membrane protein F (OmpF) is one of the most studied porins in . In this study, we have developed a comprehensive OM model with lipopolysaccharides (LPS), enterobacterial common antigen (ECA), and capsular polysaccharides (CPS) in the outer leaflet and with phospholipids in the inner leaflet. Using extensive all-atom molecular dynamics simulations of OmpF in this realistic asymmetric OM environment, we have investigated the structure and dynamics of OmpF within the OM and its interactions with the OM.

Proteomics-Based Exploration of the Hepatoprotective Mechanism of α-Lipoic Acid in Rats with Iron Overload-Induced Liver Injury.

Excessive iron accumulation poses a significant threat to liver health, primarily through oxidative stress and autophagy dysregulation. α-Lipoic acid (ALA), a natural antioxidant with hepatoprotective properties, may alleviate iron-induced liver damage, but its underlying mechanisms are not fully understood. This study utilized male Sprague Dawley rats and BRL-3A cells to explore the protective effects of ALA against iron overload in vivo and in vitro, respectively.

Influence of Cu on the Mechanical and Shape Memory Properties of TiNi Alloys.

The significant phase transformation hysteresis in TiNi alloys limits their performance. To address this, copper (Cu) was added as an alloying element to reduce hysteresis. This study synthesized three compositions of TiNiCu (x = 0, 5, 7 at.

Influence of Deformation Degree on Microstructural Evolution and Tensile Behavior of TiB-Reinforced IMI834 Composites.

Modern aero-engines need alloys that sustain both strength and ductility at high temperatures. However, conventional titanium alloys face inherent trade-offs between strength and ductility. In situ TiB-reinforced titanium matrix composites could fill this gap, but their texture evolution and hot-working mechanics are still poorly understood.

A First-Principles Comparative Study on the Elastic and Related Properties of TiAC (A = Si, Ir, and Au) MAX Phases.

The elastic, mechanical, acoustic, and thermal properties of Ti3SiC2, Ti3IrC2, and Ti3AuC2 MAX phases were systematically investigated using first-principles calculations based on density functional theory. The computed lattice parameters and elastic, mechanical, and acoustic properties were consistent with existing experimental and theoretical findings, confirming the intrinsic mechanical stability of these MAX phases. Single-crystal elastic stiffness constants were used to derive polycrystalline elastic moduli, directional dependencies of bulk, shear, and Young's moduli, and anisotropic factors.

Study on Formability and Microstructure Evolution of Usibor2000 Sheet Under Different Forming Temperatures in Deep Drawing Process.

Due to the need for weight reduction in the automobile structure, effective and accurate forming is demanded to take advantage of ultrahigh-strength steels. Research on the deep-drawing formability of Usibor2000 has an important impact on the application of lightweight automotive bodies. The microstructure and formability of Usibor2000 sheets at different temperatures were investigated by the Swift test.

Ferroptosis: Therapeutic Potential and Strategies in Non-Small Cell Lung Cancer.

Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and a leading cause of cancer-related morbidity and mortality worldwide. Despite advancements in therapeutic strategies, the prognosis for NSCLC patients remains unfavorable. The effective treatment of NSCLC remains challenging due to its aggressive metastatic and invasive properties.

Nonlinear Classifiers Based on DNA Logic Circuits for Cancer Diagnosis.

DNA logical circuits can be applied to accurate classification of cancer status, benefiting from their excellent biocompatibility and parallelism. However, the existing cancer diagnosis models based on DNA logic circuits mainly adopt a linear structure, which makes it difficult to fully capture the complex nonlinear distribution characteristics in the disease data. In addition, DNA logic circuits cannot directly sense the expression levels of microRNAs (miRNAs).

High-Efficiency Carriers' Separation Strategy Based Ultrasmall-Bandgap CuWO Sono-Enhances GSH Antagonism for Cuproptosis Cascade Immunotherapy.

The spatiotemporal sequential treatment strategy of promoting rapid separation of charge carriers, amplifying oxidative stress, increasing the low content of intracellular Cu, enhancing cuproptosis, and cascading activation of immunotherapy is considered one of the most effective techniques for improving the comprehensive therapy of tumors. Herein, copper tungstate (CuWO₄, CWO) nanoparticles with ultrasmall bandgap (1.71 eV) is developed as both piezoelectric-catalysis agents and copper nanocarriers for synergistic sono-enhanced cuproptosis.

The Application of Microfluidic Chips in Primary Urological Cancer: Recent Advances and Future Perspectives.

The research of primary urological cancers, including bladder cancer (BCa), prostate cancer (PCa), and renal cancer (RCa), has developed rapidly. Microfluidic technology provides a good variety of benefits compared to the heterogeneity of animal models and potential ethical issues of human study. Microfluidic technology and its application with cell culture (e.

Amine Functionalization and Structural Design for Constructing Tubular MoS-Based Composites through an APTES-Assisted Self-Templating Strategy.

MoS-based composites have attracted considerable attention in catalysis owing to their exceptional catalytic properties. However, challenges such as severe nanosheets (NSs) aggregation and inherent difficulties in functionalization have significantly hindered their practical application. Herein, one-dimensional (1D) APTES microtubes decorated with MoS NSs (APTES@MoS) were synthesized through a self-template-directed synthesis approach.

Insulin level regulators may affect cognitive ability caused by motion sickness: an experimental study.

Abnormal acceleration induced motion sickness (MS) and elevated blood glucose levels, showing obviously cognitive impairments. The mechanism of cognitive impairment caused by MS is still unclear. Here, blood metabolite detection, insulin level regulators, stress hormones, cytokines and MS assessment were conducted for the population and MS model rats, correlation analysis of motion sickness index (MSI) and above factors were conducted by correlation analysis.

A high-voltage Zn-ion hybrid supercapacitor based on a conjugated polyphthalocyanine framework cathode and a Zn@Zn phthalocyanine anode through the pH-decoupling strategy.

Aqueous Zn-ion hybrid supercapacitors have shown extraordinary promise for electrochemical energy storage, due to low cost, high security, large power density and acceptable energy density. Rational optimization of electrodes and electrolytes has always been the key for boosting the electrochemical energy storage performances of aqueous Zn-ion hybrid supercapacitors. We propose a pH-decoupling Zn-ion hybrid supercapacitor based on a conjugated polyphthalocyanine (PPc) framework cathode and a Zn@Zn phthalocyanine (Pc) anode.

Advances in α-Lipoic Acid for Disease Prevention: Mechanisms and Therapeutic Insights.

α-Lipoic acid (ALA) is a naturally occurring compound with diverse biological functions, widely distributed in animal and plant tissues. It has attracted considerable attention due to its versatile therapeutic potential. However, despite these promising prospects, the clinical application of ALA remains limited by its low bioavailability and chemical instability and an incomplete understanding of its multifaceted mechanisms across various diseases.

Performance Evolution and Damage Evaluation of CRTS I Track Slab in Service Status.

This study develops a quantitative framework to assess performance degradation and damage evolution in CRTS I ballastless track slabs. Based on the impact-echo method, the internal void distribution characteristics of the new and old track slabs were obtained. The track slabs were sampled separately by drilling cores to verify the distribution of voids, and uniaxial compression tests were conducted simultaneously to quantify the attenuation of bearing capacity.

Prediction of pharmacokinetic/pharmacodynamic properties of aldosterone synthase inhibitors at drug discovery stage using an artificial intelligence-physiologically based pharmacokinetic model.

The objective of this study is to develop an artificial intelligence-physiologically based pharmacokinetic (AI-PBPK) model to predict the pharmacokinetic (PK) and pharmacodynamic (PD) properties of aldosterone synthase inhibitors (ASIs), enabling selection of the right candidate with high potency and good selectivity at the drug discovery stage. On a web-based platform, an AI-PBPK model, integrating machine learning and a classical PBPK model for the PK simulation of ASIs, was developed. Baxdrostat, with the most clinical data available, was selected as the model compound.

[Relationship between mobile phone addiction and musculoskeletal disorders among secondary vocational school students in Shanghai in 2023].

Objective: To understand the current situation of smartphone addiction and musculoskeletal disorders among students of secondary vocational schools in Shanghai, and to analyze the correlation between the two.

Methods: A stratified random sampling method was used to select 4897 students from 10 secondary vocational schools in Shanghai between March and April 2023. Smartphone Addiction Scale and the Nordic Musculoskeletal Questionnaire were used for the survey.

Biomineral/VEGF-functionalized fiber - enhanced 3D printed GelMA hydrogel to facilitate bone regeneration through osteogenesis and angiogenesis modulation.

Three-dimensionally (3D) printed hydrogels face significant challenges in promoting osteogenesis and angiogenesis for bone tissue engineering. In this study, we designed a bioactive 3D-printed hydrogel to enhance bone regeneration through osteogenesis and angiogenesis modulation. An enzymatic mineralization strategy was proposed to develop biomineral/vascular endothelial growth factor (VEGF)-functionalized poly (L-lactic acid) (PLLA) micro-nanofibers (m-PLLA@VEGF).

Molecular Mechanisms of Reversal of Multidrug Resistance in Breast Cancer by Inhibition of P-gp by Cytisine N-Isoflavones Derivatives Explored Through Network Pharmacology, Molecular Docking, and Molecular Dynamics.

The compound CNI1, identified as a novel antitumor agent based on the cytisine N-isoflavones scaffold, and its series of cytisine N-isoflavones derivatives (CNI2, CNI3, and CNI4), were first isolated from bitter bean seeds, a traditional Chinese medicinal source, by our research team. Cellular activity assays combined with virtual screening targeting P-gp revealed that CNI1, along with the three cytisine N-isoflavones derivatives, CNI2, CNI3, and CNI4, exhibited significant multidrug resistance (MDR) reversal activity in breast cancer. Despite this promising outcome, the precise molecular mechanisms and key targets involved in the MDR reversal of these compounds remain to be elucidated.

Catalyzed Asymmetric Michael Additions of 1-Pyrroline Esters with β-Fluoroalkyl Alkenyl Imides and Azodicarboxylates.

The asymmetric Michael addition reactions of 1-pyrroline esters with β-fluoroalkyl alkenyl imides and dialkyl azodicarboxylates catalyzed by the AgOAc/Ph-phosferrox or CuOAc/(R)-BINAP complex have been developed. A series of chiral 1,5,5-trisubstituted pyrroline ester derivatives have been obtained in 53%-90% yields with 80%-99% ee's and all > 20:1 dr. The gram-scale synthesis and synthetic application of the chiral trifluoromethylated 1-pyrroline adducts were exhibited: the pyrrolizidin-3-one analogue was first synthesized with 94% ee and > 20:1 dr through two steps of hydrolysis and reductive cyclization; the pyrrolidine and lactam derivatives were also successfully provided under the reducing conditions of NaBHCN and Pd/C─H, respectively.