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Modern aero-engines need alloys that sustain both strength and ductility at high temperatures. However, conventional titanium alloys face inherent trade-offs between strength and ductility. In situ TiB-reinforced titanium matrix composites could fill this gap, but their texture evolution and hot-working mechanics are still poorly understood. In this study, TiB-reinforced IMI834 titanium matrix composites were synthesized using in situ technology in a remelting furnace. Meanwhile, the evolution of microstructure and texture in the hot-rolled titanium matrix composites was examined through both Abaqus simulations and experimental observations. Results indicate that dynamic recrystallization occurred in the microstructure of the composites at a deformation level of 95%. Due to the specific orientation relationship between the TiB whiskers and Ti matrix, the hot-rolled composites developed a pronounced [11-20] // rolling direction fiber texture. TiB whiskers rotated toward the rolling direction, enhancing the intensity of the [11-20] // rolling direction fiber texture, consistent with the predictions from numerical simulations. Tensile tests revealed that the combined effects of grain refinement and the rotation of TiB whiskers along the rolling direction increased the yield strength of the hot-rolled composite to 1153 MPa, while simultaneously raising the elongation to 10%.
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http://dx.doi.org/10.3390/ma18102306 | DOI Listing |
Neurol Res
September 2025
Zeenat Qureshi Stroke Institute and Department of Neurology, University of Missouri, Columbia, MO, USA.
Background: The benefits of rehabilitation in acute ischemic stroke patients following thrombectomy remain underexplored. We assessed which activities of daily living (ADLs) show the greatest improvement after goal-directed therapy in an inpatient rehabilitation setting.
Methods: We retrospectively analyzed pre- and post-rehabilitation functional assessments in 40 acute ischemic stroke patients treated with mechanical thrombectomy.
Nanoscale
September 2025
Department of Bioengineering & Nano-Bioengineering, Research Center for Bio Materials and Process Development, Incheon National University, Incheon 22012, Republic of Korea.
Rolling circle amplification (RCA) has emerged as a highly versatile and robust isothermal amplification technology, offering exceptional sensitivity, specificity, and scalability for next-generation molecular diagnostics and multi-omics research. Its ability to generate long, repetitive DNA sequences with high fidelity has made it a pivotal tool in disease diagnostics, genomic analysis, and spatial transcriptome profiling. Recent advancements have expanded RCA into various formats, including solution-phase, solid-phase, hydrogel-based, and digital RCA, enhancing its analytical performance and adaptability across diverse biological applications.
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September 2025
National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
Purifying selection that limits the transmission of harmful mitochondrial DNA (mtDNA) mutations has been observed in both human and animal models. Yet, the precise mechanism underlying this process remains undefined. Here, we present a highly specific and efficient in situ imaging method capable of visualizing mtDNA variants that differ by only a few nucleotides at single-molecule resolution in Drosophila ovaries.
View Article and Find Full Text PDFThe microtubule cytoskeleton is comprised of dynamic, polarized filaments that facilitate transport within the cell. Polarized microtubule arrays are key to facilitating cargo transport in long cells such as neurons. Microtubules also undergo dynamic instability, where the plus and minus ends of the filaments switch between growth and shrinking phases, leading to frequent microtubule turnover.
View Article and Find Full Text PDFSci Rep
August 2025
University of Szeged, Szeged, Hungary.
Both moral cleansing and moral licensing theories suggest that moral self-concept positively influences subsequent engagement in fraudulent behavior. Specifically, a decrease in moral self-concept reduces dishonesty (moral cleansing), while an increase promotes it (moral licensing). However, within these theoretical frameworks, prior research has rarely measured moral self-concept directly, and even fewer studies have manipulated it experimentally.
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