An Antibacterial and Electroactive Chitosan-Based Dressing with Dual Stimulus-Responsive Drug Delivery for Wound Healing.

Persistent bacterial infections remain a major challenge in wound management. Although drug-loaded wound dressings have gained increasing attention, their therapeutic efficacy is often hindered by uncontrolled drug release and a lack of electrical signal responsiveness. Herein, an antibacterial dressing (CCS-PC) with electroactivity and stimulus-responsive drug release properties was fabricated via electro-assembly, wherein chitosan and ciprofloxacin hydrochloride (CIP) were co-deposited onto polypyrrole (PPy)-coated gauze.

Fast detection of melamine using silver nanoparticles capped with l-cysteine functionalized carbon dots.

Melamine is an additive used fraudulently to enrich foods with nitrogen, particularly in the dairy industry. It is also known as the main metabolite or degradation phytosanitary product of cyromazine. However, the numerous incidents involving living beings in aquatic environments, children and pets fed with products made from melamine in China and certain African countries have led to distrust of melamine in food.

Chitosan films incorporating bacterial cellulose-stabilized oregano oil emulsions: A functional approach for fresh walnut shelf-life extension.

Fresh walnuts are prone to moisture loss and spoilage after harvest, leading to reduced appearance and sensory quality. In this study, a multifunctional chitosan (CS)-based film was fabricated by incorporating a bacterial cellulose/oregano essential oil (BC/OEO) Pickering emulsion, with hydrogen bonding promoting cohesive matrix integration. The film's physicochemical properties, along with its antimicrobial and antioxidant activities, were systematically evaluated.

Synergistic enhancement effect of straw-earthworms in the reduction of sulfamethoxazole and antibiotic resistance genes.

Soil antibiotic pollution is a global concern. It has been confirmed that straw or earthworm can enhance microbial degradation of antibiotics in soil. However, in the C/N transformation processes of soil ecosystems, straw and earthworms are closely interconnected.

Flash and ultrasound-assisted extraction of polysaccharides from Lyophyllum decastes and evaluation of their fecal fermentation characteristics.

The extraction methods of polysaccharides significantly affect their characteristics and functional properties. However, the impact of flash extraction and ultrasound-assisted extraction on the physicochemical properties and prebiotic effect of Lyophyllum decastes polysaccharides remains poorly understood. In this study, polysaccharides from Lyophyllum decastes were extracted using ultrasound-assisted and flash extraction methods, yielding the fractions LDP-R and LDP-S after purification, respectively.

Discovery of Novel Drug-Conjugate Molecule with Dual p53-MDM2 and TOP1 Inhibition for the Treatment of Colorectal Cancer.

The blocking interaction between p53 and its negative regulator MDM2 is an engaging therapeutic strategy for antitumor drug development, and there are several drug candidates of p53-MDM2 inhibitors in clinical trials. In the present study, novel drug conjugates of p53-MDM2 inhibitors and topoisomerase I (TOP1) inhibitors have been designed based on bioinformatics analysis results of ten tumor tissues. Among them, showed potent antiproliferative activity against three cell lines HCT116, SJSA-1, and A549, with the strongest p53-MDM2 and TOP1 inhibitory activity.

Buried interface anchored octahedra for efficient sky-blue perovskite light-emitting diodes.

Challenges such as interfacial nonradiative recombination and halogen phase separation have impeded the progress of blue PeLEDs. Here, a triammonium citrate layer is buried beneath perovskite films, which reorganizes the phase distribution and inhibits interfacial nonradiative recombination by anchoring PbX octahedra. By settling these key issues, efficient stable sky-blue PeLEDs have been successfully developed.

Effect of different concentrations of gibberellins on antibiotics and nutrient removal using microalgae-bacteria consortia system.

Phytohormone gibberellins (GAs) were utilized to enhance the removal of tetracycline antibiotics and nutrients from swine wastewater by different algal-bacterial symbiosis. Compared to microalgae monoculture, microalgae-activated sludge, and microalgae-, microalgae-endophytic bacteria showed better growth, photosynthetic, and purification performance. At 50 mg L GAs addition concentration, the specific growth rate of -endophytic bacterial (S395-2) system was 0.

An anisotropic cardiac patch with barbed microneedles for enhanced tissue anchorage and myocardial repair.

Microneedle patches can penetrate the myocardium to facilitate integration with cardiac tissue, offering a promising approach for myocardial infarction (MI) repair. However, their clinical translation has been hindered by insufficient fixation stability during cardiac contractions and mismatch with myocardial anisotropy. To address these challenges, a bioinspired three-dimensional cardiac patch integrating barbed microneedles and an anisotropic lightweight mesh was designed.

Microbial lipases in cheese production: an in-depth review of their role in quality, texture, and flavor.

Cheese, a widely consumed dairy product globally, derives its commercial value primarily from its flavor and textural characteristics that crucially determine consumer acceptance. The quality of cheese including flavor and texture is intricately related to the enzymatic activities of microorganisms during the fermentation process. Among these enzymes, lipases play a pivotal role by hydrolyzing milk fat to generate free fatty acids, which serve as precursors for the formation of key flavor compounds, thereby significantly enhancing the sensory attributes of cheese.

Switchable synthesis of sulfinylated and sulfonylated indoles and benzofurans from -aminophenyl/-hydroxyphenyl propargyl alcohols and β-sulfinyl esters.

The cascade reaction of -aminophenyl/-hydroxyphenyl propargyl alcohols with β-sulfinyl esters was explored under basic conditions. -Aminophenyl propargyl alcohols were converted into 3-sulfinyl indoles using KOH, while 3-sulfonyl indoles were obtained using CsCO and CuI. -Hydroxyphenyl propargyl alcohols were only compatible with the sulfonylation process using CsCO and CuI, delivering 3-sulfonyl benzofurans.

Global trends and future projections of COPD burden under low-temperature risk: a 1990-2041 analysis based on GBD 2021.

Background: Low temperatures are an important risk factor for chronic obstructive pulmonary disease (COPD). However, trends and projections of the global burden of COPD at low temperatures are unclear.

Methods: Based on data from the 2021 Global Burden of Disease Study (GBD), this study assessed trends in the global and regional burden of death and disability-adjusted life years (DALYs) due to COPD from 1990 to 2021, and identified patterns of change in different regions.

Boosting Nitrate-to-Ammonia Conversion over Copper-Based Electrocatalysts by Facilitating Hydrogenation and Product Desorption.

Electrocatalytic nitrate reduction reaction (NitRR) in neutral condition offers a sustainable route for ammonia (NH) production and water purification. For the most extensively investigated Cu-based electrocatalysts that favor NO adsorption, insufficient hydrogenation capability and sluggish NH desorption hinder the ultimate performance. Herein, we report Ca-doped CuO co-modified by oxalate (Ca─CuO─OA) as a novel and high-performance NitRR electrocatalyst.

Correlation between saltiness-enhancement and fluorescence intensity of Maillard reaction intermediates from corn peptides and taste stability during subsequent thermal reaction.

Protein hydrolysates are considered as suitable reactants for the Maillard reaction due to their desirable taste characteristic and highly reactivity. However, the complexity of Maillard reaction systems involving protein hydrolysates makes it challenging to predict and control peptide taste stability. This study employed fluorescence intensity (FI) as an indicator of Maillard reaction degree to investigate its correlation with the saltiness-enhancing (SE) effect of peptides.

How plants respond to salt stress: Lessons form RBOHs.

RBOH is called respiratory burst oxidase homolog is one of the key enzymes in producing reactive oxygen species (ROS). Studies have shown that ROS (such as ·O, HO) are widely involved in plant growth development and response to various biological and abiotic stresses. In recent years, with the gradual deepening of research, more and more plant NOX/RBOH members have been identified, and their biological functions and participating signal regulatory pathways have been revealed.

Order-Disorder Phase Stabilization by Pressure-Induced Charge Transfer Enhances the Ferroelectric Photovoltaic Effect in Multiferroic BaFeO.

Multiferroic ferroelectric photovoltaic (FPV) materials, combining magnetic and ferroelectric properties, are of paramount importance for optoelectronic and photovoltaic applications. However, optimizing both the remanent polarization and the optical bandgap-key factors for enhanced FPV performance-presents a significant challenge due to their trade-off. This work shows that pressure-induced charge transfer between different metal sites can break this trade-off.

Strain-level variation in diacetyl production by Lactiplantibacillus plantarum reveals genetic drivers of flavor in fermented dairy.

Strain-level diversity in aroma formation remains undercharacterized in Lactiplantibacillus plantarum, a key adjunct culture in dairy fermentation. We screened 351 isolates from traditional Chinese fermented foods for diacetyl production and identified wide phenotypic variation, with strain WJ108 producing 26.85 ± 0.

ADP-ribose is a competitive inhibitor of methanol dehydrogenases from Bacillus methanolicus.

Methanol dehydrogenase (MDH), a representative of Type III alcohol dehydrogenases (ADHs), plays a pivotal role in methanol assimilation pathways, making it a key enzyme for the biosynthesis of chemicals and fuels from one-carbon feedstocks. An activator protein belonging to the Nudix hydrolase family, ACT, was found to increase the activity of MDH by 40-fold. Despite the widespread observation of this in vitro activation phenomenon in pairs of type III alcohol dehydrogenases and Nudix hydrolases, the mechanistic details have remained unresolved for decades.

Application of cyclodextrin-based microcapsules in food flavors and fragrances.

Food flavors and fragrances are vital for foods. They can impart aroma and flavor to foods, enhance and compensate for flavor perception of foods, and mask the undesirable flavor of foods, thus increasing overall food acceptability and consumers' purchase intention. However, most of the flavors and fragrances are sensitive to air, moisture, heat, and light, leading to difficulties in processing them and adding them to foods.

Addressing Challenges in Fluid Flow-Induced Cell Membrane Oscillation by Nanopipettes.

The mechanical properties of cell membranes are crucial to regulating cell morphology and behavior. Nanopipette-sensing has become distinctively appealing for the measurement of cell membrane mechanical properties due to its label-free operation and precise targeting. Recent progress has involved precise control of the movement and fluid flow of the nanopipet, which can induce cell membrane oscillation.

Microwave Based Non-Destructive Testing for Detecting Cold Welding Defects in Thermal Fusion Welded High-Density Polyethylene Pipes.

High-density polyethylene (HDPE) pipes are widely used in urban natural gas pipeline systems due to their excellent mechanical and chemical properties. However, welding joints are critical weak points in these pipelines, and defects, such as cold welding-caused by reduced temperature or/and insufficient pressure-pose significant safety risks. Traditional non-destructive testing (NDT) methods face challenges in detecting cold welding defects due to the polymer's complex structure and characteristics.

Mechanochemical and mass spectral approach for the analysis of maltosylated glycylglycine.

The interaction of maltose with glycylglycine was studied under ball milling condition to generate the Amadori product. Although single step milling (30 Hz, 30 min) has been shown to be efficient in the generation of Amadori products of monosaccharides with amino acids, however with disaccharides and dipeptides, single step process showed a significant intensity of unreacted disaccharide peak, prompting us to develop a multistep process where the more consumed reactant was replenished in the subsequent milling steps. Under multistep milling conditions, the Amadori compound was the main product.

Effect of neck and microthread design of narrow implants on peri-implant bone tissue: A nonlinear finite element analysis.

Purpose: The biomechanical effects of neck shape and microthread design on the bone tissue surrounding narrow-diameter implants (NDIs) were investigated using finite element analysis.

Methods: Fifteen models with different neck designs (including straight, wide, and triangular neck designs as well as smooth necks and four microthread designs with pitches of 0.15 mm, 0.

A meta-analysis of workplace exclusion on employee work behavior in the Chinese context.

This study explores the impact of workplace exclusion on employee work behavior in the Chinese context. By employing the doctrine of the mean value orientation and self-consistency theory, the study aims to enhance the understanding of local workplace exclusion in China and its effects on employees' work behavior. Furthermore, the study investigates the moderating role of employee types, data collection points, and data sources.

SensoryGAN: AI-driven design of low-toxicity dairy flavor alternatives with integrated neurosensory and cellular safety validation.

Flavoring agents are critical in the food industry, yet health concerns surrounding diacetyl (DA), a key dairy flavor compound, necessitate safer and sustainable alternatives. This study presents SensoryGAN, a novel predictive paradigm integrating Graph Convolutional Networks (GCN) with Genetic Algorithms (GA) to model and optimize aroma attributes specifically for dairy flavorants. Trained on 47 dairy-flavored compounds spanning low-to-moderate molecular complexities (Bertz/Hendrickson index: 0.