Screening for anti-dysmenorrhea components of Wenjing Decoction: spectral-effect relationship analysis, and efficacy equivalence validation.

Ethnopharmacological Relevance: Primary dysmenorrhea (PD) is common and has a major impact on women's daily activities and quality of life. Wenjing Decoction (WD), a classic Chinese medicine formula, has been widely used for thousands of years in China to treat PD. However, the key pharmacodynamic substances in WD responsible for its anti-dysmenorrhea efficacy are still unclear.

Cu-induced VBNC state formation in Shewanella xiamenensis JL2 at wastewater-relevant levels.

Heavy metals such as Cu are widely prevalent in wastewater (typically 0.04-157.4 mM in typical treatment systems), threatening microbial communities critical for pollutant removal.

Electric Field-Induced Droplet Detachment and Transport on Biomimetic Superhydrophobic Surfaces with Beetle Elytra-Seta Composite Structures.

The regulation of droplet dynamics based on external electric fields and bioinspired functional surfaces has widespread applications in various fields. However, research on the coupling of these two factors to enhance oil-water separation efficiency is urgently needed. In this study, laser-induced and solvent treatment techniques were coupled to assemble a micronano setal and bioinspired beetle elytra textured substrate with the lotus effect, A "top conductive, bottom insulating" Desert beetle elytra micronano tuft composite texture (DBE) biomimetic superhydrophobic surface was fabricated.

Impact of various reaction conditions of solvothermal synthesis on electrochemical properties of Ni-MOF materials.

A series of Ni-MOF materials were synthesized by a one-step solvothermal method under different reaction conditions, including metal source, organic ligand, reaction time and reaction temperature. The results demonstrated that the Ni-MOFs synthesized with Ni(NO3)2•6H2O as the metal source had higher crystallinity and a more uniform crystalline structure than those with NiCl2•6H2O. Different organic ligands led to the formation of Ni-MOFs in various morphologies.

Meat protein microgels assembled under various temperature-concentration conditions: Underlying its interfacial behavior.

At moderate protein concentrations (10, 20 mg/mL) and a high temperature (80 °C), meat protein (MP) self-assembled into weak gels and then intriguingly collapsed into microgels through continuous heating and annealing cooling, resulting in a sol state with exposed hydrophobic groups and disulfide bonds. The different prepared microgel groups were labeled as MP and MP, respectively. Compared with the control group (Con: 7.

Evaluation of the C protein of BVDV as a vaccine candidate: Immunoprotective studies in mice.

Bovine Viral Diarrhea Virus (BVDV) is a major pathogen associated with calf diarrhea and reproductive disorders in cattle. This study evaluated the immune-protective potential of a subunit vaccine based on the capsid C protein of the BVDV HNL-1 strain. In mice model, the C protein subunit vaccine exhibits a favorable safety and elicits robust immune-protective efficacy comparable to commercial inactivated vaccines.

Long-wavelength emission carbon dots as ratiometric fluorescent and colorimetric dual-mode sensors for environmental sensing and bioimaging of hypochlorite.

For the first time, long-wavelength red emission carbon dots (R-CDs) were prepared as ratiometric fluorescent and colorimetric dual-mode sensors for detecting ClO using a simple one-step hydrothermal method. R-CDs exhibited intrinsic red fluorescence at 587 nm. Upon interaction with ClO, a new and enhanced green fluorescence at 535 nm was observed, which was attributed to resulting from the oxidation of surface hydroxyl (-OH) groups to carbonyl (CO) groups.

Simultaneous removal of NO and propane by solid electrolyte cells with LaPrBaNiO bifunctional electrodes.

Solid electrolyte cell is a novel gas purification approach, which has unique superiority in simultaneous nitrogen oxides (NO) and volatile organic compounds (VOCs) removal. The development of effective electrode materials and the comprehensive understanding of reaction mechanisms are essential to advancing this technology. In this study, LaPrBaNiO (x = 0, 0.

Airborne human-associated ARGs in municipal wastewater treatment plants.

Antibiotic resistance genes (ARGs) in bioaerosols pose significant health hazards to humans because of their inhalability. Municipal wastewater treatment plants (MWTPs) are one of the typical sources of bioaerosol generation. However, there is a lack of clear understanding of human-associated ARGs (HA-ARGs) in bioaerosols from MWTPs.

Accurate theoretical characterization of MgS: rovibrational line intensities and absorption cross-sections for astrophysical modeling.

The electronic structure, spectroscopic constants, and transition parameters of the diatomic molecule Magnesium monosulfide (MgS) were investigated using high-level multi-reference configuration interaction calculations with the Davidson correction (MRCI+Q) and a consistent basis set for both Mg and S atoms. Potential energy curves and dipole moment functions were computed, allowing for accurate predictions of rovibrational energy levels. Key transition properties, including radiative lifetimes and Franck-Condon factors, were evaluated for transitions within the ground electronic state and the first excited singlet state.

Targeting annexin A2 enhances anti-PD-1 immunotherapy in pancreatic ductal adenocarcinoma by remodeling the tumor immune microenvironment.

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor prognosis, underscoring the need for novel therapeutic approaches. In this study, we investigate the role of Annexin A2 (ANXA2) in PDAC progression and its potential as a therapeutic target. Single-cell RNA sequencing of PDAC tissues identified distinct subpopulations of ductal cells, with elevated ANXA2 expression strongly correlating with poor patient prognosis.

Associations of urinary metabolite concentrations of phthalates and their alternatives with reproductive outcomes among women receiving in vitro fertilization: A repeated measurement analysis.

Background: Studies suggest that phthalates (PAEs) may disrupt female reproductive health, but few have explored repeated measurements of PAE and their alternative exposure and their joint impact on reproductive outcomes.

Objectives: To evaluate the associations of repeatedly measured urinary levels of PAE and their alternative metabolites with reproductive outcomes in women receiving in vitro fertilization (IVF).

Methods: This study included 704 women undergoing IVF between February and October 2023 in Chongqing, China.

Compositional "plainification" in biodegradable magnesium-rare earth alloys - Achieving well-balanced performance in an ultra-lean Mg-Pr alloy.

Contrary to the traditional strengthening route by adding multiple & high-dosage alloying elements, we here explored extremely compositional and phase-constituent "simplification" in rare earth (RE) containing biodegradable magnesium alloys for better biocompatibility. An ultra-lean Mg-0.1Pr alloy with a multiscale microstructure has been developed through casting and extrusion, which showed well-balanced performances that match the commercial Mg-based orthopedic products.

Recent advances in eutectogels: Preparation, properties and applications.

Multiple stretchable gels with conductivity have been thoroughly prepared in diverse solvents historically to modulate their superlative properties in a multitude of applications, such as soft robotics, wearable devices, and e-skins. Eutectogels are considered as an emerging class of gels that combine the best features of both hydrogels and organogels, including environmental friendliness, thermal stability and customizable nature. Eutectogels, composed of deep eutectic solvents (DES) immobilized within different matrices, not only inherit the merits of DES, but also show some additional properties derived from the special structure and compositions, which are conducive to development potential.

Unlocking potential of blast furnace slag: CO adsorption performance and mechanism of slag-derived zeolite.

For meeting requirements of "green steel" and "circular economy", there was great potential and value to synthesize CO adsorbent with low price and excellent performance by using multiple solid wastes. In this study, a novel method was proposed to synthesize zeolite by blast furnace slag. CO adsorption isotherm, thermodynamic and kinetic were investigated comprehensively.

Multifunctional triple-network ionic hydrogel sensors engineered by Al/Zn bimetallic salt solution: From cellulose solvent to conductive network architecture.

Ionic conductive hydrogels show promise for flexible sensors in wearables and e-skins, but balancing mechanical strength with high conductivity remains challenging. Herein, a triple-network ionic conductive hydrogel based on poly(acrylic acid) (PAA) was developed, synergistically reinforced by dissolved cellulose (dCel) and aramid nanofibers (ANF), with Al/Zn bimetallic ions serving as the conductive medium. Intriguingly, dCel was in-situ generated using the concentrated Al/Zn bimetallic salt solutions as the cellulose solvent, following the complete dissolution of the pulp fibers driven by the intensive ionic hydration of Al/Zn ions.

Fabrication of a Mo-based catalyst with high DDS pathway selectivity for hydrodesulfurization of dibenzothiophene.

With the trend of heavy and inferior crude oil, the design of hydrodesulfurization (HDS) catalysts with excellent activity and high active metal utilization is an inevitable trend for the upgrading of refining technology. In this study, a highly dispersed Mo catalyst confined within nitrogen-doped porous carbon (xMo@NC) was prepared using an in situ encapsulation-pyrolysis approach and used in the HDS reaction of dibenzothiophene (DBT). The methods of XRD, HRTEM, HAADF-STEM, N physisorption, FT-IR, Raman, and XPS were used to carry out thorough microstructural characterization.

Substrate-modulated interfacial proton adsorption on graphene.

Ion adsorption at the solid-liquid interface of two-dimensional (2D) materials is ubiquitous and plays a pivotal role in interfacial physicochemical interactions. In practical applications, 2D materials are typically supported on solid substrates. Understanding the role of the supporting substrate is therefore critical for advancing our fundamental knowledge of interfacial interactions and downstream application success.

Discovery of novel indazole derivatives as type Ⅰ PRMTs inhibitors for the treatment of triple-negative breast cancer.

Type I protein arginine methyltransferases (PRMTs) play significant roles in various diseases, including cancer. The inhibition of type I PRMTs significantly suppresses the growth of breast cancer, particularly triple-negative breast cancer (TNBC). The development of potent and selective type I PRMTs inhibitors has become a research hotspot in recent years.

Design, synthesis, and evaluation of novel matrine derivatives as topoisomerase I inhibitors for anticancer agents.

A series of novel matrine derivatives incorporating thiosemicarbazide moieties was designed and synthesized. The in vitro cytotoxicity of these compounds was evaluated against four human cancer cell lines: MCF-7, HepG2, SGC-7901, and A549. Results demonstrated that their cytotoxic activity was significantly higher than that of matrine.

Heat transfer and parameter optimization for medical waste pyrolysis in an indirectly heated rotary kiln.

This study investigated the pyrolysis of mixed medical waste (MMW) in an indirectly heated rotary kiln, focusing on the effects of operating parameters (filling ratio, heat source temperature, and rotation speed) on the heat transfer performance and product distribution. The pyrolysis behaviors of individual components (cotton swabs, paper, bandages, and plastics) and their composite mixtures were characterized using thermogravimetric-differential thermal analysis (TG-DTA). The heat transfer characteristics, chemical reaction properties, kiln operating parameters, and interactions between the processes were also investigated.

Estrogen inhibits granulosa cell apoptosis via nuclear receptors by suppressing death receptor and mitochondrial pathways in goat small antral follicles.

Small antral follicles frequently undergo atresia due to inadequate gonadotropin support, characterized by reduced estrogen synthesis and granulosa cell (GC) apoptosis. The role of estrogen in regulating GC apoptosis during follicular atresia remains incompletely defined. Caprine small antral follicles (1-2 mm) were isolated and cultured in vitro under serum- and gonadotropin-free conditions to induce atresia, with or without 17β-estradiol (E) supplementation.

Enhanced effect and mechanism of biochar on the nitrogen removal of low C/N wastewater by cold-tolerant heterotrophic nitrifying-aerobic denitrifying bacterium.

Biological denitrification is an essential method for sewage treatment, though its efficiency is often constrained by low temperatures and insufficient organic carbon sources. In this study, a novel cold-tolerant heterotrophic nitrification-aerobic denitrification bacterium, Pseudomonas fluorescens sp. Z03, was isolated from activated sludge, and its denitrification performance was evaluated.