Hybrid pneumatic-hydraulic actuation for MRI-guided robotic stereotactic neurointervention.

Stereotactic neurointervention is a common procedure for biopsy, injection, ablation, and implantation of electrodes for deep brain stimulation. Guided by preoperative imaging, conventional approaches are mostly performed manually, lacking operation stability and interactive feedback. The intraoperative magnetic resonance imaging (MRI) guidance enables both structural and functional assessment during operation, permitting interactive adaptation to tissue deformation and avoidance of critical anatomical regions.

Osten Sacken, 1865 (Diptera, Limoniidae) in China: Taxonomic Review, Updated Distribution, and DNA Barcoding.

The genus Osten Sacken, 1865 from China is taxonomically reviewed using an integrative approach that combines detailed morphological examination and molecular analysis. (Alexander, 1947), a species widely distributed across the Palaearctic region, is newly recorded from China. Updated distributional data are presented for species known from China: (Linnaeus, 1758), (Alexander, 1942), Alexander, 1924, and (Alexander, 1930).

Pirtobrutinib, a Highly Selective, Non-covalent (Reversible) BTKi in R/R Follicular Lymphoma: Phase 1/2 BRUIN Study.

Relapsed/refractory (R/R) follicular lymphoma (FL) is a chronic disease often requiring multiple lines of therapy. Covalent (c) Bruton tyrosine kinase inhibitor (BTKi) monotherapy has resulted in variable response rates, yet patients invariably experience relapse. While newer therapies such as bispecific antibodies and CAR T cell therapy are available, patient access and eligibility remain challenging.

MBE Growth of High-Quality HgCdSe for Infrared Detector Applications.

HgCdSe has recently been proposed as a potential alternative material to HgCdTe for fabricating high-performance infrared detectors. This work presents a study on the growth of high-crystalline-quality HgCdSe materials on GaSb (211)B substrates via molecular beam epitaxy and demonstration of the first prototype HgCdSe-based mid-wave infrared detectors. By optimizing the MBE growth parameters, and especially the thermal cleaning process of the GaSb substrate surface prior to epitaxial growth, high-quality HgCdSe material was achieved with a record XRD full width at half maximum of ~65 arcsec.

Real World Outcomes of Patients with Aggressive Lymphoma and Autoimmune Disease Treated with CART.

Autoimmune diseases (AIDs) have been shown to be a risk factor for the development of non-Hodgkin lymphoma (NHL), with more than 15 million Americans diagnosed with AIDs between 2011 and 2022 [...

Competitive roles of slow/delta oscillation-nesting-mediated sleep disruption under acute methamphetamine exposure in monkeys.

Abuse of amphetamine-based stimulants is a primary public health concern. Recent studies have underscored a troubling escalation in the inappropriate use of prescription amphetamine-based stimulants. However, the neurophysiological mechanisms underlying the impact of acute methamphetamine exposure (AME) on sleep homeostasis remain to be explored.

Nivolumab in Combination with R-CHOP for Treatment-Naïve Diffuse Large B-Cell Lymphoma: An Evaluation of Safety and Efficacy.

Approximately 20% of diffuse large B-cell lymphoma have aberrations involving the PD-L1/PD-L2 locus. This justifies the investigation of PD-1 checkpoint inhibitors in the frontline therapy setting in a bid to improve outcomes especially in patients with high-risk disease (antecedent low-grade lymphoma, MYC aberrancy, advanced staged disease, and intermediate/high risk IPI score). This Phase 1b study evaluated the safety and preliminary efficacy of combination nivolumab and R-CHOP using a priming approach.

Cascade reaction-driven biomimetic scintillant/metal-organic frameworks for X-ray triggered combinational therapy against glioma.

Glioblastoma (GBM) is the most aggressive primary brain tumor with a grim prognosis and low survival rates. This unfavorable therapeutic outcome is partially because of the inadequate immune infiltration and an immunosuppressive microenvironment, which compromises the effectiveness of conventional radiotherapy (RT) and chemotherapy. Inducing immunogenic cell death (ICD) to modulate the antitumor immune response has emerged as a highly promising therapeutic strategy for GBM.

Waste biomass durian shell carbon to derive N-rich porous microbial fuel cell anode for simultaneous dye degradation and electricity generation.

Waste biomass is an ideal material for electrode modification of low-cost and high-performance microbial fuel cell (MFC). MFC is mainly committed to effectively improve the power generation performance and degradation performance through anode modification. In this study, a biomass-derived N-rich 3D macroporous MFC anode (PPy-DSC/CF) with high conductivity, superhydrophilicity, and biocompatibility was successfully prepared by in-situ polymerization of pyrrole on the surface of carbonized durian shell (DS) using carbon mats as the substrate material.

Causal relationships between 4907 circulating proteins and heart failure and atrial fibrillation: A bidirectional Mendelian randomization study.

The 5-year survival rate of patients with heart failure (HF) is comparable to that of malignant tumors, with a persistently high risk of mortality. Atrial fibrillation (AF) is a common cardiac arrhythmia, with its incidence rising annually due to the aging population. Therefore finding relevant therapeutic targets for both diseases is crucial.

Development of dual detection platforms based on catalytic hairpin assembly for rapid and sensitive detection of Chlamydia trachomatis 16S rRNA.

Chlamydia trachomatis (CT) infections often remain asymptomatic yet can cause severe complications. Although nucleic acid amplification tests (NAATs) offer high sensitivity, they require expensive equipment unavailable in resource-limited settings. We developed the first application of catalytic hairpin assembly (CHA) technology combined with fluorescence immunochromatography assay (FICA) and colloidal gold immunochromatography assay (GICA) for CT 16S rRNA detection.

Zanubrutinib and Venetoclax for Patients With Treatment-Naïve Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma With and Without Del(17p)/ Mutation: SEQUOIA Arm D Results.

Purpose: Several chronic lymphocytic leukemia (CLL) studies have demonstrated promising efficacy with the combination of BCL2 and Bruton tyrosine kinase inhibitors; however, patients with CLL with del(17p) and/or mutation (mut) comprised a small percentage of study populations or were excluded entirely. The purpose of the SEQUOIA Arm D cohort was to evaluate the combination of zanubrutinib + venetoclax in treatment-naïve (TN) patients with CLL/small lymphocytic lymphoma (SLL), in a large population of patients with -aberrant disease.

Patients And Methods: Arm D is a nonrandomized cohort of patients aged 65 years and older (or 18-64 years with comorbidities).

Super-stretchable, freezing-resistant and self-powered organohydrogels for extreme environment-adaptable high-performance strain sensors.

The rapid development of wearable sensors has indeed driven the demand for multifunctional conductive soft materials to new heights. However, conventional flexible strain sensors find it difficult to adapt to complex environments due to their poor mechanical properties, susceptibility to freezing deactivation at low temperatures and insufficient long-term stability. In this study, acrylamide (AAm), [2-(methacryloyloxy)ethyl]dimethyl(3-sulfopropyl)ammonium hydroxide (DMAPS), and octadecyl acrylate (SA) were copolymerized in a glycerol/water system by one-step photopolymerization, and PEDOT : PSS was introduced to construct a super-stretching antifreeze amphiphilic ion hydrogel (HADP).

Double hit & double expressor lymphomas: a multicenter analysis of survival outcomes with CD19-directed CAR T-cell therapy.

Double-hit (DHL) and double expressor (DEL) DLBCL have poor prognosis with standard therapy but CART may overcome this poor prognostic impact. In this multicenter retrospective study, we sought to confirm this observation by evaluating survival outcomes among patients with relapsed/refractory DHL and DEL treated with CART and evaluate outcomes of relapse post-CART. A total of 408 adult patients with relapsed/refractory DLBCL from 13 academic centers were included based on the availability of DHL and DEL.

Increased proline intake during gestation alleviates obesity-related impaired fetal development and placental function in gilts.

Maternal proline (Pro) supplementation enhances fetal survival and placental development in mice. However, the effect of Pro on fetal and placental development in gilts remains to be investigated, particularly in the context of obesity-induced impaired pregnancy. Here, we investigated the effect of dietary Pro on fetal and placental development in obese gilts.

Validating Multicenter Cohort Circular RNA Model for Early Screening and Diagnosis of Gestational Diabetes Mellitus.

Backgruound: Gestational diabetes mellitus (GDM) is a metabolic disorder posing significant risks to maternal and infant health, with a lack of effective early screening markers. Therefore, identifying early screening biomarkers for GDM with higher sensitivity and specificity is urgently needed.

Methods: High-throughput sequencing was employed to screen for key circular RNAs (circRNAs), which were then evaluated using reverse transcription quantitative polymerase chain reaction.

Rapid and facile detection of Mycoplasma pneumoniae 16S rRNA based on CHA-FICA system.

Mycoplasma pneumoniae (MP) is a major a rapid, sensitive and reliable method for the detection of 16S ribosomal RNA (16S rRNA) was developed based on catalytic hairpin assembly (CHA) technology and digoxine-biotin double-labeled fluorescence immunochromatography (FICA) strip. The signal amplification achieved by CHA avoids the dependence on expensive thermal cycling equipment. The method can obtain the results within 1 h in the absence of an enzyme, and the minimum detection limit can reach 1 pM.

Dual-OR Logic-Gated Lateral Flow Strip Assay Based on Colorimetric-Fluorescence Dual Indication for Screening of HPV16/18 in Multiple Scenarios.

The incidence of cervical cancer continues to rise in underdeveloped regions due to low human papillomavirus (HPV) vaccination rates and inadequate screening systems. To achieve convenient, rapid, and accurate detection of HPV, we developed a three-wire lateral flow strip assay system based on dual-OR logic gates for rapid and simultaneous detection of HPV subtypes 16 and 18 in a single test. The system combines three-branch-catalytic hairpin assembly (TCHA)-mediated signal amplification with simple OR logic gate-based signal output to improve detection rates while enabling HPV 16/18 subtype identification.

Comparative study of the toxicity responses of Vallisneria natans and Pistia stratiotes to sulfadiazine under different planting methods.

Sulfonamides are receiving increased attention due to their persistence in the environment and potential ecological risks. However, there are currently relatively few studies on the toxicity response of aquatic plants grown under the single and mixed planting methods to sulfadiazine (SD). This study investigated the response of the Vallisneria natans (Lour.

Structural basis of FpGalNase and its combination with FpGalNAcDeAc for efficient A-to-O blood group conversion.

Transfusion safety and blood typing continue to present significant challenges in clinical practice, including risks of incorrect blood transfusions and blood shortages. One promising solution is the enzymatic conversion of all red blood cell (RBC) types into universal O-type RBCs. However, the major obstacle to this strategy is the relatively low catalytic efficiency of the enzymes involved.

[A novel carbonyl reductase for the synthesis of ()-tolvaptan].

Screening carbonyl reductases with the ability to catalyze the reduction of complex carbonyl compounds is of great significance for the biosynthesis of -tolvaptan(-TVP). In this study, the target carbonyl reductase in the crude enzyme extract of rabbit liver was separated, purified, and identified by ammonium sulfate precipitation, gel-filtration chromatography, ion exchange chromatography, affinity chromatography, and protein mass spectrometry. With the rabbit liver genome as the template, the gene encoding the carbonyl reductase was amplified by PCR and the recombinant strain was successfully constructed.

Inhibition of Interleukin-40 prevents multi-organ damage during sepsis by blocking NETosis.

Despite intensive clinical and scientific efforts, the mortality rate of sepsis remains high due to the lack of precise biomarkers for patient stratification and therapeutic guidance. Interleukin 40 (IL-40), a novel cytokine with immune regulatory functions in human diseases, was elevated at admission in two independent cohorts of patients with sepsis. High levels of secreted IL-40 in septic patients were positively correlated with PCT, CRP, lactate (LDH), and Sequential Organ Failure Assessment (SOFA) scores, in which IL-40 levels were used to stratify the early death of critically ill patients with sepsis.

Variance in development of early and late cardiotoxicities in patients with lymphoma and myeloma receiving CAR T-cell therapies.

Cardiovascular adverse events (CVAEs) are recognized complications of chimeric antigen receptor (CAR) T-cell therapies. However, data are lacking regarding subtypes of adverse events that develop in patients with different malignancies, and little is known about the timeframe in which different cardiotoxicities are most likely to occur post-CAR T-cell therapies. In this study, 211 patients, including 138 lymphoma patients and 66 myeloma patients who received CAR T-cell therapies were retrospectively identified.

Machine learning based metabolomic and genetic profiles for predicting multiple brain phenotypes.

Background: It is unclear regarding the association between metabolomic state/genetic risk score(GRS) and brain volumes and how much of variance of brain volumes is attributable to metabolomic state or GRS.

Methods: Our analysis included 8635 participants (52.5% females) aged 40-70 years at baseline from the UK Biobank.