Using robotic single-port vNOTES for gynaecological oncology: omentectomy in a patient with an ovarian granulosa cell tumor-a case study.

Background: Robotic single-port transvaginal natural orifice transluminal endoscopic surgery (RSP-vNOTES) is an emerging minimally invasive approach that combines the advantages of robotic surgery with scarless transvaginal access. Its application in gynecologic oncology remains limited, particularly for omentectomy during ovarian cancer staging.

Methods: We present the case of a 45-year-old woman with an ovarian granulosa cell tumor (GCT) who underwent supplemental staging surgery following unilateral oophorectomy.

Exploring why adolescents of disadvantaged family socio-economic status were more depressed than others: Serial mediations via personal psychological resources, loneliness, and school refusal functions.

Background: Disadvantageous family socio-economic status (DFSES) is a potential source of disparity in adolescent mental health. This study investigated the association between DFSES and probable depression and its mediation mechanisms via personal psychological resources (hope and resilience), loneliness, and school refusal functions.

Methods: A school-based anonymous survey was conducted among 8285 middle school students in China from February to March 2022; the response/eligible rate was 98.

Comparative multi-task deep learning models for protein-nucleic acid interaction prediction: Unveiling the superior efficacy of the PNI-MAMBA architecture.

Protein-nucleic acid interactions (PNI) play crucial roles in various life processes, including gene expression regulation, DNA replication, repair, recombination, and RNA processing and translation. However, accurately predicting these interactions remains challenging due to their complexity. This paper proposes a deep learning-based multi-task learning framework for predicting protein-nucleic acid interactions.

Amplification-free CRISPR/Cas12a biosensor integrating AuNPs-mediated surface plasmon resonance for human papillomavirus detection and genotyping.

Screening for high-risk human papillomavirus (hrHPV) infection is essential for cervical cancer prevention. However, developing a simple, portable, and low-cost hrHPV genotyping method remains challenging, particularly in resource-limited settings. Herein, we present an innovative amplification-free, point-of-care hrHPV genotyping platform integrating CRISPR/Cas12a with alkaline phosphatase (ALP)-mediated surface plasmon effect.

Spatial disparities in perfluoroalkyl and polyfluoroalkyl substances exposure and immunosuppressive effects on vaccine induced antibody levels in Guangzhou children.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants that are widely detected in human serum worldwide, and are associated with reduced vaccine-induced antibody responses. However, existing research has primarily focused on the effects of prenatal and adolescent PFAS exposures on antibody levels or disease incidence. A critical gap remains in understanding the association between serum PFAS concentrations and antibody levels in children.

Limosilactobacillus reuteri-butyrate axis in depression therapy: A key pathway discovered through a novel preclinical human flora-associated animal model.

The transition from preclinical to clinical drug development is critically impeded by interspecies disparities, which limit the predictive validity of preclinical efficacy for human outcomes. To address this limitation, we established a human flora-associated depression rat (HFADR) model through fecal microbiota transplantation (FMT). The HFADR model bridges the preclinical-clinical translation by recapitulating conserved microbial-host interactions identified through multi-omics analysis in a chronic unpredictable mild stress (CUMS) rat model and in patients with major depressive disorder.

Sex differences in social anxiety: A longitudinal serial mediation via perceived stress and resilience among adolescents in China.

Background: Adolescent social anxiety is consequential. There is a substantial sex difference in the prevalence. Yet, the underlying mechanisms are almost unknown; no longitudinal studies have investigated this topic.

Challenging gender essentialism with animal examples: Reducing children's prejudice toward voice-based gender nonconformity.

Grounded in developmental intergroup theory, which highlights the role of essentialist thinking in the emergence of prejudice, this study examined whether reducing children's gender essentialism could decrease prejudice against speakers with gender-nonconforming (GN) voices. A total of 162 children aged 8-12 years participated in the study. The intervention group (N = 81) received three lessons illustrating diversity in sex-related traits and behaviors in the animal kingdom to challenge essentialist beliefs about gender roles, expression, and biological sex, whereas the control group received comparable lessons without gender-related content.

Noninvasive assessment of glymphatic system alterations as potential biomarkers for predicting overall survival in glioma.

Objective: In this retrospective study, authors aimed to evaluate the glymphatic function alterations associated with glioma and explore the prognostic value of these alterations by calculating the index for diffusivity along the perivascular space (ALPS index).

Methods: The authors utilized data from the publicly available University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) dataset, which includes 501 adult patients with histopathologically confirmed diffuse glioma, per the 2021 WHO classification, who underwent preoperative MRI, initial tumor resection, and tumor genetic testing at a single medical center from 2015 to 2021.The ALPS index was calculated from diffusivity maps for noninvasive glymphatic system (GS) analysis.

Allele-Specific Regulation of PAXIP1-AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice.

Schizophrenia (SCZ) and bipolar disorder (BPD) are highly heritable psychiatric disorders with complex genetic and environmental underpinnings. Allele-specific expression (ASE) has emerged as a critical mechanism linking noncoding genetic variants to disease risk through epigenetic and environmental modulation. Here, whole-genome and transcriptome analyses of monozygotic twin pairs discordant for BPD or SCZ are performed, identifying that noncoding genetic variants drive differential ASE patterns of long noncoding RNAs (lncRNAs) in affected individuals compared to their unaffected co-twins.

Parent-Adolescent Congruence and Incongruence in Parental Involvement and Academic Achievement: The More, the Better?

Parents and adolescents can differ in their perceptions of parental involvement, yet most research relies on a single informant, potentially overlooking important discrepancies. Using data from 89,448 fifteen-year-olds (50.3% female) and their parents (78.

Triterpenoid Compounds and Their Derivatives: Emerging Pharmacological Agents for Arthritis Treatment.

Arthritis has become a global public health issue due to its diverse risk factors and high prevalence. Therefore, there is a demand for more effective drugs to improve these situations. Triterpenoids have attracted the interest of researchers because of their broad spectrum of biological activities and pharmacological effects.

Cost shifting or cost cutting by hospitals as a response to reimbursement reform? The case of diagnosis-related groups (DRG) scheme in China.

Background: Diagnosis-related group (DRG) systems for healthcare reimbursement were recently introduced among hospitals in China, raising concerns about cost-shifting, where hospitals may increase charges for self-financing patients to offset reimbursement cuts by DRG. In 2018, both Nanchang and Ganzhou Cities in Jiangxi Province installed DRG information systems, but only Nanchang fully implemented the DRG system during the 2019-2020 pilot period.

Materials And Methods: Drawing from a healthcare administrative dataset of 14,310 patients' records, this study investigates the hospitalization costs associated with Intraocular Lens (IOL) implantation procedures in Jiangxi Province, China, from 2017 to 2020.

Predictors of Stigma Among Women with Infertility: A Cross-Sectional Study in Shenzhen, China.

Purpose: The issue of infertility is a worldwide challenge, estimated to affect approximately 50 million couples. Infertility is a stressful event for women and may result in stigma. This study aimed to investigate stigma and its predictors in Chinese women with infertility.

Evaluating the role of Kasai portoenterostomy in biliary atresia older than 90 days.

Purpose: Biliary atresia (BA) patients presenting after 90 days of age face contentious treatment decisions between Kasai portoenterostomy and direct liver transplantation. This study evaluated outcomes of Kasai portoenterostomy in older BA patients to inform therapeutic decision-making.

Methods: A retrospective multicenter study analyzed 32 BA patients who underwent Kasai portoenterostomy beyond 90 days of age.

Nonlinear Associations of Depression and Stigma With Subclinical Hikikomori in Cancer Survivors.

Background: Cancer survivors often experience depression and stigma associated with chronic diseases, which may increase the risk of subclinical hikikomori.

Aims: This study examined the prevalence of subclinical hikikomori and its nonlinear associations with depression and stigma among cancer patients.

Methods: A cross-sectional survey was conducted among 1951 cancer survivors.

Discovery of novel 3-Benzyloxyaminopyridines as orally available and intracranially active selective ROS1 inhibitors for combating the resistant ROS1 mutation.

The selectivity, central nervous system progression and drug-resistant mutations have raised significant concerns regarding the effectiveness of ROS1 inhibitors. Novel entities have been designed through precise molecular simulation. Introducing larger biphenyl groups in the hydrophobic region enhances ROS1 selectivity and improves lipid solubility for better blood-brain barrier penetration.

YOLO-ED: An efficient lung cancer detection model based on improved YOLOv8.

In recent years, You Only Look Once (YOLO) models have gradually been applied to medical image object detection tasks due to their good scalability and excellent generalization performance, bringing new perspectives and approaches to this field. However, existing models overlook the impact of numerous consecutive convolutions and the sampling blur caused by bilinear interpolation, resulting in excessive computational costs and insufficient precision in object detection. To address these problems, we propose a YOLOv8-based model using Efficient modulation and dynamic upsampling (YOLO-ED) to detect lung cancer in CT images.

Promoter or inhibitor? The role played by housing prices on entrepreneurial vitality in China.

This study delves into the time-varying causal relationship between housing prices (HP) and entrepreneurial vitality (EV) in China, employing a rolling-window sub-sample testing approach. The findings reveal that HP exerts both positive and negative influences on EV across different sub-samples. Specifically, when wealth effects dominate, HP positively impacts EV, acting as a promoter.

Epidermal Growth Factor Receptor (EGFR)-Targeting Peptides and Their Applications in Tumor Imaging Probe Construction: Current Advances and Future Perspectives.

The epidermal growth factor receptor (EGFR) is a key target for both cancer diagnosis and therapeutic interventions. Assessing EGFR expression before therapy has become routine in clinical practice, yet current methods like biopsy and immunohistochemistry (IHC) have significant limitations, including invasiveness, limited repeatability, and lack of real-time, whole-body data. EGFR-targeted imaging has emerged as a promising alternative.

Proteomic and Functional Analysis Reveals Temperature-Driven Immune Evasion Strategies of in Yellowfin Seabream ().

() is a globally significant aquatic pathogen responsible for severe economic losses in aquaculture. While the infection often exhibits distinct seasonal patterns strongly correlated with water temperature, there is limited knowledge regarding the temperature-dependent immune evasion strategies of . Our results demonstrated a striking temperature-dependent virulence phenotype, with significantly higher mortality rates observed at high temperature (HT, 33 °C) compared to low temperature (LT, 23 °C).

Biomimetic semiconducting polymer dots for dual targeted NIR-II phototheranostic and multimodal coordinated immunostimulatory therapy.

Breast cancer is a global health challenge necessitating more precise and effective treatment strategies. In this study, we developed a novel drug-loaded therapeutic nanoplatform, OCPdots@CTe, which integrated near-infrared-II (NIR-II) window phototheranostic for targeted treatment of orthotopic breast tumors. The outer membrane vesicles (OMVs) can stimulate more immune responses based on precise targeting, while chelerythrine (CTe) can induce apoptosis by generating reactive oxygen species (ROS), thereby enhancing the therapeutic effect.

Versatile Applications of CRISPR-Based Programmable T-DNA Integration in Plants.

Agrobacterium-mediated T-DNA integration into plant genomes represents a cornerstone for transgenic expression in plant basic research and synthetic biology. However, random T-DNA integration can disrupt essential endogenous genes or compromise transgene expression, stressing the need for targeted integration strategies. Here we explored CRISPR-aided targeted T-DNA integration (CRISTTIN) in Arabidopsis, leveraging CRISPR-induced double-strand breaks (DSBs) to facilitate precise T-DNA insertion.