Allele-Specific Regulation of PAXIP1-AS1 by SMC3/CEBPB at rs112651172 in Psychiatric Disorders Drives Synaptic and Behavioral Dysfunctions in Mice.

Schizophrenia (SCZ) and bipolar disorder (BPD) are highly heritable psychiatric disorders with complex genetic and environmental underpinnings. Allele-specific expression (ASE) has emerged as a critical mechanism linking noncoding genetic variants to disease risk through epigenetic and environmental modulation. Here, whole-genome and transcriptome analyses of monozygotic twin pairs discordant for BPD or SCZ are performed, identifying that noncoding genetic variants drive differential ASE patterns of long noncoding RNAs (lncRNAs) in affected individuals compared to their unaffected co-twins.

Efficient Defect-Driven Cation Exchange beyond the Nanoscale Semiconductors toward Antibacterial Functionalization.

Defect engineering is an exciting tool for customizing semiconductors' structural and optoelectronic properties. Elaborating programmable methodologies to circumvent energy constraints in multievent inversions expands our understanding of the mechanisms governing the functionalization of nanomaterials. Herein, we introduce a novel strategy based on defect incorporation and solution rationalization, which triggers energetically unfavorable cation exchange reactions in extended solids.

Carbon defects-enriched NBC-CN@CoMn with ultrafast modulation of redox couples for efficient degradation of contaminant.

The inefficiency of catalysts in sulfate radical-based advanced oxidation processes (SR-AOPs) is primarily attributed to the sluggish circulation of redox couples. Herein, a carbon defects-enriched NBC-CN@CoMn (NCC) was synthesized through a self-assembly approach. The carbon defects within the NCC induce the electron trap effect, thereby facilitating the efficient cycling of redox couples in photo-Fenton-like processes during contaminant degradation.

Crystal structure of ()-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone.

The structure of ()-5-(3-acetyl-5-chloro-2-ethoxy-6-fluorophenyl)-2-oxazolidinone, CHClFNO, at 100 K has monoclinic (2) symmetry. The compound has a polymeric structure propagated by a screw axis parallel to the axis with N-H⋯O hydrogen bonding. It is of inter-est with respect to efforts in the synthesis of a candidate anti-cancer drug, parsaclisib.

Pyrite-assisted degradation of methoxychlor by laccase immobilized on FeS/earthworm-like mesoporous SiO.

Laccase immobilized and cross-linked on FeS/earthworm-like mesoporous SiO (FeS/EW-mSiO) was used to degrade methoxychlor (MXC) in aqueous environments. The effects of various parameters on the degradation of MXC were determined using free and immobilized laccase. Immobilization improved the thermal stability and reuse of laccase significantly.

Degradation of trichloroacetic acid by Fe/Ni bimetallic reactive PMS with hierarchical layered structure.

Overuse of chlorinated disinfectants leads to a significant accumulation of disinfection by-products. Trichloroacetic acid (TCA) is a typical carcinogenic disinfection by-product. The efficacy of the conventional degradation process is reduced by the complex nature of its structure, causing a yearly increase in its prevalence within the ecological environment and consequent infliction of significant harm.

Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders.

Background: Major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD) are complex genetic mental illnesses. Their non-Mendelian features, such as those observed in monozygotic twins discordant for SCZ or BPD, are likely complicated by environmental modifiers of genetic effects. 5-Hydroxymethylcytosine (5hmC) is an important epigenetic mark in gene regulation, and whether it is linked to genetic variants that contribute to non-Mendelian features remains largely unexplored.

Carbon Additive Manufacturing with a Near-Replica "Green-to-Brown" Transformation.

Nanocomposites containing nanoscale materials offer exciting opportunities to encode nanoscale features into macroscale dimensions, which produces unprecedented impact in material design and application. However, conventional methods cannot process nanocomposites with a high particle loading, as well as nanocomposites with the ability to be tailored at multiple scales. A composite architected mesoscale process strategy that brings particle loading nanoscale materials combined with multiscale features including nanoscale manipulation, mesoscale architecture, and macroscale formation to create spatially programmed nanocomposites with high particle loading and multiscale tailorability is reported.

Catalytic degradation of "trinitrogen" by Fe-Ce-SiO /TiO aerogel.

The "trinitrogen" [ammonia nitrogen (NH  - N), nitrate nitrogen (NO  - N), and nitrite nitrogen (NO - N)] from industrial or domestic wastewater can lead to eutrophication of water bodies. When ammonia nitrogen is converted into nitrate nitrogen, it will cause high nitrogen oxygen demand, which will also lead to hyperammonemia. High nitrite content in water bodies will increase the risk of human cancer.

Load and release of gambogic acid via dual-target ellipsoidal-FeO@SiO@mSiO-C@dopamine hydrochloride -graphene quantum dots-folic acid and its inhibition to VX2 tumor cells.

Ellipsoidal-FeO@SiO@mSiO-C@dopamine hydrochloride-graphene quantum dots-folic acid (ellipsoidal-HMNPs@PDA-GQDs-FA), a dual-functional drug carrier, was stepwise constructed. The-FeOellipsoidal nanoparticles were prepared by a hydrothermal method, and then coated with SiOby Stöber method. The resulting core-shell structure, FeO@SiO@mSiO-Cmagnetic nano hollow spheres, abbreviated as HMNPs, was finally grafted with graphene quantum dots (GQDs), dopamine hydrochloride (PDA) and folic acid (FA) by amide reaction to obtain HMNPs@PDA-GQDs-FA.

Preparation of FeO@Fe(0) immobilized enzyme to enhance the efficient degradation of methoxychlor.

The presence of methoxychlor (MXC) in soil and wastewater is considered a nonnegligible environmental threat. Herein, FeO@Fe(0) was obtained by NaBH reduction of FeO nanoparticles and served as a carrier for laccase to construct catalyst. The catalyst was evaluated for the degradation of MXC in treated wastewater and soil with 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) being used as cocatalyst.

LncRNA RP5-998N21.4 promotes immune defense through upregulation of IFIT2 and IFIT3 in schizophrenia.

Schizophrenia is a complex polygenic disease that is affected by genetic, developmental, and environmental factors. Accumulating evidence indicates that environmental factors such as maternal infection and excessive prenatal neuroinflammation may contribute to the onset of schizophrenia by affecting epigenetic modification. We recently identified a schizophrenia-associated upregulated long noncoding RNA (lncRNA) RP5-998N21.

TEM of Electrochemical Incidents: Effects of Biasing and Electron Beam on Electrochemistry.

TEM utilizing specialized holders and MEMS chips allows the investigation of the interaction, evolution, property, and function of nanostructures and devices responding to designed environments and/or stimuli. This mini-review summarizes the recent progress of TEM with a liquid cell and a flow channel for the investigation of interactions among aqueous nanoparticles, electrolytes, and electrodes under the influence of electric bias and electron beam. A focus is made on nanoparticle growth by electrodeposition, particle nucleation induced by electric biasing or electron beam, self-assembly, and electrolyte breakdown.

Chain-Length Dependence of Thermal Conductivity in 2D Alkylammonium Lead Iodide Single Crystals.

In 2D organic-inorganic hybrid perovskite materials, layers of conducting inorganic material are separated by insulating organic spacers whose length and composition can be tuned. We report the heat capacity and cross-plane thermal conductivity of 2D alkylammonium lead iodide single crystals with increasing chain length, (CHNH)PbI ( = 4-7). The measured thermal conductivities are some of the lowest ever recorded for single crystals, with averages in the range = 0.

A versatile strategy for controlled assembly of plasmonic metal/semiconductor hemispherical nano-heterostructure arrays.

Recent advances in manipulating plasmonic properties of metal/semiconductor heterostructures have opened up new avenues for basic research and applications. Herein, we present a versatile strategy for the assembly of arrays of plasmonic metal/semiconductor hemispherical nano-heterostructures (MSHNs) with control over spacing and size of the metal/semiconductor heterostructure array, which can facilitate a wide range of scientific studies and applications. The strategy combines nanosphere lithography for generating the metal core array with solution-based chemical methods for the semiconductor shell that are widely available and kinetically controllable.

Si-thiol supported atomic-scale palladium as efficient and recyclable catalyst for Suzuki coupling reaction.

Atomic-scale catalysts leverage the advantages of both heterogeneous catalysts for their stability and reusability and homogeneous catalysts for their isolated active sites. Here, a palladium catalyst supported by Si-thiol, a commercially available mercaptopropyl-modified and TMS-passivated amorphous silica, was synthesized and characterized by SEM,TEM, aberration-corrected STEM-HAADF, XRD, FT-IR and XPS. Statistical analysis revealed that the catalytic Pd species predominantly consisted of intermediate sized nanoparticles (<2 nm), small amounts of essentially isolated atoms (ca.

LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia.

Schizophrenia is a complex genetic disorder, the non-Mendelian features of which are likely complicated by epigenetic factors yet to be elucidated. Here, we performed RNA sequencing of peripheral blood RNA from monozygotic twins discordant for schizophrenia, and identified a schizophrenia-associated upregulated long noncoding RNA (lncRNA, AC006129.1) that participates in the inflammatory response by enhancing SOCS3 and CASP1 expression in schizophrenia patients and further validated this finding in AC006129.

Full spectrum driven SCR removal of NO over hierarchical CeVO/attapulgite nanocomposite with high resistance to SO and HO.

Removal of hazardous NO at low temperature via photo-assisted selective catalytic reduction (photo-SCR) strategy is promising, however fully harvesting of solar energy and achieving high SO/HO tolerance still remain a challenge. Herein, the phosphoric acid modified natural attapulgite(P-ATP) was employed as a matrix to immobilize CeVO by microwave hydrothermal method. Results show that P-ATP provides abundant active sites facilitating the in situ grow of CeVO nanorods on its surface which hierarchically construct a dendritic-like photocatalyst.

Enhancement of Mechanical Properties and Rolling Formability in AZ91 Alloy by RD-ECAP Processing.

In this study, the influence of rotary-die equal channel angular pressing (RD-ECAP) processing on the mechanical properties and rolling formability of AZ91 alloys was investigated. The as-cast and pre-homogenized AZ91 alloys were pre-processed by RD-ECAP for 16 passes at 573 K and subjected to post-ECAP rolling at 573 K with a rolling speed of 10 m/min. The microstructure and deformation characteristics of the AZ91 alloys were characterized.

Energy Band Architecture of a Hierarchical ZnO/Au/CuO Nanoforest by Mimicking Natural Superhydrophobic Surfaces.

The ZnO/CuO heterojunction promises high efficiency in photocurrent conversion and other light-driven processes, but the lattice mismatch between ZnO and CuO leads to slow electron transfer and low conversion efficiency. In addition, the stability of CuO is still the main challenging and limiting factor for device applications in real environments. CuO is a mixed semiconductor of CuO and CuO, which is a promising alternative to CuO in device fabrication due to its better stability and photocatalytic efficiency.

Graphene Oxide Covalently Grafted Fe₂B@SiO₂ Nanoparticles for Epirubicin Loading and Releasing.

In this work, stable superparamagnetic core-shell Fe₂B@SiO₂ nanoparticles were prepared by "one pot" chemical reduction of ferric ion salts with NaBH₄ and silica shell coating in the presence of citric acid stabilizer. The X-ray (XRD) and selection of electron diffraction (SAED) revealed that Fe₂B@SiO₂ nanoparticles were chiefly composed of silica shell and Fe₂B with a small amount of -Fe. Then, graphene oxide (GO) was assembled onto core-shell Fe₂B@SiO₂ nanoparticles for Epirubicin (EPI) loading and releasing, and the adsorption isotherm of EPI on Fe₂B@SiO₂@GO was analyzed.

Characterization of enzyme-immobilized catalytic support and its exploitation for the degradation of methoxychlor in simulated polluted soils.

Chiral mesoporous silica (SiO) with helical structure was synthesized by using anionic surfactants as template. Pre-prepared graphene oxide (GO) was then loaded onto SiO to synthesize composite carrier chial-meso-SiO@GO for the immobilization of laccase. The enzyme activity, thermostability, acid stability, and repeatability of the immobilized enzyme were significantly improved after immobilization.

Construction of Carbon Dots Coated Magnetic Hollow Silica Spheres.

Magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were prepared using functionalized SiO₂ spheres as templates, on which the magnetic particles were uniformly deposited on their surface. The obtained MHSS exhibited a super-paramagnetic behavior at room temperature. Due to large hollow cavity space and super-paramagnetic characteristics, the MHSS were coated with carbon dots with assistance of (3-Aminopropyl) trimethoxysilane (APS).

Preparation and Biological Applications of Graphene Oxide Functionalized Water-Based Magnetic Fluids.

Magnetic fluids (MFs) with good dispersion were prepared by speed-controlled co-precipitation method, using polyethylene glycol (PEG-4000) as dispersing agent. To functionalize the MFs with graphene oxide (GO), highly dispersed nano-magnetic particles (NMPs) were firstly prepared by low-temperature freeze-drying technique. 3-aminopropyltriethoxysilane (APTES) was then attached on the surface of NMPs to form amino functionalized NMPs.

Preparation and Biodistribution of Ultra-Small Superparamagnetic Iron Oxide Nanoparticles with High Magnetic Targeting Response.

The ultra-small superparamagnetic iron oxide (USPIO) particles with high saturation magnetization and good superparamagnetism were prepared by reverse micro-emulsions using novel C16E15 as surfactant, which can reduce magnetic dipole-dipole interaction, hence decreasing the critical blocking temperature (TB). Powder X-ray diffraction (XRD), Infrared spectrum (FT-IR), Transmission electron microscope (TEM), X-ray photoelectron spectroscopy (XPS), and Vibrating sample magnetometer (VSM) were used to characterize the magnetic particles. The higher ratio of Fe2+/Fe3+ caused redundant FeO on the USPIO surface.