The Role of MHC-II Diversity over Enclosure Design in Gut Microbiota Structuring of Captive Bengal Slow Lorises.

The endangered Bengal slow loris () relies heavily on captive/rescue populations for conservation. This study investigated the critical link between Major Histocompatibility Complex (MHC) class II DRB1 exon 2 () genetic variation and gut microbiota in 46 captive individuals, aiming to improve ex situ management. Using standardized conditions across three enclosure types, we characterized polymorphism via targeted sequencing and analyzed fecal microbiota using 16S rRNA gene amplicon sequencing.

Explainable ensemble learning for predicting pine wilt disease spread.

The rapid global spread of Pine Wilt Disease (PWD) has resulted in considerable ecological and economic losses, underscoring the necessity for precise forecasts of its future dissemination as a pivotal element in the control of the disease. In contrast to traditional semi-empirical models, which are unable to be applied to the increasing number of outbreak areas, machine learning (ML) models are better able to capture the hidden patterns of PWD spread. However, ML models have poor interpretability, and the imbalance between infected and potentially infected samples, coupled with the high dimensionality of the influencing factors, makes it challenging for any single ML model to achieve satisfactory performance.

A new wearable e monitoring technology for evaluation of left ventricular remodeling after transcatheter aortic valve replacement.

Aims: Pathological left ventricular (LV) remodelling following aortic stenosis (AS) confers high risk for heart failure and significantly decreases survival. This study aims to introduce a new wearable acoustic cardiography (ACG) device measuring electromechanical activation time (EMAT) to identify the regression of cardiac remodelling in AS patients undergoing transcatheter aortic valve replacement (TAVR).

Methods And Results: This prospective cohort study consecutively enrolled patients with severe symptomatic AS who underwent successful TAVR.

Populus PtrbHLH011 Is a Transcriptional Co-Regulator Involved in the Activation of Cell Wall Biosynthesis by Iron Deprivation.

The lack of a mechanistic understanding of the environmental plasticity of secondary cell wall (SCW) biosynthesis restricts large-scale biomass and bioenergy production on marginal lands. Using Populus (poplar), a key bioenergy crop, we discovered that iron deprivation, a prevalent abiotic stress on marginal lands, stimulates SCW biosynthesis in stems. We identified the transcription factor PtrbHLH011 as a critical regulator underlying this response.

Clinicopathological features of cranial-nasal-orbital communicating lesions and diagnostic indicators for differentiating benign and malignant neoplasms.

Aim: To investigate the clinicopathological features of cranial-nasal-orbital communicating lesions and identify key diagnostic indicators for differentiating benign and malignant neoplasms.

Methods: The retrospective cohort study analyzed 74 histologically confirmed cases stratified by anatomical involvement at the Wuhan Union Hospital between January 2010 and December 2020: Group A (orbital-nasal group, =29), Group B (orbital-cranial group, =27), and Group C (cranial-nasal-orbital group, =18). Clinicopathological profiles including symptom presentation, histopathology, and invasion patterns were systematically evaluated.

Investigating the effects of dendrobine on fibrosis and inflammation in orbital fibroblasts of thyroid-associated ophthalmopathy via network pharmacology, molecular docking, and transcriptomics.

This study aims to evaluate the effects and mechanisms of dendrobine against thyroid-associated ophthalmopathy (TAO). Potential targets of dendrobine and TAO were selected to construct a protein-protein interaction network, elucidating the potential mechanisms of dendrobine against TAO. The potential mechanisms systematically were verified by molecular docking, transcriptomics and in vitro experiments.

Endometriosis in patients with female genital tract congenital anomalies: A retrospective cohort study.

Introduction And Hypothesis: The relationship between female genital tract congenital anomalies and endometriosis is less clear. This study aimed to analyze the prevalence and high-risk factors of endometriosis in patients diagnosed with female genital tract congenital anomalies with functioning endometrium.

Methods: In this study that included 675 patients who were diagnosed with female genital tract anomalies with functioning endometrium and underwent surgery between January 2013 and December 2023.

Targeting intracellular LMP2 with costimulatory signal-armed antibody-like TCR T cells.

Expanding the repertoire of CAR therapies to include intracellular antigens holds promise for treating a broad spectrum of malignancies. TCR-like T cells, capable of recognizing intracellular antigen-derived peptides in complex with HLA molecules (pHLA), represent a promising strategy in the field of engineered cellular therapy. This study introduced antibody-like TCR (abTCR) T cells that specifically targeted HLA-A*02:01-restricted LMP2426 peptides, a typical Epstein-Barr virus (EBV) latency II protein, for the treatment of EBV-associated lymphoproliferative diseases (EBV-LPDs).

Suitability mapping of native tree species in dry-hot valleys of Yunnan based on InVEST-MaxEnt coupled modeling: model validation framework with native tree species actual distribution and seed germination.

Introduction: The target valleys along the Jinsha, Nujiang, Lancang, and Yuanjiang Rivers exhibit acute human-land conflicts and ecosystem vulnerability. Predicting the distribution of potential suitable habitats for native tree species in Yunnan Province provides basin-scale insights for the management of ecosystems in dry and hot valleys, thereby advancing restoration planning in dry-hot valleys.

Methods: This study investigates native tree species suitability in Yunnan's dry-hot valleys using an integrated MaxEnt-InVEST modeling framework.

A single-cell transcriptomic atlas of all cell types in the brain of 5xFAD Alzheimer mice in response to dietary inulin supplementation.

Background: Alzheimer's disease (AD) is a progressive neurodegenerative disease that is a major threat to the aging population. Due to lack of effective therapy, preventive treatments are important strategies to limit AD onset and progression, of which dietary regimes have been implicated as a key factor. Diet with high fiber content is known to have beneficial effects on cognitive decline in AD.

Study on the evaluation of workface wall stability based on cloud model.

To address the uncertainty and fuzziness during conventional workface rib spalling prediction, a rating system of workface wall stability considering subjective experience factor, mechanical performance of coal mass, workface production condition, and support/surrounding rock coupling was constructed, fuzzy factors such as the number of cracks, crack distribution, and feedback of wall/roof tapping were analyzed systematically and quantitatively based on the long-term inspection experience of coal mine safety inspectors, and rating criteria of workface wall stability were established; the AHP-CRTIC-Game Theory integrated weighting method was used to determine the optimized overall weight. Additionally, the normal cloud model was used to determine the workface wall stability level. The application of this model in the Workface 25,221 of a mine in Xinjiang, China revealed that the workface wall stability was at Level III, suggesting an unstable condition, which was consistent with the on-site observations.

Giant electrocaloric effect in high-polar-entropy perovskite oxides.

Materials with a high electrocaloric effect (ECE) tend to favour a disordered yet easily tunable polar structure. Perovskite ferroelectrics stand out as ideal candidates owing to their high dielectric responses and reasonable thermal conductivity. The introduction of multielement atomic distortions induces a high-polar-entropy state that notably increases the ECE by effectively overcoming the constraints imposed by highly ordered, polar-correlated perovskite structures.

Study on the Micro-Surfacing Properties of SBR Modified Asphalt Emulsion with Reclaimed Asphalt Pavement.

With the updates and differences in the usage of reclaimed asphalt pavement (RAP) separation technology, the production of fine-particle RAP exceeds their usage, resulting in an excess of fine-particle RAP. How to apply this excess RAP on a large scale in micro-surfacing technology has become a challenge. This study aims to investigate the advantages and disadvantages of incorporating RAP into micro-surfacing.

Characterization of subcutaneous and visceral de-differentiated fat cells.

Objective: The capacity of mature adipocytes to de-differentiate into fibroblast-like cells has been demonstrated in vitro and a few, rather specific in vivo conditions. A detailed comparison between de-differentiated fat (DFAT) cells and adipose stem and progenitor cells (ASPCs) from different adipose depots is yet to be conducted. Moreover, whether de-differentiation of mature adipocytes from classical subcutaneous and visceral depots occurs under physiological conditions remains unknown.

Electrodeposited Nitrate-Intercalated NiFeCe-Based (Oxy)hydroxide Heterostructure as a Competent Electrocatalyst for Overall Water Splitting.

Electrochemical water splitting is a promising method for the generation of "green hydrogen", a renewable and sustainable energy source. However, the complex, multistep synthesis processes, often involving hazardous or expensive chemicals, limit its broader adoption. Herein, a nitrate (NO) anion-intercalated nickel-iron-cerium mixed-metal (oxy)hydroxide heterostructure electrocatalyst is fabricated on nickel foam (NiFeCeOH@NF) via a simple electrodeposition method followed by cyclic voltammetry activation to enhance its surface properties.

Sensor Fusion Method for Object Detection and Distance Estimation in Assisted Driving Applications.

The fusion of multiple sensors' data in real-time is a crucial process for autonomous and assisted driving, where high-level controllers need classification of objects in the surroundings and estimation of relative positions. This paper presents an open-source framework to estimate the distance between a vehicle equipped with sensors and different road objects on its path using the fusion of data from cameras, radars, and LiDARs. The target application is an Advanced Driving Assistance System (ADAS) that benefits from the integration of the sensors' attributes to plan the vehicle's speed according to real-time road occupation and distance from obstacles.

Psychological sense of community as mediator and growth mindset as moderator in the impact of institutional integrity and perceived teacher support on student thriving: Evidence from private universities in China.

Previous research may have focused more on the direct rather than indirect effects of psychological characteristics on student success. This study explored the mediating effect of psychological sense of community and the moderating effect of growth mindset on the impacts of institutional integrity and perceived teacher support on student thriving in academic, interpersonal, and psychological domains. The hypothesized research model was proposed based on the Thriving Model, and the study was carried out in the setting of private universities in China.

Biofilm-modified Prussian blue improves memory function in late-stage Alzheimer's disease mice with triple therapy.

Alzheimer's disease (AD) is a neurodegenerative disease that is significantly characterized by cognitive and memory impairments, which worsen significantly with age. In the late stages of AD, metal ion disorders and an imbalance of reactive oxygen species (ROS) levels occur in the brain microenvironment, which causes abnormal aggregation of β-amyloid (Aβ), leading to a significant worsening of the AD symptoms. Therefore, we designed a composite nanomaterial of macrophage membranes-encapsulated Prussian blue nanoparticles (PB NPs/MM).

STEAP3 is a potential preliminary prognostic biomarker of glioblastoma.

Six-transmembrane epithelial antigen of prostate 3 (STEAP3), a member of the iron regulation protein family, is characterized by a high recurrence rate and a short survival time. Nevertheless, studies investigating the role of STEAP3 in glioblastoma (GB) are scarce. In this study, the prognostic value of STEAP3 was evaluated utilizing mRNA expression profiles from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases as the validation and training cohorts, respectively.

New wearable cardiac acoustic monitoring technology for evaluation of subclinical leaflet thrombosis after transcatheter aortic valve replacement.

Background: Subclinical leaflet thrombosis (SLT) is a common complication after transcatheter aortic valve replacement (TAVR). Multidimensional CT (MDCT) is the main imaging mortality for the diagnosis of SLT but it enhances the risk of contrast-induced nephropathy. Our study aimed to use an innovative wearable acoustic cardiography (ACG) device to diagnose SLT as an alternative option.

Accelerating Tandem Electroreduction of Nitrate to Ammonia via Multi-Site Synergy in Mesoporous Carbon-Supported High-Entropy Intermetallics.

The electrochemical nitrate reduction reaction (NO RR) for ammonia (NH) synthesis represents a significant technological advancement, yet it involves a cascade of elementary reactions alongside various intermediates. Thus, the development of multi-site catalysts for enhancing NO RR and understanding the associated reaction mechanisms for NH synthesis is vital. Herein, a versatile approach is presented to construct platinum based high-entropy intermetallic (HEI) library for NH synthesis.

The properties of laryngeal electromyography in the non-paralyzed sides of patients with idiopathic vocal cord paralysis.

Objective: To evaluate the injuries of the recurrent laryngeal nerve (RLN), superior laryngeal nerve (SLN), and their innervated laryngeal muscles on the non-paralyzed sides in patients with idiopathic vocal cord paralysis (IVCP).

Methods: Eighty-four cases of patients with IVCP were evaluated using stroboscopic laryngoscopy, voice analysis, and laryngeal electromyography(LEMG). Concurrently, twenty-eight cases involving healthy volunteers without vocal cord paralysis were enrolled and examined using LEMG during the same period.

Aeration-Free Photo-Fenton-Like Reaction Mediated by Heterojunction Photocatalyst toward Efficient Degradation of Organic Pollutants.

The regulation of peroxymonosulfate (PMS) activation by photo-assisted heterogeneous catalysis is under in-depth investigation with potential as a replaceable advanced oxidation process in water purification, yet it remains a significant challenge. Herein, we demonstrate a strategy to construct polyethylene glycol (PEG) well-coupled dual-defect V-M-CoO@CN S-scheme heterojunction to degrade organic pollutants without aeration, which dramatically provides abundant active sites, excellent photo-thermal property, and distinct charge transport pathway for PMS activation. The degradation rate of V-M-CoO@CN in anaerobic conditions shows a higher efficient rate (4.