Adjuvant conditioning enhances neutrophil function while inducing a suppressive peritoneal macrophage phenotype.

Adjuvants are widely used to boost the immune response during vaccination protocols. Our group has previously reported that repeated intraperitoneal administration of alum in mice, known as adjuvant conditioning (AC), creates an immunosuppressive environment that delays allogeneic graft rejection through NLRP3-dependent MDSC expansion. However, little is known about the effects of AC on the reprogramming of peritoneal cavity cells, particularly the different peritoneal macrophage populations, and the impact on the adaptive immune response.

Genome-wide gene expression changes in breast cancer cells following very low-dose exposure to pesticides (glyphosate and atrazine) at drinking water levels.

Glyphosate and atrazine, two widely used herbicides, may induce subtle molecular changes even at low levels encountered in the drinking water of some populations. This study assessed structural and RNA expression changes in MCF-7 and MDA-MB-231 breast cancer cell lines after 72-h exposures to glyphosate (50 or 500 ppb) and atrazine (2 or 20 ppb). These doses are commonly found in drinking water and falls below or within the maximum residue levels recommended or allowed in the drinking water of populations in Brazil and the USA.

Maresin 2, a Specialized Pro-Resolution Lipid Mediator, Reduces Pain and Inflammation Induced by Venom in Mice.

The venom of (BjV) induces intense and prolonged pain, which is not alleviated by antivenom, along with hemorrhage and inflammation. In this study, we investigated the effects of the specialized pro-resolving lipid mediator (SPM) maresin 2 (MaR2) in a murine model of BjV-evoked pain and inflammation. Mice received a single intraperitoneal (i.

Synergistic Relationship Between Muscle Thickness, Muscular Strength, and Functional Fitness After Resistance Training in Older Women.

Stavinski, N, Cavazzotto, TG, Carneiro, MAS, Kunevaliki, G, Francsuel, J, Costa, B, Kassiano, W, Tricoli, I, Castro-E-Souza, P, Prado, A, Cyrino, LT, Rodrigues, RJ, Silva, DRP, Cavaglieri, CR, Silva, AM, Sardinha, LB, and Cyrino, ES. Synergistic relationship between muscle thickness, muscular strength, and functional fitness after resistance training in older women. J Strength Cond Res XX(X): 000-000, 2025-This study examined the synergistic relationship between changes in muscle thickness (MT) and muscular strength and functional fitness after a resistance training (RT) program in older women.

Effects of the Flavonoid Diosmin on Post Exercise Muscle Soreness - A Randomized Controlled Trial.

women's league. A randomized, double‑blind and placebo‑controlled crossover trial was conducted in 15 professional futsal female athletes. They received one daily capsule of DSM or placebo (750 mg) for 3 days as a preventive regimen, and an intense dynamic exercise protocol (concentric/eccentric actions) was applied to the lower limbs.

Clinical and Trichoscopy Features in Trichorhinophalangeal Syndrome: A Multicenter Retrospective Study.

Introduction: Trichorhinophalangeal syndrome (TRPS) is a rare autosomal dominant genetic disorder characterized by trichological, craniofacial, and skeletal abnormalities. To date, limited data are available on hair involvement in TRPS, especially those focusing on trichoscopy.

Objective: We aimed to describe the epidemiology and the clinical and trichoscopy features of TRPS.

Systematic Review and Meta-Analysis of the Prevalence of Physical Activity in South American Children.

Objectives: This study aimed to systematically review and apply meta-analytic procedures to investigate the prevalence and time spent in different physical activity (PA) intensities among South American children across the childhood spectrum, according to sex and protocol used.

Methods: We searched PubMed, Web of Science, Scopus, Latin American and Caribbean Health Sciences Literature (LILACS), and Scientific Electronic Library Online (SCiELO); only studies with children between 0 and 11 years were included. Random-effects meta-analysis models were used to calculate the pooled estimates with their respective 95% confidence intervals (CI).

Cortical venous opacification score predicts outcomes after thrombectomy in large vessel occlusion stroke: a systematic review and meta-analysis.

Purpose: This study aimed to assess whether the Cortical Vein Opacification Score (COVES), a visual scoring system based on single-phase Computed Tomography Angiography (CTA), is associated with clinical and radiological outcomes in patients with acute ischemic stroke due to large vessel occlusion (AIS-LVO) after endovascular treatment (EVT).

Methods And Materials: A systematic review and meta-analysis were conducted according to PRISMA guidelines. PubMed, EMBASE, and Cochrane Library were searched from inception to early June 2025, identifying 572 articles, of which 6 were included.

Resolvin D2 Reduces UVB Skin Pathology by Targeting Cytokines, Oxidative Stress, and NF-κB Activation.

UVB skin pathology is initiated by reactive oxygen species (ROS), differentiating this condition from other inflammatory diseases involving first the immune cell activation by danger or pathogen molecular patterns followed by oxidative stress. Resolvin D2 (RvD2) has been found to reduce inflammation in preclinical models. However, whether or not RvD2 reduces skin pathology caused by UVB irradiation is not yet known.

Scorpion Venom-Induced Nociceptive Responses Depend on TRPV1, Immune Cells, and Pro-Inflammatory Cytokines.

For centuries, researchers have been fascinated by the composition of scorpion venom and its local and systemic effects on humans. During a sting, scorpions inject peptides and proteins that can affect immune cells and neurons. While the immune and nervous systems have been studied independently in the context of scorpion stings, here we reveal part of the mechanism by which venom induces hyperalgesia in mice.

Sitosterolemia caused by compound heterozygosis of 2 allelic variants in the ABCG5 gene-21 years of follow-up.

Background: Sitosterolemia is a rare autosomal recessive disease characterized by elevated phytosterol levels in the bloodstream and tissues due to increased absorption and reduced biliary excretion. This condition arises from mutations in one of two genes, ABCG5 or ABCG8, located on chromosome 2p21.

Objective: We report the case of a patient, and his first-degree relatives, diagnosed with sitosterolemia at the age of 23.

Perceptual and hypoalgesic responses to submaximal knee extension exercise with different pressures and modes of blood flow restriction: Effect of estimated muscle metabolites.

Purpose: To investigate the effects of exercise-induced metabolites on the perceptions of pain and fatigue.

Method: Fifty-three adults completed six visits. The first visit involved multiple baseline tests, including a blood-flow-restricted exercise performance test (i.

Physical activity trajectories and accumulation over adulthood and their associations with all-cause and cause-specific mortality: a systematic review and meta-analysis.

Objective: To understand the associations of trajectories and accumulation of physical activity (PA) over adulthood with all-cause, cardiovascular disease (CVD), and cancer mortality.

Design: Systematic review and meta-analyses.

Data Sources: PubMed, Embase, Scopus, Cochrane Library, Web of Science, CINAHL, MEDLINE, SPORTDiscus, and reference lists of included studies.

Oregano essential oil induces death in a resistant strain of isolated from a naturally infected dog through increased production of reactive oxygen species, mitochondrial damage and cell metabolic disruption.

Leishmaniasis is a neglected tropical disease caused by protozoa of the genus, transmitted by phlebotomine sandflies. Clinical manifestations vary depending on the parasite's species and the host's immune system, ranging from self-healing skin lesions to lethal visceral diseases. Visceral leishmaniasis (VL), mainly caused by and , is a serious public health issue.

Subfoveal Choroidal Thickness After Successful Retinal Detachment Repair with Persistent Subretinal Fluid at the Macula.

Objective: To explore the relationship between subfoveal choroidal thickness (SFCT) and persistent subretinal fluid (pSRF) at the macula after successful rhegmatogenous retinal detachment (RRD) surgery.

Methods: This is a retrospective multicenter comparative study of Caucasian subjects with successful RRD repair. SFCT was measured in 2 groups: Group 1 with persistent subretinal fluid (pSRF) 1 month after repair, and Group 2 with absence of pSRF.

Pharmacotherapy of Neuropathic Pain.

Despite advances in recent decades, the management of neuropathic pain remains one of the greatest challenges in modern clinical medicine [...

Assessing the impacts of nanoencapsulated geraniol on amphibians: A step toward sustainable pesticide alternatives?

Amphibians are vulnerable to the effects of pesticides, and nanoencapsulation of geraniol in zein nanocapsules may provide a more sustainable alternative to synthetic pesticides. These nanoformulations enhance the targeting of active ingredients, reduce the amount of pesticide applied, and may reduce impacts on non-target organisms. Thus, the effects of geraniol (GER), nanoencapsulated geraniol (nGER), and zein nanocapsules (NANO) were evaluated on Aquarana catesbeiana tadpoles after 24 and 96 h exposure.

Fructose-1,6-Bisphosphate Reduces Chronic Constriction Injury Neuropathic Pain in Mice by Targeting Dorsal Root Ganglia Nociceptive Neuron Activation.

Fructose-1,6-bisphosphate (FBP) is an intermediate product of the glycolytic pathway with analgesic effect in acute inflammatory pain model via the production of adenosine. However, whether FBP is active in neuropathic pain is unknown. Therefore, we reason that it would be suitable to investigate the analgesic effect and mechanism of action of FBP in a model of chronic constriction injury (CCI) of sciatic nerve-induced neuropathic pain in mice.

Visual Outcomes and Clinical Features of Extensive Macular Atrophy with Pseudodrusen (EMAP).

Purpose: To describe extensive macular atrophy with pseudodrusen (EMAP) using multimodal imaging and analyze factors associated with visual loss.

Methods: This observational case seriesretrospectively reviewed the clinical and multimodal imaging (color fundus photography [CFP], fluorescein angiography, fundus autofluorescence (FAF), and optical coherence tomography [OCT]) of patients between January and December 2023. The EMAP diagnosis was based on early-onset macular atrophy, pseudodrusen, and bilateral disease.

Combined Zn and Mn affect osmoregulation of the freshwater teleost Prochilodus lineatus in distinct ways from isolated metals.

Juveniles of the freshwater teleost Prochilodus lineatus were used to evaluate the osmoregulatory effects of the essential metals zinc (Zn), manganese (Mn) and iron (Fe), both individually and in different combinations. Fish were subjected to three independent 96-h exposure tests, each including its respective control group (CTR; fish exposed only to water): (i) Zn test, with exposures to 0.18, 1.

Feeding weanling piglets for optimal health and performance: what can we learn from research on complex diets?

Weaning and introduction to a solid diet result in physiological stress in piglets. This can be offset by using complex diets. The terms 'complexity' and 'complex diets' are used in practice and academia but are not precisely defined.

Online Meta-Recommendation of CUSUM Hyperparameters for Enhanced Drift Detection.

With the increasing demand for time-series analysis, driven by the proliferation of IoT devices and real-time data-driven systems, detecting change points in time series has become critical for accurate short-term prediction. The variability in patterns necessitates frequent analysis to sustain high performance by acquiring the hyperparameter. The Cumulative Sum (CUSUM) method, based on calculating the cumulative values within a time series, is commonly used for change detection due to its early detection of small drifts, simplicity, low computational cost, and robustness to noise.

Description of a sheep abortion caused by atypical genotype of Toxoplasma gondii in the state of Mato Grosso, Brazil.

Toxoplasma gondii is one of the major causes of abortion in sheep in many countries. We report an episode of a novel atypical genotype of T. gondii-associated abortion in a sheep flock belonging to the Veterinary School Hospital of the University of Cuiabá located in Midwestern Brazil.

Resilience capacity in older women engaged in resistance training: physiological and functional adaptations to training interruption imposed by the COVID-19 pandemic followed by retraining.

Two years of training interruption imposed by the COVID-19 pandemic impair physiological and functional outcomes in older women engaged in resistance training. Retraining led to resilience capacity only in muscular strength gains.

An ecological view on the correlates of sedentary behavior in Brazilian adolescents: a cross-sectional study with network analysis.

Background: Sedentary behavior has been identified as a public health concern. The present study analyzed the correlates of sedentary behavior in Brazilian adolescents through network analysis, in the light of an ecological approach.

Methods: The sample consisted of 126,354 adolescents, participating in the fourth edition of the Brazilian National School Health Survey.