Physical activity trajectories and accumulation over adulthood and their associations with all-cause and cause-specific mortality: a systematic review and meta-analysis.

Objective: To understand the associations of trajectories and accumulation of physical activity (PA) over adulthood with all-cause, cardiovascular disease (CVD), and cancer mortality.

Design: Systematic review and meta-analyses.

Data Sources: PubMed, Embase, Scopus, Cochrane Library, Web of Science, CINAHL, MEDLINE, SPORTDiscus, and reference lists of included studies.

A gaint mesenteric cystic lymphangioma of small intestinal in an adult: A case report and literature review.

Rationale: Lymphangioma (LA) is a benign tumor that predominantly occurs in children, and is characterized by abnormal proliferation of lymphatic vessels. It is commonly present in areas such as the head, neck, and axilla. Mesenteric cystic lymphangioma (MCL) is relatively rare in adults.

Bacteria modulate microalgal aging physiology through the induction of extracellular vesicle production to remove harmful metabolites.

The bloom and bust patterns of microalgae in aquatic systems contribute massively to global biogeochemical cycles. The decline of algal blooms is mainly caused by nutrient limitation resulting in cell death, the arrest of cell division and the aging of surviving cells. Nutrient intake can re-initiate proliferation, but the processes involved are poorly understood.

Participation in Sports/Recreational Activities and the Occurrence of Psychological Distress in Mid-Aged Adults: Findings From the HABITAT Cohort Study.

Objectives: The aim of this study was to investigate prospective associations between participation in sports/recreational activities and the occurrence of moderate-to-severe psychological distress over 2 years in a sample of mid-aged Australians.

Methods: This prospective study used data from 6699 adults aged 40+ years, living in Brisbane in 2007, and surveyed in 2009, 2011 and 2013. Participants provided self-reported data on frequency of participation in each of 11 sports/recreational activities in past 12 months and completed the Kessler Psychological Distress 6-item Scale (K6).

Coupling and interaction mechanism between green urbanization and tourism competitiveness based an empirical study in the Yellow River Basin of China.

Exploring the spatial coupling relationship and interaction mechanism between green urbanization (GU) and tourism competitiveness (TC) is of great significance for promoting urban sustainable development. However, the lack of research on the interaction mechanism between GU and TC limits the formulation of effective environmental management policy and urban planning. Taking 734 counties in the Yellow River Basin (YRB) as the study area, this paper analyzes the spatial coupling relationship between GU and TC on the basis of comprehensive evaluation of GU and TC.

Accurate estimation of fractional vegetation cover for winter wheat by integrated unmanned aerial systems and satellite images.

Accurate estimation of fractional vegetation cover (FVC) is essential for crop growth monitoring. Currently, satellite remote sensing monitoring remains one of the most effective methods for the estimation of crop FVC. However, due to the significant difference in scale between the coarse resolution of satellite images and the scale of measurable data on the ground, there are significant uncertainties and errors in estimating crop FVC.

Bidirectional association between infectious gastroenteritis and inflammatory bowel disease: a population-based study.

Background: Intertwined association between infectious gastroenteritis (IGE) and inflammatory bowel disease (IBD) has not been investigated clearly. We aimed to examine the bidirectional association between IGE and IBD.

Methods: A bidirectional study using the Taiwan National Health Insurance Research Database was designed.

Cross-validation of the peppermint benchmarking experiment across three analytical platforms.

The Peppermint Experiment is a breath analysis benchmarking initiative that seeks to address the lack of inter-comparability of outcomes across independent breath biomarker studies. In this experiment, the washout profiles of volatile terpene constituents of encapsulated peppermint oil (mainly-pinene,-pinene, limonene and 1,8-cineole) in exhaled breath are characterized through a series of measurements at defined sampling intervals up to 6 h after ingestion of the capsule. In the present work, the Peppermint Experiment was carried out on a cohort of volunteers (= 11) that provided breath samples in three sittings on different days (i.

Estimation of wheat tiller density using remote sensing data and machine learning methods.

The tiller density is a key agronomic trait of winter wheat that is essential to field management and yield estimation. The traditional method of obtaining the wheat tiller density is based on manual counting, which is inefficient and error prone. In this study, we established machine learning models to estimate the wheat tiller density in the field using hyperspectral and multispectral remote sensing data.

Wheat yield estimation using remote sensing data based on machine learning approaches.

Accurate predictions of wheat yields are essential to farmers'production plans and to the international trade in wheat. However, only poor approximations of the productivity of wheat crops in China can be obtained using traditional linear regression models based on vegetation indices and observations of the yield. In this study, Sentinel-2 (multispectral data) and ZY-1 02D (hyperspectral data) were used together with 15709 gridded yield data (with a resolution of 5 m × 5 m) to predict the winter wheat yield.

Silencing miRNA-324-3p protects against cerebral ischemic injury via regulation of the GATA2/A1R axis.

Previous studies have suggested that miR-324-3p is related to the pathophysiology of cerebral ischemia, but the mechanism underlying this relationship is unclear. In this study, we found that miR-324-3p expression was decreased in patients with acute ischemic stroke and in in vitro and in vivo models of ischemic stroke. miR-324-3p agomir potentiated ischemic brain damage in rats subjected to middle cerebral artery occlusion, as indicated by increased infarct volumes and cell apoptosis rates and greater neurological deficits.

Dex-Aco coating simultaneously increase the biocompatibility and transfection efficiency of cationic polymeric gene vectors.

Cationic polymeric vectors attracted plenty of attentions in gene therapy due to nonimmunogenicity, easy to synthesis and flexible properties. However, biocompatibility challenge such as nonspecific interactions with blood cells and serum proteins, may affect the delivery efficiency of cationic vectors; besides, inefficient endosomal escape causes low transfection efficiency. Herein, we synthesized an anionic coating polymer dextran-g-aconic anhydride (Dex-Aco, DA) through a simple esterification reaction, which can protect cationic polymer poly(cystamine-bis-acrylamide)-agmatine-histamine (PCAH, PC) constructed nanomedicine against interactions with blood cells and serum proteins, improving biocompatibility.

A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units.

A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.

Regulating the Golgi apparatus by co-delivery of a COX-2 inhibitor and Brefeldin A for suppression of tumor metastasis.

Finding a cure for breast cancer currently remains a medical challenge in due to the failure of common treatment methods to inhibit invasion and metastasis of cancer cells, which eventually leads to recurrence of breast cancer. Many secreted proteins are overexpressed and play crucial roles in tumorigenesis and development. The Golgi apparatus is a key protein processing and secretion factory in which metastasis-associated proteins are modified, transported and secreted; thus, regulating the Golgi apparatus of tumor cells is a viable strategy to inhibit tumor metastasis.