Gender Differences in the Association Between Sexting and Self-Harm Behavior Among Taiwanese Adolescents.

Objective: Sexting has been linked to negative mental health outcomes. This Taiwan-based study addresses the links between sexting, cyberbullying, self-harm, and gender differences in the association of sexting and self-harm behavior.

Methods: A two-stage stratified sampling of 5,190 Taiwanese adolescents aged 11-18 completed an online questionnaire measuring sexting, bullying/cyberbullying, and self-harm.

5-HT antagonists confer analgesia via suppression of neurotrophin overproduction in submucosal nerves of mouse models with visceral hypersensitivity.

Dysregulated serotonin/5-hydroxytryptamine (5-HT) metabolism and dense mucosal neurite distribution are associated with visceral hypersensitivity (VH), which plays a key role in irritable bowel syndrome (IBS) pain symptoms. The 5-HT receptor subtype 7 (5-HT) is involved in neuroplasticity. We aim to investigate the analgesic effects of 5-HT antagonists in mouse models and explore downstream changes of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in the enteric neurons.

[Keeping Children Away From Precocious Puberty: A Nursing Perspective].

Supporting healthy growth in children is a core objective of health care systems. However, numerous factors in modern society can expose children to risks such as precocious puberty, which may further lead to harm to their physical and mental health. In this article, we summarize the state-of-the-art of knowledge on precocious puberty, including its definition, stages, comprehensive influencing factors, natural environmental hormones, and environmental endocrine disruptors (e.

Illicit substance exposure in pregnancy and infant mortality risk: a nationwide Taiwan study.

Background: To investigate the association between prenatal illicit substance exposure and infant mortality, addressing the unclear links between specific and multiple substances and increased mortality.

Methods: This 16-year retrospective cohort study used Taiwan's National Health Insurance Research Database, the Taiwan Maternal and Child Health dataset, and the Integrated Illegal Drug Database, including 1 937 301 pregnant women who delivered from 2004 to 2019. Among them, 11 477 used illicit drugs during pregnancy, with a matched control group of 45 908 non-users based on maternal age, income, and childbirth year.

Risk of neurodevelopmental disorders in the offspring of mothers with a history of endometriosis in Taiwanese women.

Several neurodevelopmental disorders have been linked to early life immune activation and inflammation, including developmental delay, cerebral palsy, intellectual disabilities, and other neurodevelopmental and psychiatric disorders. Certain inflammatory cytokines, such as interleukin-1β, interleukin-6, and tumor necrosis factor-α, secreted by endometriosis cells cause chronic pelvic inflammation and pain. The aim of this study was to evaluate whether maternal endometriosis increased the risk of neurodevelopmental disorders in offspring in Taiwanese women.

Effects of a Family-Centered Teaching Model on Occupational Therapy Interns' Perceptions and Children's Occupational Performance.

Aims: To compare perceptions of family-centered behaviors and children's occupational performance between occupational therapy interns in Taiwan who received a family-centered teaching (FACT) model and those who received a conventional family approach.

Methods: A two-group quasi-experimental design was employed. Participants included 49 interns, 44 caregivers, and 45 children with disabilities under 6 years old.

The Electroluminescent Application of V-shaped Tröger's Base Compounds.

We report the design and evaluation of three V-shaped Tröger's base (TB) derivatives-TB-PhCz, TB-CzPh, and TB-oPhCz-featuring phenylcarbazole moieties as potential host materials for red and green phosphorescent OLEDs. The TB-hosts exhibited high decomposition temperatures (353 °C-399 °C) and glass transition temperatures (∼197 °C), demonstrating excellent thermal stability-an essential attribute for vacuum deposition processes and long-term device reliability. Two device architectures, single-host and co-host systems, were investigated to assess their influence on device performance.

Interface densification in a microphase-separated diblock copolymer resolved by small-angle X-ray scattering.

In block copolymers exhibiting lower critical ordering transition behavior, the segregation strength increases with temperature due to the significantly different thermal expansivities of the constituent blocks. Using synchrotron small-angle X-ray scattering, we reveal a phenomenon of segmental densification at the microdomain interface in this type of system, where the local electron density in a specific region of the interface surpasses that of the denser domain. As a result, the interfacial electron density profile deviates significantly from the hyperbolic tangent function expected for an incompressible melt.

Custom-Designed Portable Potentiostat and Indirect Cyclic Voltammetry Index Analysis for Rapid Pesticide Detection Using Molecularly Imprinted Polymer Sensors.

Water pesticide contamination represents a major threat to ecological systems and public health, particularly in agricultural regions. Although conventional detection methods such as liquid chromatography and electrochemical analysis are highly accurate, they are expensive, require skilled operators, and cannot provide real-time results. This study developed a portable miniaturized electrochemical analysis platform based on cyclic voltammetry (CV) for rapid pesticide detection.

The efficacy and safety of anti-amyloid monoclonal antibody versus acetylcholinesterase inhibitor with an in-depth analysis across genotypes and disease stages: a systematic review and meta-analysis.

Background: To date, studies have not compared the efficacy and safety of monoclonal antibodies (mABs) with acetylcholinesterase inhibitors (AChEIs).

Methods: Five electronic databases were systemic searched from inception to 10 November 2024 for double-blinded randomized controlled trial (RCT) of patients diagnosed with MCI or mild AD treated with mABs or AChEIs for at least 6 months. The primary outcome was change in cognitive function, measured by the Alzheimer's Disease Assessment Scale-cognitive subscale 14-item (ADAS-Cog) and Clinical Dementia Rating Scale-Sum of Boxes (CDR-SOB).

Rest-Activity Rhythm Patterns and Their Associations With Depression and Obesity: A Study Using Actigraphy and Human-Smartphone Interactions.

This study aimed to empirically derive subgroups based on both actigraphy- and app-measured rest-activity rhythm (RAR) patterns and investigate the relationship between these profiles and health outcomes, including depression and obesity. We developed a mobile app, Rhythm, to record human-smartphone interactions and calculate RAR patterns alongside standard actigraphy in 135 participants (mean age: 43.8 ± 12.

Differential efficacy of olfactory neurospheres from deviated nasal septum and chronic rhinosinusitis patients in regenerating olfactory epithelium.

Background: Olfactory epithelial stem cells hold significant potential for treating olfactory dysfunction by facilitating tissue maintenance and repair. Understanding the inherent qualities of these stem cells is crucial for optimizing their therapeutic efficacy.

Methods: Olfactory epithelial samples were collected from patients with deviated nasal septum (DNS) and chronic rhinosinusitis (CRS).

Mechanisms of reduced efficacy of HER2-targeted therapy in HER2-low breast cancer by long-term nicotine exposure in patient-derived xenograft mouse tumor models.

The effects of long-term nicotine exposure on the treatment of HER2-positive breast cancer have only been studied epidemiologically, leaving the molecular mechanisms unclear. Therefore, it's challenging for clinicians to devise effective treatments based on this correlation. Our investigation explores the effects of prolonged nicotine exposure on the interaction between α9-nAChR and HER2 in HER2-positive breast cancer cells, highlighting its impact on anti-HER2 drug therapy efficacy.

Alda‑1 restores ALDH2‑mediated alcohol metabolism to inhibit the NF‑κB/VEGFC axis in head and neck cancer.

The adaptation of cancer cells to hostile environments often necessitates metabolic pathway alterations to sustain proliferation and invasion. Head and neck cancer (HNC) has unfavorable outcomes. Therefore, elucidating the functional effects and molecular mechanisms underlying metabolic changes is key.

A Comparative Analysis of Laser-Ablated Surface Characteristics Between the Si Face and C Face of Silicon Carbide Substrates.

Silicon carbide (SiC) has significant potential as a third-generation semiconductor material due to its exceptional thermal and electronic properties, yet its high hardness and brittleness make processing costly and complex. This study introduces ultraviolet laser ablation as a method for direct SiC material removal, investigating the effects of varying scanning speeds on surface composition, hardness, and ablation depth. The results indicate optimal processing speeds for the Si and C faces at 200 mm/s and 100 mm/s, respectively.

Biocompatible Heterogeneous Packaging and Laser-Assisted Fluid Interface Control for In Situ Sensor in Organ-on-a-Chip.

The development of bionic organ-on-a-chip technology relies heavily on advancements in in situ sensors and biochip packaging. By integrating precise biological and fluid condition sensing with microfluidics and electronic components, long-term dynamic closed-loop culture systems can be achieved. This study aims to develop biocompatible heterogeneous packaging and laser surface modification techniques to enable the encapsulation of electronic components while minimizing their impact on fluid dynamics.

What does it mean when the pleasant smells come and go? Correlation between UPSIT odor identification status and fluctuation of non-motor symptoms in Parkinson's disease.

Parkinson's disease (PD) is characterized by motor and non-motor symptoms, including olfactory dysfunction. Prior studies have shown that olfaction deteriorates with disease progression, however fluctuations in olfaction and related PD symptoms have been less explored. This study aimed to investigate correlations between changes in odor identification ability and PD symptoms.

Interfacial Elemental Analysis of Slanted Edge-Contacted Monolayer MoS Transistors via Directionally Angled Etching.

Edge contacts offer a significant advantage for enhancing the performance of semiconducting transition metal dichalcogenide (TMDC) devices by interfacing with the metallic contacts on the lateral side, which allows the encapsulation of all of the channel material. However, despite intense research, the fabrication of feasible electrical edge contacts to TMDCs to improve device performance remains a great challenge, as interfacial chemical characterization via conventional methods is lacking. A major bottleneck in explicitly understanding the chemical and electronic properties of the edge contact at the metal-two-dimensional (2D) semiconductor interface is the small cross section when characterizing nominally one-dimensional edge contacts.

Prolapsed fallopian tube to the vagina after hysterectomy a year ago: A case report.

Objective: This case report aims to present a rare occurrence of fallopian tube prolapse into the vaginal vault following hysterectomy, underscoring the importance of recognizing this uncommon complication.

Case Report: A 45-year-old woman, with a history of hysterectomy for adenomyosis, presented with symptoms mimicking a vaginal tumor, including persistent discharge, abdominal pain, postcoital bleeding, and weight loss. Imaging raised concerns of malignancy, but surgery revealed a prolapsed fallopian tube with chronic inflammation.

Clinical Outcomes of a Modified Technique Combining Submucosal Turbinectomy and Extended Neural Targeting in Chronic Rhinitis Management.

Background/aim: This study evaluated the outcomes of combining submucosal turbinectomy with extensive disruption of the pterygopalatine ganglionic efferent nerve fibers through a minimucosal incision in patients with intractable rhinitis, irrespective of their dependency on the posterior nasal nerve.

Patients And Methods: We describe an endoscopic extended neurectomy procedure performed via a minimucosal pocket. The primary outcome measures included the Total Nasal Symptom Score (TNSS), Visual Analog Scale (VAS) score, and runny nose and nasal obstruction subdomains of the Sino-Nasal Outcome Test-22 (SNOT-22), which were assessed pre-procedure and at 3 and 6 months post-procedure.

Barriers to quality cancer care: a qualitative exploration of oncology case managers' experiences in facilitating guideline implementation in Taiwan.

Background: In cancer care, the use of clinical practice guidelines (CPGs) has been shown to improve the quality and effectiveness of medical services. To facilitate physicians' adherence to these guidelines, Taiwan established the position of oncology case manager (OCM) in 2010, one of whose responsibilities is to monitor physicians' compliance. However, there have been few explorations of their experiences and the barriers they face in facilitating guideline implementation.