In vitro and in vivo degradation behavior of an assembled magnesium alloy suture anchor for ligament-bone reconstruction.

Biodegradable magnesium alloys suture anchors face rapid anchor eyelet degradation, compromising mechanical strength. In this study, an assembled-structure magnesium alloy suture anchor was proposed to mitigate the fast failure of anchor eyelet. In vitro and in vivo experiments were conducted to evaluate the degradation behavior and biomechanical performance of assembled ZE21C magnesium alloy suture anchors.

High matrix stiffness triggers testosterone decline in aging males by disrupting stem Leydig cell pool homeostasis.

Aging is closely related to the decline of male reproductive endocrine function, which is manifested as insufficient testosterone production. It is well known that stem cell pool stability is crucial for maintaining tissue function. However, the relationship between aging and the stem Leydig cell (SLC) pool homeostasis remains unclear.

Efficacy of 3D-Printed Bioactive Glass Tetrahedral Particles for Vertical Bone Regeneration: A Comparative Study.

This study was designed to systematically evaluate the osteogenic efficacy of 3D-printed tetrahedral bioactive glass particles in vertical bone regeneration and compare their performance with that of conventional bone substitute materials. In this investigation, 3D tetrahedral bioactive glass particles were fabricated using digital light processing (DLP) additive manufacturing technology. The structural integrity and chemical composition of the particles were characterized by scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), and X-ray diffraction (XRD) to confirm their conformity to design specifications.

Exogenous adenosine promotes barnacle (Amphibalanus amphitrite) cyprid settlement through molecular signaling and improved adhesive mechanics.

Marine biofouling caused by barnacle gregarious settlement poses significant challenges to various industries and ecosystems, such as increased drag on ship hulls, elevated fuel consumption, and heightened maintenance costs. While natural chemical cues are instrumental in driving barnacle settlement, the underlying mechanisms remain incompletely understood. In this work, we investigated the effects of adenosine (Ado), a settlement pheromone of Amphibalanus amphitrite cyprids, on cyprid exploration behavior, nano-mechanical properties of footprints, and gene expression using atomic force microscopy (AFM) and omics analysis.

Simulation-Based Design of an Electrically Tunable Beam-Steering Metasurface Driven by a Triboelectric Nanogenerator.

This study presents a simulation-based feasibility analysis of a beam steering metasurface, theoretically driven by mechanical energy harvested from human motion via a triboelectric nanogenerator (TENG). In the proposed model, the TENG converts biomechanical motion into alternating current (AC), which is rectified into direct current (DC) to bias varactor diodes integrated into each metasurface unit cell. These bias voltages are numerically applied to dynamically modulate the local reflection phase, enabling beam steering without external power.

Uncovering the Kinematic Signature of Freezing of Gait in Parkinson's Disease Through Wearable Inertial Sensors.

Parkinson's disease (PD) is a disorder that causes a decrease in motor skills. Among the symptoms that have been observed, the most significant is the occurrence of Freezing of Gait (FoG), which manifests as an abrupt cessation of walking. This study investigates the impact of spatiotemporal gait parameters using wearable inertial measurement units (IMUs).

Poly(Vinyl Alcohol)-Carbon Nanotube Self-Adhesive Hydrogels for Wearable Strain Sensors.

Wearable conductive hydrogel sensors, which are highly convenient, have attracted attention for their great potential in human motion monitoring and smart healthcare. However, the self-adhesive properties, sensing performance, and stability of traditional hydrogels are not ideal, which seriously hinders their use in monitoring and diagnosing joints throughout the human body. Here, CaCl is used to crosslink PVA to improve its self-adhesive properties, and it is then combined with a CNT conductive network.

Tough Hydrogel Reinforced by Meta-Aramid Nanofibers for Flexible Sensors.

Hydrogels exhibit significant promise for advanced flexible sensing applications owing to their intrinsic softness, biocompatibility, and customizable functionalities. Nevertheless, their limited mechanical strength poses a critical barrier to practical implementation. In this study, we engineered a mechanically robust alginate/chitosan (SA/CS) hydrogel reinforced with meta-aramid (PMIA) nanofibers.

Replication of the GWAS-Identified GALNT13 rs10196189 Polymorphism in Relation to Speed-Power Elite Active Athlete Status and Multidimensional Phenotypic Differences in Chinese Han Males: A Pilot Study.

: Previous multi-ethnic genome-wide association studies (GWAS) have identified the GALNT13 rs10196189 polymorphism as a potential genetic marker linked to sprint-power performance. However, its relevance in East Asian populations, particularly the Han Chinese, remains untested. This study aimed to replicate the association of rs10196189 with elite sprint-power athlete status in Han Chinese males and examine its potential influence on physical performance traits and tissue-specific gene regulation.

Current Mechanobiological Pathways and Therapies Driving Spinal Health.

Spinal health depends on the dynamic interplay between mechanical forces, biochemical signaling, and cellular behavior. This review explores how key molecular pathways, including integrin, yeas-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), Piezo, and Wingless/Integrated (Wnt) with β-catenin, actively shape the structural and functional integrity of spinal tissues. These signaling mechanisms respond to physical cues and interact with inflammatory mediators such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-α), driving changes that lead to disc degeneration, vertebral fractures, spinal cord injury, and ligament failure.

A comparative analysis of cardiopulmonary features in patients with systemic sclerosis and mixed connective tissue disease: results from SOPHIE registry.

Purpose: We aimed to identify various cardiopulmonary involvement patterns in patients with systemic sclerosis (SSc) and mixed connective tissue disease (MCTD).

Methods: Laboratory experiments, pulmonary function test, 6-min walk distance (6MWD), transthoracic echocardiography, and 12-lead electrocardiography were used to evaluate cardiopulmonary function in patients with SSc and those with MCTD..

Dosimetric and Clinical Effects of Polyethylene Glycol Gel in Radical Concurrent Chemoradiotherapy for Cervical Cancer: A Phase III Prospective Multicenter Randomized Controlled Trial.

Purpose: This study evaluated the safety and efficacy of PEG hydrogels in reducing rectal radiation dose and complication during cervical cancer radical concurrent chemoradiotherapy.

Methods And Design: This phase 3, randomized, parallel-controlled trial (NCT05690906) conducted across nine centers in China (July 2022-January 2025). Participants were randomized 1:1 to receive a 10 mL PEG hydrogel injection (experimental group) or no injection (control group) after 50.

Timosaponin B- II Enhances Osteogenic Differentiation of Human Periodontal Ligament Stem Cells via PI3K/AKT/GSK3β Signaling Pathway.

Background: This investigation aims to elucidate the effects of Timosaponin B-II (TB-II) on the proliferation and osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) through both in vitro experiments and an in vivo orthodontic tooth movement model utilizing rats. The primary objective is to clarify the mechanisms by which TB-II influences the remodeling of periodontal tissue under biomechanical stress, thereby providing insights into its potential role in reducing relapses after orthodontic tooth movement.

Methods: hPDLSCs were isolated and characterized via flow cytometry and multilineage differentiation assays (osteogenic and adipogenic induction).

Assessing the impact of long-term captivity on Saiga Antelope calcaneus mechanical characteristics by three-dimensional finite element simulation.

Background: This study investigates the mechanical properties of the calcaneus bone in saiga antelope (Saiga tatarica) compared to sheep (Ovis aries) to assess the impact of long-term captivity on bone characteristics. Mechanical testing was conducted to determine the compressive elastic modulus (E) and ultimate stress (σ) of cancellous and cortical bone. Additionally, finite element analysis (FEA) based on 3D models from Micro-CT scans was used to simulate stress distribution during running at full speed in saiga antelope.

Morphological and biomechanical responses of Lespedeza bicolor turcz. roots to long-term phosphorus addition at high altitudes.

Plant root morphology and mechanics are key determinants of slope stability. Soil phosphorus availability is typically limited in high-altitude regions subjected to engineering disturbances. Understanding how phosphorus supply shapes root traits is therefore crucial for enhancing vegetation restoration and slope stabilization in disturbed landscapes.

Microdamage in biological hard tissues and its repair mechanisms.

Microdamage often occurs in biological hard tissues which mainly include bone tissue and tooth hard tissue, and it primarily comprises diffuse damage and microcracks. The unique microscopic structures of biological hard tissues directly influence the initiation and progression of microcracks. Mechanical forces, loading methods, macroscopic tissue characteristics, aging-related changes, diseases, and medication factors contribute to the complexity of analysis in studying microdamage of biological hard tissues.

Comparison of corneal biomechanics in post-smile, post-LASEK, and normal eyes with Brillouin microscopy.

Purpose: To characterize corneal biomechanics in post-small-incision lenticule extraction (SMILE), post-laser-assisted subepithelial keratomileusis (LASEK), and normal eyes using Brillouin microscopy.

Methods: This study included myopic patients who underwent corneal refractive surgery (SMILE or LASEK) at least 1 month prior to ensure corneal stability. A total of 177 eyes (79 post-SMILE, 24 post-LASEK, and 74 untreated normal eyes) from 177 patients were evaluated using Pentacam HR and Brillouin microscopy for morphological and biomechanical assessment, respectively.

Carbohydrate Quantity vs. Quality in Polycystic Ovary Syndrome: Population-Based Meta-Analysis Combined with GBD Data-Driven Assessment.

Introduction: Polycystic ovary syndrome (PCOS), a common metabolic-endocrine disorder, is linked to low-quality carbohydrate intake, though evidence remains controversial. This research aimed to evaluate carbohydrate quantity/quality impacts on PCOS by combining global trends from the Global Burden of Disease (GBD) 2021 database with pooled study from individual-level data.

Methods: We analyzed GBD 2021 data to assess annual trends in PCOS incidence and low-grain/high-sugar-sweetened beverage consumption.

Pressure-Activated Breathable Liquid-Metal Electrodes for Long-Term Sleep Electroencephalogram Monitoring.

Sleep electroencephalography monitoring has become an effective strategy for health evaluation. However, conventional gel electrodes suffer from inherent limitations such as moisture loss and poor breathability, compromising long-term signal stability and wear comfort. Here, we present a facile strategy for fabricating breathable, biocompatible liquid-metal electrodes with enhanced interfaces.

Numerical study on low-density lipoprotein transport in intracranial aneurysms and its association with wall enhancement.

The frequent detection of wall enhancement by vessel wall imaging in unstable or ruptured intracranial aneurysms (IAs) implies the potential involvement of blood substance transport in the pathogenesis of IAs. In this study, we developed a new method for simulating the transport of low-density lipoprotein (LDL) in IAs. The method was characterized by the coupled solution of LDL transport behaviors in lumen, across endothelium, and within vessel wall, and the incorporation of a sub-model that accounts for the combined effect of wall shear stress (WSS) magnitude and oscillatory shear index (OSI) on endothelial permeability to LDL.

Advances in Fracture Fixation: Enhancing Stability and Promoting Healing.

Advancements in fracture fixation have significantly reshaped orthopedic trauma management by improving mechanical stability and promoting biological healing. This retrospective observational study assessed clinical and biomechanical outcomes in 500 patients who underwent surgical fixation for radiologically confirmed fractures. Patients were categorized into two groups: Group A received conventional fixation methods (e.

Safety evaluation for heavy vehicle drivers using extreme value model based on the multi-source sensing data.

Increasingly, the collection of multi-source sensing data from heavy vehicles through intelligent networked platforms has become prevalent for safety management and supervision. However, practical approaches for crash risk management and safety evaluation have not been fully developed to capitalize on this high-value driving data. This study proposed a safety evaluation framework for heavy vehicles using the extreme value modeling approach.

Tumor Stiffness-Enhanced Room Temperature Phosphorescence Imaging Using Dual-Ligand Nanoprobes.

Organic room temperature phosphorescence (RTP) materials offer high tumor-to-background imaging contrast owing to their long afterglow and minimal autofluorescence interference. In this work, a targeted phosphorescent nanoprobe is prepared based on a pyrene/benzophenone (PyBP) guest-host system and further functionalized it with folic acid and cyclic Arg-Gly-Asp peptide for enhanced tumor specificity. In oral squamous cell carcinoma (OSCC) xenograft models, this dual-ligand nanoprobe can help achieve a four-fivefold increase in the tumor signal over the background.

Microchannel-confined droplet-based electricity generator for biomechanical energy conversion and sensing.

Triboelectric nanogenerators (TENGs) are positioned as a critical sustainable power solution for harvesting low-frequency mechanical energy or sensing. Although solid-solid contact-based TENGs can provide sustainable power to diminish external battery reliance and enhance portability and operational longevity, suboptimal energy output at low-frequency excitation, irreversible material damage under long-term operation and inadequate energy supply remain a challenge. Solid-liquid contact-based TENGs present an alternative approach, but rigid and bulky configurations hinder their integration toward wearable devices and the development of real applications.

Implants for fixation of intertrochanteric femoral fracture: a systematic review and network meta-analysis of randomized controlled trials.

Background: A variety of implant devices have been used for treatment of intertrochanteric femoral fractures (IFF), but the optimal has long been disputed. We aim to summarize the latest evidence for the effectiveness and safety of implants for IFF.

Methods: This systematic review and network meta-analysis included searches of PubMed, Embase, the Cochrane Library, and Web of Science from January 1, 2000 to August 31, 2024, for randomized controlled trials of implants in older adult patients with intertrochanteric femoral fracture.