Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes.

Background: Tooth implant treatment is frequently accompanied by postoperative pain and swelling. While dexamethasone is known to mitigate these symptoms, the optimal administration method remains unclear. This study compared the effects of different administration methods of dexamethasone on alleviating pain and swelling after flap implantation surgery.

[Research Advances in the Replication of Animal Models for Periodontal Diseases].

Rodent models play a crucial role in research on human periodontal diseases, providing key evidence for investigation into the pathological mechanisms of periodontal bone defects. Relevant research in the field involves gene expression, inflammatory regulation mechanisms, host-microbial interactions, as well as disease resolution and healing processes. Research methodology in the field falls under 2 categories-periodontal inflammation models and surgical defect models.

Audio-visual crossmodal connectivity in perceiving distorted speech: A comparison between patients with cleft palate and typical listeners.

This study investigates audio-visual crossmodal connectivity during the perception of distorted speech using task-based functional magnetic resonance imaging (fMRI). A randomized block design was employed, involving 20 patients with cleft palate and 20 typical listeners. Participants underwent perceptual tasks involving both cleft-related glottal stop and typical speech while fMRI scans were conducted.

Single cell dissection reveals SFRP2+ fibroblasts amplifying inflammatory responses in oral lichen planus.

Objectives: Oral lichen planus (OLP) is a chronic inflammatory mucosal disease with an incompletely understood pathogenesis. This study aimed to investigate the role of disease-specific fibroblasts in OLP.

Methods: We performed single-cell RNA sequencing on buccal mucosa of 4 OLP patients and one healthy control.

Comprehensive 3D measurements of condyle changes in patients with class III asymmetry after bimaxillary orthognathic surgery.

Objectives: The present study was aimed to assess three-dimensional (3D) quantitative changes of condyle in patients with Class III facial asymmetry after bimaxillary orthognathic surgery.

Materials And Methods: Fifty-five eligible patients with Class III facial asymmetry received Le Fort I osteotomy and bilateral sagittal split osteotomy (BSSO) with or without genioplasty from January 2020 to June 2022 were included. Cone-beam computed tomography (CBCT) for each patient was collected at 3 stages: 1 week preoperatively (T0), immediately after surgery (T1) and at least 12 months postoperatively (T2).

M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway.

Background: Research indicates that the mitochondrial function of mesenchymal stem cells in the periodontal inflammatory microenvironment is impaired, leading to insufficient osteogenic differentiation. Mitochondrial transplantation has emerged as a promising treatment for mitochondrial dysfunction. In this study, we transplant M2 macrophage-derived mitochondria (M2-MT) into human periodontal ligament stem cells (hPDLSCs) in inflammatory states, and investigate its effect on the regulation and mechanism of osteogenic differentiation and metabolic status of hPDLSCs.

Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery.

Peri-implant keratinized mucosa (PIKM) augmentation refers to surgical procedures aimed at increasing the width of PIKM. Consensus reports emphasize the necessity of maintaining a minimum width of PIKM to ensure long-term peri-implant health. Currently, several surgical techniques have been validated for their effectiveness in increasing PIKM.

A generalized defect-data-free defect inspection method based on image reconstruction and anomaly detection.

This paper presents a novel framework based on hierarchical image reconstruction, employing image reconstruction and anomaly detection techniques. Unlike traditional supervised methods, our approach operates without the need for defect-specific training data, enabling generalization across diverse product types. Using hierarchical reconstruction modules and a self-attention mechanism, our method achieves an average precision of 97.

Bioactive glass-induced B cell depletion remodels the osteoimmunological microenvironment to enhance osteogenesis.

B cells are critical in bone homeostasis, and their dysfunction is linked to various bone disorders. Bioactive glasses (BGs) are known for their immunomodulatory properties and are increasingly utilized in bone regeneration. However, the specific effects of BGs on B cells and their subsequent impact on osteogenesis remain unclear.

10-MDP in dentin bonding: a novel role in pulp protection via modulation of dental pulp stem cell behavior.

Objectives: 10-methacryloyloxydecyl dihydrogen phosphate (10-MDP)-containing adhesives applied to deep dentin cavities near the pulp have demonstrated clinical success without pulp capping. 10-MDP has been reported to exhibit cytotoxic effects on the pulp. However, within the dentin bonding interface, 10-MDP predominantly exists in the form of calcium salts.

[A preliminary exploration of an intelligent system for personalized tooth morphology reconstruction based on deep learning].

To integrate implicit templates with deep learning techniques, a novel neural network, the tooth-deformable deep implicit network (T-DDIN), was constructed to achieve high-precision shape completion of tooth defects in a personalized manner. A total of 550 intraoral scan models were collected from patients treated at the Department of Orthodontics and Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University (500 for training and 50 for testing), between March 2022 and March 2024. T-DDIN reconstructed defective tooth morphology using an implicit template and a latent encoding prediction network.

IL1RA inhibits the progression of oral squamous cell carcinoma by mediating type Ⅰ interferon response.

Interleukin-1 receptor antagonist (IL1RA) is an anti-inflammatory and anti-tumor protein, and a member of the Interleukin-1 (IL-1) family. Our previous finding showed that IL1RA is a tumor marker for oral squamous cell carcinoma (OSCC), but the exact mechanism is unknown. The present study aims to investigate the biological role of IL1RA in the progression of OSCC in vitro and in vivo and the underlying molecular mechanism.

High VEGF Secretion Using Co and B Co-doped Bioactive Mesoporous Glass Nanoparticles for Enhanced Angiogenesis.

This investigation presents a novel approach to engineering mesoporous bioactive glass nanoparticles (MBGNs) through selective ion doping. This method can significantly potentiate their physicochemical properties and biological performance. We elucidate the effects of boron (B) and cobalt (Co) doping, individually and in combination, on MBGNs' structural, functional, and biocompatible characteristics.

Molecular-Level Strategy from Bottom-Up to Acquire High-Efficiency Antimicrobial Peptides.

The escalating threat of multidrug-resistant pathogens necessitates efficient antimicrobial development, in which antimicrobial peptides (AMPs) have been extensively studied due to their broad-spectrum antibiotic activity. Combining sum frequency generation and molecular dynamics simulation, we rationally designed AMPs by identifying two structural principles. Simply increasing the number of basic amino acids does not reliably improve antimicrobial efficacy; terminal (N' and C') phenylalanine residues can enhance AMP's membrane interfacial activity via the hydrophobic effect.

p16INK4a downregulation alleviates temporomandibular joint osteoarthritis combined with type 2 diabetes by driving M2 polarization.

Temporomandibular joint osteoarthritis (TMJOA), sometimes combined with type 2 diabetes (T2DM-TMJOA), has a restricting effect on quality of life and currently has few efficacious treatment options. As such, this project sought to determine the role of p16INK4a (p16) in T2DM-TMJOA development. In vivo, p16 knockout (P16KO) mice experienced less condylar bone loss and altered macrophage polarities from the inflammatory M1 to anti-inflammatory M2.

Porphyromonas gingivalis Outer Membrane Vesicles Promote Gingival Fibroblasts Senescence via IL21R-AS1.

Aims: Periodontitis, a chronic inflammatory disease, is associated with accelerated cellular senescence. This study aims to explore how Porphyromonas gingivalis (P. gingivalis) outer membrane vesicles (OMVs) induce senescence and senescence-associated secretory phenotype (SASP) in human gingival fibroblasts (HGFs), focusing on the role of lncRNAs in promoting periodontitis progression.

Impact of Soft Palate Extension and Elevation on Pharyngeal Airflow in Cleft Palate Patients: A Computational Fluid Dynamics Study.

The aim of the study was to investigate the changes in pharyngeal airflow pressure and velocity in cleft palate patients following palatoplasty with different soft palate lengths and heights using computational fluid dynamics (CFD) analysis. A pathological model of velopharyngeal insufficiency was developed based on computed tomography data from patients with cleft palate. Computational fluid dynamics analysis was performed to simulate soft palate extension and elevation during palatoplasty, and the aerodynamic characteristics of the upper airway and the impact of these modifications on velopharyngeal closure were analyzed.

aggravates inflammatory response in mice oral mucositis through regulating Th17/Treg imbalance.

Introduction: Microbial dysbiosis links to mucosal immune dysregulation, but the specific bacterial contributions to oral mucosal inflammation remain unclear. (), a pathogen well-characterized in mucosal immunity and immune regulation studies, has been observed to be enriched in chronic oral inflammatory lesions and was reported to modulate T helper 17 cells (Th17)/T regulatory cells (Treg) homeostasis. Here, we developed an oral mucositis mouse model via tongue scratch and topical application to investigate its role in Th17/Treg imbalance.

Association between 3D characteristics of single unilaterally impacted mesiodens and root development of adjacent maxillary central incisors: a retrospective study with cone-beam computed tomography.

Objectives: This study aimed to evaluate the detrimental effects of single unilaterally impacted mesiodens on the root development of adjacent maxillary central incisors and to explore the key influencing factors.

Methods: A total of 552 patients aged 5-12 years with single unilaterally impacted mesiodens were included in the study. The maxillary central incisor with greater overlap with the mesiodens in the coronal view was identified as the affected tooth, while the contralateral central incisor served as the control one.

Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.

Objectives: This study aimed to evaluate the effects of Biodentine on human Dental Pulp Stem Cells (hDPSCs) proliferation and senescence and explore the underlying anti-aging mechanism.

Methods: hDPSCs were isolated from two groups of patients aged 18 to 27 and 60 to 70 years and treated with Biodentine extract. The optimal concentration of Biodentine extract was determined using the CCK-8 assay.

PDGF-BB overexpressing dental pulp stem cells improve angiogenesis in dental pulp regeneration.

Introduction: Angiogenesis represents a critical challenge in dental pulp regeneration due to the tissue's restricted nutrient supply through a 0.5-mm apical foramen. While dental pulp stem cells (DPSCs) hold regenerative potential, their limited vascularization capacity impedes clinical applications.

OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca transfer.

Aims: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease linked to disrupted chondrocyte activity and cartilage homeostasis. This study aimed to clarify the protective role of optineurin (OPTN) in preventing chondrocyte apoptosis during TMJ OA progression.

Materials And Methods: Using bioinformatics analysis, Optn was identified as a key gene in chondrocyte regulation.

Release of microplastics during dental procedures and denture wear: Impact on dental personnel and patients.

Plastic products are widely used in modern dentistry, including dental instruments and resin-based materials. In recent years, microplastics (MPs) that are generated from plastic products have been demonstrated to pose negative impacts on human health. However, the possible exposure of MP during dental procedures has been rarely explored.

In Vitro Antimicrobial Efficacy of Irrigants With Ni-Ti Instruments on Mixed Biofilm in Premolar Root Canals With Conservative Access Cavity.

Conservative access cavity (ConsAC) has been increasingly advocated to preserve tooth structure, but its effect on disinfection efficacy against complex biofilms remains unclear. This study evaluated the effectiveness of different irrigants combined with Ni-Ti instruments on mixed biofilms of Enterococcus faecalis and Candida albicans in maxillary premolars with ConsAC or traditional access cavity (TradAC). A total of 208 extracted intact premolars were divided into ConsAC and TradAC groups.