Nanoscale metal-organic frameworks as a versatile platform for synergistic combination tumor therapy.

As the second most common cause of death globally, tumor significantly impacts human health and quality of life. Although monotherapy has achieved remarkable progress, its therapeutic effectiveness remains less than ideal. The current strategy is increasingly inclined towards a combination of different treatments.

Bacteroides dorei RX2020-derived bile acid alleviates influenza virus infection through TGR5 signaling.

Background: The role of the gut microbiome in respiratory infections is increasingly recognized. We have found that a gut commensal strain, Bacteroides dorei RX2020 (B. dorei) previously isolated from healthy human fecal microbiota, alleviates influenza virus infection, but the underlying mechanisms remain elusive.

Regulation of mitochondrial autophagy via the PINK1/Parkin pathway to improve cognitive function in vascular dementia using governor vessel acupuncture.

Background: As a common cognitive impairment disease, vascular dementia (VD) belongs to the category of "dementia" in Chinese medicine, and should be treated with the principle "Governor Vessel" as the primary focus. The occurrence of VD is closely related to cerebral ischemia, hippocampal neuron damage, and excessive mitochondrial autophagy activation, which has been considered as is a key mechanism of PINK1/Parkin signaling pathway regulation. Our study aims to investigate molecular mechanisms of the Governor Vessel acupuncture method in improving VD cognitive dysfunction by regulating mitochondrial autophagy.

Integrating piezoelectric dressings with botanicals as emerging smart dressings for diabetic wound healing.

Diabetic foot ulcers (DFUs) are a common type of chronic wound characterized by slow healing, susceptibility to infection, and high amputation rates, causing significant suffering and economic burden to patients. Unfortunately, existing first-line treatments often fail to deliver desired outcomes, highlighting the urgent need for more effective solutions. Appropriate wound dressings can provide a favorable microenvironment for healing, making them an essential component of effective DFU management.

Asthma Detection Research Based on Voice Signal Processing and Machine Learning.

To analyze voice signals and identify asthma patients using voice signal analysis and machine learning techniques, we collected clear, low-noise fixed-pattern voice signals from 50 asthma patients and 50 healthy controls to build an analysis database. The research conducted multi-dimensional voice signal analysis based on MATLAB and selected voice feature indicators with significant differences between asthma patients and healthy controls. After dimensionality reduction analysis on differential phonetic features, the processed features were incorporated into subsequent SVM and RF modeling and classification research.

Huangqi Guizhi Wuwu decoction ameliorates myocardial damage in ovariectomized rats by regulating the structure and function of myocardial microvessels and intestinal flora.

Huangqi Guizhi Wuwu decoction (HGWD) is commonly used to treat cardiovascular diseases (CVDs), and HGWD could regulate intestinal flora and myocardial microvessels, this study aimed to examine whether HGWD could ameliorate myocardial damage in ovariectomized (OVX) rats by regulating the structure and function of myocardial microvessels and intestinal flora. A model of OVX rats was created, and histological examination through hematoxylin and eosin staining alongside TEM was employed to assess the microstructural lesions present in the myocardium. Myocardial microvasculature density was assessed using immunofluorescent staining.

Efficacy and safety of berberine on the components of metabolic syndrome: a systematic review and meta-analysis of randomized placebo-controlled trials.

Background: Metabolic syndrome (MetS) is a prevalent metabolic disease that significantly increases the risk of type 2 diabetes, cardiovascular diseases, and overall mortality. Current medications have limited effects on the various components of MetS. Berberine has demonstrated unique comprehensive therapeutic benefits for MetS, but its efficacy remains uncertain.

Advancements in bladder cancer immunotherapy: a focus on intravesical approaches.

Recent advances in bladder cancer immunotherapy have shown promise, particularly in addressing limitations of the current gold standard, Calmette-Guérin (BCG). Novel combinations, such as sasanlimab (a PD-1 monoclonal antibody) with BCG, have improved event-free survival in high-risk non-muscle-invasive bladder cancer (NMIBC). Intravesical anti-PD-1/PD-L1 agents like pembrolizumab and nadofaragene firadenovec have demonstrated efficacy and safety in BCG-unresponsive NMIBC, leading to regulatory approval.

A bibliometric and visualized analysis of research on mitochondria in myocardial ischemia from 2015 to 2024.

Background: Mitochondria, as the powerhouse of myocardial energy metabolism, have garnered considerable interest in the realm of myocardial ischemia (MI) therapy research. The purpose of this study is to illustrate the hot spots and frontiers of mitochondrial research in MI in the past decade through bibliometric analysis.

Methods: Both articles and reviews of mitochondrial research in MI from 2015 to 2024 were retrieved from the Web of Science Core Collection database.

Integrated chemical composition, transcriptomics, and network pharmacology to reveal the mechanism of Jia-Wei-Si-Miao-Yong-An Decoction in ACS model rats.

Background: Acute Coronary Syndrome (ACS), as the most critical pathological type of coronary atherosclerotic heart disease, has a high morbidity and lethality, and the long-term treatment of modern medicine is still faced with the problems of restenosis, microcirculation obstruction and drug resistance. The addition of Traditional Chinese Medicine provides new ideas for ACS treatment. Our previous study found that Jia-Wei-Si-Miao-Yong-An decoction (HJ11) can improve the inflammatory response and cardiac function in ACS.

Oral Health and Diabetic Cardiomyopathy: Mechanisms, Biomarkers, and Early Screening Approaches.

Diabetic Cardiomyopathy (DCM) is a common cardiovascular complication in patients with diabetes. In recent years, the association between oral health and diabetic heart disease has gained increasing attention. This perspective reviews the potential mechanisms of oral diseases in diabetic heart disease, oral indicators for early screening of diabetic heart disease, and proposes future research directions.

Tissue distribution of seven coptidis alkaloids in normal and insomnia rats affected by Cinnamomi cortex (Cinnamomum cassia) using liquid chromatography-tandem mass spectrometry.

Jiao-Tai-Wan (JTW), composed of Coptidis Rhizoma (CR) and Cinnamomi Cortex (CC) in a 10:1 ratio (w/w), is an ancient prescription effectively used for treating insomnia in China. The pharmacodynamic components of JTW are primarily coptidis alkaloids from CR; however, the therapeutic mechanism remains unclear now. This study aimed to discuss the effects of CC on pharmacokinetic characteristics of CR by analyzing the tissue distribution of seven main coptidis alkaloids.

Natural small molecule smart hydrogels inhibited the Hsp90/NF-κB signaling axis in inflammation to achieve sustained antipyretic effect.

In general, pseudoephedrine (PE) is a safe and universally employed in cold medicine, which displays powerful effect on antipyretic. Nonetheless, the sustained drug delivery system can effectively put an end to the above problems attributable to the drawbacks of low bioavailability and short intervals of administration. "Complexation" hydrogels are capturing enormous attention in a diverse array of fields in that there is no necessity to carry out external intervention for drug delivery.

Electrospun natural product-based Shidu Formula for the management of psoriasis.

The Shidu Formula (SDF) ointment is a natural product-based medicine that has a long history of use in treating psoriasis. Compared to standard first-line clinical medications, SDF remedies present certain advantages, particularly in terms of causing minimal skin irritations. However, several challenges have limited their widespread applications.

Identifying the target, mechanism, and agonist of α-ketoglutaric acid in delaying mesenchymal stem cell senescence.

α-ketoglutaric acid (AKG), a tricarboxylic acid cycle metabolite central to aerobic metabolism and longevity, retains unresolved anti-aging protein targets. Here, we demonstrate that reduced isocitrate dehydrogenase 1 (IDH1) expression during senescence lowers AKG production, accelerating the aging of mesenchymal stem cells (MSCs). Exogenous AKG or IDH1 overexpression restores AKG levels, enabling 2-oxoglutarate and Fe(II)-dependent oxygenase domain-containing protein 1 (OGFOD1)-catalyzed hydroxylation of ribosomal protein S23 (RPS23) at proline 62.

Efficacy of indigo naturalis nanofibrous patches in the treatment of chronic plaque psoriasis: a 4-week prospective, randomized, semi-compartmental paired, positive drug-controlled trial.

Background: Indigo Naturalis (IN) has been traditionally used for psoriasis treatment. We developed an IN-poly (ε -caprolactone, PCL)/poly (ethylene oxide, PEO) nanofibrous patch using electrospinning technology. Preliminary studies demonstrated its potential to reduces keratinocyte proliferation, inflammation, and neovascularization, addressing limitations of conventional IN formulations such as poor absorption and skin staining.

Risk Factors for Depression and Nomogram Prediction Among Chinese Coronary Heart Disease Patients: A Multi-Center Study from 2016 to 2018.

Background: This study aimed to assess the prevalence and identify risk factors associated with depression among coronary heart disease (CHD) patients at different stages in China.

Methods: Conducted as a hospital-based, cross-sectional study across 48 hospitals in 23 provinces, the research spanned from October 2016 to April 2018. A total of 9044 patients were initially recruited, with 8353 deemed eligible for participation.

Acupotomy for Musculoskeletal Pain: Exploring Therapeutic Potential and Future Directions.

Musculoskeletal pain imposes a significant burden due to its high prevalence and complex pathophysiology. This perspective paper examines the current knowledge regarding the underlying mechanisms of musculoskeletal pain conditions and explores the therapeutic potential of acupotomy. Preliminary evidence suggests that acupotomy holds promise in effectively alleviating pain, improving functional outcomes, and facilitating myofascial tissue healing in individuals with musculoskeletal pain.

Acupuncture with different frequencies for tobacco dependence: a randomized controlled trial.

Objective: To observe the effect of different acupuncture frequencies on the abstinence rate which could be used as a reference for optimizing acupuncture cessation programs.

Methods: From July 2018 to June 2022, a total of 220 smokers were recruited based on inclusion criteria and randomly divided into the high-frequency acupuncture group (HF group, 110): 5 times a week from the 1st to the 4th week, from weeks 5 to 8, three times a week and the low-frequency acupuncture group (LF group, = 110): 3 times a week from the 1st to the 4th week, from weeks 5 to 8, twice a week, then treated for 8 weeks and follow-up at 1 month in Beijing.

Results: In total, 162 subjects completed the whole study with a drop-out rate of 20.

Dingzhen pills inhibit neuronal ferroptosis and neuroinflammation by inhibiting the cGAS-STING pathway for Parkinson's disease mice.

Background: Parkinson's disease (PD) is a neurodegenerative disease whose cause and molecular mechanism remain unclear. Dingzhen pill (DZP), a water extract from crude herbs, is thought to possibly play a neuroprotective role in PD. However, the underlying pharmacological mechanisms of the DZP and its impact on the potential pathways against PD have not been elucidated.

Continuous glucose monitoring combined with artificial intelligence: redefining the pathway for prediabetes management.

Prediabetes represents an early stage of glucose metabolism disorder with significant public health implications. Although traditional lifestyle interventions have demonstrated some efficacy in preventing the progression to type 2 diabetes, their limitations-such as lack of personalization, restricted real-time monitoring, and delayed intervention-are increasingly apparent. This article systematically explores the potential applications of continuous glucose monitoring (CGM) technology combined with artificial intelligence (AI) in the management of prediabetes.

Panax notoginseng protects blood-retinal barrier by modulating microglia polarization via TLR4/MyD88/NF-κB pathway in endotoxin-induced uveitis.

Background: Panax notoginseng is a traditional Chinese medicine for promoting blood circulation and removing blood stasis. Panax notoginseng compound is widely used in the treatment of uveitis, however, the current research focuses on the compound, and the role of Panax notoginseng in the compound has not been elucidated.

Objective: The aim of this study was to explore the effects and potential molecular mechanism of Panax notoginseng against uveitis.

Synergistic multi-target anti-inflammatory mechanisms of luteolin, chikusetsusaponin IVa and carabrone in Houyanqing formula.

Ethnopharmacological Relevance: Identifying the effective active ingredients in herbs, screening their targets, and elucidating their mechanisms of action may represent a crucial strategy for discovering new combination drugs. Houyanqing (HYQ) formula is a patented plant extract approved for marketing in China, which exhibits good anti-inflammatory effects in clinical practice. However, it is currently unclear which chemical components play the main anti-inflammatory role.