Village and age based precision mapping of schistosomiasis and soil-transmitted helminths in Chevakadzi ward of Shamva district in Zimbabwe.

Schistosomiasis is earmarked for elimination as a public health problem, while morbidity control is a priority for soil-transmitted helminthiasis (STH) by 2030. To develop targeted interventions for the two diseases, micro-mapping and an understanding of disease transmission dynamics across different age groups are necessary. This study determined the age-stratified and ward-level prevalence of schistosomiasis and STH in Chevakadzi ward, Shamva district, Mashonaland Central province, Zimbabwe.

Understanding the Feasibility to Implement Schistosomiasis Elimination Project Under China-Zimbabwe Cooperation: A Pilot Study Protocol.

Background: Schistosomiasis is one of the major neglected tropical diseases in Africa, accounting for approximately 90% of the global burden. In Zimbabwe, Schistosoma haematobium and S. mansoni infections are endemic.

MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction.

One‑carbon metabolism plays an important role in cancer progression. Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), a mitochondrial enzyme in one‑carbon metabolism, is dysregulated in several cancer types. However, the precise role and mechanisms of MTHFD2 in esophageal squamous cell carcinoma (ESCC) remain unclear.

Snail control as a crucial approach to schistosomiasis elimination: evidence from the People's Republic of China.

Background: Asian schistosomiasis is projected to be eliminated by 2030 according to World Health Organization road map for neglected tropical diseases 2021-2030. Snail control is an important measure but has not yet been systematically evaluated at a country scale. Here, we report the findings from a nationwide survey to demonstrate the dynamics of Oncomelania and its potential role in transmission interruption of schistisomiasis in the People's Republic of China (P.

Surgical techniques for modular one-stage emergent pancreaticoduodenectomy for blunt abdominal trauma: experiences from three centres and a review of the literature.

Background: In this study, we report the use of a complex surgical intervention termed modular one-stage emergent pancreaticoduodenectomy (MOEPD) for the treatment of acute Grade IV or V pancreaticoduodenal injuries in haemodynamically stable patients. We summarize the experiences of surgeons performing MOEPD in 12 patients from 3 centres.

Methods: From 2015 to 2021, the clinical data of patients with blunt abdominal trauma who underwent MOEPD were extracted from three Chinese centres.

Proliferation of MDSCs may indicate a lower T cell immune response in schistosomiasis japonica.

Background: Schistosoma japonicum (S. japonicum) is the main species of Schistosoma prevalent in China. Myeloid-derived suppressor cells (MDSCs) are important immunoregulatory cells and generally expand in parasite infection, but there is little research relating to MDSCs in Schistosoma infection.

Using blood routine indicators to establish a machine learning model for predicting liver fibrosis in patients with Schistosoma japonicum.

This study intends to use the basic information and blood routine of schistosomiasis patients to establish a machine learning model for predicting liver fibrosis. We collected medical records of Schistosoma japonicum patients admitted to a hospital in China from June 2019 to June 2022. The method was to screen out the key variables and six different machine learning algorithms were used to establish prediction models.

[Spatial distribution characteristics of the prevalence of advanced schistosomiasis and seroprevalence of anti- antibody in Hunan Province in 2020].

Objective: To investigate the spatial distribution characteristics of the prevalence of advanced schistosomiasis and seroprevalence of anti- antibody, and to examine the correlation between the prevalence of advanced schistosomiasis and seroprevalence of anti- antibody in Hunan Province in 2020, so as to provide insights into advanced schistosomiais control in the province.

Methods: The epidemiological data of schistosomiasis in Hunan Province in 2020 were collected, including number of permanent residents in survey villages, number of advanced schistosomiasis patients, number of residents receiving serological tests and number of residents seropositive for anti- antibody, and the prevalence advanced schistosomiasis and seroprevalence of anti- antibody were descriptively analyzed. Village-based spatial distribution characteristics of prevalence advanced schistosomiasis and seroprevalence of anti- antibody were identified in Hunan Province in 2020, and the correlation between the revalence advanced schistosomiasis and seroprevalence of anti- antibody was examined using Spearman correlation analysis.

The characteristics of intestinal microbiota in patients with chronic schistosomiasis -induced liver fibrosis by 16S rRNA gene sequence.

Background: The intestinal microbiota is known to play a role in the development of liver disease, there is a limited understanding of the intestinal microbiota associated with chronic schistosomiasis . This study sought to explore the characteristics of the intestinal microbiota in patients with chronic schistosomiasis and identify potential biomarkers that could aid diagnosis.

Methods: A total of 40 residents of Qingshan Island in Yueyang (Hunan, China) were enrolled in this cross-sectional study.

IgG persistence showed weak clinical aspects in chronic schistosomiasis patients.

Schistosomiasis is a chronic parasitic disease, which affects the quality of daily life of patients and imposes a huge burden on society. Hepatic fibrosis in response to continuous insult of eggs to the liver is a significant cause of morbidity and mortality. However, the mechanisms of hepatic fibrosis in schistosomiasis are largely undefined.

[Preliminary study on the mechanism underlying the ecological isolation of populations in Changde City].

Objective: To investigate ecological isolation between snail populations in hilly regions and marshland and lake regions in Yuanjiang valley, Changde City, Hunan Province, and to unravel its underlying mechanisms.

Methods: Taoyuan County, Shimen County, Linli County and Lixian County in Changde City were selected as snail sampling sites in hilly regions, and Lixian County, Jinshi City, West Lake Administration District, Hanshou County and Dingcheng District were selected as snail sampling sites in marshland and lake areas. Cytochrome C oxidase 1 () gene was amplified in snail samples and sequenced.

Spatial Analysis of Schistosomiasis in Hunan and Jiangxi Provinces in the People's Republic of China.

Understanding the spatial distribution of schistosome infection is critical for tailoring preventive measures to control and eliminate schistosomiasis. This study used spatial analysis to determine risk factors that may impact infection and predict risk in Hunan and Jiangxi Provinces in the People's Republic of China. The study employed survey data collected in Hunan and Jiangxi in 2016.

[Progress of researches on schistosomiasis-associated pulmonary arterial hypertension].

Schistosomiasis-associated pulmonary arterial hypertension (Sch-PAH) is categorized as WHO Group I PAH because its clinical manifestations, laboratory and hemodynamic features share with PAH of other etiologies, such as idiopathic, heritable, HIV and autoimmune disorders. Sch-PAH is usually a life-threatening complication of hepatosplenic schistosomiasis characterized by changes in the vascular wall, remodeling and vasoconstriction with lesions primarily located in the precapillary segments of the pulmonary vasculature, which may result in a marked and sustained increase in pulmonary vascular resistance, right ventricular failure and ultimately death. Although egg deposition into lung and subsequent inflammatory cascades are key factors in the pathogenesis of Sch-PAH, the exact pathogenesis, course of disease and treatment of Sch-PAH remain largely uncertain.

[Diagnostic efficacy of indirect haemagglutination assay for detection of infections among boatmen and fishermen in the Dongting Lake region].

Objective: To evaluate the diagnostic efficacy of indirect haemagglutination assay (IHA) for detection of infections among boatmen and fishermen in Dongting Lake region, so as to provide insights into improving the schistosomiasis surveillance program among boatmen and fishermen.

Methods: The boatmen and fishermen were detected for infections using IHA and Kato-Katz technique or miracidium hatching test nylon gauze simultaneously at schistosomiasis testing sites in the anchor sites for boatmen and fishermen in the Dongting Lake region during the period from 2014 to 2016, and using IHA for serological screening followed by parasitological testing of seropositives during the period from 2017 to 2019. The sensitivity and specificity of IHA were evaluated for detection of infections among boatmen and fishermen, with the 2014-2016 parasitological testing results as a gold standard.

[Analysis of the new WHO guideline to accelerate the progress towards elimination of schistosomiasis in China].

On February 2022, WHO released the evidence-based guideline on control and elimination of human schistosomiasis, with aims to guide the elimination of schistosomiasis as a public health problem in disease-endemic countries by 2030 and promote the interruption of schistosomiasis transmission across the world. Based on the One Health concept, six evidence-based recommendations were proposed in this guideline. This article aims to analyze the feasibility of key aspects of this guideline in Chinese national schistosomiasis control program and illustrate the significance to guide the future actions for Chinese national schistosomiasis control program.

A case of severe hookworm infection.

With the improvement of sanitation, the infection rate of hookworm is greatly reduced and the severe infected case is rarely reported. Combined morphological and molecular biological examinations, a severe hookworm infection patient was diagnosed in Department of Laboratorial Examination, Quanzhou First Affiliated Hospital of Fujian Medical University. The morphological methods such as direct fecal smear microscopy, saturated brine flotation and hookworm larvae culture methods were used to identify the eggs and larvae from stool samples of the patient.

Schistosomiasis in the People's Republic of China - down but not out.

Schistosomiasis has been subjected to extensive control efforts in the People's Republic of China (China) which aims to eliminate the disease by 2030. We describe baseline results of a longitudinal cohort study undertaken in the Dongting and Poyang lakes areas of central China designed to determine the prevalence of Schistosoma japonicum in humans, animals (goats and bovines) and Oncomelania snails utilizing molecular diagnostics procedures. Data from the Chinese National Schistosomiasis Control Programme (CNSCP) were compared with the molecular results obtained.

Assessment of knowledge, attitude and practices and the analysis of risk factors regarding schistosomiasis among fishermen and boatmen in the Dongting Lake Basin, the People's Republic of China.

Background: Fishermen and boatmen are a population at-risk for contracting schistosomiasis due to their high frequency of water contact in endemic areas of schistosomiasis in the People's Republic of China (P. R. China).

High-resolution remote sensing-based spatial modeling for the prediction of potential risk areas of schistosomiasis in the Dongting Lake area, China.

The geographical distribution of snail (i.e., the intermediate host of schistosomiasis) is consistent with that of endemic areas.

[Global burden and challenges of parasitic diseases in Africa].

Parasitic diseases are common infectious diseases closely related to poverty, which are mainly endemic in the tropical and subtropical regions. Africa is the major epidemic area of parasitic diseases, and the global burden of malaria and schistosomiasis is over 85% in Africa. This paper reviews the disease burden, regional distribution and control strategies of the main parasitic diseases in Africa, in order to promote the prevention and control of parasitic diseases in this area.

Impact of the Three Gorges project on ecological environment changes and snail distribution in Dongting Lake area.

Background: The Three Gorges Dam (TGD) is a remarkable, far-reaching project in China. This study was conducted to assess the impact of TGD on changes in the ecological environment, snail distribution and schistosomiasis transmission in Dongting Lake area.

Methods: Hydrological data were collected from 12 monitoring sites in Hunan section of Yangtze River before and after TGD was established.