Remimazolam besylate versus propofol as sedative agents in cardiac surgery: A randomized noninferiority clinical trial.

Background: Remimazolam besylate, despite being widely used in various clinical settings, lacks evidence in cardiac anesthesia. This trial compared its efficacy with propofol in elective cardiac surgery.

Methods: A total of 320 adult patients undergoing elective cardiac surgery via cardiopulmonary bypass between December 2024 and March 2025 were randomized 1:1 to either propofol (1 mg/kg for induction and 1-1.

Recaticimab in adult heterozygous familial hypercholesterolemia (REMAIN-3): A multicentre, randomised, double-blind, placebo-controlled phase 3 study.

Aims: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disorder, characterised by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) from birth. This study aimed to assess the efficacy and safety of recaticimab, a new humanised anti-PCSK9 antibody capable of reducing LDL-C levels in patients with poorly controlled HeFH.

Methods And Results: REMAIN-3 was a multicentre, randomised, double-blind, placebo-controlled phase 3 study done at 25 sites in China.

Clinical Outcomes of RA FE-TLIF Compared to FE-TLIF in Patients With Lumbar Spondylolisthesis: A Retrospective Study.

Background: Lumbar spondylolisthesis (LS) is a spinal disorder that often necessitates surgical intervention. However, evidence on the comparative clinical value of robot-assisted full-endoscopic transforaminal lumbar interbody fusion (RA FE-TLIF) versus conventional FE-TLIF in early-grade (Grades I and II) LS remains limited, leaving uncertainty about its true clinical value in this patient population. This study aims to compare the clinical efficacy and safety of FE-TLIF with RA FE-TLIF in patients with Grade I and II LS.

The global burden of chronic kidney disease attributable to high sodium intake: a comprehensive analysis of trends from 1990 to 2021 and burden prediction to 2040.

Background: Chronic kidney disease (CKD) is a progressive condition affecting over 10% of the global population, with high sodium intake identified as a critical modifiable risk factor. This study investigated the global burden of CKD due to excessive sodium intake in 204 countries and territories from 1990 to 2021 and made the first future projections to 2040, addressing gaps in longitudinal analysis of sodium-related CKD trends and demographic differences.

Methods: Data from the Global Burden of Disease (GBD) 2021 database were analyzed to quantify CKD-related deaths and disability-adjusted life years (DALYs) linked to high sodium intake.

Dynamic mechanisms and targeted interventions in cerebral ischemia-reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies.

Cerebral ischemia-reperfusion injury (CI/RI) is a critical event causing secondary neurological deterioration following vascular recanalization in patients with ischemic stroke (IS), involving multiple interrelated pathological processes that synergistically aggravate brain injury. However, the underlying mechanisms remain incompletely elucidated, necessitating systematic investigation. This review systematically elucidates the dynamic pathological mechanisms underlying CI/RI during ischemic and reperfusion phases.

Artificial intelligence technologies for enhancing neurofunctionalities: a comprehensive review with applications in Alzheimer's disease research.

Alzheimer's disease (AD) is a progressive neurodegenerative condition that impairs memory and cognition, presenting a growing global healthcare burden. Despite major research efforts, no cure exists, and treatments remain focused on symptom relief. This narrative review highlights recent advancements in artificial intelligence (AI), particularly machine learning (ML) and deep learning (DL), which enhance early diagnosis, predict disease progression, and support personalized treatment strategies.

MKRN2 attenuates LPS-induced apoptosis in lung epithelial cells via ubiquitination-mediated p53 degradation.

The complex pathogenesis of acute respiratory distress syndrome (ARDS) underscores the therapeutic potential of targeting lung epithelial cell apoptosis. Makorin ring finger protein 2 (MKRN2), functioning as an E3 ubiquitin ligase, plays a critical role in regulating cell proliferation and apoptosis by specifically recognizing and promoting the degradation of p53. However, the precise mechanisms by which MKRN2 contributes to ARDS progression remain poorly understood.

Bioresorbable biliary stents: A step forward.

The case report by Elsayed presented a multidisciplinary approach to treating recurrent biliary strictures following proximal bile duct injury. Bioresorbable biliary stents, an innovative option for managing biliary strictures in recent years, are a key part of this approach. Unlike traditional metal/plastic stents, bioresorbable stents made from materials like polylactic acid (PLA) or polycaprolactone gradually degrade in the body.

Giant Morel-Lavallée lesion complicated with open pelvic fracture: a rare case report.

Background: Morel-Lavallée lesion (MLL) is a rare closed degloving injury from high-energy shear/crush trauma, often linked to pelvic/acetabular fractures. Due to limited clinical awareness, it is highly prone to misdiagnosis, potentially causing severe complications like infection and skin necrosis. Existing literature rarely documents giant MLL with open pelvic fractures.

Mechanism of action of cuproptosis and prospects for anti-tumor therapy.

In the study published in the by Xu , the expression profiles of cuproptosis-related genes in esophageal cancer and their prognostic significance were investigated. Cuproptosis, a novel form of copper-dependent cell death, has garnered significant attention in cancer research due to its mechanism closely linked to mitochondrial metabolism and protein lipoylation. This research systematically analyzed the prognostic value of cuproptosis-related genes by integrating multi-omics data from 151 esophageal cancer and normal tissue samples.

Study on the trajectory and influencing factors of post-stroke cognitive development: based on a group-based trajectory model.

Background: Post-stroke cognitive impairment (PSCI) is one of the major complications of stroke and exhibits a dynamic progression. This study uses the Group-Based Trajectory Model (GBTM) to fit cognitive development trajectories in stroke patients and analyze the influencing factors and trends of PSCI across trajectory groups. It aims to facilitate early identification and intervention for high-risk PSCI patients, providing a theoretical basis for optimizing intervention strategies.

Pharmacokinetics and pharmacodynamics studies of Relugolix long-acting microcrystalline formulation in male Beagle dogs.

Relugolix is the first oral GnRH receptor antagonist. However, its oral formulation requires daily administration, leading to poor patient adherence and suboptimal treatment outcomes for long-term users. To address these issues, we developed a long-acting microcrystalline formulation of relugolix administered once every 28 days.

CBX2 and EZH2 cooperatively contribute to 5-Fu resistance in gastric cancer by suppressing ferroptosis via trimethylation of H3k27.

Background And Objective: Chromobox 2 (CBX2) plays a pivotal role in the malignant phenotypes of several cancers, which has been found to up-regulated in gastric cancer (GC). This study aimed to investigate the specific function and underlying mechanism of CBX2 in GC.

Methods: The potential role of CBX2 in GC was uncovered based on online bioinformatic analysis.

RAS-RH up-regulates the level of miR-126 and inhibits the opening of mPTP in a rat model of coronary microvascular disease.

Background: Coronary microvascular dysfunction (CMVD) significantly impairs cardiac function and worsens prognosis in patients with cardiovascular diseases, yet no definitively effective pharmacological treatment currently exists. Endothelial cell injury stands as the core pathogenic mechanism of CMVD, however, the molecular mechanisms underlying X-ray radiation-induced endothelial damage remain poorly understood. Although our research group has previously demonstrated that RAS-RH possesses pro-angiogenic properties, its therapeutic potential and mechanistic basis in treating CMVD remain unexplored.

Targeting colorectal adenomatous polyps in type 2 diabetes: development of a risk assessment model.

Background And Aims: This study aimed to identify independent risk factors for colorectal adenomatous polyps in patients with type 2 diabetes mellitus (T2DM) and to develop a predictive model to facilitate early and targeted screening.

Methods: A total of 521 T2DM patients undergoing colonoscopy at Gansu Provincial People's Hospital (January 2022-May 2025) were retrospectively analyzed. Patients were randomly divided into a training set ( = 366) and a validation set ( = 155).

Near-Infrared Fluorescent Probe for the Early Diagnosis of Alzheimer's Disease.

Alzheimer's disease (AD) is a common progressive neurodegenerative disease characterized by abnormal deposition of amyloid-β protein (Aβ) and the formation of neurofibrillary tangles (NFT). Although there are drugs available for clinical treatment, they do not fundamentally cure AD, so early diagnosis and intervention for AD are essential. In recent years, near-infrared fluorescent (NIRF) probes have been widely used in diagnosing AD due to their advantages of high tissue penetration, low autofluorescence interference, and non-invasiveness.

A prognostic nomogram utilized lymph node ratio for signet ring cell gastric cancer patients post-surgery.

Background: Signet ring cell (SRC) gastric cancer is known for its aggressive behavior and poor prognosis. To date, no nomogram has been specifically developed for SRC gastric cancer patients post-surgery. Our objective was to create a nomogram to personalize the prediction of both overall survival (OS) and cancer-specific survival (CSS).

Application of 5G robotic telesurgery in urology: a multicenter study in the real world.

Background: The current literature still lacks robust real-life evidence to support the practical implications of telesurgery. We conduct the current study to evaluate the safety and effectiveness of telesurgery over a high-speed remote communication network (the 5G network) in the real world.

Methods: A total of 37 patients were enrolled across the participating hospitals from December 2023 to June 2024.

[Clinical Characteristics and Prognostic Analysis of Peripheral T-Cell Lymphoma, Not Otherwise Specified].

Objective: To investigate the clinical characteristics and prognosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS).

Methods: Clinical data of 10 patients with PTCL-NOS in Gansu Provincial Hospital from May 2016 to June 2023 were collected. The treatment outcomes were evaluated, and the factors affecting prognosis were analyzed.

The differential role of IL-33 and IL-38 in prostate cancer, contradictory roles.

Prostate cancer (PCa) is still as a major cause of morbidity and mortality in men at the global level, highlighting the necessity for improved diagnostic and therapeutic strategies beyond current PSA screening limitations. This mini-review focuses on the complex and often opposing roles of two key cytokines, IL-33 and IL-38, within the tumour microenvironment and their implications for host immunosurveillance in PCa. Intra-tumoral IL-33 expression is significantly reduced in PCa tissues and correlates with aggressive disease features such as higher Gleason scores and lymphatic metastasis, suggesting an inherent anti-tumour function.

The clinical application of mitoxantrone hydrochloride tracing in endoscopic radical resection of thyroid carcinoma.

To evaluate the effectiveness of tracer mitoxantrone hydrochloride injection (MHI) in mapping central lymph nodes and its role in preserving parathyroid function during endoscopic radical resection of thyroid carcinoma. A retrospective analysis was conducted on 82 patients with primary papillary thyroid carcinoma (PTC) who were treated at the Department of General Surgery, Gansu Provincial People's Hospital, from May, 2022 to May, 2024. All patients underwent endoscopic total thyroidectomy with central lymph node dissection (CLND), with 42 receiving intraoperative tracer mitoxantrone hydrochloride injection (observation group) and 40 not receiving the injection (control group).

The burden of Parkinson's disease, 1990-2021: a systematic analysis of the Global Burden of Disease study 2021.

Background: The pathogenesis of Parkinson's disease (PD) remains incompletely understood, has drawn significant attention within the scope of the Global Burden of Disease (GBD) study. Therefore, to explore PD's global burden and devise countermeasures is indispensable.

Methods: Data from GBD 2021 to analyze age standardized incidence rate (ASIR), prevalence rate (ASPR), mortality rate (ASMR), and disability adjusted life years (DALYs) rate (ASDR) burden of PD globally.

Advances in research on the correlation between LTCCBs and cardiovascular diseases: A review.

The prevalence of cardiovascular diseases has been rising globally, and various therapies have made significant strides in controlling the progression of these conditions and improving prognosis. Among these, pharmacological therapies have evolved rapidly and are increasingly integrated into clinical practice. Pharmacological treatments play a pivotal role in both basic research and clinical applications, particularly in deriving accurate conclusions from drug-related trials to address clinical challenges in drug selection and improve the cure rates of various diseases.