Green synthesis of iron-doped cobalt sulfide synergistic electronic and structural engineering in ethaline deep eutectic solvent for efficient oxygen evolution reaction.

The development of high-efficiency, earth-abundant electrocatalysts for the oxygen evolution reaction (OER) is essential for scalable green hydrogen production, yet challenges persist in balancing activity, stability, and cost. Herein, we present a sustainable approach to synthesize Fe-doped cobalt sulfide (Co-S-30Fe) nanoparticles using an ethaline deep eutectic solvent-mediated strategy, which enables precise control over Fe incorporation to optimize both structural and electronic properties. The engineered Co-S-30Fe/NF electrode exhibited exceptional OER performance in alkaline media, requiring an overpotential of only 278 mV at 100 mA cm, with a Tafel slope of 44.

Long-Chain Fatty Acid Redistribution Induced by SLC27A2 Deficiency Facilitates Hypoxic Adaptation and Immunosuppression in Hepatocellular Carcinoma.

Hypoxia, immune evasion, and metabolic reprogramming are key features of hepatocellular carcinoma (HCC) that limit the efficacy of therapies. Members of the solute carrier (SLC) family regulate metabolite homeostasis within tumor cells to maintain tumor survival under stressed conditions like hypoxia. Investigating the SLC family members could offer insights into the hypoxic microenvironment of HCC and potentially help identify improved therapeutic strategies.

Deep learning-driven multi-hierarchical granularity integration for surgical scene understanding: experimental study.

Background: A comprehensive understanding of surgical scenes by computers is a crucial foundation for achieving intelligent surgical assistance and autonomous decision-making. Surgical scene information encompasses coarse-grained data reflecting the overall process and fine-grained details showcasing specific operations. This study aims to construct a standardized, full-grained annotation dataset for laparoscopic radical nephrectomy and develop a deep learning framework for multi-hierarchical granularity integration, providing support for clinical intelligent applications.

Hierarchically Reinforcing Hydrogel for Multidimensional Bone Homeostasis Modulation to Regenerate Osteoporotic Defect.

To balance the requirement of high mechanical properties and convenient injectability for the hydrogel design of osteoporotic bone defects (OBD) repair, a hierarchical hydrogel stiffening strategy is proposed through the synergetic utilizing of rapidly formed dynamic hydrazone crosslinking, high-strength double-bond chemical crosslinking, and contraction of activated shape-memory short fibers (SMSFs). In detail, the Schiff Base reaction mediated first network enabled stable precursor retention at the injection site without compromising injectability. Subsequent radical polymerization by photocrosslinking enhanced the hydrogel stiffness from 9.

The relationship between occupational stress and burnout among primary and secondary school physical education teachers: evidence from multiverse-style analysis and diary method.

Background: To investigate the relationship between occupational stress and burnout among primary and secondary school physical education (PE) teachers and its underlying mechanisms.

Method: Study 1 utilized a large cross-sectional sample of 4,397 teachers and employed multiverse-style analysis to examine the robustness of the relationship between occupational stress and burnout. Study 2 applied a 21-day diary method to a sample of 324 teachers to explore the intrinsic mechanisms through which occupational stress affects burnout.

Integrating single-cell RNA sequencing and artificial intelligence for multitargeted drug design for combating resistance in liver cancer.

Hepatocellular carcinoma (HCC) is an aggressive and heterogeneous liver cancer with restricted therapy selections and poor diagnosis. Although there have been great advances in genomics, the molecular mechanisms essential to HCC progression are not yet fully implicit, particularly at the single-cell stage. This research utilized single-cell RNA sequencing technology to evaluate transcriptional heterogeneity, immune cell infiltration, and potential therapeutic targets in HCC.

An MRI-pathology foundation model for noninvasive diagnosis and grading of prostate cancer.

Prostate cancer is a leading health concern for men, yet current clinical assessments of tumor aggressiveness rely on invasive procedures that often lead to inconsistencies. There remains a critical need for accurate, noninvasive diagnosis and grading methods. Here we developed a foundation model trained on multiparametric magnetic resonance imaging (MRI) and paired pathology data for noninvasive diagnosis and grading of prostate cancer.

New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from Kadsura jaonica.

Phytochemical investigation of Kadsura japonica led to the isolation and characterization of six new lignans, including four tetrahydrobenzocyclooctabenzofuranone ones designated as kadjaponins A - D (1-4), and two dibenzocyclooctadiene ones named kadjaponins E and F (5 and 6), along with eighteen known analogues (7-24). The structural elucidation of these compounds was achieved through comprehensive spectroscopic analyses, including NMR, MS, and electronic circular dichroism (ECD). Notably, compounds 1 and 2 were found to feature an unprecedented epoxy moiety, prompting the expected structural revisions of three previously reported compounds, heteroclitin J, longipedlignan O, and longipedlignan P.

Influences of inter-bubble interactions on ultrasonic cavitation dynamics and subharmonic emissions in viscoelastic media with nonlinear elasticity.

Ultrasonic cavitation in viscoelastic media is a physical process that features in a variety of chemical reactions, food processing, and biomedical applications due to a range of cavitation-associated physical, chemical, and biological effects. The cavitation effects are essentially caused by the dynamic behaviors of oscillating bubbles, which are strongly influenced by the complex and various inter-bubble interactions. However, how cavitation bubbles interact with each other and these interactions subsequently influence the ultrasonic cavitation dynamics and acoustic emissions in viscoelastic materials still remain poorly understood.

Profiles of resilience and patient activation among patients with colorectal cancer and an enterostomy: A latent profile analysis.

Objective: This study aims to identify the latent profiles of resilience among patients with colorectal cancer and an enterostomy, analyze potential influencing factors, and explore the differences in patient activation across different profiles.

Methods: This cross-sectional study recruited a total of 375 patients with colorectal cancer and an enterostomy from three large public hospitals in Chongqing, China, between August 2024 and January 2025 using convenience sampling. Questionnaires used include sociodemographic information, a 10-item Connor-Davidson Resilience Scale, and a Patient Activation Measure.

Linoleic acid drives pulmonary lymphoepithelioma-like carcinoma progression via PPAR-α/TF axis.

Background: Primary pulmonary lymphoepithelioma-like carcinoma (pLELC) is a rare subtype of non-small cell lung cancer(NSCLC) with unclear etiological mechanisms. This study aimed to investigate the underlying molecular mechanisms and therapeutic targets for pLELC.

Methods: Retrospectively collected samples from advanced pLELC patients underwent proteomic and metabolomic analyses, and patient-derived xenograft (PDX) models were established for validation.

Copper-catalysed oxy-alkylation of styrenes enabled by halogen-atom transfer.

Herein, we present a mechanistically distinct approach to the multicomponent difunctionalisation of styrenes with alkyl halides and oxygen by integrating α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with copper catalysis under air-equilibrated conditions. This strategy eliminates the need for external peroxides or photoredox conditions, offering a streamlined and efficient alternative. Mechanism studies uncover a unique role for the copper catalyst: instead of directly activating alkyl halides, inexpensive CuCl oxidizes a tertiary amine to generate an α-aminoalkyl radical, which then drives XAT to release alkyl radicals.

Case Report: Polymyxin E-associated reversible leukopenia.

Introduction: With the increasing challenge of antibiotic resistance, polymyxin E is considered a last-line treatment option for infections caused by highly resistant bacteria. However, its use may lead to various adverse reactions, such as nephrotoxicity, neurotoxicity, and allergic reactions.

Case Presentation: This study describes a case of polymyxin E-associated leukopenia in a 50-year-old female treated for infection.

Abnormal structural changes and disturbed functional connectivity in patients with Crohn's disease and abdominal pain: a voxel-based morphometry and functional magnetic resonance imaging study.

Background: Abdominal pain is a prevalent and debilitating manifestation of Crohn's disease (CD) that significantly impacts the lives of those affected. The neurological pathways responsible for abdominal pain in patients with CD remain unidentified. Therefore, the purpose of this study was to characterize the structural alterations in the brain and associated functional connectivity (FC) in patients with CD and abdominal pain.

HDTV: a high-order directional total variation reconstruction algorithm from sparse and limited-angle data in electron paramagnetic resonance imaging.

Background: Electron paramagnetic resonance imaging (EPRI)-based oxygen imaging technology enables adaptive radiation therapy, thereby improving tumor control rates. However, the long scanning time limits the development of EPRI. In this study, we endeavored to reduce the scanning time.

Artificial intelligence-enhanced ultrasound imaging for thyroid nodule detection and malignancy classification: a study on YOLOv11.

Background: Thyroid nodules are a common clinical concern, with accurate diagnosis being critical for effective treatment and improved patient outcomes. Traditional ultrasound examinations rely heavily on the physician's experience, which can lead to diagnostic variability. The integration of artificial intelligence (AI) into medical imaging offers a promising solution for enhancing diagnostic accuracy and efficiency.

Repurposing drugs for the human dopamine transporter through WHALES descriptors-based virtual screening and bioactivity evaluation.

Computational approaches, encompassing both physics-based and machine learning (ML) methodologies, have gained substantial traction in drug repurposing efforts targeting specific therapeutic entities. The human dopamine (DA) transporter (hDAT) is the primary therapeutic target of numerous psychiatric medications. However, traditional hDAT-targeting drugs, which interact with the primary binding site, encounter significant limitations, including addictive potential and stimulant effects.

Stroke risk in women with or without hysterectomy and/or bilateral oophorectomy: evidence from the NHANES 1999-2018 and meta-analysis.

Objective: We aimed to assess the relationship between hysterectomy and/or bilateral oophorectomy and the risk of stroke-a topic of ongoing debate in current research.

Methods: We utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 to estimate both crude and multivariable-adjusted hazard ratios (HRs) and 95% CIs, applying survey-weighted Cox proportional hazards regression model. The modeling incorporated sampling weights and design variables to address NHANES's multistage probability sampling framework.

Single-Molecule Nanopore Detection of Non-Canonical Thymine-Melamine Hydrogen Bonding Base Pair in DNA Abasic Site.

The binding of small molecules to DNA may represent a mutagenic process capable of inducing genomic structural alterations and functional impairment. Melamine (MA), a toxic small molecule, exhibits a hydrogen-bonding interface structurally analogous to adenine, enabling to form non-canonical thymine-melamine (T-MA) base pairs like Watson-Crick pairing. This property allows MA to program DNA nanostructure formation.

Revealing Microstructural Evolution and Boron Depletion-Driven Acid Site Formation in Cr-Doped Aluminoborate for Xylose-To-Lactic Acid Catalysis.

Ionic doping is widely used to regulate surface acidity in catalytic materials, yet the microscopic mechanisms remain difficult to observe. Clarifying them is essential for acid catalysis design. Prior work showed that Cr doping into the AlO-based open-framework aluminoborate PKU-1 alters acidity.

Enantioselective Synthesis of -Cyclopentenyl Sulfoximines via the Catalytic Asymmetric Aza-Piancatelli Reaction.

Using sulfoximine as the amine source, a catalytic enantioselective aza-Piancatelli rearrangement of furylcarbinols was developed under chiral Brønsted acid (CBA) catalysis. This method enables the diastereo- and enantioselective synthesis of diverse -alkyl α-chiral sulfoximines in high yields under mild conditions. Selected derivatizations of the resulting products were conducted to showcase their chemical modifiability.

Development of an early prediction model for risk of influenza A and influenza B based on complete blood count examination.

Background: Influenza A (IAV) and B (IBV) viruses are the primary etiologic agents driving seasonal influenza epidemics and global pandemics. Early prediction plays a crucial role in epidemic control and reducing mortality rates. Complete blood count (CBC), a widely used clinical tool, provides rapid and non-invasive hematological biomarkers that offer diagnostic value during the pre-pathogen confirmation phase.

Development of a low-cost and high-throughput LC-MS method for newborn screening of thalassemia and abnormal hemoglobin disorders.

Background: Screening and pre-symptomatic diagnosis in newborns allows early treatment of thalassemia and abnormal hemoglobin (Hb) disorders in childhood. However, there remains a lack of efficient methods to screen for hemoglobinopathies in newborns. This study aimed to establish a bottom-up mass spectrometry (MS)-based method for efficient screening of hemoglobinopathies in newborns using dried blood spot (DBS) samples.