Long-term predictions of COVID-19 waves in China based on an improved SEIRS-Q model of antibody failure.

Introduction: China had already experienced two COVID-19 epidemics since the promulgation of 10 new prevention and control measures in December 2022.

Methodology: In response to the current frequent epidemics of severe acute respiratory syndrome coronavirus 2 variants in China and the gradual relaxation of prevention and control policies, we built and ran a susceptible-exposed-infective-removed-susceptible-quarantined model incorporating self-isolation to predict future cases of COVID-19.

Results: Four waves of outbreaks were predicted to occur in November 2023, and in April, July, and November 2024.

Unveiling the drivers of vancomycin-resistant enterococcus in China: A comprehensive ecological study.

Background: Vancomycin resistant enterococci (VRE) are now considered a global public health issue. In this study, we explored the relationship between vancomycin resistance incidence and various demographic and climatic factors.

Methods: This retrospective study was performed between January 1st, 2014 and December 31st, 2021.

Isolation, genetic, and biological characterization of human adenovirus type 55 positive isolates from Wuhan, China.

Background: Human adenovirus (HAdV) infection causes acute respiratory diseases in immunocompetent individuals worldwide. Infections by HAdV-55, one of the important pathogens leading to respiratory tract infections, often develop into pneumonia and are frequently associated with outbreaks in military camps and schools.

Methods: We studied 186 HAdV-55-positive nasopharyngeal swab samples that were collected from patients with respiratory infection in Wuhan, China, from 2018 to 2019.

Epidemiological Features and Evolutionary Analysis of Recombinant CVA24v in the Context of a Re-Emerging AHC Outbreak in China, 2023.

China experienced another outbreak of acute hemorrhagic conjunctivitis (AHC) in 2023, with a total of 195 297 recorded cases. This marks the third nationwide outbreak in nearly two decades, following previous outbreaks in 2007 and 2010. Descriptive epidemiological analysis shows that the number of cases in 2023 peaked in September, similar to the last two outbreaks.

Establishment of Real-Time PCR Method to Differentiate (Diptera, Psychodidae) from s.s. Based on Whole Mitochondrial Genome Analysis.

, considered a potential vector for visceral leishmaniasis (VL), is distributed in the southern Gansu and northern Sichuan regions in China. However, the high similarity in the morphology of and s.s.

Spherical Nucleic Acid Probes on Floating-Gate Field-Effect Transistor Biosensors for Attomolar-Level Analyte Detection.

Field-effect transistor (FET) sensors are attractive for the label-free detection of target biomolecules, offering ultrahigh sensitivity and a rapid response. However, conventional methods for modifying biomolecular probes on sensors often involve intricate and time-consuming procedures that require specialized training. Herein, we propose a simple and versatile approach to functionalize floating-gate (FG) FET sensors by exploiting the strong binding ability of polyvalent interactions and the three-dimensional structure of densely functionalized spherical nucleic acids (SNAs).

MicroNet-MIMRF: a microbial network inference approach based on mutual information and Markov random fields.

Motivation: The human microbiome, comprises complex associations and communication networks among microbial communities, which are crucial for maintaining health. The construction of microbial networks is vital for elucidating these associations. However, existing microbial networks inference methods cannot solve the issues of zero-inflation and non-linear associations.

Site Effect of Electron Acceptors on Ultralong Organic Room-Temperature Phosphorescence.

Herein, we successfully observe the site effect of electron acceptors on ultralong organic room-temperature phosphorescence (UORTP) in the case of 7-benzo[]carbazole (BCz) derivatives: cyanophenyl on the nitrogen site can promote intersystem crossing (ISC) efficiency and enhance phosphorescence intensity by facilitating -π* transitions but make a slight change to the phosphorescence wavelength; cyanophenyl on the naphthalene site can cause a remarkable red shift of phosphorescence wavelength by reducing the T energy level of BCz derivatives and also enhance phosphorescence intensity by promoting ISC but weaken phosphorescence intensity by lowering the molecular symmetry. Three BCz derivatives (1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN) with the electron acceptor cyanophenyl at different sites (nitrogen site and naphthalene site) were synthesized through a combination of the nucleophilic substitution reaction and the Suzuki coupling reaction. The phosphorescence properties of 1-BCzPhCN, 2-BCzPhCN, and 3-BCzPhCN in toluene solution, in a copolymerized MMA film, and in a PVA film were measured and analyzed.

Resveratrol Alleviated T-2 Toxin-Induced Liver Injury via Preservation of Nrf2 Pathway and GSH Synthesis.

T-2 toxin is a trichothecene mycotoxin and is considered as an extremely inevitable pollutant with potent hepatotoxicity. However, the approach to alleviation of T-2 toxin-triggered hepatotoxicity has been recognized as a serious challenge. Resveratrol (Res) is a polyphenol natural product isolated from various plant species, but its protective effect against T-2 toxin hepatotoxicity and detailed mechanism remains obscure.

Trim47 prevents hematopoietic stem cell exhaustion during stress by regulating MAVS-mediated innate immune pathway.

The maintenance of hematopoietic stem cell (HSC) functional integrity is essential for effective hematopoietic regeneration when suffering from injuries. Studies have shown that the innate immune pathways play crucial roles in the stress response of HSCs, whereas how to precisely modulate these pathways is not well characterized. Here, we identify the E3 ubiquitin ligase tripartite motif-containing 47 (Trim47) as a negative regulator of the mitochondrial antiviral-signaling protein (MAVS)-mediated innate immune pathway in HSCs.

Development of a TaqMan probe-based multiplex real-time PCR for the simultaneous detection of four clinically important filamentous fungi.

Unlabelled: Filamentous fungi present significant health hazards to immunocompromised individuals globally; however, the prompt and precise identification of them during infection remains challenging. In this study, a TaqMan probe-based multiplex real-time PCR (M-qPCR) assay was developed to detect simultaneously the target genes of four important pathogenic filamentous fungi: gene of gene of spp, mitochondrial gene of Mucorales, and gene of . In this M-qPCR assay, the limit of detection (LoD) to all four kinds of fungi was 100 copies and the correlation coefficients (R) were above 0.

Genotypic and phenotypic characteristics of Acinetobacter baumannii isolates from the people's hospital of Qingyang City, Gansu province.

Background: Acinetobacter baumannii (A. baumannii) is a common opportunistic pathogen in hospitals that causes nosocomial infection. In order to understand the phenotypic and genotypic characteristics of A.

SARS-CoV-2 seroprevalence and associated factors among people living with HIV in Sierra Leone.

Background: Human immunodeficiency virus (HIV) infection is an important risk factor for Coronavirus Disease 2019 (COVID-19), but data on the prevalence of COVID-19 among people living with HIV (PLWH) is limited in low-income countries. Our aim was to assess the seroprevalence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific antibodies and associated factors among PLWH in Sierra Leone.

Methods: We conducted a cross-sectional survey of PLWH aged 18 years or older in Sierra Leone between August 2022 and January 2023.

Relevance of genetic causes and environmental adaptation of Cronobacter spp. isolated from infant and follow-up formula production factories and retailed products in China: A 7-year period of continuous surveillance based on genome-wide analysis.

The possible contamination routes, environmental adaptation, and genetic basis of Cronobacter spp. in infant and follow-up formula production factories and retailed products in mainland China have been determined by laboratory studies and whole-genome comparative analysis in a 7-year nationwide continuous surveillance spanning from 2012 to 2018. The 2-year continuous multicenter surveillance of the production process (conducted in 2013 and 2014) revealed that the source of Cronobacter spp.

Effective of different industrial disinfection in subzero cold-chain environment.

Effective disinfection methods are crucial in the cold chain transportation process of food due to the specificity of temperature and the diversity of contaminated flora. The objective of this study was to investigate the sanitizing effect of different disinfectants on various fungi at - 20 °C to achieve accurate disinfection of diverse bacterial populations. Peracetic acid, hydrogen peroxide, and potassium bisulfate were selected as low-temperature disinfectants and were combined with antifreeze.

Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring bla in E. Coli ST167: implications for antibiotic resistance management.

Background: The emergence of multidrug-resistant (MDR) Escherichia coli strains poses significant challenges in clinical settings, particularly when these strains harbor New Delhi metallo-ß-lactamase (NDM) gene, which confer resistance to carbapenems, a critical class of last-resort antibiotics. This study investigates the genetic characteristics and implications of a novel bla-carrying plasmid pNDM-5-0083 isolated from an E. coli strain GZ04-0083 from clinical specimen in Zhongshan, China.

Lag effect of ambient temperature on respiratory emergency department visits in Beijing: a time series and pooled analysis.

Background: Although the association between ambient temperature and mortality of respiratory diseases was numerously documented, the association between various ambient temperature levels and respiratory emergency department (ED) visits has not been well studied. A recent investigation of the association between respiratory ED visits and various levels of ambient temperature was conducted in Beijing, China.

Methods: Daily meteorological data, air pollution data, and respiratory ED visits data from 2017 to 2018 were collected in Beijing.

Initiating PeriCBD to probe perinatal influences on neurodevelopment during 3-10 years in China.

Adverse perinatal factors can interfere with the normal development of the brain, potentially resulting in long-term effects on the comprehensive development of children. Presently, the understanding of cognitive and neurodevelopmental processes under conditions of adverse perinatal factors is substantially limited. There is a critical need for an open resource that integrates various perinatal factors with the development of the brain and mental health to facilitate a deeper understanding of these developmental trajectories.

Hybrid Sequencing-Based Genomic Analysis of from Urinary Tract Infections Among Inpatients at a Tertiary Hospital in Beijing.

Background: Urinary tract infection (UTI) associated with poses a serious threat for inpatients. This study aimed to describe the genomic characteristics of causing UTI in a tertiary-care hospital in Beijing, China.

Methods: A total of 20 strains collected from 2020 to 2021 were performed whole-genome sequencing.