Mechanically Heterogeneous Architecture Enables Robust and Ultrathin Bioelectronics for High-Fidelity Biosignal Monitoring.

High-fidelity biosignal monitoring is essential for daily health tracking and the diagnosis of chronic diseases. However, developing bioelectrodes capable of withstanding repeated use and mechanical deformation on wet tissue surfaces remains a significant challenge. Here, we present a robust and ultrathin bioelectrode (RUB), featuring a mechanically heterogeneous architecture and a thickness of ∼3 μm.

Multimodal Manipulation of Particles Based on Optothermal Controlled Marangoni Convection in Dynamic Microfluidics.

Optical manipulation techniques have been widely applied in the biomedical field. However, the key issues limiting the efficiency of optical manipulation techniques are the weak driving force of optical scattering and the small working range of optical gradient forces. The optothermal Marangoni convection enables effective control of flow fields through optical means, and particle manipulation based on this mechanism offers advantages such as a wide working range, strong driving force, and high flexibility.

UV2 and LW opsin genes mediate phototactic responses in the Asian lady beetle, Harmonia axyridis.

Phototaxis is a critical behavior in insects and is closely linked to vision and environmental adaptation. Understanding how insects perceive light and exhibit phototactic responses is crucial for assessing the ecological impact of artificial light at night. However, the molecular and neural mechanisms that regulate phototactic responses in insects remain largely unknown.

Research on statistical measure under double carbon target - Self-moving regression model of grey prediction based on entropy weight method.

Background: At the 2020 UN General Assembly, China pledged to peak carbon emissions before 2030 and achieve carbon neutrality by 2060. However, the traditional social development model has led to increasing carbon emissions annually, highlighting the need to resolve the contradiction between development and carbon reduction. This study examines the relationship between carbon emissions, economy, population, and energy consumption in a specific region to support carbon peak and neutrality goals.

Novel photocatalytic SrTiO@TiO/SrSO heterojunction and its high performance in RhB degradation.

Building a heterogeneous structure is favorable for improving the performance of photocatalyst materials. In this study, we fabricated a ternary SrTiO@TiO/SrSO heterojunction material with a porous shell composite structure a simple one-step direct high-temperature treatment using the commercial strontium titanate and ZnSO. The effect of the synthesis temperature on the ZS-STO- products was investigated.

Origin and mitigation of the imprint effect in hafnia-based ferroelectrics.

The potential of hafnia-based ferroelectric materials for Ferroelectric Random Access Memory (FeRAM) applications is limited by the imprint effect, which compromises readout reliability. Here, we systematically investigate the asymmetric imprint behavior in W/HfZrO/W ferroelectric capacitors, demonstrating that the imprint direction correlates directly with the ferroelectric polarization state. Notably, a pre-pulse of specific polarity can temporarily suppress the imprint effect.

Globular proteins as functional-mechanical materials: a multiscale perspective on design, processing, and applications.

Globular proteins, traditionally regarded as non-structural biomolecules due to the limited load-bearing capacity in their monomeric states, are increasingly recognized as valuable building blocks for functional-mechanical materials. Their inherent bioactivity, chemical versatility, and structural tunability enable the design of materials that combine biological functionality with tailored mechanical performance. This review highlights recent advances in engineering globular proteins-spanning natural systems (serum albumins, enzymes, milk globulins, silk sericin, and soy protein isolates) to recombinant architectures including tandem-repeat proteins-into functional-mechanical platforms.

Chronological differentiation of printed or handwritten text and stamps based on hyperspectral imaging and convolutional neural networks.

To address the technical challenges associated with determining the chronological order of overlapping stamps and textual content in forensic document examination, this study proposes a novel non-destructive method that integrates hyperspectral imaging (HSI) with convolutional neural networks (CNNs). A multi-type cross-sequence dataset was constructed, comprising 60 samples of handwriting-stamp sequences and 20 samples of printed text-stamp sequences, all subjected to six months of natural aging. Spectral responses were collected across the 400-1000 nm range in the overlapping regions.

The Transcription Factor MYB8 Positively Regulates Flavonoid Biosynthesis of Scutellaria baicalensis in Response to Drought Stress.

Drought stress dynamically reprograms specialised metabolism in medicinal plants. However, the transcriptional regulatory modules governing stress-adaptive metabolite synthesis remain poorly characterised. Here, we identified SbMYB8 as a drought-responsive transcription factor showing nuclear localisation and dose-dependent induction under drought in Scutellaria baicalensis.

Type-I Supramolecular Photosensitizer Enables GSH Depletion by Hydrogen Atom Transfer.

Photodynamic therapy (PDT) induces oxidative stress that triggers a compensatory upregulation of intracellular glutathione (GSH), thereby diminishing PDT efficacy. The simultaneous generation of reactive oxygen species and depletion of GSH holds promise for amplifying oxidative damage and enhancing therapeutic outcomes yet remains a challenge. In this work, we present a Type-I supramolecular photosensitizer designed to deplete GSH through a hydrogen atom transfer mechanism while concurrently generating superoxide radicals.

Recent Advances in P450 Enzyme Engineering for the Production of Natural Products.

Natural products exhibit a wide range of biological activities and are the crucial resources for drug development and compound modification. Cytochrome P450 enzymes (P450s, CYP) are a class of multifunctional and stereoselective biocatalysts that utilize heme as a cofactor and can be employed in the biosynthesis of natural products. With the development of biotechnology, P450s have been widely applied in the synthesis of natural products.

Discovery of Tricyclic Derivative as Novel and Potent Respiratory Syncytial Virus Fusion Glycoprotein Inhibitor with an Improved Pharmacokinetic Profile.

Respiratory syncytial virus (RSV) is a major pathogen causing acute respiratory infections, and the RSV fusion glycoprotein (F) has been identified as a key target for developing small-molecule inhibitors. Based on our prior identification of lonafarnib as an F protein inhibitor, medicinal chemistry efforts led to the development of , which exhibits significantly enhanced potency against both laboratory and clinical RSV isolates in cellular assays. Time-of-addition and SPR assays indicate that inhibits viral entry by targeting the RSV F protein, but has farnesyltransferase-independent antiviral efficacy.

In Situ Construction of Optical Resonators from MXene Inks for Highly Modifiable and Scalable Structural Colors.

Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for Structural colors offer distinct advantages over traditional chemical colors (such as pigments and dyes), including high saturation, resistance to fading, and environmental friendliness. However, unlike traditional dyes or pigments that allow for arbitrary color adjustments during the coloring process, current structural color surfaces lack flexibility in control, as their colors are difficult to reprocess or adjust once formed.

The Epigenetic Regulation of Agronomic Traits and Environmental Adaptability in Brassicas.

As essential sources of vegetables, oilseeds, and forage, Brassica crops exhibit complex epigenetic regulation mechanisms involving histone modifications, DNA modifications, RNA modifications, noncoding RNAs, and chromatin remodelling. The agronomic traits and environmental adaptability of crops are regulated by both genetic and epigenetic mechanisms, while epigenetic variation can affect plant phenotypes without changing gene sequences. Furthermore, the impact of epigenetic modifications on plant phenotype has accelerated the crop breeding process.

Continuous resonance Rayleigh scattering determination of titanium and iron ions using an FeO@MIP nanoprobe.

A novel magnetic nanostructured molecularly imprinted polymer probe (FeO@MIP) was developed for the continuous detection of Ti/Fe. The synthesis employed 50 nm FeO nanoparticles as the core matrix, with Ti and Fe serving as template molecules. Functional monomers α-methylacrylic acid (MAA) and acrylamide (AM) were used, along with ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent and 2,2'-azobisisobutyronitrile (AIBN) as the polymerization initiator, utilizing a microwave-assisted procedure.

Mitochondrial ClpX Inhibition Induces Ferroptosis and Blocks Pancreatic Cancer Cell Proliferation.

The ATPase caseinolytic protease X (ClpX), forming the ClpXP complex with caseinolytic protease P (ClpP), is essential for mitochondrial protein homeostasis. While ClpP targeting is a recognized anticancer strategy, the role of ClpX in cancer remains underexplored. In pancreatic ductal adenocarcinoma (PDAC), elevated CLPX expression correlates with poor prognosis, suggesting its oncogenic function.

Predictive role of loneliness on mortality before the age 85 years among mid- to later-life adults in the United States: a 10-year retrospective cohort study.

Aims: Loneliness is a common public health concern, particularly among mid- to later-life adults. However, its impact on early mortality (deaths occurring before reaching the oldest old age of 85 years) remains underexplored. This study examined the predictive role of loneliness on early mortality across different age groups using data from the Health and Retirement Study (HRS).

Enzyme-Click Postsynthetic Modification of Covalent Organic Frameworks for Photocatalytic HO Production.

Postsynthetic modification (PSM) is a powerful strategy for tailoring the structure and functionality of covalent organic frameworks (COFs). In this work, we present a novel enzymatic PSM strategy for functional group engineering within COFs. By taking advantage of enzymatic catalysis, 2-hydroxyethylthio (-S-EtOH) and ethylthio (-S-Et) groups were covalently implanted within the COF pore channels with high grafting efficiency under ambient aqueous conditions, highlighting the mild, efficient, and ecofriendly nature of this approach.

Diastereoselective Iron-Catalyzed [4 + 1] Cycloadditions of Imines with Sulfoxonium Ylides Enable Modular Synthesis of Oxazolidin-2-ones: O- versus N-Nucleophilic Attack.

Presented herein is a protocol for the iron-catalyzed [4 + 1] cycloadditions of -Boc-imines with β-ketosulfoxonum ylides through a succession of nucleophilic additions and intramolecular annulation, giving access to functionalized oxazolidine-2-ones in generally good yields. In contrast to the renown Corey-Chaykovsky reaction via N attack to furnish aziridines, this method afforded oxazolidine-2-ones via an O-nucleophilic attack. Features of this strategy include readily accessible starting materials, sustainable catalyst, post-functionalizations of complex molecules, scalability, and exceptional control over diastereoselectivity.

Covalently Supported Phenazine for Electrochemical Capture of Low Concentration CO.

Electrochemical CO capture (eCC) excels in selectivity, reversibility, low-temperature operation, and reusability, yet liquid-phase systems struggle with mass transfer limitations. In this study, a phenazine-based capture agent was chemically grafted onto carboxylated carbon nanotubes, achieving an active loading of 4.4 wt %.

Quality Difference Analysis of Pomegranate Peels Based on Multidimensional Fingerprint With Chemical Pattern Recognition.

To evaluate the quality of pomegranate peels from different cultivars, pomegranate peel samples from 47 cultivars were compared and classified based on fingerprints and chemical components obtained using HPLC-PDA-MS/MS combined with chemometric methods. Three pattern recognition methods, namely, hierarchical cluster analysis, principal component analysis, and partial least square-discriminant analysis, were used to establish classification models. Results showed that the contents of 10 components from pomegranate peel were determined.

Copper-Catalyzed Coupling of -Acyl-'-Substituted Hydrazines with (Hetero)aryl Chlorides/Bromides.

The coupling of -acyl-'-substituted hydrazines with (hetero)aryl bromides and chlorides is efficiently catalyzed by CuI/4-hydroxy picolinamide and Cu(OAc)/6-hydroxy picolinohydrazide, respectively. Under these conditions, a broad range of (hetero)aryl halides and -acyl-'-substituted hydrazines react smoothly at 80-120 °C, affording the corresponding products in good to excellent yields in most cases.